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SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation.
Abstract
In contrast to stably repressive, constitutive heterochromatin and stably active, euchromatin, facultative heterochromatin has the capacity to alternate between repressive and activated states of transcription. As such, it is an instructive source to understand the molecular basis for changes in chromatin structure that correlate with transcriptional status. Sirtuin 1 (SIRT1) and suppressor of variegation 3-9 homologue 1 (SUV39H1) are amongst the enzymes responsible for chromatin modulations associated with facultative heterochromatin formation. SUV39H1 is the principal enzyme responsible for the accumulation of histone H3 containing a tri-methyl group at its lysine 9 position (H3K9me3) in regions of heterochromatin. SIRT1 is an NAD+-dependent deacetylase that targets histone H4 at lysine 16 (refs 3 and 4), and through an unknown mechanism facilitates increased levels of H3K9me3 (ref. 3). Here we show that the mammalian histone methyltransferase SUV39H1 is itself targeted by the histone deacetylase SIRT1 and that SUV39H1 activity is regulated by acetylation at lysine residue 266 in its catalytic SET domain. SIRT1 interacts directly with, recruits and deacetylates SUV39H1, and these activities independently contribute to elevated levels of SUV39H1 activity resulting in increased levels of the H3K9me3 modification. Loss of SIRT1 greatly affects SUV39H1-dependent H3K9me3 and impairs localization of heterochromatin protein 1. These findings demonstrate a functional link between the heterochromatin-related histone methyltransferase SUV39H1 and the histone deacetylase SIRT1.
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“SUV39H1 function is also modulated by the SIRT1 deacetylase, which regulates SUV39H1 in two separate ways: (1) by deacetylating SUV39H1 lysine residue 266 (K266) (Vaquero et al., 2007) and (2) by deacetylating lysine 9 of histone H3 (H3K9Ac) to allow SUV39H1 methylation (Vaquero et al., 2004, 2007).”
From USP7 Is a Master Regulator of Genome Stability (2020) · cites this paper as Vaquero et al., 2007
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“SUV39H1 function is also modulated by the SIRT1 deacetylase, which regulates SUV39H1 in two separate ways: (1) by deacetylating SUV39H1 lysine residue 266 (K266) (Vaquero et al., 2007) and (2) by deacetylating lysine 9 of histone H3 (H3K9Ac) to allow SUV39H1 methylation (Vaquero et al., 2004, 2007).”
BackgroundDiverse lamin-dependent mechanisms interact to control chromatin dynamics
Camozzi, D., Capanni, C., Cenni, V., Mattioli, E., Columbaro, M., Squarzoni, S., & Lattanzi, G. (2014) · Nucleus · doi:10.4161/nucl.36289 · Cited by 118
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The conserved role of sirtuins in chromatin regulation
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Self-citationATM protein kinase: the linchpin of cellular defenses to stress
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Metadata
- Authors
- Vaquero, A., Scher, M., Erdjument-Bromage, H., Tempst, P., Serrano, L., & Reinberg, D.
- Affiliations
- Howard Hughes Medical Institute (US)
- Memorial Sloan Kettering Cancer Center (US)
- Rutgers, The State University of New Jersey (US)
- Corresponding author
- Reinberg, Danny
- Venue
- Nature
- Published
- 2007-11-15
- Volume
- 450
- Issue
- 7168
- Pages
- 440-444
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2012147370
- Cited by
- 439
- References
- 17
- Citations by year
- 2026: 17 · 2025: 17 · 2024: 22 · 2023: 11 · 2022: 24 · 2021: 20 · 2020: 23 · 2019: 20 · 2018: 24 · 2017: 32 · 2016: 16 · 2015: 29 · 2014: 24 · 2013: 36 · 2012: 32
- FWCI
- 8.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Keywords
- SIRT1, SUV39H1, facultative heterochromatin, heterochromatin formation, histone deacetylase, histone methyltransferase, H3K9me3, HP1, chromatin regulation, transcriptional repression
- MeSH terms
- Histone Methyltransferases, Acetylation, Amino Acid Sequence, Animals, Cell Line, Fibroblasts, HeLa Cells, Heterochromatin, Histones, Humans, Methyltransferases, Molecular Sequence Data, Niacinamide, Protein Binding, Histone-Lysine N-Methyltransferase, Protein Methyltransferases, Repressor Proteins, Sirtuins, Chromatin Assembly and Disassembly, Mice, Sirtuin 1
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