The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Photon capture and signalling by melanopsin retinal ganglion cells
Open accessAbstract
A subset of retinal ganglion cells has recently been discovered to be intrinsically photosensitive, with melanopsin as the pigment. These cells project primarily to brain centres for non-image-forming visual functions such as the pupillary light reflex and circadian photoentrainment. How well they signal intrinsic light absorption to drive behaviour remains unclear. Here we report fundamental parameters governing their intrinsic light responses and associated spike generation. The membrane density of melanopsin is 104-fold lower than that of rod and cone pigments, resulting in a very low photon catch and a phototransducing role only in relatively bright light. Nonetheless, each captured photon elicits a large and extraordinarily prolonged response, with a unique shape among known photoreceptors. Notably, like rods, these cells are capable of signalling single-photon absorption. A flash causing a few hundred isomerized melanopsin molecules in a retina is sufficient for reaching threshold for the pupillary light reflex.
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Phototransduction by retinal ganglion cells that set the circadian clock
Berson, D. M., Dunn, F. A., & Takao, M. (2002) · Science · doi:10.1126/science.1067262 · Cited by 3,629
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Responses of retinal rods to single photons.
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Self-citationMelanopsin: An opsin in melanophores, brain, and eye
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Melanopsin cells are the principal conduits for rod–cone input to non-image-forming vision
Güler, A. D., Ecker, J. L., Lall, G. S., Haq, S., Altimus, C. M., Liao, H.-W., Barnard, A. R., Cahill, H., Badea, T. C., Zhao, H., et al. (2008) · Nature · doi:10.1038/nature06829 · Cited by 876
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Cited by
Measuring and using light in the melanopsin age
Lucas, R. J., Peirson, S. N., Berson, D. M., Brown, T. M., Cooper, H. M., Czeisler, C. A., Figueiro, M. G., Gamlin, P. D., Lockley, S. W., O’Hagan, J. B., et al. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2013.10.004 · Cited by 1,278
The RNA binding protein RBPMS is a selective marker of ganglion cells in the mammalian retina
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“Specificity of this antibody has been shown by immunostaining of the tdTomato-fluorescent cells in the melanopsin:tdTomato mouse retina (Do et al., 2009).”
BackgroundMelanopsin and the Intrinsically Photosensitive Retinal Ganglion Cells: Biophysics to Behavior
Do, M. T. H. (2019) · Neuron · doi:10.1016/j.neuron.2019.07.016 · Cited by 312
Self-citationMammalian Near-Infrared Image Vision through Injectable and Self-Powered Retinal Nanoantennae
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Metadata
- Authors
- Do, M. T. H., Kang, S. H., Xue, T., Zhong, H., Liao, H.-W., Bergles, D. E., & Yau, K.-W.
- Venue
- Nature
- Published
- 2008-12-31
- Volume
- 457
- Issue
- 7227
- Pages
- 281-287
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2081024860
- Cited by
- 306
- References
- 50
- FWCI
- 5.91
- Type
- journal article
- Language
- en
- Open access
- green
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