The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Bifidobacteria can protect from enteropathogenic infection through production of acetate
Abstract
The human gut is colonized with a wide variety of microorganisms, including species, such as those belonging to the bacterial genus Bifidobacterium, that have beneficial effects on human physiology and pathology. Among the most distinctive benefits of bifidobacteria are modulation of host defence responses and protection against infectious diseases. Nevertheless, the molecular mechanisms underlying these effects have barely been elucidated. To investigate these mechanisms, we used mice associated with certain bifidobacterial strains and a simplified model of lethal infection with enterohaemorrhagic Escherichia coli O157:H7, together with an integrated 'omics' approach. Here we show that genes encoding an ATP-binding-cassette-type carbohydrate transporter present in certain bifidobacteria contribute to protecting mice against death induced by E. coli O157:H7. We found that this effect can be attributed, at least in part, to increased production of acetate and that translocation of the E. coli O157:H7 Shiga toxin from the gut lumen to the blood was inhibited. We propose that acetate produced by protective bifidobacteria improves intestinal defence mediated by epithelial cells and thereby protects the host against lethal infection.
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In the citing paper
“Additional support for the role of enteric bacteria in maintaining normal barrier function is provided by data that SCFA (e.g., butyrate and acetate) improve intestinal barrier function (64, 84).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [64]
In the citing paper
“Numerous in vitro studies have demonstrated that bifidobacteria can inhibit pathogens through the production of organic acids (38), antibacterial peptides (39), quorum-sensing inhibitors (40, 41), or immune stimulation (42) among other mechanisms, providing molecular clues of their capacity to prevent certain infections.”
From Bifidobacteria and Their Health-Promoting Effects (2017) · cites this paper as [38]
In the citing paper
“these bacteria have been linked to fortification of the gut mucosal protection through activities against pathogens12, 13.”
From Diet and the Intestinal Microbiome: Associations, Functions, and Implications for Health and Disease (2014) · cites this paper as [13]
In the citing paper
“which have been shown in vitro and in vivo to support the integrity of the intestinal mucosa in a variety of ways (Fukuda et al., 2011; Gaudier et al., 2004; Macia et al., 2015; Willemsen et al., 2003; Wrzosek et al., 2013).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Fukuda et al., 2011
In the citing paper
“Bifidobacterium longum has been shown to protect mice from enterohemorrhagic E. coli O157 infection through the production of SCFAs, that prevent IEC apoptosis and inflammation, thus preserving gut epithelium integrity, and reducing the spread of Stx2 toxin into the bloodstream, ultimately improving host survival [52].”
From Antibiotic-Induced Changes in the Intestinal Microbiota and Disease (2016) · cites this paper as [52]
In the citing paper
“Acetate production was associated with protection against Escherichia coli O157 in mice that were mono-colonized by Bifidobacterium [39].”
From Role of the gut microbiota in nutrient competition and protection against intestinal pathogen colonization (2023) · cites this paper as [39]
Citations
Cites
tRNAscan-SE: A Program for Improved Detection of Transfer RNA Genes in Genomic Sequence
Lowe, T. M., & Eddy, S. R. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.5.955 · Cited by 11,200
Summaries of Affymetrix GeneChip probe level data
Irizarry, R. A. (2003) · Nucleic Acids Research · doi:10.1093/nar/gng015 · Cited by 4,837
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
Maslowski, K. M., Vieira, A. T., Ng, A., Kranich, J., Sierro, F., Yu, D., Schilter, H. C., Rolph, M. S., Mackay, F., Artis, D., et al. (2009) · Nature · doi:10.1038/nature08530 · Cited by 3,241
Improved microbial gene identification with GLIMMER
Delcher, A. L. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.23.4636 · Cited by 2,493
Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome
Tarr, P. I., Gordon, C. A., & Chandler, W. L. (2005) · The Lancet · doi:10.1016/s0140-6736(05)71144-2 · Cited by 1,791
Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators
Staels, B., Köenig, W., Habib, A., Merval, R., Lebret, M., Pineda‐Torra, I., Delerive, P., Fadel, A., Chinetti, G., Fruchart, J., et al. (1998) · Nature · doi:10.1038/31701 · Cited by 1,138
Liver X receptors as integrators of metabolic and inflammatory signaling
Zelcer, N. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27883 · Cited by 978
Schell, M. A., Karmirantzou, M., Snel, ., Vilanova, D., Berger, B. W., Pessi, G., Zwahlen, M.-C., Desiere, F., Peer Bork, B., Delley, M., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.212527599 · Cited by 942
Sela, D. A., Chapman, J., Adeuya, A., Kim, J., Chen, F., Whitehead, T. R., Lapidus, A. L., Rokhsar, D. S., Lebrilla, C. B., German, J. B., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809584105 · Cited by 895
Tedelind, S., Westberg, F., Kjerrulf, M., & Vidal, A. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i20.2826 · Cited by 880
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Items 501–600 of 1,007
Is metformin poised for a second career as an antimicrobial?
Malik, F. R., Mehdi, S. F., Ali, H., Patel, P., Basharat, A., Kumar, A., Ashok, F., Stein, J., Brima, W., Malhotra, P., et al. (2017) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2975 · Cited by 89
From genetics of inflammatory bowel disease towards mechanistic insights
Graham, D. B., & Xavier, R. J. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.04.001 · Cited by 90
Environmental factors influencing the efficacy of probiotic bacteria
Marco, M. L., & Tachon, S. (2012) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2012.10.002 · Cited by 91
Hanson, C., Lyden, E. R., Rennard, S. I., Mannino, D. M., Rutten, E. P. A., Hopkins, R. J., & Young, R. P. (2016) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201509-609oc · Cited by 87
Biochemical Features of Beneficial Microbes: Foundations for Therapeutic Microbiology
Engevik, M. A., & Versalovic, J. A. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.bad-0012-2016 · Cited by 87
Button, J. E., Autran, C. A., Reens, A. L., Cosetta, C. M., Smriga, S., Ericson, M. E., Pierce, J. V., Cook, D. N., Lee, M. L., Sun, A. K., et al. (2022) · Cell Host & Microbe · doi:10.1016/j.chom.2022.04.001 · Cited by 86
Sharon, G., Segal, D., Zilber‐Rosenberg, I., & ROSENBERG, E. B. (2011) · Gut Microbes · doi:10.4161/gmic.2.3.16103 · Cited by 89
Maintenance of a healthy trajectory of the intestinal microbiome during aging: A dietary approach
Candela, M., Biagi, E., Brigidi, P., O’Toole, P. W., & de Vos, W. M. (2013) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.12.004 · Cited by 87
Phạm, V. H., Abbas, W., Huang, J., He, Q., Zhen, W., Guo, Y., & Wang, Z. (2021) · Poultry Science · doi:10.1016/j.psj.2021.101563 · Cited by 84
Gut Microbiome‐Induced Shift of Acetate to Butyrate Positively Manages Dysbiosis in High Fat Diet
Si, X., Shang, W., Zhou, Z., Strappe, P., Wang, B., Bird, A. R., & BLANCHARD, C. L. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700670 · Cited by 85
Microbiota-Derived Metabolic Factors Reduce Campylobacteriosis in Mice
Sun, X., Winglee, K., Gharaibeh, R. Z., Gauthier, J., He, Z., Tripathi, P., Avram, D., Bruner, S. D., Fodor, A. A., & Jobin, C. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.01.042 · Cited by 87
Kosumi, K., Hamada, T., Koh, H., Borowsky, J., Bullman, S., Twombly, T. S., Nevo, D., Masugi, Y., Liu, L., da Silva, A., et al. (2018) · American Journal Of Pathology · doi:10.1016/j.ajpath.2018.08.015 · Cited by 85
Song, X., Dou, X., Chang, J., Zeng, X., Xu, Q., & Xu, C. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2414805 · Cited by 84
Christensen, E. G., Licht, T. R., Leser, T. D., & Bahl, M. I. (2014) · BMC Research Notes · doi:10.1186/1756-0500-7-660 · Cited by 84
Bai, J., Zhu, Y. G., & Dong, Y. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.12.050 · Cited by 85
Gotoh, A., Nara, M., Sugiyama, Y., Sakanaka, M., Yachi, H., Kitakata, A., Nakagawa, A., Minami, H., Okuda, S., Katoh, T., et al. (2017) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2017.1359486 · Cited by 83
Tuo, Y., Song, X., Song, Y., Liu, W., Tang, Y., Gao, Y., Jiang, S., Qian, F., & Mu, G. (2018) · Journal of Dairy Science · doi:10.3168/jds.2017-13654 · Cited by 82
Sencio, V., Gallerand, A., Machado, M. G., Deruyter, L., Heumel, S., Soulard, D., Barthelemy, J., Cuinat, C., Vieira, A. T., Barthélémy, A., et al. (2021) · Infection and Immunity · doi:10.1128/iai.00734-20 · Cited by 87
Prebiotics to Fight Diseases: Reality or Fiction?
Bartolomeo, F. D., Startek, J. B., & den Ende, W. V. (2012) · Phytotherapy Research · doi:10.1002/ptr.4901 · Cited by 85
Vigsnæs, L. K., Holck, J., Meyer, A. S., & Licht, T. R. (2011) · Applied and Environmental Microbiology · doi:10.1128/aem.05895-11 · Cited by 82
Beneficial Effects of Fecal Microbiota Transplantation on Ulcerative Colitis in Mice
Tian, Z., Liu, J., Liao, M., Li, W., Zou, J., Han, X., Kuang, M., Shen, W., & Li, H. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-016-4060-2 · Cited by 82
Pourabedin, M., Xu, Z., Baurhoo, B., Chevaux, E., & Zhao, X. (2014) · Canadian Journal of Microbiology · doi:10.1139/cjm-2013-0899 · Cited by 87
Huang, A., Cai, R., Wang, Q., Shi, L., Li, C., & Yan, H. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00322 · Cited by 82
Human Gut Microbiota Predicts Susceptibility to Vibrio cholerae Infection
Midani, F. S., Weil, A. A., Chowdhury, F., Begum, Y. A., Khan, A. I., Debela, M. D., Durand, H. K., Reese, A. T., Nimmagadda, S. N., Silverman, J. D., et al. (2018) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiy192 · Cited by 82
Wang, Y., Xie, Q., Sun, S., Huang, B., Zhang, Y., Xu, Y., Zhang, S., & Xiang, H. (2018) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-018-9438-y · Cited by 82
The gut microbiome-immune axis as a target for nutrition-mediated modulation of food allergy
Wang, Z., Zhong, J., Meng, X., Gao, J., Li, H., Sun, J., Li, X., & Chen, H. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.05.021 · Cited by 81
Drabińska, N., Jarocka‐Cyrta, E., Markiewicz, L. H., & Krupa‐Kozak, U. (2018) · Nutrients · doi:10.3390/nu10020201 · Cited by 82
NSAID enteropathy and bacteria: a complicated relationship
Syer, S. D., Blackler, R. W., Martin, R., de Palma, G., Rossi, L., Verdu, E., Bercik, P., Surette, M. G., Aucouturier, A., Langella, P., et al. (2015) · Journal of Gastroenterology · doi:10.1007/s00535-014-1032-1 · Cited by 80
Hu, L., Zhu, S., Peng, X., Li, K., Peng, W., Zhong, Y., Kang, C., Cao, X., Liu, Z., & Zhao, B. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200035 · Cited by 80
Kumar, H., Collado, M. C., Wopereis, H., Salminen, S., Knol, J., & Roeselers, G. (2020) · Microorganisms · doi:10.3390/microorganisms8121855 · Cited by 81
Oral magnesium prevents acetaminophen-induced acute liver injury by modulating microbial metabolism
Li, D., Chen, Y., Wan, M., Mei, F., Wang, F., Gu, P., Zhang, X., Wei, R., Zeng, Y., Zheng, H., et al. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.11.006 · Cited by 80
Moutsopoulos, N. M., Chalmers, N. I., Barb, J. J., Abusleme, L., Greenwell‐Wild, T., Dutzan, N., Paster, B. J., Munson, P. J., Fine, D. H., Uzel, G., et al. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004698 · Cited by 80
NOD-like receptors in intestinal homeostasis and epithelial tissue repair
Parlato, M., & Yeretssian, G. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15069594 · Cited by 79
Extracellular Vesicles Produced by Bifidobacterium longum Export Mucin-Binding Proteins
Nishiyama, K., Takaki, T., Sugiyama, M., Fukuda, I., Aiso, M., Mukai, T., Odamaki, T., Xiao, J., Osawa, R., & Okada, N. (2020) · Applied and Environmental Microbiology · doi:10.1128/aem.01464-20 · Cited by 81
Hypoxia: The “Invisible Pusher” of Gut Microbiota
Han, N., Pan, Z., Liu, G., Yang, R., & Bi, Y. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.690600 · Cited by 80
Lee, Y., Kim, T., Kim, Y., Kim, S., Lee, S.-H., Seo, S., Zhou, B. O., Eunju, O., Kim, K. S., & Kweon, M. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00667-y · Cited by 83
Matsuki, T., Pédron, T., Regnault, B., Mulet, C., Hara, T., & Sansonetti, P. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063053 · Cited by 81
Vongbhavit, K., & Underwood, M. A. (2016) · Clinical Therapeutics · doi:10.1016/j.clinthera.2016.01.006 · Cited by 79
Beneficial microbiota. Probiotics and pharmaceutical products in functional nutrition and medicine
Novik, G. I., & Savich, V. V. (2019) · Microbes and Infection · doi:10.1016/j.micinf.2019.06.004 · Cited by 79
Mucosal Inflammatory Response to Salmonella typhimurium Infection
Patel, S. N., & McCormick, B. A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00311 · Cited by 85
Gut-microbiota derived bioactive metabolites and their functions in host physiology
Debnath, N., Kumar, R., Kumar, A., Mehta, P. K., & Yadav, A. K. (2021) · Biotechnology and Genetic Engineering Reviews · doi:10.1080/02648725.2021.1989847 · Cited by 77
López‐Tello, J., Schofield, Z., Kiu, R., Dalby, M. J., van Sinderen, D., Gall, G. L., Sferruzzi-Perri, A. N., & Hall, L. J. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04379-y · Cited by 78
The gut microbiome: scourge, sentinel or spectator?
Korecka, A., & Arulampalam, V. (2012) · Journal of Oral Microbiology · doi:10.3402/jom.v4i0.9367 · Cited by 82
The mouse gut microbiome revisited: From complex diversity to model ecosystems
Clavel, T., Lagkouvardos, I., Blaut, M., & Stecher, B. (2016) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2016.03.002 · Cited by 84
Lactose and lactose-derived oligosaccharides: More than prebiotics?
Chen, X. Y., & Gänzle, M. G. (2016) · International Dairy Journal · doi:10.1016/j.idairyj.2016.10.001 · Cited by 77
Nishiyama, K., Yamamoto, Y., Sugiyama, M., Takaki, T., Urashima, T., Fukiya, S., Yokota, A., Okada, N., & Mukai, T. (2017) · mBio · doi:10.1128/mbio.00928-17 · Cited by 77
Commensal Bacteria-Specific CD4+ T Cell Responses in Health and Disease
Sorini, C., Cardoso, R. F., Gagliani, N., & Villablanca, E. J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02667 · Cited by 77
Gehrig, J. L., Portik, D. M., Driscoll, M. D., Jackson, E., Chakraborty, S., Gratalo, D., Ashby, M., & Valladares, R. B. (2022) · Microbial Genomics · doi:10.1099/mgen.0.000794 · Cited by 80
The role of gut microbiota in Clostridium difficile infection
Samarkos, M., Mastrogianni, E., & Kampouropoulou, O. (2018) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2018.02.006 · Cited by 75
Host cell attachment elicits posttranscriptional regulation in infecting enteropathogenic bacteria
Katsowich, N., Elbaz, N., Pal, R. R., Mills, E., Koby, S., Kahan, T., & Rosenshine, I. (2017) · Science · doi:10.1126/science.aah4886 · Cited by 75
Kim, W.-G., Kang, G., Kim, H., Han, M. J., & Kim, D.-H. (2018) · Beneficial Microbes · doi:10.3920/bm2017.0146 · Cited by 75
You, L., Gong, Y., Li, C., Hu, X., Brennan, C. S., & Kulikouskaya, V. I. (2019) · International Journal of Food Science & Technology · doi:10.1111/ijfs.14408 · Cited by 78
Casaburi, G., Duar, R. M., Brown, H. K., Mitchell, R. D., Kazi, S., Chew, S., Cagney, O., Flannery, R. L., Sylvester, K. G., Frese, S. A., et al. (2021) · Scientific Reports · doi:10.1038/s41598-020-80583-9 · Cited by 76
Zhang, J., Liu, J., Zhu, S., Fang, Y., Wang, B., Jia, Q., Hao, H., Kao, J. Y., He, Q., Song, L., et al. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-00601-4 · Cited by 75
Takeda, T., Asaoka, D., Nojiri, S., Yanagisawa, N., Nishizaki, Y., Osada, T., Koido, S., Nagahara, A., Katsumata, N., Odamaki, T., et al. (2022) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000002028 · Cited by 76
Linking microbiota and respiratory disease
Hauptmann, M., & Schaible, U. E. (2016) · FEBS Letters · doi:10.1002/1873-3468.12421 · Cited by 77
Broom, L. J. (2018) · Poultry Science · doi:10.3382/ps/pey021 · Cited by 75
Impact of Prebiotics on Poultry Production and Food Safety.
Ricke, S. C. (2018) · Europe PMC (PubMed Central) · Cited by 75
Deciphering the quorum-sensing lexicon of the gut microbiota
Oliveira, R. A., Cabral, V., Torcato, I., & Xavier, K. B. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.03.015 · Cited by 74
Microbiome: Effects of Ageing and Diet
Salazar, N., González, S., Nogacka, A. M., Ríos-Covián, D., Arboleya, S., Gueimonde, M., & Reyes‐Gavilán, C. G. D. L. (2019) · Current Issues in Molecular Biology · doi:10.21775/cimb.036.033 · Cited by 75
Epithelial Cells as a Transmitter of Signals From Commensal Bacteria and Host Immune Cells
Goto, Y. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02057 · Cited by 78
Early life gut microbiome and its impact on childhood health and chronic conditions
Núñez, H., Nieto, P. A., Mars, R. A. T., Ghavami, M., Hoy, C. S., & Sukhum, K. V. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2463567 · Cited by 80
Connolly, J. P. R., Finlay, B. B., & Roe, A. J. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00568 · Cited by 77
Tolerance of Bifidobacterium human isolates to bile, acid and oxygen
Andriantsoanirina, V., Allano, S., Butel, M. J., & Aires, J. (2013) · Anaerobe · doi:10.1016/j.anaerobe.2013.04.005 · Cited by 75
Normal to cancer microbiome transformation and its implication in cancer diagnosis
Khan, A. A., Shrivastava, A., & Khurshid, M. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.05.005 · Cited by 75
Gut Microbiome in Down Syndrome
Biagi, E., Candela, M., Centanni, M., Consolandi, C., Rampelli, S., Turroni, S., Severgnini, M., Peano, C., Ghezzo, A., Scurti, M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112023 · Cited by 74
Van den Abbeele, P., Verstrepen, L., Ghyselinck, J., Albers, R., Marzorati, M., & Mercenier, A. (2020) · Nutrients · doi:10.3390/nu12071917 · Cited by 73
Ose, R., Hirano, K., Maeno, S., Nakagawa, J., Salminen, S., Tochio, T., & Endo, A. (2018) · Anaerobe · doi:10.1016/j.anaerobe.2018.04.018 · Cited by 76
Kleerebezem, M., Binda, S., Bron, P. A., Gross, G., Hill, C., Vlieg, J. E. V. H., Lebeer, S., Satokari, R. M., & Ouwehand, A. C. (2018) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2018.09.007 · Cited by 75
The Microbiome in Celiac Disease
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Insights into the Role of Human Gut Microbiota in Clostridioides difficile Infection
Kachrimanidou, M., & Tsintarakis, E. (2020) · Microorganisms · doi:10.3390/microorganisms8020200 · Cited by 75
The gut microbiota and colorectal surgery outcomes: facts or hype? A narrative review
Agnes, A., Puccioni, C., D’Ugo, D., Gasbarrini, A., Biondi, A., & Persiani, R. (2021) · BMC Surgery · doi:10.1186/s12893-021-01087-5 · Cited by 74
Gut microbiota in autoimmunity: potential for clinical applications
Kim, D.-H., Yoo, S., & Kim, W. (2016) · Archives of Pharmacal Research · doi:10.1007/s12272-016-0796-7 · Cited by 72
Hughes, K. R., Harnisch, L. C., Alcon-Giner, C., Mitra, S., Wright, C. J., Ketskemety, J., van Sinderen, D., Watson, A. J. M., & Hall, L. J. (2017) · Open Biology · doi:10.1098/rsob.160155 · Cited by 72
Characterization and Quantification of Oligosaccharides in Human Milk and Infant Formula
Nijman, R., Liu, Y., Bunyatratchata, A., Smilowitz, J. T., Stahl, B., & Barile, D. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b01515 · Cited by 72
The neonatal bowel microbiome in health and infection
Berrington, J. E., Stewart, C. J., Cummings, S. P., & Embleton, N. D. (2014) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0000000000000061 · Cited by 73
Zuo, F., Chen, S., & Marcotte, H. (2020) · Biotechnology Advances · doi:10.1016/j.biotechadv.2020.107654 · Cited by 72
Zhou, Q., Fu, X., Dhital, S., Zhai, H., Huang, Q., & Zhang, B. (2021) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2021.106941 · Cited by 71
Inhibition of Paenibacillus larvae by lactic acid bacteria isolated from fermented materials
Yoshiyama, M., Wu, M., Sugimura, Y., Takaya, N., Kimoto‐Nira, H., & Suzuki, C. (2012) · Journal of Invertebrate Pathology · doi:10.1016/j.jip.2012.09.002 · Cited by 71
Vazquez-Gutierrez, P., de Wouters, T., Werder, J., Chassard, C., & Lacroix, C. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01480 · Cited by 76
Smilowitz, J. T., Moya, J. J., Breck, M. A., Cook, C., Fineberg, A. E., Angkustsiri, K., & Underwood, M. A. (2017) · BMC Pediatrics · doi:10.1186/s12887-017-0886-9 · Cited by 71
Yamada, M., Takahashi, N., Matsuda, Y., Sato, K., Yokoji, M., Sulijaya, B., Maekawa, T., Ushiki, T., Mikami, Y., Hayatsu, M., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-27408-y · Cited by 71
Colonization and probiotic function of Bifidobacterium longum
Zhang, C., Yu, Z., Zhao, J., Zhang, H., Zhai, Q., & Chen, W. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.12.022 · Cited by 74
Bottom-Up Approaches to Synthetic Cooperation in Microbial Communities
Rodríguez Amor, D., & Dal Bello, M. (2019) · Life · doi:10.3390/life9010022 · Cited by 71
Duar, R. M., Kyle, D., & Casaburi, G. (2020) · High-Throughput · doi:10.3390/ht9020007 · Cited by 70
Kikuchi, J., Tsuboi, Y., Komatsu, K., Gomi, M., Chikayama, E., & Date, Y. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b02311 · Cited by 71
Self-citationPostbiotic-Enabled Targeting of the Host-Microbiota-Pathogen Interface: Hints of Antibiotic Decline?
Puccetti, M., Xiroudaki, S., Ricci, M., & Giovagnoli, S. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12070624 · Cited by 59
Duar, R. M., Casaburi, G., Mitchell, R. D., Scofield, L. N. C., Ramírez, C. A. O., Barile, D., Henrick, B. M., & Frese, S. A. (2020) · Nutrients · doi:10.3390/nu12113247 · Cited by 72
Gut Microbiota‐Bile Acid Crosstalk in Diarrhea‐Irritable Bowel Syndrome
Zhan, K., Zheng, H., Jian-qing, L., Wu, H., Qin, S., Luo, L., & Huang, S. (2020) · BioMed Research International · doi:10.1155/2020/3828249 · Cited by 72
Ma, F., Sun, M., Song, Y., Wang, A., Jiang, S., Qian, F., Mu, G., & Tuo, Y. (2022) · Nutrients · doi:10.3390/nu14091916 · Cited by 70
Bacterial acetate metabolism and its influence on human epithelia.
Hosmer, J., McEwan, A. G., & Kappler, U. (2024) · PubMed Central · doi:10.1042/etls20220092 · Cited by 78
Epigenomic regulation of host–microbiota interactions
Alenghat, T., & Artis, D. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.09.007 · Cited by 72
Møller, M. S., Fredslund, F., Majumder, A., Nakai, H., Poulsen, J.-C. N., Leggio, L. L., Svensson, B., & Hachem, M. A. (2012) · Journal of Bacteriology · doi:10.1128/jb.00622-12 · Cited by 74
Wang, H.-G., Shi, P., Zuo, L., Dong, J., Zhao, J., Liu, Q., & Zhu, W. (2016) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjw065 · Cited by 70
Wu, Y., Pan, L., Shang, Q., Ma, X., Long, S., Xu, Y., & Piao, X. (2017) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2017.05.013 · Cited by 74
Microbiome and the immune system: From a healthy steady-state to allergy associated disruption
Mezouar, S., Chantran, Y., Michel, J., Fabre, A., Dubus, J. ‐., Léone, M., Sérémé, Y., Mège, J., Ranque, S., Desnues, B., et al. (2018) · Human Microbiome Journal · doi:10.1016/j.humic.2018.10.001 · Cited by 73
Xia, Y., Wang, T., Yu, S.-M., Liang, J., & Kuang, H. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.11.097 · Cited by 70
Bailey, M. T. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.02.006 · Cited by 69
Suzuki, Y., Ikeda, K., Sakuma, K., Kawai, S., Sawaki, K., Asahara, T., Takahashi, T., Tsuji, H., Nomoto, K., Nagpal, R., et al. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00847 · Cited by 71
The Regulation of Ruminal Short-Chain Fatty Acids on the Functions of Rumen Barriers
Shen, H., Xu, Z., Shen, Z., & Lu, Z. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01305 · Cited by 70
Metadata
- Authors
- Fukuda, S., Toh, H., Hase, K., Oshima, K., Nakanishi, Y., Yoshimura, K., Tobe, T., Clarke, J. M., Topping, D. L., Suzuki, T., Taylor, T. D., Itoh, K., Kikuchi, J., Morita, H., Hattori, M., & Ohno, H.
- Affiliations
- RIKEN (JP)
- RIKEN Advanced Science Institute (JP)
- The University of Tokyo (JP)
- The University of Osaka (JP)
- Commonwealth Scientific and Industrial Research Organisation (AU)
- Gifu University (JP)
- Azabu University (JP)
- Chiba University (JP)
- Corresponding author
- Hattori, Masahira
- Ohno, Hiroshi
- ORCID
- Venue
- Nature
- Published
- 2011-01
- Volume
- 469
- Issue
- 7331
- Pages
- 543-547
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2045119680
- Cited by
- 2,387
- References
- 48
- Citations by year
- 2026: 138 · 2025: 166 · 2024: 199 · 2023: 161 · 2022: 208 · 2021: 244 · 2020: 199 · 2019: 155 · 2018: 162 · 2017: 155 · 2016: 130 · 2015: 129 · 2014: 121 · 2013: 90 · 2012: 93
- FWCI
- 158.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Japan Society for the Promotion of Science (22689017)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Immunology and Microbiology › Microbiology › Escherichia coli research studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- Bifidobacterium longum, acetate, Escherichia coli O157:H7, probiotics, ABC transporters, carbohydrate transport, gut microbiota
- MeSH terms
- Acetates, Animals, Bifidobacterium, Chlorocebus aethiops, Escherichia coli Infections, Molecular Sequence Data, Vero Cells, Genome, Bacterial, Escherichia coli O157, Gene Expression Profiling, Mice
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