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Common variants conferring risk of schizophrenia
Open accessAbstract
Schizophrenia is a complex disorder, caused by both genetic and environmental factors and their interactions. Research on pathogenesis has traditionally focused on neurotransmitter systems in the brain, particularly those involving dopamine. Schizophrenia has been considered a separate disease for over a century, but in the absence of clear biological markers, diagnosis has historically been based on signs and symptoms. A fundamental message emerging from genome-wide association studies of copy number variations (CNVs) associated with the disease is that its genetic basis does not necessarily conform to classical nosological disease boundaries. Certain CNVs confer not only high relative risk of schizophrenia but also of other psychiatric disorders. The structural variations associated with schizophrenia can involve several genes and the phenotypic syndromes, or the 'genomic disorders', have not yet been characterized. Single nucleotide polymorphism (SNP)-based genome-wide association studies with the potential to implicate individual genes in complex diseases may reveal underlying biological pathways. Here we combined SNP data from several large genome-wide scans and followed up the most significant association signals. We found significant association with several markers spanning the major histocompatibility complex (MHC) region on chromosome 6p21.3-22.1, a marker located upstream of the neurogranin gene (NRGN) on 11q24.2 and a marker in intron four of transcription factor 4 (TCF4) on 18q21.2. Our findings implicating the MHC region are consistent with an immune component to schizophrenia risk, whereas the association with NRGN and TCF4 points to perturbation of pathways involved in brain development, memory and cognition.
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“Further, results from SGENE+ 60 implicate NRGN (neurogranin) which may act as a calcium sensor. 61”
From Genetic architectures of psychiatric disorders: the emerging picture and its implications (2012) · cites this paper as [61]
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Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482
Inference of Population Structure Using Multilocus Genotype Data
Pritchard, J. K., Stephens, M., & Donnelly, P. (2000) · Genetics · doi:10.1093/genetics/155.2.945 · Cited by 33,871
Statistical Aspects of the Analysis of Data From Retrospective Studies of Disease
(1959) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/22.4.719 · Cited by 14,689
A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
Statistical Methods for Research Workers
Fisher, R. A. (1945) · American Journal of Clinical Pathology · doi:10.1093/ajcp/15.11.552b · Cited by 10,883
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442
Self-citationCommon polygenic variation contributes to risk of schizophrenia and bipolar disorder
The International Schizophrenia Consortium (2009) · Nature · doi:10.1038/nature08185 · Cited by 4,821
Genomic Control for Association Studies
Devlin, B., & Roeder, K. (1999) · Biometrics · doi:10.1111/j.0006-341x.1999.00997.x · Cited by 3,162
The Wellcome Trust Case Control Consortium, U.K.
Mossman, K. (2008) · Scientific American · doi:10.1038/scientificamerican0108-42a · Cited by 2,714
Large recurrent microdeletions associated with schizophrenia.
GROUP, Stefansson, H., Rujescu, D., Cichon, S., Pietiläinen, O. P. H., Ingason, A., Steinberg, S., Fossdal, R., Sigurdsson, E., Sigmundsson, T., et al. (2008) · Nature · doi:10.1038/nature07229 · Cited by 1,745
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Causal influences of neuroticism on mental health and cardiovascular disease
Zhang, F., Baranova, A. V., Zhou, C., Cao, H., Chen, J., Zhang, X., & Xu, M. (2021) · Human Genetics · doi:10.1007/s00439-021-02288-x · Cited by 144
Genetics of Schizophrenia: Overview of Methods, Findings and Limitations
Henriksen, M. G., Nordgaard, J., & Jansson, L. B. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00322 · Cited by 169
Recent advances in nutrition, genes and brain health
Dauncey, M. J. (2012) · Proceedings of The Nutrition Society · doi:10.1017/s0029665112000237 · Cited by 143
Genome-wide Association Studies: Findings at the Major Histocompatibility Complex Locus in Psychosis
Corvin, A. P., & Morris, D. W. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.09.018 · Cited by 136
Sepp, M., Kannike, K., Eesmaa, A., Urb, M., & Timmusk, T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022138 · Cited by 140
Narcolepsy with hypocretin/orexin deficiency, infections and autoimmunity of the brain
Kornum, B. R., Faraco, J. H., & Mignot, E. J.-M. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.09.003 · Cited by 135
Molecular Mechanisms and Timing of Cortical Immune Activation in Schizophrenia
Volk, D. W., Chitrapu, A., Edelson, J. R., Roman, K. M., Moroco, A. E., & Lewis, D. A. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.15010019 · Cited by 138
Analysis of miR-137 expression and rs1625579 in dorsolateral prefrontal cortex
Guella, I., Sequeira, A., Rollins, B. L., Morgan, L., Torri, F., van Erp, T. G. M., Myers, R., Barchas, J. D., Schatzberg, A. F., Watson, S. J., et al. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.05.021 · Cited by 132
Timms, A. E., Dorschner, M. O., Wechsler, J., Choi, K. Y., Kirkwood, R., Girirajan, S., Baker, C. A., Eichler, E. E., Korvatska, O., Roche, K. W., et al. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.1195 · Cited by 137
Schizophrenia and the gut–brain axis
Nemani, K., Hosseini Ghomi, R., McCormick, B., & Fan, X. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.08.018 · Cited by 151
High rate of disease-related copy number variations in childhood onset schizophrenia
Ahn, K., Gotay, N., Andersen, T. M., Anvari, A. A., Gochman, P., Lee, Y., Sanders, S., Guha, S., Darvasi, A., Glessner, J., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.59 · Cited by 133
Kaminsky, Z. A., Tochigi, M., Jia, P., Pal, M., Mill, J. S., Kwan, A., Ioshikhes, I. P., Vincent, J. B., Kennedy, J. L., Strauss, J., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.64 · Cited by 135
Brzózka, M. M., Radyushkin, K., Wichert, S. P., Ehrenreich, H., & Rossner, M. J. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.03.015 · Cited by 132
Wermter, A., Laucht, M., SCHIMMELMANN, B. G., Banaschewski, T., Sonuga-Barke, E. J. S., Rietschel, M., & Becker, K. (2009) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-009-0082-z · Cited by 146
Self-citationImmature Dentate Gyrus: An Endophenotype of Neuropsychiatric Disorders
Hagihara, H., Takao, K., Walton, N. M., Matsumoto, M., & Miyakawa, T. (2013) · Neural Plasticity · doi:10.1155/2013/318596 · Cited by 123
Two distinct ontogenies confer heterogeneity to mouse brain microglia
De, S., Deren, D. A. V., Peden, E., Hockin, M., Boulet, A. M., Titen, S. W. A., & Capecchi, M. R. (2018) · Development · doi:10.1242/dev.152306 · Cited by 139
Nielsen, P. R., Benros, M. E., & Mortensen, P. B. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt200 · Cited by 129
Self-citationSuggestion of Roles for Both Common and Rare Risk Variants in Genome-wide Studies of Schizophrenia
Owen, M. J., Craddock, N. J., & O’Donovan, M. C. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.69 · Cited by 127
Schizophrenia: susceptibility genes, dendritic-spine pathology and gray matter loss
Bennett, M. R. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.08.003 · Cited by 129
Fanous, A. H., Zhou, B., Aggen, S. H., Bergen, S. E., AMDUR, R. L., Duan, J., Sanders, A. R., Shi, J., Mowry, B. J., D, A. O. M., et al. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.12020218 · Cited by 127
Bigdeli, T. B., Genovese, G., Georgakopoulos, P., Meyers, J. L., Peterson, R. E., Iyegbe, C. O., Medeiros, H., Valderrama, J., Achtyes, E. D., Kotov, R., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0517-y · Cited by 122
Neuroinflammation in schizophrenia: the role of nuclear factor kappa B
Murphy, C. E., Walker, A. K., & Weickert, C. S. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01607-0 · Cited by 128
Nascimento, J. M., & Martins‐de‐Souza, D. (2015) · Schizophrenia · doi:10.1038/npjschz.2014.3 · Cited by 125
Prenatal inflammation and neurodevelopment in schizophrenia: A review of human studies
Miller, B. J., Culpepper, N. H., Rapaport, M. H., & Buckley, P. F. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.03.010 · Cited by 125
Major Histocompatibility Complex I in Brain Development and Schizophrenia
McAllister, A. K. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.10.003 · Cited by 130
Genome-wide association study of Alzheimer's disease with psychotic symptoms
Hollingworth, P., Sweet, R. A., Sims, R., Harold, D. H., Russo, G., Abraham, R., Stretton, A., Jones, N., Gerrish, A., Chapman, J., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.125 · Cited by 123
The Anorexia Nervosa Genetics Initiative (ANGI): Overview and methods
Thornton, L. M., Munn‐Chernoff, M. A., Baker, J. H., Juréus, A., Parker, R., Henders, A. K., Larsen, J. T., Petersen, L. V., Watson, H. J., Yılmaz, Z., et al. (2018) · Contemporary Clinical Trials · doi:10.1016/j.cct.2018.09.015 · Cited by 120
Self-citationSchizophrenia Gene Networks and Pathways and Their Applications for Novel Candidate Gene Selection
Sun, J., Jia, P., Fanous, A. H., van den Oord, E. J. C. G., Chen, X., Riley, B. P., AMDUR, R. L., Kendler, K. S., & Zhao, Z. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011351 · Cited by 124
Hiroi, N., Takahashi, T., Hishimoto, A., Izumi, T., Boku, S., & Hiramoto, T. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.92 · Cited by 126
Pearlman, D. M., & Najjar, S. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.05.001 · Cited by 123
Richards, A. L., Jones, L., Moskvina, V, Kirov, G., Gejman, P. V., Levinson, D. F., Sanders, A. R., Molecular Genetics of Schizophrenia Collaboration (MGS), International Schizophrenia Consortium (ISC), Purcell, S., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.11 · Cited by 123
Dopamine Transporter Activity Is Modulated by α-Synuclein*
Butler, B., Saha, K., Rana, T., Becker, J., Sambo, D. O., Davari, P., Goodwin, J., & Khoshbouei, H. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.691592 · Cited by 65
Greenwood, T. A., Swerdlow, N. R., Gur, R. E., Cadenhead, K. S., Calkins, M. E., Dobie, D. J., Freedman, R., Green, M. F., Gur, R. C., Lazzeroni, L. C., et al. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.12020186 · Cited by 124
Holloway, T. D., Moreno, J. L., Umali, A., Rayannavar, V., Hodes, G. E., Russo, S. J., & González‐Maeso, J. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2331-12.2013 · Cited by 124
Imaging Microglial Activation in Untreated First-Episode Psychosis: A PET Study With [18F]FEPPA
Hafizi, S., Tseng, H., Rao, N. P., Selvanathan, T., Kenk, M., Bazinet, R. P., Suridjan, I., Wilson, A. A., Meyer, J. H., Remington, G. J., et al. (2016) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2016.16020171 · Cited by 129
Sahoo, T., Theisen, A., Rosenfeld, J. A., Lamb, A. N., Ravnan, J. B., Schultz, R. A., Torchia, B. S., Neill, N., Casci, I., Bejjani, B. A., et al. (2011) · Genetics in Medicine · doi:10.1097/gim.0b013e3182217a06 · Cited by 115
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Plomin, R. J. (2012) · Child Development · doi:10.1111/j.1467-8624.2012.01757.x · Cited by 125
Genomic Copy Number Variation in Disorders of Cognitive Development
Morrow, E. M. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2010.08.009 · Cited by 124
Zhang, H., Kang, E., Wang, Y., Yang, C., Yu, H., Wang, Q., Chen, Z.-Y., Zhang, C., Christian, K. M., Song, H., et al. (2016) · Nature Communications · doi:10.1038/ncomms11773 · Cited by 119
Functional genomics reveal gene regulatory mechanisms underlying schizophrenia risk
Huo, Y., Li, S., Liu, J., Li, X., & Luo, X. (2019) · Nature Communications · doi:10.1038/s41467-019-08666-4 · Cited by 117
SZDB: A Database for Schizophrenia Genetic Research
Wu, Y., Yao, Y., & Luo, X. (2016) · Schizophrenia Bulletin · doi:10.1093/schbul/sbw102 · Cited by 117
Schmidt‐Kastner, R., van Os, J., Esquivel, G., Steinbusch, H. W. M., & Rutten, B. P. F. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.183 · Cited by 120
Knight, H. M., Pickard, B. S., Maclean, A. W., Malloy, M. P., Soares, D. C., McRae, A. F., Condie, A., White, A., Hawkins, W., McGhee, K. A., et al. (2009) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2009.11.003 · Cited by 123
Connectomic Intermediate Phenotypes for Psychiatric Disorders
Fornito, A., & Bullmore, E. T. (2012) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2012.00032 · Cited by 121
Lee, K. W., Woon, P. S., Teo, Y. Y., & Sim, K. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.09.001 · Cited by 119
Contributions of the d-serine pathway to schizophrenia
Labrie, V., Wong, A. H. C., & Roder, J. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.01.030 · Cited by 121
Unravelling the genetic basis of schizophrenia and bipolar disorder with GWAS: A systematic review
Prata, D. P., Costa-Neves, B., Cosme, G., & Vassos, E. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.04.007 · Cited by 123
Self-citationToulopoulou, T., Goldberg, T. E., Mesa, I. R., Picchioni, M., Rijsdijk, F. V., Stahl, D. R., Cherny, S. S., Sham, P. C., Faraone, S. V., Tsuang, M. T., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.99 · Cited by 117
Self-citationSocial Stress and Psychosis Risk: Common Neurochemical Substrates?
Mizrahi, R. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.274 · Cited by 122
Rietschel, M., Mattheisen, M., Degenhardt, F., GROUP Investigators, Genetic Risk and Outcome in Psychosis (GROUP Investigators), Kahn, R. S., LINSZEN, D. H., van Os, J., Wiersma, D., Bruggeman, R., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.80 · Cited by 119
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Self-citationA systematic, quantitative review of blood autoantibodies in schizophrenia
Ezeoke, A., Mellor, A. L., Buckley, P. F., & Miller, B. J. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.07.029 · Cited by 115
de Bartolomeis, A., Barone, A., Vellucci, L., Mazza, B., Austin, M. C., Iasevoli, F., & Ciccarelli, M. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02976-3 · Cited by 113
The Genetic Architecture of Schizophrenia: New Mutations and Emerging Paradigms
Rodriguez‐Murillo, L., Gogos, J. A., & Karayiorgou, M. (2011) · Annual Review of Medicine · doi:10.1146/annurev-med-072010-091100 · Cited by 121
Forrest, M. P., Waite, A. J., Martin‐Rendon, E., & Blake, D. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073169 · Cited by 112
Hochstenbach, R., Buizer‐Voskamp, J. E., Vorstman, J. A. S., & Ophoff, R. A. (2011) · Cytogenetic and Genome Research · doi:10.1159/000332928 · Cited by 114
Self-citationGlutamate in schizophrenia: Neurodevelopmental perspectives and drug development
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Genome-wide association studies: a primer
Corvin, A. P., Craddock, N. J., & Sullivan, P. F. (2009) · Psychological Medicine · doi:10.1017/s0033291709991723 · Cited by 111
Needleman, L. A., Liu, X.-B., El-Sabeawy, F., Jones, E. G., & McAllister, A. K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006087107 · Cited by 105
Genetic contributions to behavioural diversity at the gene-environment interface
Bendesky, A., & Bargmann, C. I. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3065 · Cited by 103
ZNF804a Regulates Expression of the Schizophrenia-Associated Genes PRSS16, COMT, PDE4B, and DRD2
Girgenti, M. J., Loturco, J., & Maher, B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032404 · Cited by 110
Pettersson‐Yeo, W., Benetti, S., Marquand, A. F., Dell’Acqua, F., Williams, S., Allen, P., Prata, D. P., McGuire, P. K., & Mechelli, A. (2013) · Psychological Medicine · doi:10.1017/s003329171300024x · Cited by 110
The Relationship Between Polygenic Risk Scores and Cognition in Schizophrenia
Richards, A. L., Pardiñas, A. F., Frizzati, A., Tansey, K. E., Lynham, A. J., Holmans, P., Legge, S. E., Savage, J. E., Agartz, I., Andreassen, O. A., et al. (2019) · Schizophrenia Bulletin · doi:10.1093/schbul/sbz061 · Cited by 112
Self-citationJia, P., Wang, L., Fanous, A. H., Pato, C. N., Edwards, T. L., & Zhao, Z. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002587 · Cited by 110
Novel immune response to gluten in individuals with schizophrenia
Samaroo, D., Dickerson, F., Kasarda, D. D., Green, P. H. R., Briani, C., Yolken, R. H., & Alaedini, A. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.08.009 · Cited by 110
The Major Histocompatibility Complex (MHC) in Schizophrenia: A Review
Mokhtari, R., & Lachman, H. M. (2016) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.1000479 · Cited by 117
Sepp, M., Pruunsild, P., & Timmusk, T. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds112 · Cited by 108
(ICCBD), M. O. T. I. C. C. F. B. D., Song, J., Bergen, S. E., Florio, A. D., Karlsson, R., Charney, A. W., Ruderfer, D. M., Stahl, E. A., Chambert, K. D., Moran, J. L., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.165 · Cited by 105
Immune system gene dysregulation in autism and schizophrenia
Michel, M., Schmidt, M. J., & Mirnics, K. (2012) · Developmental Neurobiology · doi:10.1002/dneu.22044 · Cited by 107
Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes
Yang, C., Li, X., Wu, Y., Shen, Q., Zeng, Y., Xiong, Q., Wei, M., Chen, C., Liu, J., Huo, Y., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03247-3 · Cited by 106
Neurodevelopmental and neuropsychiatric behaviour defects arise from 14-3-3ζ deficiency
Cheah, P.-S., Ramshaw, H. S., Thomas, P. Q., Toyo‐oka, K., Xu, X., Martin, S., Coyle, P. V., Guthridge, M. A., Stomski, F. C., van den Buuse, M., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.158 · Cited by 110
Bormuth, I., Yan, K., Yonemasu, T., Gummert, M. N., Zhang, M., Wichert, S. P., Grishina, O., Pieper, A., Zhang, W., Goebbels, S., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0899-12.2013 · Cited by 104
Narrowing the Boundaries of the Genetic Architecture of Schizophrenia
Wray, N. R., & Visscher, P. M. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp137 · Cited by 106
Fraguas, D., Díaz‐Caneja, C. M., Rodríguez-Quiroga, A., & Arango, C. (2017) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx015 · Cited by 106
Self-citationDo common variants play a role in risk for autism? Evidence and theoretical musings
Devlin, B., Melhem, N., & Roeder, K. (2011) · Brain Research · doi:10.1016/j.brainres.2010.11.026 · Cited by 105
Mouse models of genetic effects on cognition: Relevance to schizophrenia
Papaleo, F., Lipska, B. K., & Weinberger, D. R. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.04.025 · Cited by 107
Common variant at 16p11.2 conferring risk of psychosis
Steinberg, S., de Jong, S., Mattheisen, M., Costas, J., Demontis, D., Jamain, S., Pietiläinen, O. P. H., Lin, K., Papiol, S., Huttenlocher, J., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2012.157 · Cited by 104
Self-citationLiu, C. H., Keshavan, M. S., Tronick, E., & Seidman, L. J. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbv047 · Cited by 104
Impact of antipsychotics on cytokine production in-vitro
Himmerich, H., Schönherr, J., Fulda, S., Sheldrick, A. J., Bauer, K., & Sack, U. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.04.009 · Cited by 104
Duan, J., Shi, J., Fiorentino, A., Leites, C., Chen, X., Moy, W., Chen, J., Alexandrov, B. S., Usheva, A., S, D. H. B., et al. (2014) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2014.11.001 · Cited by 107
Exposure to Prenatal Infection and Risk of Schizophrenia
Brown, A. S. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00063 · Cited by 107
Zhao, Z., Webb, B. T., Jia, P., Bigdeli, T. B., Maher, B. S., van den Oord, E. J. C. G., Bergen, S. E., AMDUR, R. L., O’Neill, F. A., Walsh, D., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067776 · Cited by 103
Fernández-Egea, E., Vértes, P. E., Flint, S. M., Turner, L., Mustafa, S. J., Hatton, A., Smith, K. G. C., Lyons, P., & Bullmore, E. T. (2016) · PLoS ONE · doi:10.1371/journal.pone.0155631 · Cited by 106
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Gurung, R. A. R., & Prata, D. P. (2015) · Psychological Medicine · doi:10.1017/s0033291715000537 · Cited by 103
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Metadata
- Authors
- †Genetic Risk and Outcome in Psychosis (GROUP), Stefansson, H., Ophoff, R. A., Steinberg, S., Andreassen, O. A., Cichon, S., Rujescu, D., Werge, T., Pietiläinen, O. P. H., Mors, O., Mortensen, P. B., Sigurdsson, E., Gustafsson, O., Nyegaard, M., Tuulio-Henriksson, A., Ingason, A., Hansen, T., Suvisaari, J., Lonnqvist, J., Paunio, T., Børglum, A. D., Hartmann, A., Fink-Jensen, A., Nordentoft, M., Hougaard, D., Norgaard-Pedersen, B., Böttcher, Y., Olesen, J., Breuer, R., Möller, H.-J., Giegling, I., Rasmussen, H. B., Timm, S., Mattheisen, M., Bitter, I., Réthelyi, J. M., Magnusdottir, B. B., Sigmundsson, T., Olason, P., Masson, G., Gulcher, J. R., Haraldsson, M., Fossdal, R., Thorgeirsson, T. E., Thorsteinsdottir, U., Ruggeri, M., Tosato, S., Franke, B., Strengman, E., Kiemeney, L. A., Melle, I., Djurovic, S., Abramova, L., Kaleda, V., Sanjuan, J., de Frutos, R., Bramon, E., Vassos, E., Fraser, G., Ettinger, U., Picchioni, M., Walker, N., Toulopoulou, T., Need, A. C., Ge, D., Lim Yoon, J., Shianna, K. V., Freimer, N. B., Cantor, R. M., Murray, R., Kong, A., Golimbet, V., Carracedo, A., Arango, C., Costas, J., Jönsson, E. G., Terenius, L., Agartz, I., Petursson, H., Nöthen, M. M., Rietschel, M., Matthews, P. M., Muglia, P., Peltonen, L., St Clair, D., Goldstein, D. B., Stefansson, K., & Collier, D. A.
- Affiliations
- deCODE Genetics (Iceland) (IS)
- University of Bonn (DE)
- Sankt Hans Hospital (DK)
- Aarhus University Hospital (DK)
- Aarhus University (DK)
- Copenhagen University Hospital (DK)
- Statens Serum Institut (DK)
- Heidelberg University (DE)
- Ludwig-Maximilians-Universität München (DE)
- Semmelweis University (HU)
- University of Verona (IT)
- Radboud University Medical Center (NL)
- University of Oslo (NO)
- Mental Health Research Center of Russian Academy of Medical Sciences (RU)
- King's College London (GB)
- Duke University (US)
- University of California, Los Angeles (US)
- Hospital General Universitario Gregorio Marañón (ES)
- Karolinska Institutet (SE)
- University of Iceland (IS)
- GlaxoSmithKline (United Kingdom) (GB)
- Wellcome Sanger Institute (GB)
- University of Aberdeen (GB)
- ORCID
- Ophoff, Roel A.
- Steinberg, Stacy
- Andreassen, Ole A.
- Cichon, Sven
- Rujescu, Dan
- Werge, Thomas
- Pietiläinen, Olli P. H.
- Mors, Ole
- Mortensen, Preben B.
- Nyegaard, Mette
- Hansen, Thomas
- Suvisaari, Jaana
- Paunio, Tiina
- Børglum, Anders D.
- Hartmann, Annette
- Nordentoft, Merete
- Hougaard, David
- Böttcher, Yvonne
- Olesen, Jes
- Möller, Hans-Jürgen
- Giegling, Ina
- Mattheisen, Manuel
- Bitter, István
- Réthelyi, János M.
- Olason, Pall
- Haraldsson, Magnus
- Thorgeirsson, Thorgeir E.
- Ruggeri, Mirella
- Tosato, Sarah
- Franke, Barbara
- Strengman, Eric
- Kiemeney, Lambertus A.
- Melle, Ingrid
- Djurovic, Srdjan
- Bramon, Elvira
- Vassos, Evangelos
- Ettinger, Ulrich
- Picchioni, Marco
- Need, Anna C.
- Ge, Dongliang
- Freimer, Nelson B.
- Cantor, Rita M.
- Murray, Robin
- Kong, Augustine
- Arango, Celso
- Costas, Javier
- Jönsson, Erik G.
- Terenius, Lars
- Agartz, Ingrid
- Nöthen, Markus M.
- Rietschel, Marcella
- Matthews, Paul M.
- Muglia, Pierandrea
- Peltonen, Leena
- Goldstein, David B.
- Collier, David A.
- Venue
- Nature
- Published
- 2009-07-01
- Volume
- 460
- Issue
- 7256
- Pages
- 744-747
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3077530
- OpenAlex
- W2127205775
- Cited by
- 1,677
- References
- 39
- Citations by year
- 2026: 21 · 2025: 39 · 2024: 47 · 2023: 38 · 2022: 47 · 2021: 65 · 2020: 62 · 2019: 66 · 2018: 56 · 2017: 90 · 2016: 116 · 2015: 148 · 2014: 140 · 2013: 165 · 2012: 196
- FWCI
- 116.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Lirias (KU Leuven) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- VU Research Portal (submittedVersion)
- Hirsla (Landspítali University Hospital) (submittedVersion, other-oa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Funders
- GlaxoSmithKline
- Wellcome Trust (089061)
- National Institute for Health and Care Research (PDA/02/06/016)
- Bundesministerium für Bildung und Forschung (NGFN-2)
- Alfried Krupp von Bohlen und Halbach-Stiftung
- National Institutes of Health (6r01hl087679-03)
- National Heart, Lung, and Blood Institute (R01 HL087679, 1-R01HL087679-01)
- National Institute of Mental Health (R01MH078075, MH078075)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Keywords
- schizophrenia, genetic susceptibility, single nucleotide polymorphisms, copy number variation, major histocompatibility complex, neurogranin, TCF4, immune function, brain development, memory and cognition, mental illness
- MeSH terms
- Transcription Factor 4, Chromosomes, Human, Pair 11, Chromosomes, Human, Pair 18, Chromosomes, Human, Pair 6, DNA-Binding Proteins, Genetic Markers, Genotype, Humans, Major Histocompatibility Complex, Schizophrenia, Transcription Factors, Genome, Human, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Neurogranin, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Genome-Wide Association Study
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