The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Common variants conferring risk of schizophrenia
Open accessAbstract
Schizophrenia is a complex disorder, caused by both genetic and environmental factors and their interactions. Research on pathogenesis has traditionally focused on neurotransmitter systems in the brain, particularly those involving dopamine. Schizophrenia has been considered a separate disease for over a century, but in the absence of clear biological markers, diagnosis has historically been based on signs and symptoms. A fundamental message emerging from genome-wide association studies of copy number variations (CNVs) associated with the disease is that its genetic basis does not necessarily conform to classical nosological disease boundaries. Certain CNVs confer not only high relative risk of schizophrenia but also of other psychiatric disorders. The structural variations associated with schizophrenia can involve several genes and the phenotypic syndromes, or the 'genomic disorders', have not yet been characterized. Single nucleotide polymorphism (SNP)-based genome-wide association studies with the potential to implicate individual genes in complex diseases may reveal underlying biological pathways. Here we combined SNP data from several large genome-wide scans and followed up the most significant association signals. We found significant association with several markers spanning the major histocompatibility complex (MHC) region on chromosome 6p21.3-22.1, a marker located upstream of the neurogranin gene (NRGN) on 11q24.2 and a marker in intron four of transcription factor 4 (TCF4) on 18q21.2. Our findings implicating the MHC region are consistent with an immune component to schizophrenia risk, whereas the association with NRGN and TCF4 points to perturbation of pathways involved in brain development, memory and cognition.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Further, results from SGENE+ 60 implicate NRGN (neurogranin) which may act as a calcium sensor. 61”
From Genetic architectures of psychiatric disorders: the emerging picture and its implications (2012) · cites this paper as [61]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482
Inference of Population Structure Using Multilocus Genotype Data
Pritchard, J. K., Stephens, M., & Donnelly, P. (2000) · Genetics · doi:10.1093/genetics/155.2.945 · Cited by 33,871
Statistical Aspects of the Analysis of Data From Retrospective Studies of Disease
(1959) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/22.4.719 · Cited by 14,689
A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
Statistical Methods for Research Workers
Fisher, R. A. (1945) · American Journal of Clinical Pathology · doi:10.1093/ajcp/15.11.552b · Cited by 10,883
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442
Self-citationCommon polygenic variation contributes to risk of schizophrenia and bipolar disorder
The International Schizophrenia Consortium (2009) · Nature · doi:10.1038/nature08185 · Cited by 4,821
Genomic Control for Association Studies
Devlin, B., & Roeder, K. (1999) · Biometrics · doi:10.1111/j.0006-341x.1999.00997.x · Cited by 3,162
The Wellcome Trust Case Control Consortium, U.K.
Mossman, K. (2008) · Scientific American · doi:10.1038/scientificamerican0108-42a · Cited by 2,714
Large recurrent microdeletions associated with schizophrenia.
GROUP, Stefansson, H., Rujescu, D., Cichon, S., Pietiläinen, O. P. H., Ingason, A., Steinberg, S., Fossdal, R., Sigurdsson, E., Sigmundsson, T., et al. (2008) · Nature · doi:10.1038/nature07229 · Cited by 1,745
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Items 601–700 of 1,001
Peripheral complement is increased in schizophrenia and inversely related to cortical thickness
Ji, E., Boerrigter, D., Cai, H. Q., Lloyd, D., Bruggemann, J. M., O׳Donnell, M., Galletly, C. A., Lloyd, A. R., Liu, D., Lenroot, R., et al. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.11.014 · Cited by 44
A population-based association study of 2q32.3 and 8q21.3 loci with schizophrenia in Han Chinese
Guan, F., Wei, S., Zhang, C., Zhang, H., Zhang, B., Xing, B., Feng, Z., Gao, C., Liu, X., & Li, S. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.01.025 · Cited by 43
DISC1 as a therapeutic target for mental illnesses
Hikida, T., Gamo, N. J., & Sawa, A. (2012) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2012.719879 · Cited by 42
Sex-specific rates of transmission of psychosis in the New England high-risk family study
Goldstein, J. M., Cherkerzian, S., Seidman, L. J., Petryshen, T. L., Fitzmaurice, G. M., Tsuang, M. T., & Buka, S. L. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.01.019 · Cited by 44
Dieset, I., Hope, S., Ueland, T., Bjella, T. D., Agartz, I., Melle, I. S., Aukrust, P., Røssberg, J. I., & Andreassen, O. A. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.06.040 · Cited by 43
Self-citationHan, K., Cooke, S. F., & Xu, W. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.084 · Cited by 43
Endophenotypes in Schizophrenia: Digging Deeper to Identify Genetic Mechanisms
Greenwood, T. A., Shutes‐David, A., & Tsuang, D. W. (2019) · Journal of Psychiatry and Brain Science · doi:10.20900/jpbs.20190005 · Cited by 46
Li, M., Wu, D., Yao, Y., Huo, Y., Liu, J.-W., Su, B., Chasman, D. I., Chu, A. Y., Huang, T., Qi, L., et al. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbv070 · Cited by 43
Genetic liability for schizophrenia predicts risk of immune disorders
Stringer, S., Kahn, R. S., de Witte, L. D., Ophoff, R. A., & Derks, E. M. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.09.004 · Cited by 42
Self-citationCommon Variants in the BCL9 Gene Conferring Risk of Schizophrenia
Li, J., Zhou, G., Ji, W., Feng, G., Zhao, Q., Liu, J., Li, T., Li, Y., Chen, P., Zeng, Z., et al. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.1 · Cited by 43
Lennertz, L., Wagner, M., Wölwer, W., Schuhmacher, A., Frommann, I., Berning, J., Schulze‐Rauschenbach, S., Landsberg, M. W., Steinbrecher, A., Alexander, M., et al. (2011) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-011-0233-3 · Cited by 45
Xiu, M. H., Tian, L., Chen, S., Tan, Y., Chen, D. C., Chen, J., Chen, N., Yang, F. D., Licinio, J., Kosten, T. R., et al. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.03.005 · Cited by 43
Ingason, A., Giegling, I., Hartmann, A. M., Genius, J., Konte, B., Friedl, M., Ripke, S., Sullivan, P. F., Clair, D. S., Collier, D. A., et al. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.151 · Cited by 41
Self-citationCariaga-Martínez, A. E., Sáiz-Ruiz, J., & Alelú‐Paz, R. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00202 · Cited by 48
The use of vector bootstrapping to improve variable selection precision in Lasso models
Laurin, C., Boomsma, D. I., & Lubke, G. H. (2016) · Statistical Applications in Genetics and Molecular Biology · doi:10.1515/sagmb-2015-0043 · Cited by 40
Cohort Profile: The Nijmegen Biomedical Study (NBS)
Galesloot, T. E., Vermeulen, S. H. H. M., Swinkels, D. W., de Vegt, F., Franke, B., den Heijer, M., Graaf, J. D., Verbeek, A. L. M., & Kiemeney, L. A. L. M. (2017) · International Journal of Epidemiology · doi:10.1093/ije/dyw268 · Cited by 41
Self-citationHardwick, S. A., Bassett, S. D., Kaczorowski, D. C., Blackburn, J., Barton, K., Bartoniček, N., Carswell, S., Tilgner, H., Loy, C. T., Halliday, G. M., et al. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00309 · Cited by 41
The role of the TCF4 gene in the phenotype of individuals with 18q segmental deletions
Hasi, M., Soileau, B. T., Sebold, C. D., Hill, A., Hale, D. E., O’Donnell, L., & Cody, J. D. (2011) · Human Genetics · doi:10.1007/s00439-011-1020-y · Cited by 42
Chang, S., Fang, K., Zhang, K., & Wang, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133404 · Cited by 41
Elevated Viral Restriction Factor Levels in Cortical Blood Vessels in Schizophrenia
Siegel, B. I., Sengupta, E. J., Edelson, J. R., Lewis, D. A., & Volk, D. W. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.09.019 · Cited by 42
The Wnt/beta-catenin signaling pathway establishes neuroanatomical asymmetries and their laterality
Hüsken, U., & Carl, M. (2012) · Mechanisms of Development · doi:10.1016/j.mod.2012.09.002 · Cited by 41
Luo, X., Huang, L., Jia, P., Li, M., Su, B., Zhao, Z., & Gan, L. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt066 · Cited by 40
Schizophrenia: The “BLOC” May Be in the Endosomes
Ryder, P. V., & Faúndez, V. (2009) · Science Signaling · doi:10.1126/scisignal.293pe66 · Cited by 41
Ohi, K., Hashimoto, R., Yamamori, H., Yasuda, Y., Fujimoto, M., Umeda‐Yano, S., Fukunaga, M., Watanabe, Y., Iwase, M., Kazui, H., et al. (2013) · Behavioral and Brain Functions · doi:10.1186/1744-9081-9-40 · Cited by 41
High-Quality Exome Sequencing of Whole-Genome Amplified Neonatal Dried Blood Spot DNA
Poulsen, J. B., Lescai, F., Grove, J., Bækvad‐Hansen, M., Christiansen, M., Hagen, C. M., Maller, J., Stevens, C. R., Li, S., Li, Q., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0153253 · Cited by 40
Self-citationXia, H.-Z., Jahr, F. M., Kim, N.-K., Xie, L., Shabalin, A. A., Bryois, J., Sweet, D. H., Kronfol, M. M., Palasuberniam, P., McRae, M., et al. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy222 · Cited by 41
Common variants in polygenic schizophrenia
Glessner, J., & Hakonarson, H. H. (2009) · Genome biology · doi:10.1186/gb-2009-10-9-236 · Cited by 41
FIREcaller: Detecting frequently interacting regions from Hi-C data
Crowley, C., Yang, Y., Qiu, Y., Hu, B., Abnousi, A., Lipiński, J., Plewczyński, D., Wu, D., Won, H., Ren, B., et al. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2020.12.026 · Cited by 37
Jia, X., Zhang, T., Li, L., Fu, D., Lin, H., Chen, G., Liu, X., & Guan, F. (2016) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32491 · Cited by 40
Whole genome association studies in complex diseases: where do we stand?
Need, A. C., & Goldstein, D. B. (2010) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2010.12.1/aneed · Cited by 40
Self-citationSchizophrenia Genetics: Putting All the Pieces Together
Girard, S., Dion, P. A., & Rouleau, G. A. (2012) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-012-0266-7 · Cited by 41
Predictive and Diagnostic Genetic Testing in Psychiatry
Mitchell, P. B., Meiser, B., Wilde, A., Fullerton, J. M., Donald, J. A., Wilhelm, K. A., & Schofield, P. R. (2010) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2010.07.001 · Cited by 41
Patient participation in fundamental psychiatric genomics research: a Dutch case study
Baart, I., & Abma, T. (2010) · Health Expectations · doi:10.1111/j.1369-7625.2010.00634.x · Cited by 40
Seasonal changes in gene expression represent cell-type composition in whole blood
de Jong, S., Neeleman, M., Luykx, J. J., ten Berg, M. J., Strengman, E., Breeijen, H. H. D., Stijvers, L. C., Buizer‐Voskamp, J. E., Bakker, S. C., Kahn, R. S., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddt665 · Cited by 40
Self-citationKotlar, A., Mercer, K. B., Zwick, M. E., & Mullé, J. G. (2015) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2015.10.008 · Cited by 42
Interaction between BDNF and TNF-α genes in schizophrenia
Zhang, Y., Fang, X., Fan, W., Tang, W., Cai, J., Song, L., & Zhang, C. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.12.024 · Cited by 40
From Infection to the Microbiome: An Evolving Role of Microbes in Schizophrenia
Severance, E. G., & Yolken, R. H. (2019) · Current topics in behavioral neurosciences · doi:10.1007/7854_2018_84 · Cited by 40
Evolving toward a human-cell based and multiscale approach to drug discovery for CNS disorders
Schadt, E. E., Buchanan, S., Brennand, K. J., & Merchant, K. M. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00252 · Cited by 39
Abdelmoity, A. T., LePichon, J.-B., Nyp, S. S., Soden, S. E., Daniel, C. A., & Yu, S. (2012) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/dbp.0b013e31826052ae · Cited by 44
Voineskos, A. N. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.03.034 · Cited by 39
Shin, J. H., Park, S. J., Kim, E. S., Jo, Y. K., Hong, J., & Cho, D. (2012) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b12-00009 · Cited by 39
Comparative immunogenetics of autism and schizophrenia
Crespi, B. J., & Thiselton, D. L. (2011) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2011.00710.x · Cited by 39
MHC class I protein is expressed by neurons and neural progenitors in mid-gestation mouse brain
Chacón, M. A., & Boulanger, L. M. (2012) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2012.11.004 · Cited by 39
Fine Mapping on Chromosome 13q32–34 and Brain Expression Analysis Implicates MYO16 in Schizophrenia
Rodriguez‐Murillo, L., Xu, B., Roos, J. L., Abecasis, G. R., Gogos, J. A., & Karayiorgou, M. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.293 · Cited by 40
Effects of cis-regulatory variation differ across regions of the adult human brain
Buonocore, F., Hill, M., Campbell, C. D., Oladimeji, P. O., Jeffries, A. R., Troakes, C., Hortobágyi, T., Williams, B. P., Cooper, J. D., & Bray, N. J. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq380 · Cited by 39
Analysis of exome sequence in 604 trios for recessive genotypes in schizophrenia
Rees, E., Kirov, G., Walters, J., Richards, A. L., Howrigan, D. P., Kavanagh, D. H., Pocklington, A. J., Fromer, M., Ruderfer, D. M., Georgieva, L., et al. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.99 · Cited by 40
Intermediate or brainless phenotypes for psychiatric research?
Meyer‐Lindenberg, A. (2009) · Psychological Medicine · doi:10.1017/s0033291709991929 · Cited by 39
Luo, X., Huang, L., Han, L., Luo, Z., Hu, F., Tieu, R., & Gan, L. (2014) · Schizophrenia Bulletin · doi:10.1093/schbul/sbu045 · Cited by 38
Addington, A. M., & Rapoport, J. L. (2011) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2011.02478.x · Cited by 41
Rapid, experience-dependent translation of neurogranin enables memory encoding
Jones, K. J., Templet, S., Zemoura, K., Kuźniewska, B., Pena, F. X., Hwang, H., Ding, L. J., Haensgen, H., Nguyen, S. J., Saenz, C., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1716750115 · Cited by 41
Differential gene expression analysis in blood of first episode psychosis patients
Leirer, D. J., Iyegbe, C. O., Forti, M. D., Patel, H., Carra, E., Fraietta, S., Colizzi, M., Mondelli, V., Quattrone, D., Lally, J., et al. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2019.05.011 · Cited by 41
Self-citationGlia‐related genes and their contribution to schizophrenia
Wang, C., Aleksić, B., & Ozaki, N. (2015) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12290 · Cited by 39
Rizig, M., McQuillin, A., Ng, A., Robinson, M., Harrison, A., Zvelebil, M., Hunt, S., & Gurling, H. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881112450780 · Cited by 39
Development of animal models for schizophrenia
Arguello, P. A., Markx, S., Gogos, J. A., & Karayiorgou, M. (2010) · Disease Models & Mechanisms · doi:10.1242/dmm.003996 · Cited by 40
Suárez‐Pinilla, P., Roiz‐Santiáñez, R., de la Foz, V. O., Guest, P. C., Ayesa‐Arriola, R., Córdova‐Palomera, A., Tordesillas‐Gutiérrez, D., & Crespo‐Facorro, B. (2015) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2015.05.005 · Cited by 37
Kvajo, M., McKellar, H., & Gogos, J. A. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.07.051 · Cited by 40
Rowe, A. R., Mercer, L., Casetti, V., Sendt, K.-V., Giaroli, G., Shergill, S. S., & Tracy, D. K. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881114564096 · Cited by 41
Ikeda, M., Aleksić, B., Yamada, K., Iwayama‐Shigeno, Y., Matsuo, K., Numata, S., Watanabe, Y., Ohnuma, T., Kaneko, T., Fukuo, Y., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.74 · Cited by 38
Zakharyan, R., Boyajyan, A. S., Arakelyan, A., Gevorgyan, A., Mrázek, F., & Petřek, M. (2011) · Human Immunology · doi:10.1016/j.humimm.2011.05.018 · Cited by 38
Progress in defining the biological causes of schizophrenia
Pickard, B. S. (2011) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399411001955 · Cited by 40
Schmitt, A., Martins‐de‐Souza, D., Akbarian, S., Cassoli, J. S., Ehrenreich, H., Fischer, A., Fonteh, A. N., Gattaz, W. F., Gawlik, M., Gerlach, M., et al. (2016) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2016.1224929 · Cited by 43
Deciphering microbiome and neuroactive immune gene interactions in schizophrenia
Severance, E. G., & Yolken, R. H. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.11.016 · Cited by 41
The impact of inflammation on neurocognition and risk for psychosis: a critical review
Kogan, S., Ospina, L. H., Mittal, V. A., & Kimhy, D. (2019) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-019-01073-2 · Cited by 38
Aas, M., Vecchio, C., Pauls, A. M., Mehta, M. A., Williams, S., Hazelgrove, K. M., Biaggi, A., Pawlby, S. J., Conroy, S., Seneviratne, G., et al. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104558 · Cited by 41
Betaine ameliorates schizophrenic traits by functionally compensating for KIF3-based CRMP2 transport
Yoshihara, S., Jiang, X., Morikawa, M., Ogawa, T., Ichinose, S., Yabe, H., Kakita, A., Toyoshima, M., Kunii, Y., Yoshikawa, T., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108971 · Cited by 38
Ukong, S., Krailas, D., Dangprasert, T., & Channgarm, P. (2007) · PubMed · Cited by 38
Allen, J. A., Yadav, P. N., Setola, V, Farrell, M., & Roth, B. L. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.35 · Cited by 37
Wahłsten, D. (2012) · Developmental Psychobiology · doi:10.1002/dev.21043 · Cited by 38
Genetic studies of schizophrenia: an update
Chen, J., Cao, F., Liu, L., Wang, L., & Chen, X. (2015) · Neuroscience Bulletin · doi:10.1007/s12264-014-1494-4 · Cited by 39
Changes in gene expression and methylation in the blood of patients with first-episode psychosis
Ota, V., Noto, C. D. S., Gadelha, A., Santoro, M. L., Spíndola, L., Gouvêa, E. S., Stilhano, R. S., Ortiz, B. B., Silva, P. N., Sato, J. R., et al. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.09.008 · Cited by 37
Rajkumar, A. P., Balasubramanian, P., Kuruvilla, A., Srivastava, A., Jacob, M., & Jacob, K. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2773-2 · Cited by 36
Association between bovine casein antibody and new onset schizophrenia among US military personnel
Niebuhr, D. W., Li, Y., Cowan, D. N., Weber, N. S., Fisher, J. A., Ford, G. M., & Yolken, R. H. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.02.005 · Cited by 37
Wang, H., Liu, G.-H., Zhang, R., Xue, F., Wu, D., Chen, Y.-C., Ye, P., Peng, Z., & Tan, Q.-R. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv088 · Cited by 37
Liu, J., Ye, Z., Mayer, J. G., Hoch, B. A., Green, C., Rolak, L. A., Cold, C. J., Khor, S., Zheng, X., Miyagawa, T., et al. (2016) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2016-103867 · Cited by 38
Hill, M., Killick, R., Navarrete, K., Maruszak, A., McLaughlin, G. M., Williams, B. P., & Bray, N. J. (2017) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.160073 · Cited by 39
Consensus on potential biomarkers developed for use in clinical tests for schizophrenia
Lin, P., Sun, J., Lou, X., Li, D., Shi, Y., Li, Z., Ma, P., Li, P., Chen, S., Jin, W., et al. (2022) · General Psychiatry · doi:10.1136/gpsych-2021-100685 · Cited by 39
Bentsen, H., Solberg, D. K., Refsum, H., & Bøhmer, T. (2012) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2012.05.005 · Cited by 38
A re‐review of the association between the NOTCH4 locus and schizophrenia
Shayevitz, C., Cohen, O. S., Faraone, S. V., & Glatt, S. J. (2012) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32050 · Cited by 37
Influence of the NRGN gene on intellectual ability in schizophrenia
Ohi, K., Hashimoto, R., Yasuda, Y., Fukumoto, M., Yamamori, H., Umeda‐Yano, S., Fujimoto, M., Iwase, M., Kazui, H., & Takeda, M. (2013) · Journal of Human Genetics · doi:10.1038/jhg.2013.82 · Cited by 35
Linkage and association studies of anxiety disorders
Hamilton, S. P. (2009) · Depression and Anxiety · doi:10.1002/da.20615 · Cited by 35
Animal Model for Schizophrenia That Reflects Gene-Environment Interactions
Nagai, T., Ibi, D., & Yamada, K. (2011) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.34.1364 · Cited by 36
Ivorra, J. L., Rivero, O., Costas, J., Iniesta, R., Arrojo, M., Ramos‐Ríos, R., Carracedo, Á., Palomo, T., Rodríguez–Jiménez, R., Cervilla, J. A., et al. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.07.004 · Cited by 35
Self-citationComparison of gene expression profiles in the blood, hippocampus and prefrontal cortex of rats
Witt, S. H., Sommer, W. H., Hansson, A. C., Sticht, C., Rietschel, M., & Witt, C. C. (2013) · In Silico Pharmacology · doi:10.1186/2193-9616-1-15 · Cited by 36
Self-citationThe Effect of Neurogranin on Neural Correlates of Episodic Memory Encoding and Retrieval
Krug, A., Krach, S., Jansen, A., Nieratschker, V., Witt, S. H., Shah, N. J., Nöthen, M. M., Rietschel, M., & Kircher, T. T. J. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr076 · Cited by 39
Self-citationWu, J. Q., Green, M. J., Gardiner, E. J., Tooney, P. A., Scott, R. J., Carr, V. J., & Cairns, M. J. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.12.010 · Cited by 36
Genomics and Pharmacogenomics of Schizophrenia
Cacabelos, R., & Martínez‐Bouza, R. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00187.x · Cited by 36
Deficits in trace fear memory in a mouse model of the schizophrenia risk gene TCF4
Brzózka, M. M., & Rossner, M. J. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.10.001 · Cited by 36
Kas, M. J., Krishnan, V., Gould, T. D., Collier, D. A., Olivier, B., Lesch, K., Domenici, E., Fuchs, E., Gross, C. T., & Ċastrén, E. (2011) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2010.12.001 · Cited by 36
Self-citationNeurophysiologic effect of GWAS derived schizophrenia and bipolar risk variants
Hall, M., Levy, D. L., Salisbury, D. F., Haddad, S., Gallagher, P., Lohan, M., Cohen, B. M., Öngür, D., & Smoller, J. W. (2013) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32212 · Cited by 35
Psychiatric Disorders - Trends and Developments
Uehara, T. (2011) · InTech eBooks · doi:10.5772/2330 · Cited by 36
Immune activation by casein dietary antigens in bipolar disorder
Severance, E. G., Dupont, D., Dickerson, F., Stallings, C. R., Origoni, A. E., Krivogorsky, B., Yang, S., Haasnoot, W., & Yolken, R. H. (2010) · Bipolar Disorders · doi:10.1111/j.1399-5618.2010.00879.x · Cited by 34
Currently recognized genes for schizophrenia: High‐resolution chromosome ideogram representation
Butler, M. G., McGuire, A., Masoud, H., & Manzardo, A. M. (2015) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32391 · Cited by 35
Braunewell, K. H., Dwary, A. D., Richter, F., Trappe, K., Zhao, C., Giegling, I., Schönrath, K., & Rujescu, D. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.20 · Cited by 36
Self-citationZhu, X., Gu, H., Liu, Z., Xu, Z., Chen, X., Sun, X., Zhai, J., Zhang, Q.-M., Chen, M., Wang, K., et al. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.234 · Cited by 35
Ferentinos, P. P., & Dikeos, D. (2012) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e3283568537 · Cited by 37
A single-cell genomic atlas for maturation of the human cerebellum during early childhood
Ament, S. A., Cortes-Gutierrez, M., Herb, B. R., Mocci, E., Colantuoni, C., & McCarthy, M. M. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.ade1283 · Cited by 35
Next‐generation sequencing in schizophrenia and other neuropsychiatric disorders
Schreiber, M. A., Dorschner, M. O., & Tsuang, D. W. (2013) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32156 · Cited by 34
Li, M., Luo, X., Xiao, X., Shi, L., Liu, X., Yin, L.-D., Ma, X., Yang, S.-Y., Pu, X., Yu, J. S., et al. (2011) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2011.587891 · Cited by 35
A survey of rare coding variants in candidate genes in schizophrenia by deep sequencing
Hu, X., Zhang, B., Liu, W., Paciga, S. A., He, W., Lanz, T. A., Kleiman, R. J., Dougherty, B. A., Hall, S. K., McIntosh, A. M., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.131 · Cited by 34
Chang, M., Womer, F. Y., Bai, C., Zhou, Q., Wei, S., Jiang, X., Geng, H., Zhou, Y., Tang, Y., & Wang, F. (2016) · PLoS ONE · doi:10.1371/journal.pone.0163749 · Cited by 34
Metadata
- Authors
- †Genetic Risk and Outcome in Psychosis (GROUP), Stefansson, H., Ophoff, R. A., Steinberg, S., Andreassen, O. A., Cichon, S., Rujescu, D., Werge, T., Pietiläinen, O. P. H., Mors, O., Mortensen, P. B., Sigurdsson, E., Gustafsson, O., Nyegaard, M., Tuulio-Henriksson, A., Ingason, A., Hansen, T., Suvisaari, J., Lonnqvist, J., Paunio, T., Børglum, A. D., Hartmann, A., Fink-Jensen, A., Nordentoft, M., Hougaard, D., Norgaard-Pedersen, B., Böttcher, Y., Olesen, J., Breuer, R., Möller, H.-J., Giegling, I., Rasmussen, H. B., Timm, S., Mattheisen, M., Bitter, I., Réthelyi, J. M., Magnusdottir, B. B., Sigmundsson, T., Olason, P., Masson, G., Gulcher, J. R., Haraldsson, M., Fossdal, R., Thorgeirsson, T. E., Thorsteinsdottir, U., Ruggeri, M., Tosato, S., Franke, B., Strengman, E., Kiemeney, L. A., Melle, I., Djurovic, S., Abramova, L., Kaleda, V., Sanjuan, J., de Frutos, R., Bramon, E., Vassos, E., Fraser, G., Ettinger, U., Picchioni, M., Walker, N., Toulopoulou, T., Need, A. C., Ge, D., Lim Yoon, J., Shianna, K. V., Freimer, N. B., Cantor, R. M., Murray, R., Kong, A., Golimbet, V., Carracedo, A., Arango, C., Costas, J., Jönsson, E. G., Terenius, L., Agartz, I., Petursson, H., Nöthen, M. M., Rietschel, M., Matthews, P. M., Muglia, P., Peltonen, L., St Clair, D., Goldstein, D. B., Stefansson, K., & Collier, D. A.
- Affiliations
- deCODE Genetics (Iceland) (IS)
- University of Bonn (DE)
- Sankt Hans Hospital (DK)
- Aarhus University Hospital (DK)
- Aarhus University (DK)
- Copenhagen University Hospital (DK)
- Statens Serum Institut (DK)
- Heidelberg University (DE)
- Ludwig-Maximilians-Universität München (DE)
- Semmelweis University (HU)
- University of Verona (IT)
- Radboud University Medical Center (NL)
- University of Oslo (NO)
- Mental Health Research Center of Russian Academy of Medical Sciences (RU)
- King's College London (GB)
- Duke University (US)
- University of California, Los Angeles (US)
- Hospital General Universitario Gregorio Marañón (ES)
- Karolinska Institutet (SE)
- University of Iceland (IS)
- GlaxoSmithKline (United Kingdom) (GB)
- Wellcome Sanger Institute (GB)
- University of Aberdeen (GB)
- ORCID
- Ophoff, Roel A.
- Steinberg, Stacy
- Andreassen, Ole A.
- Cichon, Sven
- Rujescu, Dan
- Werge, Thomas
- Pietiläinen, Olli P. H.
- Mors, Ole
- Mortensen, Preben B.
- Nyegaard, Mette
- Hansen, Thomas
- Suvisaari, Jaana
- Paunio, Tiina
- Børglum, Anders D.
- Hartmann, Annette
- Nordentoft, Merete
- Hougaard, David
- Böttcher, Yvonne
- Olesen, Jes
- Möller, Hans-Jürgen
- Giegling, Ina
- Mattheisen, Manuel
- Bitter, István
- Réthelyi, János M.
- Olason, Pall
- Haraldsson, Magnus
- Thorgeirsson, Thorgeir E.
- Ruggeri, Mirella
- Tosato, Sarah
- Franke, Barbara
- Strengman, Eric
- Kiemeney, Lambertus A.
- Melle, Ingrid
- Djurovic, Srdjan
- Bramon, Elvira
- Vassos, Evangelos
- Ettinger, Ulrich
- Picchioni, Marco
- Need, Anna C.
- Ge, Dongliang
- Freimer, Nelson B.
- Cantor, Rita M.
- Murray, Robin
- Kong, Augustine
- Arango, Celso
- Costas, Javier
- Jönsson, Erik G.
- Terenius, Lars
- Agartz, Ingrid
- Nöthen, Markus M.
- Rietschel, Marcella
- Matthews, Paul M.
- Muglia, Pierandrea
- Peltonen, Leena
- Goldstein, David B.
- Collier, David A.
- Venue
- Nature
- Published
- 2009-07-01
- Volume
- 460
- Issue
- 7256
- Pages
- 744-747
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3077530
- OpenAlex
- W2127205775
- Cited by
- 1,677
- References
- 39
- Citations by year
- 2026: 21 · 2025: 39 · 2024: 47 · 2023: 38 · 2022: 47 · 2021: 65 · 2020: 62 · 2019: 66 · 2018: 56 · 2017: 90 · 2016: 116 · 2015: 148 · 2014: 140 · 2013: 165 · 2012: 196
- FWCI
- 116.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Lirias (KU Leuven) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- VU Research Portal (submittedVersion)
- Hirsla (Landspítali University Hospital) (submittedVersion, other-oa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Funders
- GlaxoSmithKline
- Wellcome Trust (089061)
- National Institute for Health and Care Research (PDA/02/06/016)
- Bundesministerium für Bildung und Forschung (NGFN-2)
- Alfried Krupp von Bohlen und Halbach-Stiftung
- National Institutes of Health (6r01hl087679-03)
- National Heart, Lung, and Blood Institute (R01 HL087679, 1-R01HL087679-01)
- National Institute of Mental Health (R01MH078075, MH078075)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Keywords
- schizophrenia, genetic susceptibility, single nucleotide polymorphisms, copy number variation, major histocompatibility complex, neurogranin, TCF4, immune function, brain development, memory and cognition, mental illness
- MeSH terms
- Transcription Factor 4, Chromosomes, Human, Pair 11, Chromosomes, Human, Pair 18, Chromosomes, Human, Pair 6, DNA-Binding Proteins, Genetic Markers, Genotype, Humans, Major Histocompatibility Complex, Schizophrenia, Transcription Factors, Genome, Human, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Neurogranin, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Genome-Wide Association Study
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
