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Common variants conferring risk of schizophrenia
Open accessAbstract
Schizophrenia is a complex disorder, caused by both genetic and environmental factors and their interactions. Research on pathogenesis has traditionally focused on neurotransmitter systems in the brain, particularly those involving dopamine. Schizophrenia has been considered a separate disease for over a century, but in the absence of clear biological markers, diagnosis has historically been based on signs and symptoms. A fundamental message emerging from genome-wide association studies of copy number variations (CNVs) associated with the disease is that its genetic basis does not necessarily conform to classical nosological disease boundaries. Certain CNVs confer not only high relative risk of schizophrenia but also of other psychiatric disorders. The structural variations associated with schizophrenia can involve several genes and the phenotypic syndromes, or the 'genomic disorders', have not yet been characterized. Single nucleotide polymorphism (SNP)-based genome-wide association studies with the potential to implicate individual genes in complex diseases may reveal underlying biological pathways. Here we combined SNP data from several large genome-wide scans and followed up the most significant association signals. We found significant association with several markers spanning the major histocompatibility complex (MHC) region on chromosome 6p21.3-22.1, a marker located upstream of the neurogranin gene (NRGN) on 11q24.2 and a marker in intron four of transcription factor 4 (TCF4) on 18q21.2. Our findings implicating the MHC region are consistent with an immune component to schizophrenia risk, whereas the association with NRGN and TCF4 points to perturbation of pathways involved in brain development, memory and cognition.
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“Further, results from SGENE+ 60 implicate NRGN (neurogranin) which may act as a calcium sensor. 61”
From Genetic architectures of psychiatric disorders: the emerging picture and its implications (2012) · cites this paper as [61]
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Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482
Inference of Population Structure Using Multilocus Genotype Data
Pritchard, J. K., Stephens, M., & Donnelly, P. (2000) · Genetics · doi:10.1093/genetics/155.2.945 · Cited by 33,871
Statistical Aspects of the Analysis of Data From Retrospective Studies of Disease
(1959) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/22.4.719 · Cited by 14,689
A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
Statistical Methods for Research Workers
Fisher, R. A. (1945) · American Journal of Clinical Pathology · doi:10.1093/ajcp/15.11.552b · Cited by 10,883
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442
Self-citationCommon polygenic variation contributes to risk of schizophrenia and bipolar disorder
The International Schizophrenia Consortium (2009) · Nature · doi:10.1038/nature08185 · Cited by 4,821
Genomic Control for Association Studies
Devlin, B., & Roeder, K. (1999) · Biometrics · doi:10.1111/j.0006-341x.1999.00997.x · Cited by 3,162
The Wellcome Trust Case Control Consortium, U.K.
Mossman, K. (2008) · Scientific American · doi:10.1038/scientificamerican0108-42a · Cited by 2,714
Large recurrent microdeletions associated with schizophrenia.
GROUP, Stefansson, H., Rujescu, D., Cichon, S., Pietiläinen, O. P. H., Ingason, A., Steinberg, S., Fossdal, R., Sigurdsson, E., Sigmundsson, T., et al. (2008) · Nature · doi:10.1038/nature07229 · Cited by 1,745
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Luo, X.-J., Mei, L. I., Huang, L., Steinberg, S., Mattheisen, M., Liang, G., Donohoe, G. J., Shi, Y., Chen, C., Yue, W., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.103 · Cited by 56
Self-citationGuan, F., Lin, H., Chen, G., Li, L., Chen, T., Liu, X., Han, J., & Li, T. (2016) · Scientific Reports · doi:10.1038/srep38048 · Cited by 57
Prestwood, T. R., Asgariroozbehani, R., Wu, S., Agarwal, S. M., Logan, R. W., Ballon, J. S., Hahn, M., & Freyberg, Z. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.113101 · Cited by 67
DNA methylome profiling using neonatal dried blood spot samples: A proof-of-principle study
Hollegaard, M. V., Bybjerg‐Grauholm, J., Nørgaard‐Pedersen, B., & HOUGAARD, D. M. (2013) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2013.01.016 · Cited by 55
Self-citationImmune system: A possible nexus between cannabinoids and psychosis
Suárez‐Pinilla, P., López-Gil, J., & Crespo‐Facorro, B. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.01.018 · Cited by 56
Luo, X., Mattheisen, M., Li, M., Huang, L., Rietschel, M., Børglum, A. D., Als, T. D., van den Oord, E. J. C. G., Åberg, K. A., Mors, O. N., et al. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbv017 · Cited by 54
Self-citationQuednow, B. B., Brinkmeyer, J., Mobascher, A., Nothnagel, M., Musso, F., Gründer, G., Savary, N., Petrovsky, N., Frommann, I., Lennertz, L., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1118051109 · Cited by 56
Wolf, C., Mohr, H., Schneider-Axmann, T., Reif, A., Wobrock, T., Scherk, H., Kraft, S., Schmitt, A., Falkai, P., & Gruber, O. (2013) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-013-0427-y · Cited by 56
Malavia, T. A., Chaparala, S., Wood, J. A., Chowdari, K. V., Prasad, K. M. R., McClain, L. L., Jegga, A. G., Ganapathiraju, M. K., & Nimgaonkar, V. L. (2017) · Schizophrenia · doi:10.1038/s41537-017-0010-z · Cited by 53
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Yang, J., Yang, X. W., & Tang, K. (2021) · FEBS Journal · doi:10.1111/febs.15872 · Cited by 54
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Nyegaard, M., Severinsen, J. E., Als, T. D., Hedemand, A., Straarup, S., Nordentoft, M., McQuillin, A., Bass, N. J., Lawrence, J., Thirumalai, S., et al. (2009) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31023 · Cited by 54
Self-citationAutism spectrum disorder and epileptic encephalopathy: common causes, many questions
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Zhou, Y., Dong, F., Lanz, T. A., Reinhart, V., Li, M., Liu, L., Zou, J., Xi, H. S., & Mao, Y. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.166 · Cited by 53
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Chan, M. K., Guest, P. C., Levin, Y., Umrania, Y., Schwarz, E., Bahn, S., & Rahmoune, H. (2011) · International review of neurobiology · doi:10.1016/b978-0-12-387718-5.00005-5 · Cited by 54
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Haworth, C. M. A., & Plomin, R. J. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2010.01.026 · Cited by 55
Complement C1q formation of immune complexes with milk caseins and wheat glutens in schizophrenia
Severance, E. G., Gressitt, K. L., Halling, M., Stallings, C. R., Origoni, A. E., Vaughan, C., Khushalani, S., Alaedini, A., Dupont, D., Dickerson, F., et al. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.07.005 · Cited by 53
Pocklington, A. J., O’Donovan, M. C., & Owen, M. J. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12489 · Cited by 57
The complement system in neurodegenerative and inflammatory diseases of the central nervous system
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Transcriptional targets of the schizophrenia risk gene MIR137
Collins, A. L., Kim, Y., Bloom, R. J., Kelada, S. N. P., Sethupathy, P., & Sullivan, P. F. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.42 · Cited by 52
Variants of the RELA Gene are Associated with Schizophrenia and their Startle Responses
Hashimoto, R., Ohi, K., Yasuda, Y., Fukumoto, M., Yamamori, H., Takahashi, H., Iwase, M., Okochi, T., Kazui, H., Saitoh, O., et al. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.78 · Cited by 52
Wu, Y., Liu, X., Luo, H., Deng, W., Zhao, G., Wang, Q., Zhang, L., Ma, X., Liu, X., Murray, R. M., et al. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2012.01.020 · Cited by 52
Self-citationHouenou, J., d’Albis, M.-A., Daban, C., Hamdani, N., Delavest, M., Lépine, J., Vederine, F.-E., Carde, S., Lajnef, M., Cabon, C., et al. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.09.003 · Cited by 53
Bramon, E., Pirinen, M., Strange, A., Lin, K., Freeman, C., Bellenguez, C., Su, Z., Band, G., Pearson, R. D., Vukcevic, D., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.03.033 · Cited by 54
Self-citationSrinivas, L., Vellichirammal, N. N., Alex, A. M., Nair, C. M., Nair, I. V., & Banerjee, M. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0569-8 · Cited by 52
Hafizi, S., Silva, T. M. S., Gerritsen, C. J., Kiang, M., Bagby, R. M., Prce, I., Wilson, A. A., Houle, S., Rusjan, P., & Mizrahi, R. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.111 · Cited by 56
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Transcriptomic evidence for immaturity of the prefrontal cortex in patients with schizophrenia
Hagihara, H., Ohira, K., Takao, K., & Miyakawa, T. (2014) · Molecular Brain · doi:10.1186/1756-6606-7-41 · Cited by 52
Nelson, P. A., Sage, J. R., Wood, S. C., Davenport, C. M., Anagnostaras, S. G., & Boulanger, L. M. (2013) · Learning & Memory · doi:10.1101/lm.031351.113 · Cited by 49
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Kendler, K. S., & O’Donovan, M. C. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.1776 · Cited by 51
Rammos, A., Gonzalez, L. A. N., Weinberger, D. R., Mitchell, K. J., & Nicodemus, K. K. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0410-z · Cited by 52
Schizophrenia genetics: progress, at last
Mullé, J. G. (2012) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2012.02.011 · Cited by 52
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Takata, A., Iwayama, Y., Fukuo, Y., Ikeda, M., Okochi, T., Maekawa, M., Toyota, T., Yamada, K., Hattori, E., Ohnishi, T., et al. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.10.024 · Cited by 51
Prasad, K. M. R., Chowdari, K. V., D’Aiuto, L., Iyengar, S., Stanley, J. A., & Nimgaonkar, V. L. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0181-z · Cited by 51
Nature and nurture in neuropsychiatric genetics: where do we stand?
Dick, D. M., Riley, B. P., & Kendler, K. S. (2010) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2010.12.1/ddick · Cited by 52
Prefrontal Cortical Dysfunction After Overexpression of Histone Deacetylase 1
Jakovcevski, M., Bharadwaj, R. A., Straubhaar, J., Gao, G., Gavin, D. P., Jakovčevski, I., Mitchell, A., & Akbarian, S. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.03.020 · Cited by 50
MAGI1 Copy Number Variation in Bipolar Affective Disorder and Schizophrenia
Karlsson, R., Graae, L., Lekman, M., Wang, D., Favis, R., Axelsson, T., Galter, D., Belin, A. C., & Paddock, S. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.01.020 · Cited by 52
TCF4 (e2‐2; ITF2): A schizophrenia‐associated gene with pleiotropic effects on human disease
Navarrete, K., Pedroso, I., de Jong, S., Stefánsson, H., Steinberg, S., Stefánsson, K., Ophoff, R. A., Schalkwyk, L. C., & Collier, D. A. (2012) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32109 · Cited by 50
Self-citationSáiz, P. A., García‐Portilla, M. P., Arango, C., Morales, B., Arias, B., Corcoran, P. E., Fernández, J. M., Álvarez, V., Coto, E., Bobes-Bascarán, T., et al. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.09.008 · Cited by 50
Self-citationFunctional analysis of schizophrenia genes using GeneAnalytics program and integrated databases
Sundararajan, T., Manzardo, A. M., & Butler, M. G. (2017) · Gene · doi:10.1016/j.gene.2017.10.035 · Cited by 53
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Hwang, H., Szucs, M. J., Ding, L. J., Allen, A., Ren, X., Haensgen, H., Gao, F., Rhim, H., Andrade, A., Pan, J. Q., et al. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.07.014 · Cited by 49
Neurogranin Targets Calmodulin and Lowers the Threshold for the Induction of Long-Term Potentiation
Zhong, L., & Gerges, N. Z. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041275 · Cited by 51
Mullin, A. P., Sadanandappa, M. K., Ma, W., Dickman, D. K., VijayRaghavan, K., Ramaswami, M., Sanyal, S., & Faúndez, V. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3542-14.2015 · Cited by 50
Ohi, K., Sumiyoshi, C., Fujino, H., Yasuda, Y., Yamamori, H., Fujimoto, M., Sumiyoshi, T., & Hashimoto, R. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00293 · Cited by 48
Attenuated Notch signaling in schizophrenia and bipolar disorder
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Self-citationModulation of prepulse inhibition through both M1 and M4 muscarinic receptors in mice
Thomsen, M., Wess, J., Fulton, B. S., Fink‐Jensen, A., & Caine, S. B. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1740-z · Cited by 48
Self-citationNeurodevelopmental Origins of Schizophrenia
Weinberger, D. R., & Levitt, P. R. (2010) · Wiley eBooks · doi:10.1002/9781444327298.ch19 · Cited by 49
Dow, D. J., Huxley-Jones, J., Hall, J. M., Francks, C., Maycox, P. R., Kew, J. N. C., Gloger, I. S., Mehta, N. A. L., Kelly, F. M., Muglia, P., et al. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2010.12.009 · Cited by 48
Self-citationKelly, D. L., Demyanovich, H. K., Rodriguez, K. M., Čiháková, D., Talor, M. V., McMahon, R. P., Richardson, C. M., Vyas, G. R., Adams, H. A., August, S. M., et al. (2019) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.180174 · Cited by 48
The genetic architecture of schizophrenia: review of large-scale genetic studies
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Neonatal levels of acute phase proteins and later risk of non-affective psychosis
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Lin, M., Zhao, D., Hrabovsky, A., Pedrosa, E., Zheng, D., & Lachman, H. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094968 · Cited by 50
The MDGA1 gene confers risk to schizophrenia and bipolar disorder
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De Novo Truncating Mutation in Kinesin 17 Associated with Schizophrenia
Tarabeux, J., Champagne, N., Brustein, E., Hamdan, F. F., Gauthier, J., Lapointe, M., Maios, C., Piton, A., Spiegelman, D., Henrion, É., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.04.018 · Cited by 52
Ersland, K. M., Christoforou, A., Stansberg, C. T., Espeseth, T., Mattheisen, M., Mattingsdal, M., Hardarson, G. A., Hansen, T. F., Fernandes, C. P. D., Giddaluru, S., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031687 · Cited by 49
Self-citationUezato, A., Kimura-Sato, J., Yamamoto, N., Iijima, Y., Kunugi, H., & Nishikawa, T. (2012) · Behavioral and Brain Functions · doi:10.1186/1744-9081-8-2 · Cited by 48
Ohi, K., Shimada, T., Nemoto, K., Kataoka, Y., Yasuyama, T., Kimura, K., Okubo, H., Uehara, T., & Kawasaki, Y. (2017) · NeuroImage Clinical · doi:10.1016/j.nicl.2017.08.008 · Cited by 46
Common Pathophysiology in Multiple Mouse Models of Pitt–Hopkins Syndrome
Thaxton, C., Kloth, A. D., Clark, E. P., Moy, S. S., Chitwood, R. A., & Philpot, B. D. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1305-17.2017 · Cited by 50
van Mierlo, H. C., Schot, A., Boks, M. P., & de Witte, L. D. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2019.05.028 · Cited by 49
MicroRNA schizophrenia: Etiology, biomarkers and therapeutic targets
Zhang, H.-C., Du, Y., Chen, L., Yuan, Z., & Cheng, Y. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105064 · Cited by 47
Dual Cases of Type 1 Narcolepsy with Schizophrenia and Other Psychotic Disorders
Cañellas, F., Lin, L., Juliá, M. R., Clemente, A., Vives-Bauzá, C., Ollila, H. M., Hong, S., Arboleya, S., Einen, M. A., Faraco, J. H., et al. (2014) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.4040 · Cited by 47
Schizophrenia: from Epidemiology to Rehabilitation
Mura, G., Петретто, Д. Р., Bhat, K. M., & Carta, M. G. (2012) · Clinical Practice and Epidemiology in Mental Health · doi:10.2174/1745017901208010052 · Cited by 47
Refining and integrating schizophrenia pathophysiology – Relevance of the allostatic load concept
Misiak, B., Frydecka, D., Zawadzki, M., Krefft, M., & Kiejna, A. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.06.004 · Cited by 47
Nagai, T., Kitahara, Y., Ibi, D., Nabeshima, T., Sawa, A., & Yamada, K. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.07.049 · Cited by 49
Li, M., Wang, Y., Zheng, X.-B., Ikeda, M., Iwata, N., Luo, X., Chong, S. A., Lee, J., Rietschel, M., Zhang, F., et al. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.10.008 · Cited by 47
Self-citationNeurodevelopment in Schizophrenia: The Role of the Wnt Pathways
Panaccione, I., Napoletano, F., Forte, A. M., Kotzalidis, G. D., CASALE, A. D., Rapinesi, C., Brugnoli, C., Serata, D., Caccia, F., Cuomo, I., et al. (2013) · Current Neuropharmacology · doi:10.2174/1570159x113119990037 · Cited by 49
Lennertz, L., Rujescu, D., Wagner, M., Frommann, I., Schulze‐Rauschenbach, S., Schuhmacher, A., Landsberg, M. W., Franke, P. E., Möller, H., Wölwer, W., et al. (2011) · Neuropsychobiology · doi:10.1159/000317844 · Cited by 47
Self-citationVolk, D. W. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.12.019 · Cited by 47
Axon guidance pathway genes are associated with schizophrenia risk
Wang, Z., Li, P., Wu, T., Zhu, S., Deng, L., & Cui, G. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.6781 · Cited by 47
Identification and replication of RNA-Seq gene network modules associated with depression severity
Le, T. T., Savitz, J. B., Suzuki, H., Misaki, M., Teague, T. K., White, B. C., Marino, J. H., Wiley, G. B., Gaffney, P. M., Drevets, W. C., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0234-3 · Cited by 47
Decanalization, brain development and risk of schizophrenia
McGrath, J. J., Hannan, A. J., & Gibson, G. C. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.16 · Cited by 48
Association of AADAC Deletion and Gilles de la Tourette Syndrome in a Large European Cohort
Bertelsen, B., Stefánsson, H., Jensen, L. R., Melchior, L., Debes, N. M., Groth, C., Skov, L., Werge, T. M., Karagiannidis, I., Tárnok, Z., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.08.027 · Cited by 45
Self-citationKoide, T., Banno, M., Aleksić, B., Yamashita, S., Kikuchi, T., Kohmura, K., Adachi, Y., Kawano, N., Kushima, I., Nakamura, Y., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036836 · Cited by 46
Elevated gliadin antibody levels in individuals with schizophrenia
Okusaga, O. O., Yolken, R. H., LANGENBERG, P. W., Sleemi, A., Kelly, D. L., Vaswani, D., Giegling, I., Hartmann, A. M., Konte, B., Friedl, M., et al. (2013) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2012.747699 · Cited by 46
Self-citationLuo, X., Li, M., Huang, L., Nho, K. T., Deng, M., Chen, Q., Weinberger, D. R., Vásquez, A. A., Rijpkema, M., Mattay, V. S., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050375 · Cited by 46
Self-citationExploring Transcription Factors-microRNAs Co-regulation Networks in Schizophrenia
Xu, Y. J., Yue, W., Shugart, Y. Y., Li, S., Cai, L., Li, Q., Cheng, Z., Wang, G., Zhou, Z., Jin, C., et al. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbv170 · Cited by 46
D’Rozario, M., Zhang, T., Waddell, E. A., Zhang, Y., Sahin, C., Sharoni, M. A., Hu, T., Nayal, M., Kutty, K., Liebl, F. L. W., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.03.034 · Cited by 46
The Clinical Challenge of Autoimmune Psychosis: Learning from Anti-NMDA Receptor Autoantibodies
Ellul, P., Groc, L., Tamouza, R., & Leboyer, M. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00054 · Cited by 46
Association between SNPs and gene expression in multiple regions of the human brain
Kim, S. Y., Cho, H., Lee, D., & Webster, M. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.42 · Cited by 46
Electrophysiological Endophenotypes for Schizophrenia
Owens, E. M., Bachman, P., Glahn, D. C., & Bearden, C. E. (2016) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000110 · Cited by 50
Bilousova, T. V., Dang, H. N., Xu, W., Gustafson, S., Jin, Y., Wickramasinghe, L., Won, T., Bobarnac, G., Middleton, B., Tian, J., et al. (2012) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2012.03.008 · Cited by 46
The Val66Met polymorphism of the BDNF gene in anorexia nervosa: New data and a meta-analysis
Brandys, M. K., Kas, M. J., Elburg, A. A. V., Ophoff, R. A., Landt, M., Middeldorp, C. M., Boomsma, D. I., van Furth, E. F., Slagboom, P. E., & Adan, R. A. H. (2011) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2011.605470 · Cited by 48
Self-citationKumarasinghe, N., Tooney, P. A., & Schall, U. (2012) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867412442405 · Cited by 45
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Dieset, I., Djurovic, S., Tesli, M., Hope, S., Mattingsdal, M., Michelsen, A. E., Joa, I., Larsen, T. K., Agartz, I., Melle, I. S., et al. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.11091431 · Cited by 45
Self-citationImaging Genetics and Psychiatric Disorders
Hashimoto, R., Ohi, K., Yamamori, H., Yasuda, Y., Fujimoto, M., Umeda‐Yano, S., Watanabe, Y., Fukunaga, M., & Takeda, M. (2015) · Current Molecular Medicine · doi:10.2174/1566524015666150303104159 · Cited by 45
Xu, Y., Zhang, L., Shi, T., Zhou, Y., Cai, H., Lan, X., Zhang, C., Lei, C., & Chen, H. (2013) · Mammalian Genome · doi:10.1007/s00335-013-9483-x · Cited by 45
Jacobson, M. R., Watts, J. J., Boileau, I., Tong, J., & Mizrahi, R. (2019) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.12.014 · Cited by 45
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Sinkus, M. L., Adams, C. E., Logel, J., Freedman, R., & Leonard, S. S. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.01.087 · Cited by 46
Kähler, A. K., Djurovic, S., Rimol, L. M., Brown, A. A., Athanasiu, L., Jönsson, E. G., Hansen, T., Gústafsson, Ó., Hall, H., Giegling, I., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.07.035 · Cited by 48
Self-citationPACSIN proteins in vivo: Roles in development and physiology
Dumont, V., & Lehtonen, S. H. (2022) · Acta Physiologica · doi:10.1111/apha.13783 · Cited by 41
Demontis, D., Nyegaard, M., Buttenschøn, H. N., Hedemand, A., Pedersen, C. B., Grove, J., Flint, T. J., Nordentoft, M., Werge, T. M., HOUGAARD, D. M., et al. (2011) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31234 · Cited by 44
Self-citationChen, J., Lin, M., Hrabovsky, A., Pedrosa, E., Dean, J. T., Jain, S., Zheng, D., & Lachman, H. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0124597 · Cited by 43
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Yamamoto, H., Hagino, Y., Kasai, S., & Ikeda, K. (2015) · Current Molecular Medicine · doi:10.2174/1566524015666150330142807 · Cited by 48
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Benros, M. E., Trabjerg, B. B., Meier, S. M., Mattheisen, M., Mortensen, P. B., Mors, O. N., Børglum, A. D., HOUGAARD, D. M., Nørgaard‐Pedersen, B., Nordentoft, M., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.04.008 · Cited by 44
Self-citation
Metadata
- Authors
- †Genetic Risk and Outcome in Psychosis (GROUP), Stefansson, H., Ophoff, R. A., Steinberg, S., Andreassen, O. A., Cichon, S., Rujescu, D., Werge, T., Pietiläinen, O. P. H., Mors, O., Mortensen, P. B., Sigurdsson, E., Gustafsson, O., Nyegaard, M., Tuulio-Henriksson, A., Ingason, A., Hansen, T., Suvisaari, J., Lonnqvist, J., Paunio, T., Børglum, A. D., Hartmann, A., Fink-Jensen, A., Nordentoft, M., Hougaard, D., Norgaard-Pedersen, B., Böttcher, Y., Olesen, J., Breuer, R., Möller, H.-J., Giegling, I., Rasmussen, H. B., Timm, S., Mattheisen, M., Bitter, I., Réthelyi, J. M., Magnusdottir, B. B., Sigmundsson, T., Olason, P., Masson, G., Gulcher, J. R., Haraldsson, M., Fossdal, R., Thorgeirsson, T. E., Thorsteinsdottir, U., Ruggeri, M., Tosato, S., Franke, B., Strengman, E., Kiemeney, L. A., Melle, I., Djurovic, S., Abramova, L., Kaleda, V., Sanjuan, J., de Frutos, R., Bramon, E., Vassos, E., Fraser, G., Ettinger, U., Picchioni, M., Walker, N., Toulopoulou, T., Need, A. C., Ge, D., Lim Yoon, J., Shianna, K. V., Freimer, N. B., Cantor, R. M., Murray, R., Kong, A., Golimbet, V., Carracedo, A., Arango, C., Costas, J., Jönsson, E. G., Terenius, L., Agartz, I., Petursson, H., Nöthen, M. M., Rietschel, M., Matthews, P. M., Muglia, P., Peltonen, L., St Clair, D., Goldstein, D. B., Stefansson, K., & Collier, D. A.
- Affiliations
- deCODE Genetics (Iceland) (IS)
- University of Bonn (DE)
- Sankt Hans Hospital (DK)
- Aarhus University Hospital (DK)
- Aarhus University (DK)
- Copenhagen University Hospital (DK)
- Statens Serum Institut (DK)
- Heidelberg University (DE)
- Ludwig-Maximilians-Universität München (DE)
- Semmelweis University (HU)
- University of Verona (IT)
- Radboud University Medical Center (NL)
- University of Oslo (NO)
- Mental Health Research Center of Russian Academy of Medical Sciences (RU)
- King's College London (GB)
- Duke University (US)
- University of California, Los Angeles (US)
- Hospital General Universitario Gregorio Marañón (ES)
- Karolinska Institutet (SE)
- University of Iceland (IS)
- GlaxoSmithKline (United Kingdom) (GB)
- Wellcome Sanger Institute (GB)
- University of Aberdeen (GB)
- ORCID
- Ophoff, Roel A.
- Steinberg, Stacy
- Andreassen, Ole A.
- Cichon, Sven
- Rujescu, Dan
- Werge, Thomas
- Pietiläinen, Olli P. H.
- Mors, Ole
- Mortensen, Preben B.
- Nyegaard, Mette
- Hansen, Thomas
- Suvisaari, Jaana
- Paunio, Tiina
- Børglum, Anders D.
- Hartmann, Annette
- Nordentoft, Merete
- Hougaard, David
- Böttcher, Yvonne
- Olesen, Jes
- Möller, Hans-Jürgen
- Giegling, Ina
- Mattheisen, Manuel
- Bitter, István
- Réthelyi, János M.
- Olason, Pall
- Haraldsson, Magnus
- Thorgeirsson, Thorgeir E.
- Ruggeri, Mirella
- Tosato, Sarah
- Franke, Barbara
- Strengman, Eric
- Kiemeney, Lambertus A.
- Melle, Ingrid
- Djurovic, Srdjan
- Bramon, Elvira
- Vassos, Evangelos
- Ettinger, Ulrich
- Picchioni, Marco
- Need, Anna C.
- Ge, Dongliang
- Freimer, Nelson B.
- Cantor, Rita M.
- Murray, Robin
- Kong, Augustine
- Arango, Celso
- Costas, Javier
- Jönsson, Erik G.
- Terenius, Lars
- Agartz, Ingrid
- Nöthen, Markus M.
- Rietschel, Marcella
- Matthews, Paul M.
- Muglia, Pierandrea
- Peltonen, Leena
- Goldstein, David B.
- Collier, David A.
- Venue
- Nature
- Published
- 2009-07-01
- Volume
- 460
- Issue
- 7256
- Pages
- 744-747
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3077530
- OpenAlex
- W2127205775
- Cited by
- 1,677
- References
- 39
- Citations by year
- 2026: 21 · 2025: 39 · 2024: 47 · 2023: 38 · 2022: 47 · 2021: 65 · 2020: 62 · 2019: 66 · 2018: 56 · 2017: 90 · 2016: 116 · 2015: 148 · 2014: 140 · 2013: 165 · 2012: 196
- FWCI
- 116.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Lirias (KU Leuven) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- VU Research Portal (submittedVersion)
- Hirsla (Landspítali University Hospital) (submittedVersion, other-oa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Funders
- GlaxoSmithKline
- Wellcome Trust (089061)
- National Institute for Health and Care Research (PDA/02/06/016)
- Bundesministerium für Bildung und Forschung (NGFN-2)
- Alfried Krupp von Bohlen und Halbach-Stiftung
- National Institutes of Health (6r01hl087679-03)
- National Heart, Lung, and Blood Institute (R01 HL087679, 1-R01HL087679-01)
- National Institute of Mental Health (R01MH078075, MH078075)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Keywords
- schizophrenia, genetic susceptibility, single nucleotide polymorphisms, copy number variation, major histocompatibility complex, neurogranin, TCF4, immune function, brain development, memory and cognition, mental illness
- MeSH terms
- Transcription Factor 4, Chromosomes, Human, Pair 11, Chromosomes, Human, Pair 18, Chromosomes, Human, Pair 6, DNA-Binding Proteins, Genetic Markers, Genotype, Humans, Major Histocompatibility Complex, Schizophrenia, Transcription Factors, Genome, Human, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Neurogranin, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Genome-Wide Association Study
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