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A single type of progenitor cell maintains normal epidermis
Open accessAbstract
According to the current model of adult epidermal homeostasis, skin tissue is maintained by two discrete populations of progenitor cells: self-renewing stem cells; and their progeny, known as transit amplifying cells, which differentiate after several rounds of cell division. By making use of inducible genetic labelling, we have tracked the fate of a representative sample of progenitor cells in mouse tail epidermis at single-cell resolution in vivo at time intervals up to one year. Here we show that clone-size distributions are consistent with a new model of homeostasis involving only one type of progenitor cell. These cells are found to undergo both symmetric and asymmetric division at rates that ensure epidermal homeostasis. The results raise important questions about the potential role of stem cells on tissue maintenance in vivo.
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“adult epidermal homeostasis seems to rely solely on active stem cells34”
From Molecular regulation of stem cell quiescence (2013) · cites this paper as [34]
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Metadata
- Authors
- Clayton, E., Doupé, D. P., Klein, A. M., Winton, D. J., Simons, B. D., & Jones, P. H.
- Affiliations
- MRC Cancer Unit (GB)
- University of Cambridge (GB)
- Cancer Research UK (GB)
- Corresponding author
- Jones, Philip H.
- Venue
- Nature
- Published
- 2007-02-28
- Volume
- 446
- Issue
- 7132
- Pages
- 185-189
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1979812265
- Cited by
- 853
- References
- 29
- Citations by year
- 2026: 22 · 2025: 22 · 2024: 38 · 2023: 22 · 2022: 32 · 2021: 36 · 2020: 41 · 2019: 44 · 2018: 47 · 2017: 51 · 2016: 49 · 2015: 46 · 2014: 59 · 2013: 61 · 2012: 79
- FWCI
- 61.13
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Durham Research Online (Durham University) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- epidermal homeostasis, skin stem cells, progenitor cells, asymmetric cell division, symmetric cell division, transit amplifying cells, clone size distribution, tissue maintenance
- MeSH terms
- Epidermal Cells, Animals, Cell Differentiation, Cell Division, Clone Cells, Homeostasis, Models, Biological, Stem Cells, Cell Lineage, Mice
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