The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Bifidobacteria can protect from enteropathogenic infection through production of acetate
Abstract
The human gut is colonized with a wide variety of microorganisms, including species, such as those belonging to the bacterial genus Bifidobacterium, that have beneficial effects on human physiology and pathology. Among the most distinctive benefits of bifidobacteria are modulation of host defence responses and protection against infectious diseases. Nevertheless, the molecular mechanisms underlying these effects have barely been elucidated. To investigate these mechanisms, we used mice associated with certain bifidobacterial strains and a simplified model of lethal infection with enterohaemorrhagic Escherichia coli O157:H7, together with an integrated 'omics' approach. Here we show that genes encoding an ATP-binding-cassette-type carbohydrate transporter present in certain bifidobacteria contribute to protecting mice against death induced by E. coli O157:H7. We found that this effect can be attributed, at least in part, to increased production of acetate and that translocation of the E. coli O157:H7 Shiga toxin from the gut lumen to the blood was inhibited. We propose that acetate produced by protective bifidobacteria improves intestinal defence mediated by epithelial cells and thereby protects the host against lethal infection.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Additional support for the role of enteric bacteria in maintaining normal barrier function is provided by data that SCFA (e.g., butyrate and acetate) improve intestinal barrier function (64, 84).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [64]
In the citing paper
“Numerous in vitro studies have demonstrated that bifidobacteria can inhibit pathogens through the production of organic acids (38), antibacterial peptides (39), quorum-sensing inhibitors (40, 41), or immune stimulation (42) among other mechanisms, providing molecular clues of their capacity to prevent certain infections.”
From Bifidobacteria and Their Health-Promoting Effects (2017) · cites this paper as [38]
In the citing paper
“these bacteria have been linked to fortification of the gut mucosal protection through activities against pathogens12, 13.”
From Diet and the Intestinal Microbiome: Associations, Functions, and Implications for Health and Disease (2014) · cites this paper as [13]
In the citing paper
“which have been shown in vitro and in vivo to support the integrity of the intestinal mucosa in a variety of ways (Fukuda et al., 2011; Gaudier et al., 2004; Macia et al., 2015; Willemsen et al., 2003; Wrzosek et al., 2013).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Fukuda et al., 2011
In the citing paper
“Bifidobacterium longum has been shown to protect mice from enterohemorrhagic E. coli O157 infection through the production of SCFAs, that prevent IEC apoptosis and inflammation, thus preserving gut epithelium integrity, and reducing the spread of Stx2 toxin into the bloodstream, ultimately improving host survival [52].”
From Antibiotic-Induced Changes in the Intestinal Microbiota and Disease (2016) · cites this paper as [52]
In the citing paper
“Acetate production was associated with protection against Escherichia coli O157 in mice that were mono-colonized by Bifidobacterium [39].”
From Role of the gut microbiota in nutrient competition and protection against intestinal pathogen colonization (2023) · cites this paper as [39]
Citations
Cites
tRNAscan-SE: A Program for Improved Detection of Transfer RNA Genes in Genomic Sequence
Lowe, T. M., & Eddy, S. R. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.5.955 · Cited by 11,200
Summaries of Affymetrix GeneChip probe level data
Irizarry, R. A. (2003) · Nucleic Acids Research · doi:10.1093/nar/gng015 · Cited by 4,837
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
Maslowski, K. M., Vieira, A. T., Ng, A., Kranich, J., Sierro, F., Yu, D., Schilter, H. C., Rolph, M. S., Mackay, F., Artis, D., et al. (2009) · Nature · doi:10.1038/nature08530 · Cited by 3,241
Improved microbial gene identification with GLIMMER
Delcher, A. L. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.23.4636 · Cited by 2,493
Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome
Tarr, P. I., Gordon, C. A., & Chandler, W. L. (2005) · The Lancet · doi:10.1016/s0140-6736(05)71144-2 · Cited by 1,791
Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators
Staels, B., Köenig, W., Habib, A., Merval, R., Lebret, M., Pineda‐Torra, I., Delerive, P., Fadel, A., Chinetti, G., Fruchart, J., et al. (1998) · Nature · doi:10.1038/31701 · Cited by 1,138
Liver X receptors as integrators of metabolic and inflammatory signaling
Zelcer, N. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27883 · Cited by 978
Schell, M. A., Karmirantzou, M., Snel, ., Vilanova, D., Berger, B. W., Pessi, G., Zwahlen, M.-C., Desiere, F., Peer Bork, B., Delley, M., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.212527599 · Cited by 942
Sela, D. A., Chapman, J., Adeuya, A., Kim, J., Chen, F., Whitehead, T. R., Lapidus, A. L., Rokhsar, D. S., Lebrilla, C. B., German, J. B., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809584105 · Cited by 895
Tedelind, S., Westberg, F., Kjerrulf, M., & Vidal, A. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i20.2826 · Cited by 880
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–300 of 1,007
Prebiotic potential of oligosaccharides: A focus on xylan derived oligosaccharides
Singh, R. D., Banerjee, J., & Arora, A. (2014) · Bioactive Carbohydrates and Dietary Fibre · doi:10.1016/j.bcdf.2014.11.003 · Cited by 206
Probiotic Supplementation and Late-Onset Sepsis in Preterm Infants: A Meta-analysis
Rao, S. C., Athalye‐Jape, G., Deshpande, G. C., Simmer, K. N., & Patole, S. (2016) · PEDIATRICS · doi:10.1542/peds.2015-3684 · Cited by 200
Shifts in the Fecal Microbiota Associated with Adenomatous Polyps
Hale, V. L., Chen, J., Johnson, S. P., Harrington, S. C., Yab, T. C., Smyrk, T. C., Nelson, H., Boardman, L. A., Druliner, B. R., Levin, T. R., et al. (2016) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-16-0337 · Cited by 202
Weaning Stress Perturbs Gut Microbiome and Its Metabolic Profile in Piglets
Li, Y., Guo, Y., Wen, Z., Jiang, X., Ma, X., & Han, X. (2018) · Scientific Reports · doi:10.1038/s41598-018-33649-8 · Cited by 200
Barrea, L., Muscogiuri, G., Frías-Toral, E., Laudisio, D., Pugliese, G., Castellucci, B., Garcia-Velasquez, E., Savastano, S., & Colao, A. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1792826 · Cited by 207
Role of SCFAs in gut microbiome and glycolysis for colorectal cancer therapy
Wang, G., Yu, Y., Wang, Y., Wang, J., Guan, R., Sun, Y., Shi, F., Gao, J., & Fu, X. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28436 · Cited by 200
Molecular mechanisms of probiotic prevention of antibiotic-associated diarrhea
Mekonnen, S. A., Merenstein, D. J., Fraser, C. M., & Marco, M. L. (2020) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2020.01.005 · Cited by 207
Indoles from commensal bacteria extend healthspan
Sonowal, R., Swimm, A., Sahoo, A., Luo, L., Matsunaga, Y., Wu, Z., Bhingarde, J. A., Ejzak, E. A., Ranawade, A., Qadota, H., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1706464114 · Cited by 197
Therapeutic modulation of intestinal dysbiosis
Walker, A. W., & Lawley, T. D. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.09.008 · Cited by 209
Shiga Toxin-Producing Escherichia coli O104:H4: a New Challenge for Microbiology
Muniesa, M., Hammerl, J. A., Hertwig, S. T., Appel, B., & Brüssow, H. (2012) · Applied and Environmental Microbiology · doi:10.1128/aem.00217-12 · Cited by 197
Host–microbe interactions that facilitate gut colonization by commensal bifidobacteria
Ventura, M., Turroni, F., Motherway, M. O., MacSharry, J. A., & van Sinderen, D. (2012) · Trends in Microbiology · doi:10.1016/j.tim.2012.07.002 · Cited by 197
Kim, J., Jeun, E.-J., Hong, C., Kim, S. H., Jang, M. S., Lee, E.-J., Moon, S. J., Yun, C. H., Im, S.-H., Jeong, S.-G., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.08.016 · Cited by 200
Woodhams, D. C., Brandt, H., Baumgartner, S. D., Kielgast, J., Küpfer, E., Tobler, U., Davis, L. R., Schmidt, B. R., Christian, B., Hodel, S., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096375 · Cited by 202
Laffin, M., Fedorak, R., Zalasky, A., Park, H., Gill, A., Agrawal, A., Keshteli, A. H., Hotte, N., & Madsen, K. L. (2019) · Scientific Reports · doi:10.1038/s41598-019-48749-2 · Cited by 196
RS5 Produced More Butyric Acid through Regulating the Microbial Community of Human Gut Microbiota
Qin, R., Wang, J., Chao, C., Yu, J., Copeland, L., Wang, S., & Wang, S. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c08187 · Cited by 197
Short Chain Fatty Acid Metabolism in Relation to Gut Microbiota and Genetic Variability
Meyers, G. R., Samouda, H., & Bohn, T. (2022) · Nutrients · doi:10.3390/nu14245361 · Cited by 208
Protective Microbiota: From Localized to Long-Reaching Co-Immunity
Chiu, L., Bazin, T., Truchetet, M., Schaeverbeke, T., Delhaès, L., & Pradeu, T. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01678 · Cited by 208
Dietary cellulose prevents gut inflammation by modulating lipid metabolism and gut microbiota
Kim, Y., Hwang, S. W., Kim, S., Lee, Y., Kim, T., Lee, S.-H., Kim, S. J., Yoo, H. J., Kim, E. N., & Kweon, M. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1730149 · Cited by 197
Samara, J., Moossavi, S., Alshaikh, B., Ortega, V. A., Pettersen, V. K., Ferdous, T., Hoops, S. L., Soraisham, A., Vayalumkal, J., Dersch-Mills, D., et al. (2022) · Cell Host & Microbe · doi:10.1016/j.chom.2022.04.005 · Cited by 191
Sawin, E. A., Wolfe, T. J. D., Aktaş, B., Stroup, B. M., Murali, S. G., Steele, J. L., & Ney, D. M. (2015) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00211.2015 · Cited by 189
Lanis, J. M., Alexeev, E. E., Curtis, V. F., Kitzenberg, D., Kao, D. J., Battista, K. D., Gerich, M. E., Glover, L. E., Kominsky, D., & Colgan, S. P. (2017) · Mucosal Immunology · doi:10.1038/mi.2016.133 · Cited by 193
Zhang, Y., Tan, P., Zhao, Y., & Ma, X. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2055943 · Cited by 206
Salazar, N., Gueimonde, M., de los Reyes-Gavilán, C. G., & Ruas-Madiedo, P. (2016) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2013.770728 · Cited by 188
Davis, J. C. C., Lewis, Z. T., Krishnan, S., Bernstein, R. M., Moore, S. E., Prentice, A. M., Mills, D. A., Lebrilla, C. B., & Zivkovic, A. M. (2017) · Scientific Reports · doi:10.1038/srep40466 · Cited by 187
A Critical Look at Prebiotics Within the Dietary Fiber Concept
Verspreet, J., Damen, B., Broekaert, W. F., Verbeke, K., Delcour, J. A., & Courtin, C. M. (2016) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-081315-032749 · Cited by 194
Rapidly expanding knowledge on the role of the gut microbiome in health and disease
Cénit, M. C., Matzaraki, V., Tigchelaar, E. F., & Zhernakova, A. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.05.023 · Cited by 197
Garrido, D. A., Ruiz‐Moyano, S., Kirmiz, N., Davis, J. C. C., Totten, S. M., Lemay, D. G., Ugalde, J. A., German, J. B., Lebrilla, C. B., & Mills, D. A. (2016) · Scientific Reports · doi:10.1038/srep35045 · Cited by 191
Laforest‐Lapointe, I., & Arrieta, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00788 · Cited by 195
Wopereis, H., Sim, K., Shaw, A., Warner, J. O., Knol, J., & Kroll, J. S. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.05.054 · Cited by 185
The role of diet and intestinal microbiota in the development of metabolic syndrome
Santos-Marcos, J. A., Pérez‐Jiménez, F., & Camargo, A. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.03.017 · Cited by 188
Microbial-Based and Microbial-Targeted Therapies for Inflammatory Bowel Diseases
Oka, A., & Sartor, R. B. (2020) · Digestive Diseases and Sciences · doi:10.1007/s10620-020-06090-z · Cited by 188
Berger, B. W., Porta, N., Foata, F., Grathwohl, D., Delley, M., Moine, D., Charpagne, A., Siegwald, L., Descombes, P., Alliet, P. L., et al. (2020) · mBio · doi:10.1128/mbio.03196-19 · Cited by 185
Wang, B., Zhang, L., Wang, Y., Dai, T., Qin, Z., Zhou, F., & Zhang, L. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00986-0 · Cited by 187
The Role of Gut Dysbiosis in the Pathophysiology of Neuropsychiatric Disorders
Anand, N., Gorantla, V. R., & Chidambaram, S. B. (2022) · Cells · doi:10.3390/cells12010054 · Cited by 194
Gut microbiota mediates the anti-obesity effect of calorie restriction in mice
Wang, S., Huang, M., You, X., Zhao, J., Chen, L., Wang, L., Luo, Y., & Chen, Y. (2018) · Scientific Reports · doi:10.1038/s41598-018-31353-1 · Cited by 189
Intestinal Microbiota as a Host Defense Mechanism to Infectious Threats
Iacob, S. A., Iacob, D. G., & Luminos, L. M. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.03328 · Cited by 191
Bifidobacteria—Insight into clinical outcomes and mechanisms of its probiotic action
Sarkar, A., & Mandal, S. (2016) · Microbiological Research · doi:10.1016/j.micres.2016.07.001 · Cited by 190
Fecal short-chain fatty acid concentrations and dysbiosis in dogs with chronic enteropathy
Minamoto, Y., Minamoto, T. B., Isaiah, A., Sattasathuchana, P., Buono, A., Rangachari, V. R., McNeely, I. H., Lidbury, J. A., Steiner, J. M., & Suchodolski, J. S. (2019) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.15520 · Cited by 183
Recent advances in the therapeutic application of short-chain fatty acids (SCFAs): An updated review
Rauf, A., Khalil, A. A., Rahman, U.-U., Khalid, A., Naz, S., Shariati, M. A., Ребезов, М. Б., Zavala, E., de Albuquerque, R. D. D. G., Anwar, S., et al. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1895064 · Cited by 190
Smolińska, S., Popescu, F., & Zemelka‐Wiącek, M. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14113673 · Cited by 198
IL-21 and T follicular helper cells
Spolski, R. J., & Leonard, W. J. (2009) · International Immunology · doi:10.1093/intimm/dxp112 · Cited by 192
Singh, J., Metrani, R., Shivanagoudra, S. R., Jayaprakasha, G. K., & Patil, B. S. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b07306 · Cited by 187
Diversity, ecology and intestinal function of bifidobacteria
Bottacini, F., Ventura, M., van Sinderen, D., & Motherway, M. O. (2014) · Microbial Cell Factories · doi:10.1186/1475-2859-13-s1-s4 · Cited by 184
Kaiser, P., Diard, M., Stecher, B., & Hardt, W. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01070.x · Cited by 184
Roles of the intestinal microbiota in pathogen protection
Úbeda, C., Djuković, A., & Isaac, S. (2017) · Clinical & Translational Immunology · doi:10.1038/cti.2017.2 · Cited by 186
Oozeer, R., van Limpt, K., Ludwig, T., Amor, K. B., Martín, R., Wind, R. D., Boehm, G., & Knol, J. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.038893 · Cited by 183
Tong, M., Li, X., Parfrey, L. W., Roth, B. E., Ippoliti, A., Wei, B., Borneman, J., McGovern, D. P. B., Frank, D. N., Li, E., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080702 · Cited by 184
Malnutrition and Gut Microbiota in Children
Iddrisu, I., Monteagudo-Mera, A., Poveda, C. G., Pyle, S., Shahzad, M. A., Andrews, S. C., & Walton, G. (2021) · Nutrients · doi:10.3390/nu13082727 · Cited by 186
Yan, F., & Polk, D. B. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01428 · Cited by 181
Paganini, D., Uyoga, M. A., Kortman, G. A. M., Cercamondi, C. I., Moretti, D., Barth-Jaeggi, T., Schwab, C., Boekhorst, J., Timmerman, H. M., Lacroix, C., et al. (2017) · Gut · doi:10.1136/gutjnl-2017-314418 · Cited by 172
Perinatal and Early-Life Nutrition, Epigenetics, and Allergy
Acevedo, N., Alhamwe, B. A., Caraballo, L. R., Ding, M., Ferrante, A., Garn, H., Garssen, J., Hii, C. S. T., Irvine, J., Llinás-Caballero, K., et al. (2021) · Nutrients · doi:10.3390/nu13030724 · Cited by 183
Gut microbiome in modulating immune checkpoint inhibitors
Li, X., Zhang, S., Guo, G., Han, J., & Yu, J. Q. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104163 · Cited by 177
From meta-omics to causality: experimental models for human microbiome research
Fritz, J. V., Desai, M. S., Shah, P., Schneider, J. G., & Wilmes, P. (2013) · Microbiome · doi:10.1186/2049-2618-1-14 · Cited by 181
Ashique, S., Rubis, G. D., Sirohi, E., Mishra, N., Rihan, M., Garg, A., Reyes, R.-J., Manandhar, B., Bhatt, S., Jha, N. K., et al. (2022) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2022.110231 · Cited by 179
Pathogens, microbiome and the host: emergence of the ecological Koch's postulates
Vonaesch, P., Anderson, M. C., & Sansonetti, P. J. (2018) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuy003 · Cited by 177
Sugahara, H., Odamaki, T., Fukuda, S., Kato, T., Xiao, J.-Z., Abe, F., Kikuchi, J., & Ohno, H. (2015) · Scientific Reports · doi:10.1038/srep13548 · Cited by 169
Self-citationMicrocins in Enterobacteriaceae: Peptide Antimicrobials in the Eco-Active Intestinal Chemosphere
Baquero, F., Lanza, V. F., Baquero, M.-R., del Campo, R., & Bravo-Vázquez, D. A. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02261 · Cited by 174
Hu, Y. C., Leu, R. K. L., Christophersen, C. T., Somashekar, R., Conlon, M. A., Meng, X. Q., Winter, J. M., Woodman, R. J., McKinnon, R. A., & Young, G. P. (2016) · Carcinogenesis · doi:10.1093/carcin/bgw019 · Cited by 170
Li, X., Guo, R. H., Wu, X., Liu, X., Ai, L., Sheng, Y., Song, Z., & Wu, Y. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.116194 · Cited by 170
Arabinoxylans, gut microbiota and immunity
Mendis, M., Leclerc, E., & Şimşek, Ş. (2015) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2015.11.068 · Cited by 172
Stinson, L. F., Payne, M. S., & Keelan, J. A. (2016) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2016.1211088 · Cited by 167
Roles of intestinal bacteroides in human health and diseases
Wang, C., Zhao, J., Zhang, H., Lee, Y. K., Zhai, Q., & Chen, W. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1802695 · Cited by 169
Microbiota-derived lactate accelerates colon epithelial cell turnover in starvation-refed mice
Okada, T., Fukuda, S., Hase, K., Nishiumi, S., Izumi, Y., Yoshida, M., Hagiwara, T., Kawashima, R., Yamazaki, M., Oshio, T., et al. (2013) · Nature Communications · doi:10.1038/ncomms2668 · Cited by 165
Self-citationHuman-Derived Bifidobacterium dentium Modulates the Mammalian Serotonergic System and Gut–Brain Axis
Engevik, M. A., Luck, B., Visuthranukul, C., Ihekweazu, F. D., Engevik, A. C., Shi, Z., Danhof, H. A., Chang-Graham, A. L., Hall, A., Endres, B. T., et al. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2020.08.002 · Cited by 164
Dietary influences on intestinal immunity
Veldhoen, M., & Brucklacher-Waldert, V. (2012) · Nature reviews. Immunology · doi:10.1038/nri3299 · Cited by 167
Wang, L., Hu, L., Yan, S., Jiang, T., Fang, S., Wang, G., Zhao, J., Zhang, H., & Chen, W. (2017) · Food & Function · doi:10.1039/c7fo00031f · Cited by 166
Microbiomes: unifying animal and plant systems through the lens of community ecology theory
Christian, N., Whitaker, B. K., & Clay, K. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00869 · Cited by 172
Impact of Westernized Diet on Gut Microbiota in Children on Leyte Island
Nakayama, J., Yamamoto, A., Conde, L. A., Higashi, K., Sonomoto, K., Tan, J. D., & Lee, Y. K. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00197 · Cited by 171
Cereal-derived arabinoxylans: Structural features and structure–activity correlations
Wang, J., Bai, J., Fan, M., Li, T., Li, Y., Qian, H., Wang, L., Zhang, H., Qi, X., & Rao, Z. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.12.016 · Cited by 169
Influence of Gut Microbiota on Subclinical Inflammation and Insulin Resistance
Carvalho, B. M., & Saad, M. J. A. (2013) · Mediators of Inflammation · doi:10.1155/2013/986734 · Cited by 166
Co-evolution in context: The importance of studying gut microbiomes in wild animals
Amato, K. R. (2013) · Microbiome Science and Medicine · doi:10.2478/micsm-2013-0002 · Cited by 168
Hoen, A. G., Li, J., Moulton, L. A., O’Toole, G. A., Housman, M. L., Koestler, D. C., Guill, M. F., Moore, J. H., Hibberd, P. L., Morrison, H. G., et al. (2015) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2015.02.049 · Cited by 167
Bridgman, S. L., Azad, M. B., Field, C. J., Haqq, A. M., Becker, A. B., Mandhane, P. J., Subbarao, P., Turvey, S. E., Sears, M. R., Scott, J. A., et al. (2017) · Frontiers in Nutrition · doi:10.3389/fnut.2017.00011 · Cited by 171
Functional assignment of metagenomic data: challenges and applications
Prakash, T., & Taylor, T. D. (2012) · Briefings in Bioinformatics · doi:10.1093/bib/bbs033 · Cited by 164
Self-citationWhen pathogenic bacteria meet the intestinal microbiota
Rolhion, N., & Chassaing, B. (2016) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0504 · Cited by 169
Han, X., Lee, A. A., Huang, S., Gao, J., Spence, J. R., & Owyang, C. (2018) · Gut Microbes · doi:10.1080/19490976.2018.1479625 · Cited by 162
Host microbiota can facilitate pathogen infection
Stevens, E. J., Bates, K. A., & King, K. C. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009514 · Cited by 170
Gut microbiota trajectory in pediatric patients undergoing hematopoietic SCT
Biagi, E., Zama, D., Nastasi, C., Consolandi, C., Fiori, J., Rampelli, S., Turroni, S., Centanni, M., Severgnini, M., Peano, C., et al. (2015) · Bone Marrow Transplantation · doi:10.1038/bmt.2015.16 · Cited by 158
Bioactive Factors in Human Breast Milk Attenuate Intestinal Inflammation during Early Life
Thai, J. D., & Gregory, K. E. (2020) · Nutrients · doi:10.3390/nu12020581 · Cited by 166
The role of iron in host–microbiota crosstalk and its effects on systemic glucose metabolism
Mayneris‐Perxachs, J., Moreno‐Navarrete, J. M., & Fernández‐Real, J. M. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00721-3 · Cited by 161
Celiac Disease and the Microbiome
Valitutti, F., Cucchiara, S., & Fasano, A. (2019) · Nutrients · doi:10.3390/nu11102403 · Cited by 157
Bifidobacterium Abundance in Early Infancy and Vaccine Response at 2 Years of Age
Huda, M. N., Ahmad, S. M., Alam, J., Khanam, A., Kalanetra, K. M., Taft, D. H., Raqib, R., Underwood, M. A., Mills, D. A., & Stephensen, C. B. (2019) · PEDIATRICS · doi:10.1542/peds.2018-1489 · Cited by 157
Effects of lactobacillus plantarumZJ316 on pig growth and pork quality
Suo, C., Yin, Y., Wang, X., Lou, X., Song, D., Wang, X., & Gu, Q. (2012) · BMC Veterinary Research · doi:10.1186/1746-6148-8-89 · Cited by 156
Ivarsson, E., Roos, S., Liu, H. Y., & Lindberg, J. E. (2014) · animal · doi:10.1017/s1751731114001827 · Cited by 156
The impact of a helminth-modified microbiome on host immunity
Brosschot, T. P., & Reynolds, L. A. (2018) · Mucosal Immunology · doi:10.1038/s41385-018-0008-5 · Cited by 165
Gut microbiome and metabolic diseases
Fukuda, S., & Ohno, H. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0399-z · Cited by 156
Self-citationValidating bifidobacterial species and subspecies identity in commercial probiotic products
Lewis, Z. T., Shani, G., Masarweh, C. F., Popovic, M., Frese, S. A., Sela, D. A., Underwood, M. A., & Mills, D. A. (2016) · Pediatric Research · doi:10.1038/pr.2015.244 · Cited by 154
Epithelial barrier biology: good fences make good neighbours
Moens, E., & Veldhoen, M. (2011) · Immunology · doi:10.1111/j.1365-2567.2011.03506.x · Cited by 169
Impact of Probiotics on Colonizing Microbiota of the Gut
Sanders, M. E. (2011) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e318227414a · Cited by 153
Intestinal epithelial cells as mediators of the commensal–host immune crosstalk
Goto, Y., & Ivanov, I. I. (2013) · Immunology and Cell Biology · doi:10.1038/icb.2012.80 · Cited by 153
O’Sullivan, A. M., Farver, M., & Smilowitz, J. T. (2015) · Nutrition and Metabolic Insights · doi:10.4137/nmi.s29530 · Cited by 161
Infectious Threats, the Intestinal Barrier, and Its Trojan Horse: Dysbiosis
Iacob, S. A., & Iacob, D. G. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01676 · Cited by 158
Host–microbe interactions shaping the gastrointestinal environment
Kaiko, G. E., & Stappenbeck, T. S. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.08.002 · Cited by 155
Dual Metal–Organic Framework Heterointerface
Luo, Y. Y., Li, J., Liu, X., Tan, L., Cui, Z., Feng, X., Yang, X., Liang, Y., Li, Z., Zhu, S., et al. (2019) · ACS Central Science · doi:10.1021/acscentsci.9b00639 · Cited by 151
Structural diversity, functional aspects and future therapeutic applications of human gut microbiome
Ghosh, S., & Pramanik, S. (2021) · Archives of Microbiology · doi:10.1007/s00203-021-02516-y · Cited by 158
A molecular basis for bifidobacterial enrichment in the infant gastrointestinal tract
Garrido, D., Barile, D., & Mills, D. A. (2012) · Advances in Nutrition · doi:10.3945/an.111.001586 · Cited by 149
T-Cell-Driven Inflammation as a Mediator of the Gut-Brain Axis Involved in Parkinson's Disease
Campos‐Acuña, J., Elgueta, D., & Pacheco, R. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00239 · Cited by 150
Wang, L., Zhang, J., Guo, Z., Kwok, L., Ma, C., Zhang, W., Lv, Q., Huang, W., & Zhang, H. (2013) · Nutrition · doi:10.1016/j.nut.2013.11.018 · Cited by 150
A holobiont birth narrative: the epigenetic transmission of the human microbiome
Gilbert, S. F. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00282 · Cited by 155
King, W. L., Jenkins, C., Seymour, J. R., & Labbate, M. (2018) · Marine Environmental Research · doi:10.1016/j.marenvres.2018.11.007 · Cited by 157
Metadata
- Authors
- Fukuda, S., Toh, H., Hase, K., Oshima, K., Nakanishi, Y., Yoshimura, K., Tobe, T., Clarke, J. M., Topping, D. L., Suzuki, T., Taylor, T. D., Itoh, K., Kikuchi, J., Morita, H., Hattori, M., & Ohno, H.
- Affiliations
- RIKEN (JP)
- RIKEN Advanced Science Institute (JP)
- The University of Tokyo (JP)
- The University of Osaka (JP)
- Commonwealth Scientific and Industrial Research Organisation (AU)
- Gifu University (JP)
- Azabu University (JP)
- Chiba University (JP)
- Corresponding author
- Hattori, Masahira
- Ohno, Hiroshi
- ORCID
- Venue
- Nature
- Published
- 2011-01
- Volume
- 469
- Issue
- 7331
- Pages
- 543-547
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2045119680
- Cited by
- 2,387
- References
- 48
- Citations by year
- 2026: 138 · 2025: 166 · 2024: 199 · 2023: 161 · 2022: 208 · 2021: 244 · 2020: 199 · 2019: 155 · 2018: 162 · 2017: 155 · 2016: 130 · 2015: 129 · 2014: 121 · 2013: 90 · 2012: 93
- FWCI
- 158.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Japan Society for the Promotion of Science (22689017)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Immunology and Microbiology › Microbiology › Escherichia coli research studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- Bifidobacterium longum, acetate, Escherichia coli O157:H7, probiotics, ABC transporters, carbohydrate transport, gut microbiota
- MeSH terms
- Acetates, Animals, Bifidobacterium, Chlorocebus aethiops, Escherichia coli Infections, Molecular Sequence Data, Vero Cells, Genome, Bacterial, Escherichia coli O157, Gene Expression Profiling, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
