Cited by 3,347Epigenetics and DNA MethylationGenomics and Chromatin DynamicsChromatin Remodeling and Cancer

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The Polycomb complex PRC2 and its mark in life

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Margueron, Raphaël, Reinberg, Danny·2011·Nature

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Abstract

Polycomb group proteins maintain the gene-expression pattern of different cells that is set during early development by regulating chromatin structure. In mammals, two main Polycomb group complexes exist - Polycomb repressive complex 1 (PRC1) and 2 (PRC2). PRC1 compacts chromatin and catalyses the monoubiquitylation of histone H2A. PRC2 also contributes to chromatin compaction, and catalyses the methylation of histone H3 at lysine 27. PRC2 is involved in various biological processes, including differentiation, maintaining cell identity and proliferation, and stem-cell plasticity. Recent studies of PRC2 have expanded our perspectives on its function and regulation, and uncovered a role for non-coding RNA in the recruitment of PRC2 to target genes.

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Authors: Margueron, R., & Reinberg, D.
Affiliations: Institut Curie (FR)
Howard Hughes Medical Institute (US)
Corresponding author: Reinberg, Danny
ORCID: Margueron, Raphaël
Reinberg, Danny
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2011-01-19
Volume: 469
Issue: 7330
Pages: 343-349
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature09784
PMC: PMC3760771
OpenAlex: W2060608189
Cited by: 3,347
References: 97
Citations by year: 2026: 145 · 2025: 188 · 2024: 231 · 2023: 211 · 2022: 236 · 2021: 274 · 2020: 260 · 2019: 260 · 2018: 214 · 2017: 236 · 2016: 221 · 2015: 220 · 2014: 202 · 2013: 207 · 2012: 177
FWCI: 18.39
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: Howard Hughes Medical Institute
National Institutes of Health
National Institute of General Medical Sciences (R37GM037120, R01GM064844)
Institute of Cancer Research
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords: polycomb repressive complex 2, Polycomb group proteins, histone H3 lysine 27 methylation, chromatin condensation, gene expression regulation, cell identity, stem cell plasticity, non-coding RNA, chromatin structure
MeSH terms: Animals, Cell Differentiation, Chromatin, Histones, Humans, Methylation, Neoplasms, Histone-Lysine N-Methyltransferase, Repressor Proteins, Genome, Evolution, Molecular, Polycomb-Group Proteins

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The Polycomb complex PRC2 and its mark in life

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