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Cited by 853Hair Growth and DisordersSkin and Cellular Biology ResearchDevelopmental Biology and Gene Regulation

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

A single type of progenitor cell maintains normal epidermis

Open access
Clayton, Elizabeth, Doupé, David P., Klein, Allon M., Winton, Douglas J., Simons, Benjamin D., Jones, Philip H.·2007·Nature
DOI 10.1038/nature05574
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Abstract

According to the current model of adult epidermal homeostasis, skin tissue is maintained by two discrete populations of progenitor cells: self-renewing stem cells; and their progeny, known as transit amplifying cells, which differentiate after several rounds of cell division. By making use of inducible genetic labelling, we have tracked the fate of a representative sample of progenitor cells in mouse tail epidermis at single-cell resolution in vivo at time intervals up to one year. Here we show that clone-size distributions are consistent with a new model of homeostasis involving only one type of progenitor cell. These cells are found to undergo both symmetric and asymmetric division at rates that ensure epidermal homeostasis. The results raise important questions about the potential role of stem cells on tissue maintenance in vivo.

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Crossref · 10.1038/nature05574

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Metadata

Authors
Clayton, E., Doupé, D. P., Klein, A. M., Winton, D. J., Simons, B. D., & Jones, P. H.
Affiliations
  • MRC Cancer Unit (GB)
  • University of Cambridge (GB)
  • Cancer Research UK (GB)
Corresponding author
Jones, Philip H.
ORCID
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2007-02-28
Volume
446
Issue
7132
Pages
185-189
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
DOI
10.1038/nature05574
OpenAlex
W1979812265
Cited by
853
References
29
Citations by year
2026: 22 · 2025: 22 · 2024: 38 · 2023: 22 · 2022: 32 · 2021: 36 · 2020: 41 · 2019: 44 · 2018: 47 · 2017: 51 · 2016: 49 · 2015: 46 · 2014: 59 · 2013: 61 · 2012: 79
FWCI
61.13
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • Durham Research Online (Durham University) (submittedVersion, cc-by)
Topics
  • Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
epidermal homeostasis, skin stem cells, progenitor cells, asymmetric cell division, symmetric cell division, transit amplifying cells, clone size distribution, tissue maintenance
MeSH terms
Epidermal Cells, Animals, Cell Differentiation, Cell Division, Clone Cells, Homeostasis, Models, Biological, Stem Cells, Cell Lineage, Mice

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