The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Common variants conferring risk of schizophrenia
Open accessAbstract
Schizophrenia is a complex disorder, caused by both genetic and environmental factors and their interactions. Research on pathogenesis has traditionally focused on neurotransmitter systems in the brain, particularly those involving dopamine. Schizophrenia has been considered a separate disease for over a century, but in the absence of clear biological markers, diagnosis has historically been based on signs and symptoms. A fundamental message emerging from genome-wide association studies of copy number variations (CNVs) associated with the disease is that its genetic basis does not necessarily conform to classical nosological disease boundaries. Certain CNVs confer not only high relative risk of schizophrenia but also of other psychiatric disorders. The structural variations associated with schizophrenia can involve several genes and the phenotypic syndromes, or the 'genomic disorders', have not yet been characterized. Single nucleotide polymorphism (SNP)-based genome-wide association studies with the potential to implicate individual genes in complex diseases may reveal underlying biological pathways. Here we combined SNP data from several large genome-wide scans and followed up the most significant association signals. We found significant association with several markers spanning the major histocompatibility complex (MHC) region on chromosome 6p21.3-22.1, a marker located upstream of the neurogranin gene (NRGN) on 11q24.2 and a marker in intron four of transcription factor 4 (TCF4) on 18q21.2. Our findings implicating the MHC region are consistent with an immune component to schizophrenia risk, whereas the association with NRGN and TCF4 points to perturbation of pathways involved in brain development, memory and cognition.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Further, results from SGENE+ 60 implicate NRGN (neurogranin) which may act as a calcium sensor. 61”
From Genetic architectures of psychiatric disorders: the emerging picture and its implications (2012) · cites this paper as [61]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482
Inference of Population Structure Using Multilocus Genotype Data
Pritchard, J. K., Stephens, M., & Donnelly, P. (2000) · Genetics · doi:10.1093/genetics/155.2.945 · Cited by 33,871
Statistical Aspects of the Analysis of Data From Retrospective Studies of Disease
(1959) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/22.4.719 · Cited by 14,689
A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
Statistical Methods for Research Workers
Fisher, R. A. (1945) · American Journal of Clinical Pathology · doi:10.1093/ajcp/15.11.552b · Cited by 10,883
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442
Self-citationCommon polygenic variation contributes to risk of schizophrenia and bipolar disorder
The International Schizophrenia Consortium (2009) · Nature · doi:10.1038/nature08185 · Cited by 4,821
Genomic Control for Association Studies
Devlin, B., & Roeder, K. (1999) · Biometrics · doi:10.1111/j.0006-341x.1999.00997.x · Cited by 3,162
The Wellcome Trust Case Control Consortium, U.K.
Mossman, K. (2008) · Scientific American · doi:10.1038/scientificamerican0108-42a · Cited by 2,714
Large recurrent microdeletions associated with schizophrenia.
GROUP, Stefansson, H., Rujescu, D., Cichon, S., Pietiläinen, O. P. H., Ingason, A., Steinberg, S., Fossdal, R., Sigurdsson, E., Sigmundsson, T., et al. (2008) · Nature · doi:10.1038/nature07229 · Cited by 1,745
Self-citation
Cited by
Sorted by citations
Items 401–500 of 1,001
Guan, F., Zhang, T., Liu, X., Han, W., Lin, H., Li, L., Chen, G., & Li, T. (2016) · Scientific Reports · doi:10.1038/srep24914 · Cited by 70
The immunobiology of autoimmune encephalitides
Alexopoulos, H., & Dalakas, M. C. (2019) · Journal of Autoimmunity · doi:10.1016/j.jaut.2019.102339 · Cited by 73
The future of fMRI and genetics research
Meyer‐Lindenberg, A. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.10.063 · Cited by 71
Khandaker, G. M., Štochl, J., Zammit, S., Lewis, G., & Jones, P. B. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.05.019 · Cited by 71
Pathway-based analysis of GWAS datasets: effective but caution required
Jia, P., Wang, L., Meltzer, H. Y., & Zhao, Z. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710001446 · Cited by 72
Beyond the facts in schizophrenia: closing the gaps in diagnosis, pathophysiology, and treatment
Nasrallah, H. A., Tandon, R., & Keshavan, M. S. (2011) · Epidemiology and Psychiatric Sciences · doi:10.1017/s204579601100062x · Cited by 73
Wirgenes, K. V., Sønderby, I. E., Haukvik, U. K., Mattingsdal, M., Tesli, M., Athanasiu, L., Sundet, K. S., Røssberg, J. I., Dale, A. M., Brown, A. A., et al. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.39 · Cited by 71
Self-citationCostas, J., Sanjuán, J., Ramos‐Ríos, R., Paz, E., Agra, S., Ivorra, J. L., Páramo, M., Brenlla, J., & Arrojo, M. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.04.021 · Cited by 73
Self-citationKumarasinghe, N., Beveridge, N. J., Gardiner, E. J., Scott, R. J., Yasawardene, S. G., Perera, A., Mendis, J., Suriyakumara, K., Schall, U., & Tooney, P. A. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000035 · Cited by 70
Targeted SNP Genotyping Using the TaqMan® Assay
Schleinitz, D., DiStefano, J. K., & Kovacs, P. L. (2010) · Methods in molecular biology · doi:10.1007/978-1-61737-954-3_6 · Cited by 77
Jia, P., Wang, L., Fanous, A. H., Chen, X., Kendler, K. S., & Zhao, Z. (2011) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2011-100397 · Cited by 69
miRNA genes and the brain: implications for psychiatric disordersa
Forero, D. A., van der Ven, K., Callaerts, P., & Del‐Favero, J. (2010) · Human Mutation · doi:10.1002/humu.21344 · Cited by 71
Transcriptome sequencing of the choroid plexus in schizophrenia
Kim, S., Hwang, Y., Lee, D., & Webster, M. J. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.229 · Cited by 70
Buizer-Voskamp, J. E., Muntjewerff, J.-W., Strengman, E., Sabatti, C., Stefansson, H., Vorstman, J. A. S., & Ophoff, R. A. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.02.015 · Cited by 68
Self-citationBlomström, Å., Karlsson, H., Wicks, S., Yang, S., Yolken, R. H., & Dalman, C. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.06.035 · Cited by 68
van de Leemput, J., Hess, J., Glatt, S. J., & Tsuang, M. T. (2016) · Advances in genetics · doi:10.1016/bs.adgen.2016.08.001 · Cited by 71
Genetics of schizophrenia: A consensus paper of the WFSBP Task Force on Genetics
Giegling, I., Hosák, L., Mößner, R., Serretti, A., Bellivier, F., Claes, S. J., Collier, D. A., Corrales, A., DeLisi, L. E., Gallo, C., et al. (2017) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2016.1268715 · Cited by 76
Self-citationChang, H., Xiao, X., & Li, M. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.19 · Cited by 66
Liu, Y., Chang, X., Hahn, C.-G., Gur, R. E., Abou‐Sleiman, P. M., & Hakonarson, H. H. (2018) · Translational Psychiatry · doi:10.1038/s41398-017-0030-5 · Cited by 69
Roles of glial cells in schizophrenia: Possible targets for therapeutic approaches
Takahashi, N., & Sakurai, T. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.11.001 · Cited by 67
Blomstrom, A., Karlsson, H., Svensson, A. C., Frisell, T., Lee, B. K., Dal, H., Magnusson, C., & Dalman, C. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt195 · Cited by 68
Hollegaard, M. V., Bybjerg‐Grauholm, J., Nielsen, R., Grove, J., Mandrup, S., & HOUGAARD, D. M. (2013) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2013.06.004 · Cited by 66
Self-citationPouget, J. G., Gonçalves, V. F., Spain, S. L., Finucane, H. K., Raychaudhuri, S., Kennedy, J. L., & Knight, J. (2016) · Schizophrenia Bulletin · doi:10.1093/schbul/sbw059 · Cited by 71
Labad, J. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.11.028 · Cited by 67
Neurogranin Alters the Structure and Calcium Binding Properties of Calmodulin
Hoffman, L., Chandrasekar, A., Wang, X., Putkey, J. A., & Waxham, M. N. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.560656 · Cited by 66
The major histocompatibility complex and autism spectrum disorder
Needleman, L. A., & McAllister, A. K. (2012) · Developmental Neurobiology · doi:10.1002/dneu.22046 · Cited by 66
The Neuroimmunology of Schizophrenia
Annya, M., Smyth, Stephen, M., & Lawrie, S. M. (2013) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2013.11.3.107 · Cited by 68
Transcription factor 4 (TCF4) and schizophrenia: integrating the animal and the human perspective
Quednow, B. B., Brzózka, M. M., & Rossner, M. J. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1553-4 · Cited by 65
Inflammation Theories in Psychotic Disorders: A Critical Review
Suvisaari, J., & Mantere, O. (2013) · Infectious Disorders - Drug Targets · doi:10.2174/18715265112129990032 · Cited by 68
Self-citationCopy number variation in the cattle genome
Liu, G. E., & Bickhart, D. M. (2012) · Functional & Integrative Genomics · doi:10.1007/s10142-012-0289-9 · Cited by 66
Exon‐disrupting deletions of NRXN1 in idiopathic generalized epilepsy
Møller, R. S., Weber, Y. G., Klitten, L. L., Trucks, H., Muhle, H., Kunz, W. S., Mefford, H. C., Franke, A., Kautza, M., Wolf, P., et al. (2013) · Epilepsia · doi:10.1111/epi.12078 · Cited by 69
The Presynaptic Component of the Serotonergic System is Required for Clozapine's Efficacy
Yadav, P. N., Abbas, A. I., Farrell, M. S., Setola, V., Sciaky, N., Huang, X., Kroeze, W. K., Crawford, L. K., Piel, D., Keiser, M. J., et al. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.195 · Cited by 65
Erhardt, S., Pocivavsek, A., Repici, M., Liu, X.-C., Imbeault, S., Maddison, D. C., Thomas, M. A. R., Smalley, J. L., Larsson, M. K., Muchowski, P. J., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.12.011 · Cited by 66
Association Between Substance Use Disorder and Polygenic Liability to Schizophrenia
Hartz, S. M., Horton, A. C., Oehlert, M. E., Carey, C. E., Arpana Agrawal, A., Bogdan, R., Chen, L., Hancock, D. B., Johnson, E. O., Pato, C. N., et al. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.04.020 · Cited by 66
Trinucleotide Repeat Expansion in the TCF4 Gene in Fuchs' Endothelial Corneal Dystrophy in Japanese
Nakano, M., Okumura, N., Nakagawa, H., Koizumi, N., Ikeda, Y., Ueno, M., Yoshii, K., Adachi, H., Aleff, R. A., Butz, M. L., et al. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-17082 · Cited by 65
Tezuka, T., Tamura, M., Kondo, M. A., Sakaue, M., Okada, K., Takemoto, K., Fukunari, A., Miwa, K., Ohzeki, H., Kano, S.-I., et al. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.07.003 · Cited by 64
Li, Y., Zhou, K., Zhang, Z., Sun, L., Yang, J., Zhang, M., Ji, B., Tang, K., Wei, Z., He, G., et al. (2012) · Molecular BioSystems · doi:10.1039/c2mb25158b · Cited by 65
Substance Use Disorders: Realizing the Promise of Pharmacogenomics and Personalized Medicine
Hutchison, K. E. (2010) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.121208.131441 · Cited by 64
de Jong, S., van Eijk, K. R., Zeegers, D. W. L. H., Strengman, E., Janson, E., Veldink, J. H., van den Berg, L. H., Cahn, W., Kahn, R. S., Boks, M. P., et al. (2012) · European Journal of Human Genetics · doi:10.1038/ejhg.2012.38 · Cited by 64
Self-citationImmune and Neuroimmune Alterations in Mood Disorders and Schizophrenia
Drexhage, R. C., Weigelt, K., van Beveren, N., Cohen, D., Versnel, M. A., Nolen, W. A., & Drexhage, H. A. (2011) · International Review of Neurobiology · doi:10.1016/b978-0-12-387718-5.00007-9 · Cited by 71
Schmitt, A., Leonardi‐Essmann, F., Durrenberger, P. F., Parlapani, E., Schneider-Axmann, T., Spanagel, R., Arzberger, T., Kretzschmar, H. A., Herrera‐Marschitz, M., Gruber, O., et al. (2010) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2010.530690 · Cited by 64
Debnath, M., Cannon, D. M., & Venkatasubramanian, G. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.07.009 · Cited by 67
Frank, R. A. W., McRae, A. F., Pocklington, A. J., van de Lagemaat, L. N., Navarro, P., Croning, M. D. R., Komiyama, N. H., Bradley, S. J., Challiss, R. A. J., Armstrong, J. D., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019011 · Cited by 66
Schizophrenia: Treatment Targets Beyond Monoamine Systems
Ibrahim, H. M., & Tamminga, C. A. (2011) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.010909.105851 · Cited by 63
Inflammatory, cardio-metabolic and diabetic profiling of chronic schizophrenia
Balõtšev, R., Koido, K., Vasar, V., Janno, S., Kriisa, K., Mahlapuu, R., Ljubajev, U., Parksepp, M., Veiksaar, P., Volke, V., et al. (2017) · European psychiatry · doi:10.1016/j.eurpsy.2016.05.010 · Cited by 63
Genomic Analysis of Mental Illness: A Changing Landscape
McClellan, J., & King, M.-C. (2010) · JAMA · doi:10.1001/jama.2010.869 · Cited by 63
Genome-Wide Association Study of Multiplex Schizophrenia Pedigrees
Levinson, D. F., Shi, J., Wang, K., Oh, S., Riley, B. P., Pulver, A. E., Wildenauer, D. B., Laurent‐Levinson, C., Mowry, B. J., Gejman, P. V., et al. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.11091423 · Cited by 63
Walters, J., Rujescu, D., Franke, B., Giegling, I., Vásquez, A. A., Hargreaves, A., Russo, G., Morris, D. W., Hoogman, M., Costa, A. D., et al. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.12020226 · Cited by 62
Self-citationGenome-Wide Association Study of Treatment Refractory Schizophrenia in Han Chinese
Liou, Y., Wang, H.-H., Lee, M. M., Wang, S., Chiang, H., Chen, C., Lin, C., Chung, M.-S., Kuo, C.-C., Liao, D., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033598 · Cited by 63
Khandaker, G. M., Zammit, S., Lewis, G., & Jones, P. B. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.09.021 · Cited by 63
Tamouza, R., Krishnamoorthy, R., & Leboyer, M. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.09.033 · Cited by 62
The Molecular Basis of Wnt/β-Catenin Signaling Pathways in Neurodegenerative Diseases
Anand, A. A., Khan, M., Monica, V., & Kar, D. (2023) · International Journal of Cell Biology · doi:10.1155/2023/9296092 · Cited by 64
van Eijk, K. R., de Jong, S., Strengman, E., Buizer‐Voskamp, J. E., Kahn, R. S., Boks, M. P., Horvath, S., & Ophoff, R. A. (2014) · European Journal of Human Genetics · doi:10.1038/ejhg.2014.245 · Cited by 64
Self-citationAn integrated genomic analysis of gene-function correlation on schizophrenia susceptibility genes
Chu, T., & Liu, Y. (2010) · Journal of Human Genetics · doi:10.1038/jhg.2010.24 · Cited by 62
Evidence for Shared Genetic Risk Between Methamphetamine-Induced Psychosis and Schizophrenia
Ikeda, M., Okahisa, Y., Aleksić, B., Won, M., Kondo, N., Naruse, N., Aoyama‐Uehara, K., Sora, I., Iyo, M., Hashimoto, R., et al. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.94 · Cited by 64
A large genome scan for rare CNVs in amyotrophic lateral sclerosis
Blauw, H. M., Al‐Chalabi, A., Andersen, P. M., van Vught, P. W. J., Diekstra, F. P., van Es, M. A., Saris, C. G. J., Groen, E. J. N., van Rheenen, W., Koppers, M., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq323 · Cited by 63
Self-citationDrosophila as a Model Organism for the Study of Neuropsychiatric Disorders
O’Kane, C. J. (2011) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_110 · Cited by 62
Numata, S., Ye, T., Herman, M., & Lipska, B. K. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00280 · Cited by 70
Pharmacogenetics of antipsychotics: recent progress and methodological issues
Zhang, J., & Malhotra, A. K. (2012) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2013.736964 · Cited by 61
Nakamura, T., & Takata, A. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02005-2 · Cited by 72
Epigenetic signaling in schizophrenia
Ibi, D., & González‐Maeso, J. (2015) · Cellular Signalling · doi:10.1016/j.cellsig.2015.06.003 · Cited by 62
Evidence of Sex-Modulated Association of ZNF804A with Schizophrenia
Zhang, F., Chen, Q., Ye, T., Lipska, B. K., Straub, R. E., Vakkalanka, R., Rujescu, D., Clair, D. S., Hyde, T. M., Bigelow, L. B., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.01.003 · Cited by 61
Self-citationGenetics of psychiatric disorders in the GWAS era: an update on schizophrenia
Schwab, S. G., & Wildenauer, D. B. (2013) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-013-0450-z · Cited by 61
Glatt, S. J., Stone, W. S., Nossova, N., Liew, C., Seidman, L. J., & Tsuang, M. T. (2011) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31239 · Cited by 61
Homberg, J. R., Kyzar, E. J., Scattoni, M. L., Norton, W., Pittman, J. T., Gaikwad, S., Nguyen, M., Poudel, M. K., Ullmann, J. F. P., Diamond, D. M., et al. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.04.015 · Cited by 67
Group II Metabotropic Glutamate Receptors as Targets for Novel Antipsychotic Drugs
Muguruza, C., Meana, J. J., & Callado, L. F. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00130 · Cited by 61
Karis, K., Eskla, K., Kaare, M., Täht, K., Tuusov, J., Visnapuu, T., Innos, J., Jayaram, M., Timmusk, T., Weickert, C. S., et al. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00008 · Cited by 60
Druart, M., Nosten‐Bertrand, M., Poll, S., Crux, S., Nebeling, F. C., Delhaye, C., Dubois, Y., Mittag, M., Leboyer, M., Tamouza, R., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01081-6 · Cited by 60
New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis
Lee, S., Byrne, E. M., Hultman, C. M., Kähler, A. K., Vinkhuyzen, A. A. E., Ripke, S., Andreassen, O. A., Frisell, T., Gusev, A., Hu, X., et al. (2015) · International Journal of Epidemiology · doi:10.1093/ije/dyv136 · Cited by 60
Self-citationGenetic Association Studies of Antioxidant Pathway Genes and Schizophrenia
Chowdari, K. V., Bamne, M. N., & Nimgaonkar, V. L. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3508 · Cited by 60
Costas, J., Sanjuán, J., Ramos‐Ríos, R., Paz, E., Agra, S., Tolosa, A., Páramo, M., Brenlla, J., & Arrojo, M. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.01.014 · Cited by 60
Self-citationSellgren, C. M., Frisell, T., Lichtenstein, P., Landén, M., & Askling, J. (2014) · Schizophrenia Bulletin · doi:10.1093/schbul/sbu054 · Cited by 58
Cattane, N., Mora, C., Lopizzo, N., Borsini, A., Maj, C., Pedrini, L., Rossi, R., Riva, M. A., Pariante, C. M., & Cattaneo, A. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2018.07.030 · Cited by 60
A polygenic resilience score moderates the genetic risk for schizophrenia
Hess, J., Tylee, D. S., Mattheisen, M., Børglum, A. D., Als, T. D., Grove, J., Werge, T. M., Mortensen, P. B., Mors, O. N., Nordentoft, M., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0463-8 · Cited by 60
Self-citationMistry, M., Gillis, J., & Pavlidis, P. (2013) · BMC Neuroscience · doi:10.1186/1471-2202-14-105 · Cited by 59
Do Neuronal Autoantibodies Cause Psychosis? A Neuroimmunological Perspective
Coutinho, E., Harrison, P. J., & Vincent, A. C. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.07.040 · Cited by 58
MicroRNAs in the Onset of Schizophrenia
Thomas, K. T., & Zakharenko, S. S. (2021) · Cells · doi:10.3390/cells10102679 · Cited by 64
Genetics in schizophrenia: where are we and what next?
Tiwari, A. K., Zai, C. C. H., Müller, D. J., & Kennedy, J. L. (2010) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2010.12.3/atiwari · Cited by 60
Severance, E., Gressitt, K., Alaedini, A., Rohleder, C., Enning, F., Bumb, J. M., Müller, J. K., Schwarz, E., Yolken, R., & Leweke, F. M. (2014) · Brain, behavior, and immunity · doi:10.1016/j.bbi.2014.09.009 · Cited by 60
Ingason, A., Giegling, I., Cichon, S., Hansen, T. F., Rasmussen, H. B., Nielsen, J., Jűrgens, G., Muglia, P., Hartmann, A. M., Strengman, E., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq009 · Cited by 59
Self-citationRecent advances in understanding schizophrenia
Haller, C. S., Padmanabhan, J. L., Lizano, P. L., Torous, J. B., & Keshavan, M. S. (2014) · F1000Prime Reports · doi:10.12703/p6-57 · Cited by 65
Kéri, S., Szabó, C. A., & Kelemen, O. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.12.011 · Cited by 59
Epigenomics of Major Depressive Disorders and Schizophrenia: Early Life Decides
Hoffmann, A., Sportelli, V., Ziller, M. J., & Spengler, D. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18081711 · Cited by 65
Brain Lipids and Lipid Droplet Dysregulation in Alzheimer’s Disease and Neuropsychiatric Disorders
Zhao, X., Zhang, S., Sanders, A. R., & Duan, J. (2023) · Complex Psychiatry · doi:10.1159/000535131 · Cited by 54
The Genome in Three Dimensions: A New Frontier in Human Brain Research
Mitchell, A., Bharadwaj, R. A., Whittle, C., Krueger, W. H., Mirnics, K., Hurd, Y. L., Rasmussen, T. P., & Akbarian, S. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.07.015 · Cited by 58
Comparison of the Heritability of Schizophrenia and Endophenotypes in the COGS-1 Family Study
Light, G. A., Greenwood, T. A., Swerdlow, N. R., Calkins, M. E., Freedman, R., Green, M. F., Gur, R. C., Gur, R. C., Lazzeroni, L. C., Nuechterlein, K. H., et al. (2014) · Schizophrenia Bulletin · doi:10.1093/schbul/sbu064 · Cited by 60
Sanders, A. R., Drigalenko, E. I., Duan, J., Moy, W., Freda, J., Göring, H. H. H., Gejman, P. V., & on behalf of, M. G. S. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.47 · Cited by 58
The complement system in neurodegenerative diseases
Nimmo, J., Byrne, R. A. J., Daskoulidou, N., Watkins, L. M., Carpanini, S. M., Zelek, W. M., & Morgan, B. P. (2024) · Clinical Science · doi:10.1042/cs20230513 · Cited by 60
Heterogeneity of schizophrenia: Genetic and symptomatic factors
Takahashi, S. (2013) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32161 · Cited by 58
Costas, J., Carrera, N., Alonso, P., Gurriarán, X., Segalàs, C., Real, E., López‐Solà, C., Mas, S., Gassó, P., Domènech, L., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.34 · Cited by 58
Self-citationJonathan Flint, C., & Munafo, M. R. (2014) · Nature · doi:10.1038/nature13645 · Cited by 57
DOCK4 and CEACAM21 as novel schizophrenia candidate genes in the Jewish population
Alkelai, A., Lupoli, S., Greenbaum, L., Kohn, Y., Kanyas, K., Ben‐Asher, E., Lancet, D., Macciardi, F. M., & Lerer, B. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711000903 · Cited by 57
HLA Immune Function Genes in Autism
Torres, A., Westover, J. B., & Rosenspire, A. J. (2012) · Autism Research and Treatment · doi:10.1155/2012/959073 · Cited by 59
Liaury, K., Miyaoka, T., Tsumori, T., Furuya, M., Wake, R., Ieda, M., Tsuchie, K., Taki, M., Ishihara, K., Tanra, A. J., et al. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-56 · Cited by 56
Tandon, N., Shah, J. L., Keshavan, M. S., & Tandon, R. (2012) · Neuropsychiatry · doi:10.2217/npy.12.36 · Cited by 60
The Psychosis Susceptibility Gene ZNF804A: Associations, Functions, and Phenotypes
Donohoe, G. J., Morris, D. W., & Corvin, A. P. (2010) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq080 · Cited by 58
Wang, X., Gu, Z., & Jiang, H. (2013) · animal · doi:10.1017/s1751731113001183 · Cited by 58
Imaging genetics of schizophrenia
Meyer‐Lindenberg, A. (2010) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2010.12.4/amlindenberg · Cited by 57
Genes and environments in schizophrenia: The different pieces of a manifold puzzle
Réthelyi, J., Benkovits, J., & Bitter, I. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.04.010 · Cited by 56
Self-citationNeural stem cells: mechanisms and modeling
Yao, J., Mu, Y., & Gage, F. H. (2012) · Protein & Cell · doi:10.1007/s13238-012-2033-6 · Cited by 61
Metadata
- Authors
- †Genetic Risk and Outcome in Psychosis (GROUP), Stefansson, H., Ophoff, R. A., Steinberg, S., Andreassen, O. A., Cichon, S., Rujescu, D., Werge, T., Pietiläinen, O. P. H., Mors, O., Mortensen, P. B., Sigurdsson, E., Gustafsson, O., Nyegaard, M., Tuulio-Henriksson, A., Ingason, A., Hansen, T., Suvisaari, J., Lonnqvist, J., Paunio, T., Børglum, A. D., Hartmann, A., Fink-Jensen, A., Nordentoft, M., Hougaard, D., Norgaard-Pedersen, B., Böttcher, Y., Olesen, J., Breuer, R., Möller, H.-J., Giegling, I., Rasmussen, H. B., Timm, S., Mattheisen, M., Bitter, I., Réthelyi, J. M., Magnusdottir, B. B., Sigmundsson, T., Olason, P., Masson, G., Gulcher, J. R., Haraldsson, M., Fossdal, R., Thorgeirsson, T. E., Thorsteinsdottir, U., Ruggeri, M., Tosato, S., Franke, B., Strengman, E., Kiemeney, L. A., Melle, I., Djurovic, S., Abramova, L., Kaleda, V., Sanjuan, J., de Frutos, R., Bramon, E., Vassos, E., Fraser, G., Ettinger, U., Picchioni, M., Walker, N., Toulopoulou, T., Need, A. C., Ge, D., Lim Yoon, J., Shianna, K. V., Freimer, N. B., Cantor, R. M., Murray, R., Kong, A., Golimbet, V., Carracedo, A., Arango, C., Costas, J., Jönsson, E. G., Terenius, L., Agartz, I., Petursson, H., Nöthen, M. M., Rietschel, M., Matthews, P. M., Muglia, P., Peltonen, L., St Clair, D., Goldstein, D. B., Stefansson, K., & Collier, D. A.
- Affiliations
- deCODE Genetics (Iceland) (IS)
- University of Bonn (DE)
- Sankt Hans Hospital (DK)
- Aarhus University Hospital (DK)
- Aarhus University (DK)
- Copenhagen University Hospital (DK)
- Statens Serum Institut (DK)
- Heidelberg University (DE)
- Ludwig-Maximilians-Universität München (DE)
- Semmelweis University (HU)
- University of Verona (IT)
- Radboud University Medical Center (NL)
- University of Oslo (NO)
- Mental Health Research Center of Russian Academy of Medical Sciences (RU)
- King's College London (GB)
- Duke University (US)
- University of California, Los Angeles (US)
- Hospital General Universitario Gregorio Marañón (ES)
- Karolinska Institutet (SE)
- University of Iceland (IS)
- GlaxoSmithKline (United Kingdom) (GB)
- Wellcome Sanger Institute (GB)
- University of Aberdeen (GB)
- ORCID
- Ophoff, Roel A.
- Steinberg, Stacy
- Andreassen, Ole A.
- Cichon, Sven
- Rujescu, Dan
- Werge, Thomas
- Pietiläinen, Olli P. H.
- Mors, Ole
- Mortensen, Preben B.
- Nyegaard, Mette
- Hansen, Thomas
- Suvisaari, Jaana
- Paunio, Tiina
- Børglum, Anders D.
- Hartmann, Annette
- Nordentoft, Merete
- Hougaard, David
- Böttcher, Yvonne
- Olesen, Jes
- Möller, Hans-Jürgen
- Giegling, Ina
- Mattheisen, Manuel
- Bitter, István
- Réthelyi, János M.
- Olason, Pall
- Haraldsson, Magnus
- Thorgeirsson, Thorgeir E.
- Ruggeri, Mirella
- Tosato, Sarah
- Franke, Barbara
- Strengman, Eric
- Kiemeney, Lambertus A.
- Melle, Ingrid
- Djurovic, Srdjan
- Bramon, Elvira
- Vassos, Evangelos
- Ettinger, Ulrich
- Picchioni, Marco
- Need, Anna C.
- Ge, Dongliang
- Freimer, Nelson B.
- Cantor, Rita M.
- Murray, Robin
- Kong, Augustine
- Arango, Celso
- Costas, Javier
- Jönsson, Erik G.
- Terenius, Lars
- Agartz, Ingrid
- Nöthen, Markus M.
- Rietschel, Marcella
- Matthews, Paul M.
- Muglia, Pierandrea
- Peltonen, Leena
- Goldstein, David B.
- Collier, David A.
- Venue
- Nature
- Published
- 2009-07-01
- Volume
- 460
- Issue
- 7256
- Pages
- 744-747
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3077530
- OpenAlex
- W2127205775
- Cited by
- 1,677
- References
- 39
- Citations by year
- 2026: 21 · 2025: 39 · 2024: 47 · 2023: 38 · 2022: 47 · 2021: 65 · 2020: 62 · 2019: 66 · 2018: 56 · 2017: 90 · 2016: 116 · 2015: 148 · 2014: 140 · 2013: 165 · 2012: 196
- FWCI
- 116.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Lirias (KU Leuven) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- VU Research Portal (submittedVersion)
- Hirsla (Landspítali University Hospital) (submittedVersion, other-oa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Funders
- GlaxoSmithKline
- Wellcome Trust (089061)
- National Institute for Health and Care Research (PDA/02/06/016)
- Bundesministerium für Bildung und Forschung (NGFN-2)
- Alfried Krupp von Bohlen und Halbach-Stiftung
- National Institutes of Health (6r01hl087679-03)
- National Heart, Lung, and Blood Institute (R01 HL087679, 1-R01HL087679-01)
- National Institute of Mental Health (R01MH078075, MH078075)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Keywords
- schizophrenia, genetic susceptibility, single nucleotide polymorphisms, copy number variation, major histocompatibility complex, neurogranin, TCF4, immune function, brain development, memory and cognition, mental illness
- MeSH terms
- Transcription Factor 4, Chromosomes, Human, Pair 11, Chromosomes, Human, Pair 18, Chromosomes, Human, Pair 6, DNA-Binding Proteins, Genetic Markers, Genotype, Humans, Major Histocompatibility Complex, Schizophrenia, Transcription Factors, Genome, Human, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Neurogranin, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Genome-Wide Association Study
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
