The Polycomb complex PRC2 and its mark in life

High-Resolution Profiling of Histone Methylations in the Human Genome

Barski, A., Cuddapah, S., Cui, K., Roh, T.-Y., Schones, D. E., Wang, Z., Wei, G., Chepelev, I., & Zhao, K. (2007) · Cell · doi:10.1016/j.cell.2007.05.009 · Cited by 6,845

A bivalent chromatin structure marks key developmental genes in embryonic stem cells

Bernstein, B. E., Mikkelsen, T. S., Xie, X., Kamal, M., Huebert, D. J., Cuff, J., Fry, B., Meissner, A., Wernig, M., Plath, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.041 · Cited by 5,361

Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs

Rinn, J. L., Kertesz, M., Wang, J. K., Squazzo, S. L., Xu, X. H., Brugmann, S. A., Goodnough, L. H., Helms, J. A., Farnham, P., Segal, E., et al. (2007) · Cell · doi:10.1016/j.cell.2007.05.022 · Cited by 4,246

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

Mikkelsen, T. S., Ku, M., Jaffe, D. B., Issac, B., Lieberman, E., Giannoukos, G., Alvarez, P., Brockman, W., Kim, T.-K., Koche, R. P., et al. (2007) · Nature · doi:10.1038/nature06008 · Cited by 4,129

A gene complex controlling segmentation in Drosophila

Lewis, E. B. (1978) · Nature · doi:10.1038/276565a0 · Cited by 3,813

Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes

Tsai, M.-C., Manor, O., Wan, Y., Mosammaparast, N., Wang, J. K., Lan, F., Shi, Y., Segal, E., & Chang, H. Y. (2010) · Science · doi:10.1126/science.1192002 · Cited by 3,290 · cited 1×

Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression

Khalil, A. M., Guttman, M., Huarte, M., Garber, M., Raj, A., Rivea Morales, D., Thomas, K., Presser, A., Bernstein, B. E., van Oudenaarden, A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904715106 · Cited by 2,872

The polycomb group protein EZH2 is involved in progression of prostate cancer

Varambally, S., Dhanasekaran, S. M., Zhou, M., Barrette, T. R., Kumar-Sinha, C., Sanda, M. G., Ghosh, D., Pienta, K. J., Sewalt, R. G. A. B., Otte, A. P., et al. (2002) · Nature · doi:10.1038/nature01075 · Cited by 2,717

Polycomb complexes repress developmental regulators in murine embryonic stem cells

Boyer, L. A., Plath, K., Zeitlinger, J., Brambrink, T., Medeiros, L. A., Lee, T. I., Levine, S. S., Wernig, M., Tajonar, A., Ray, M. K., et al. (2006) · Nature · doi:10.1038/nature04733 · Cited by 2,568

Genome-scale DNA methylation maps of pluripotent and differentiated cells

Meissner, A., Mikkelsen, T. S., Gu, H., Wernig, M., Hanna, J., Sivachenko, A., Zhang, X., Bernstein, B. E., Nusbaum, C., Jaffe, D. B., et al. (2008) · Nature · doi:10.1038/nature07107 · Cited by 2,536

Loss of EGFR signaling-regulated miR-203 promotes prostate cancer bone metastasis and tyrosine kinase inhibitors resistance

Siu, M. K., Abou-Kheir, W. G., Yin, J. J., Chang, Y.-S., Barrett, B., Suau, F., Casey, O. M., Chen, W., Fang, L., Hynes, P. G., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.1994 · Cited by 64

Dlk1-Dio3 locus-derived lncRNAs perpetuate postmitotic motor neuron cell fate and subtype identity

Yen, Y.-P., Hsieh, W.-F., Tsai, Y.-Y., Lu, Y.-L., Liau, E. S., Hsu, H.-C., Chen, Y., Liu, T.-C., Chang, M., Li, J., et al. (2018) · eLife · doi:10.7554/elife.38080 · Cited by 63

Discovery of precision targeting EZH2 degraders for triple-negative breast cancer

Wang, C., Chen, X., Liu, X., Lu, D., Li, S., Qu, L., Yin, F., Luo, H., Zhang, Y., Luo, Z., et al. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114462 · Cited by 67

Inactivation of Intergenic Enhancers by EBNA3A Initiates and Maintains Polycomb Signatures across a Chromatin Domain Encoding CXCL10 and CXCL9

Harth-Hertle, M. L., Scholz, B. A., Erhard, F., Glaser, L. V., Dölken, L., Zimmer, R., & Kempkes, B. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003638 · Cited by 62

Discovery and Optimization of Tetramethylpiperidinyl Benzamides as Inhibitors of EZH2

Nasveschuk, C. G., Gagnon, A., Garapaty, S., Balasubramanian, S., Campbell, R., Lee, C., Zhao, F., Bergeron, L., Cummings, R. T., Trojer, P., et al. (2014) · ACS Medicinal Chemistry Letters · doi:10.1021/ml400494b · Cited by 63

Polycomb-Group Proteins andFLOWERING LOCUS TMaintain Commitment to Flowering inArabidopsis thaliana

Müller-Xing, R., Clarenz, O., Pokorny, L., Goodrich, J., & Schubert, D. S. P. (2014) · The Plant Cell · doi:10.1105/tpc.114.123323 · Cited by 63

Targeting protein lysine methylation and demethylation in cancers

He, Y., Korboukh, I., Jin, J. J., & Huang, J. L. (2011) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmr109 · Cited by 68

A lesson learned from the H3.3K27M mutation found in pediatric glioma

Chan, K. M., Han, J., Fang, D., Gan, H., & Zhang, Z. (2013) · Cell Cycle · doi:10.4161/cc.25625 · Cited by 64

EpCAM-regulated intramembrane proteolysis induces a cancer stem cell-like gene signature in hepatitis B virus-infected hepatocytes

Mani, S. K. K., Zhang, H., Diab, A., Pascuzzi, P. E., Lefrançois, L., Farés, N., Bancel, B., Merle, P., & ANDRISANI, O. M. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.05.022 · Cited by 63

The Link Between Hyperhomocysteinemia and Hypomethylation

Barroso, M., Handy, D. E., & Castro, R. (2017) · Journal of Inborn Errors of Metabolism and Screening · doi:10.1177/2326409817698994 · Cited by 63

Combination of EZH2 inhibitor and BET inhibitor for treatment of diffuse intrinsic pontine glioma

Zhang, Y., Dong, W., Zhu, J., Wang, L., Wu, X., & Shan, H. (2017) · Cell & Bioscience · doi:10.1186/s13578-017-0184-0 · Cited by 65

Local delivery of tetramethylpyrazine eliminates the senescent phenotype of bone marrow mesenchymal stromal cells and creates an anti‐inflammatory and angiogenic environment in aging mice

Gao, B., Lin, X., Jing, H., Fan, J., Ji, C., Jie, Q., Zheng, C., Wang, D., Xu, X., Hu, Y., et al. (2018) · Aging Cell · doi:10.1111/acel.12741 · Cited by 63

Arabidopsis Serrate Coordinates Histone Methyltransferases ATXR5/6 and RNA Processing Factor RDR6 to Regulate Transposon Expression

Ma, Z., Castillo-González, C., Wang, Z., Sun, D., Hu, X., Shen, X., Potok, M. E., & Zhang, X. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.05.023 · Cited by 62

The long noncoding RNA lnc-ob1 facilitates bone formation by upregulating Osterix in osteoblasts

Sun, Y., Cai, M., Zhong, J., Yang, L., Xiao, J., Jin, F., Xue, H. Y., Liu, X., Liu, H., Zhang, Y., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0053-8 · Cited by 62

‘Lnc’‐ing Wnt in female reproductive cancers: therapeutic potential of long non‐coding RNAs in Wnt signalling

Ong, M. S., Cai, W., Yuan, Y., Leong, H. C., Tan, T. Z., Mohammad, A., You, M., Arfuso, F., Goh, B. C., Warrier, S. R., et al. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13958 · Cited by 62

Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response

Amin, R., Shukla, A., Zhu, J. J., Kim, S., Wang, P., Tian, S. Z., Tran, A. D., Paul, D., Cappell, S. D., Burkett, S. S., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27451-w · Cited by 62

Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies

Huang, Y. R., Sendzik, M., Zhang, J., Gao, Z., Sun, Y., Wang, L., Gu, J., Zhao, K., Yu, Z., Zhang, L., et al. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c02148 · Cited by 61

The hormonal, metabolic, and environmental regulation of plant shoot branching

Liu, Y., Chen, S., Pal, S., Yu, J., Zhou, Y., Tran, L. P., & Xia, X. (2024) · New Crops · doi:10.1016/j.ncrops.2024.100028 · Cited by 65

Expression and Dendritic Trafficking of BDNF-6 Splice Variant are Impaired in Knock-In Mice Carrying Human BDNF Val66Met Polymorphism

Mallei, A., Baj, G., Ieraci, A., Corna, S., Musazzi, L., Lee, F. S., Tongiorgi, E., & Popoli, M. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv069 · Cited by 61

Building the Connectivity Map of epigenetics: Chromatin profiling by quantitative targeted mass spectrometry

Creech, A. L., Taylor, J. E., Maier, V., Wu, X., Feeney, C. M., Udeshi, N. D., Peach, S. E., Boehm, J. S., Lee, J. T., Carr, S. A., et al. (2014) · Methods · doi:10.1016/j.ymeth.2014.10.033 · Cited by 62

Epigenetic programming of hypoxic–ischemic encephalopathy in response to fetal hypoxia

Ma, Q., & Zhang, L. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.11.001 · Cited by 63

Chemical Probes of Histone Lysine Methyltransferases

Kanıskan, H. Ü., & Jin, J. J. (2014) · ACS Chemical Biology · doi:10.1021/cb500785t · Cited by 63

O-Linked N-Acetylglucosamine (O-GlcNAc) Expression Levels Epigenetically Regulate Colon Cancer Tumorigenesis by Affecting the Cancer Stem Cell Compartment via Modulating Expression of Transcriptional Factor MYBL1

Guo, H., Zhang, B., Nairn, A. V., Nagy, T., Moremen, K. W., Buckhaults, P., & Pierce, M. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.763201 · Cited by 63

Histone methylation in DNA repair and clinical practice: new findings during the past 5-years

Wei, S., Li, C., Yin, Z., Wen, J., Meng, H., Xue, L., & Wang, J. (2018) · Journal of Cancer · doi:10.7150/jca.23427 · Cited by 67

EZH2 Cooperates with DNA Methylation to Downregulate Key Tumor Suppressors and IFN Gene Signatures in Melanoma

Tiffen, J. C., Gallagher, S. J., Filipp, F. V., Gunatilake, D., Emran, A. A., Cullinane, C. M., Dutton‐Regester, K., Aoude, L. G., Hayward, N. K., Chatterjee, A., et al. (2020) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.02.042 · Cited by 64

Targeting the epigenome in in-stent restenosis: from mechanisms to therapy

Yang, X., Yang, Y., Guo, J., Meng, Y., Li, M., Yang, P., Liu, X., Aung, L. H. H., Yu, T., & Li, Y. (2021) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2021.01.024 · Cited by 60

EED and KDM6B Coordinate the First Mammalian Cell Lineage Commitment To Ensure Embryo Implantation

Saha, B., Home, P., Ray, S. S., Larson, M. A., Paul, A., Rajendran, G., Behr, B. R., & Paul, S. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00069-13 · Cited by 60

The controversial role of the Polycomb group proteins in transcription and cancer: how much do we not understand Polycomb proteins?

Scelfo, A., Piunti, A., & Pasini, D. (2014) · FEBS Journal · doi:10.1111/febs.13112 · Cited by 61

Development and Validation of Reagents and Assays for EZH2 Peptide and Nucleosome High-Throughput Screens

Diaz, E., Machutta, C. A., Chen, S., Jiang, Y., Nixon, C., Hofmann, G. A., Key, D. E., Sweitzer, S. M., Patel, M. P., Wu, Z., et al. (2012) · SLAS DISCOVERY · doi:10.1177/1087057112453765 · Cited by 63

A genetic polymorphism in lincRNA-uc003opf.1 is associated with susceptibility to esophageal squamous cell carcinoma in Chinese populations

Wu, H., Zheng, J., Deng, J., Hu, M., You, Y., Li, N., Li, W., Lü, J., & Zhou, Y. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt252 · Cited by 61

DNMT1 is a required genomic regulator for murine liver histogenesis and regeneration

Kaji, K., Factor, V. M., Andersen, J. B., Durkin, M. E., Tomokuni, A., Marquardt, J. U., Matter, M. S., Hoang, T., Conner, E. A., & Thorgeirsson, S. S. (2016) · Hepatology · doi:10.1002/hep.28563 · Cited by 61

Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase

Lingel, A., Sendzik, M., Huang, Y. R., Shultz, M. D., Cantwell, J., Dillon, M. P., Fu, X., Fuller, J., Gabriel, T., Gu, J., et al. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b01473 · Cited by 61

Histone Lysine Methylation and Neurodevelopmental Disorders

Kim, J., Lee, J., Lee, I., Lee, S. B., & Cho, K. S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071404 · Cited by 65

Development of Potent Type I Protein Arginine Methyltransferase (PRMT) Inhibitors of Leukemia Cell Proliferation

Wang, C., Jiang, H., Jin, J., Xie, Y., Chen, Z., Zhang, H., Lian, F., Liu, J. Y.-C., Zhang, C., Ding, H., et al. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b01134 · Cited by 62

The SUMO Ligase Su(var)2-10 Controls Hetero- and Euchromatic Gene Expression via Establishing H3K9 Trimethylation and Negative Feedback Regulation

Ninova, M., Godneeva, B. K., Chen, Y.-C. A., Luo, Y., Prakash, S. J., Jankovics, F., Erdélyi, M., Aravin, A. A., & Tóth, K. F. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.09.033 · Cited by 59

ADAR-deficiency perturbs the global splicing landscape in mouse tissuesPreprint

Kapoor, U., Licht, K., Amman, F., Jakobi, T., Martin, D., Dieterich, C., & Jantsch, M. F. (2020) · Genome Research · doi:10.1101/gr.256933.119 · Cited by 61

CBX8 Suppresses Tumor Metastasis via Repressing Snail in Esophageal Squamous Cell Carcinoma

Wang, G., Tang, J., Zhan, W., Zhang, R., Zhang, M., Liao, D., Wang, X., Wu, Y., & Kang, T. (2017) · Theranostics · doi:10.7150/thno.20717 · Cited by 60

LncRNAs regulate cancer metastasis via binding to functional proteins

Yang, L., Tang, Y., Xiong, F., He, Y., Wei, F., Zhang, S., Guo, C. J., Xiang, B., Zhou, M., Xie, N., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.22840 · Cited by 60

Early T-Cell Precursor Acute Lymphoblastic Leukemia: Diagnosis, Updates in Molecular Pathogenesis, Management, and Novel Therapies

Sin, C., & Man, P.-H. M. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.750789 · Cited by 60

Cellular Mechanisms of Somatic Stem Cell Aging

Jung, Y., & Brack, A. S. (2014) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-416022-4.00014-7 · Cited by 63

The Fork in the Road: Histone Partitioning During DNA Replication

Annunziato, A. T. (2015) · Genes · doi:10.3390/genes6020353 · Cited by 67

Influence of ND10 Components on Epigenetic Determinants of Early KSHV Latency Establishment

Günther, T., Schreiner, S., Dobner, T., Tessmer, U., & Grundhoff, A. T. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004274 · Cited by 60

The Polycomb Protein Ezh2 Impacts on Induced Pluripotent Stem Cell Generation

Ding, X., Wang, X., Sontag, S., Qin, J., Wanek, P., Lin, Q., & Zenke, M. (2013) · Stem Cells and Development · doi:10.1089/scd.2013.0267 · Cited by 60

Distinct modes of DNA accessibility in plant chromatin

Shu, H., Wildhaber, T., Siretskiy, A., Gruissem, W., & Hennig, L. (2012) · Nature Communications · doi:10.1038/ncomms2259 · Cited by 69

The role of mutations in epigenetic regulators in myeloid malignancies

Woods, B. A., & Levine, R. L. (2014) · Immunological Reviews · doi:10.1111/imr.12246 · Cited by 63

Polycomb-group proteins in hematopoietic stem cell regulation and hematopoietic neoplasms

Radulović, V., de Haan, G., & Klauke, K. (2012) · Leukemia · doi:10.1038/leu.2012.368 · Cited by 62

3D genome organization in health and disease: emerging opportunities in cancer translational medicine

Babu, D., & Fullwood, M. J. (2015) · Nucleus · doi:10.1080/19491034.2015.1106676 · Cited by 59

Signaling Control of Differentiation of Embryonic Stem Cells toward Mesendoderm

Wang, L., & Chen, Y. (2015) · Journal of Molecular Biology · doi:10.1016/j.jmb.2015.06.013 · Cited by 60

Control of Paneth Cell Fate, Intestinal Inflammation, and Tumorigenesis by PKCλ/ι

Nakanishi, Y., Reina‐Campos, M., Nakanishi, N., Lladó, V., Elmeń, L., Peterson, S. N., Campos, A. R., De, S. K., Leitges, M., Ikeuchi, H., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.08.054 · Cited by 62

Epigenetic regulation of cancer biology and anti-tumor immunity by EZH2

Christofides, A., Karantanos, T., Bardhan, K., & Boussiotis, V. A. (2016) · Oncotarget · doi:10.18632/oncotarget.12928 · Cited by 61

MiR-34 inhibits polycomb repressive complex 2 to modulate chaperone expression and promote healthy brain aging

Kennerdell, J. R., Liu, N., & Bonini, N. M. (2018) · Nature Communications · doi:10.1038/s41467-018-06592-5 · Cited by 56

PRC2 loss induces chemoresistance by repressing apoptosis in T cell acute lymphoblastic leukemia

Ariës, I. M., Bodaar, K., Karim, S., Chonghaile, T. N., Hinze, L., Burns, M., Pfirrmann, M., Degar, J., Landrigan, J., Balbach, S. T., et al. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20180570 · Cited by 60

Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7

Lamb, K. N., Bsteh, D., Dishman, S. N., Moussa, H. F., Fan, H., Stuckey, J. I., Norris, J. L., Cholensky, S. H., Li, D., Wang, J., et al. (2019) · Cell chemical biology · doi:10.1016/j.chembiol.2019.07.013 · Cited by 61

Regulatory non-coding RNAs: revolutionizing the RNA world

Huang, B., & Zhang, R. (2014) · Molecular Biology Reports · doi:10.1007/s11033-014-3259-6 · Cited by 61

Epigenetic Regulators in the Development, Maintenance, and Therapeutic Targeting of Acute Myeloid Leukemia

Sun, Y., Chen, B.-R., & Deshpande, A. J. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00041 · Cited by 64

PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome

Meng, T., Zhou, Q., Ma, X., Liu, X., Meng, Q., Huang, X., Liu, H., Lei, W., Zhao, Z., Ouyang, Y., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-20242-9 · Cited by 59

Targeting epigenetic modulators using PROTAC degraders: Current status and future perspective

Webb, T., Craigon, C., & Ciulli, A. (2022) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2022.128653 · Cited by 58

Design and Synthesis of Dual EZH2/BRD4 Inhibitors to Target Solid Tumors

Guo, Z., Sun, Y., Liang, L., Lu, W., Luo, B., Wu, Z., Huo, B., Hu, Y., Huang, P., Wu, Q., et al. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c01876 · Cited by 59

Dynamics of H3K27me3 methylation and demethylation in plant development

Gan, E., Xu, Y., & Ito, T. (2015) · Plant Signaling & Behavior · doi:10.1080/15592324.2015.1027851 · Cited by 55

The polycomb group gene EMF 2B is essential for maintenance of floral meristem determinacy in rice

Conrad, L. J., Khanday, I., Johnson, C. S., Guiderdoni, E., An, G., Vijayraghavan, U., & Sundaresan, V. (2014) · The Plant Journal · doi:10.1111/tpj.12688 · Cited by 59

PRC2 Controls Drosophila Oocyte Cell Fate by Repressing Cell Cycle Genes

Iovino, N., Ciabrelli, F., & Cavalli, G. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.06.021 · Cited by 65

Lnc ing Epigenetic Control of Transcription to Cardiovascular Development and Disease

Rizki, G., & Boyer, L. A. (2015) · Circulation Research · doi:10.1161/circresaha.117.304156 · Cited by 60

Dissecting the Roles of Polycomb Repressive Complex 2 Subunits in the Control of Skin Development

Dauber, K. L., Perdigoto, C. N., Valdés, V. J., Santoriello, F. J., Cohen, I., & Ezhkova, E. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.02.809 · Cited by 59

An RNA matchmaker protein regulates the activity of the long noncoding RNA HOTAIR

Meredith, E. K., Balas, M. M., Sindy, K., Haislop, K. S., & Johnson, A. M. (2016) · RNA · doi:10.1261/rna.055830.115 · Cited by 62

Genomic Characterization of Renal Medullary Carcinoma and Treatment Outcomes

Carlo, M. I., Chaim, J. L., Patil, S., Kemel, Y. M., Schram, A. M., Woo, K. M., Coskey, D. T., Nanjangud, G. J., Voss, M. H., Feldman, D. R., et al. (2017) · Clinical Genitourinary Cancer · doi:10.1016/j.clgc.2017.04.012 · Cited by 59

Hidden features: exploring the non-canonical functions of metabolic enzymes

Huangyang, P., & Simon, M. C. (2018) · Disease Models & Mechanisms · doi:10.1242/dmm.033365 · Cited by 60

LncRNA regulation: New frontiers in epigenetic solutions to drug chemoresistance

Zhou, Y., Sun, W. C., Qin, Z., Guo, S., Kang, Y., Zeng, S., & Yu, L. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114228 · Cited by 58

EZH2 dependent H3K27me3 is involved in epigenetic silencing of ID4 in prostate cancer

Chinaranagari, S., Sharma, P., & Chaudhary, J. (2014) · Oncotarget · doi:10.18632/oncotarget.2262 · Cited by 58

EZH2 inhibitors reverse resistance to gefitinib in primary EGFR wild-type lung cancer cells

Gong, H., Li, Y., Yin, Y., Li, W., Zhang, H., Zhang, Z., Shi, R., Liu, M., Liu, C., Chen, C., et al. (2020) · BMC Cancer · doi:10.1186/s12885-020-07667-7 · Cited by 58

Competition between PRC2.1 and 2.2 subcomplexes regulates PRC2 chromatin occupancy in human stem cells

Youmans, D. T., Gooding, A. R., Dowell, R. D., & Cech, T. R. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.11.044 · Cited by 58

Targeting EZH2 as cancer therapy

Hanaki, S., & Shimada, M. (2021) · The Journal of Biochemistry · doi:10.1093/jb/mvab007 · Cited by 56

Harnessing the cyclization strategy for new drug discovery

Tang, K., Wang, S., Gao, W., Song, Y., & Yu, B. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.09.022 · Cited by 59

Epigenetic alterations in hematopoietic malignancies

Chung, Y. R., Schatoff, E. M., & Abdel-Wahab, O. I. (2012) · International Journal of Hematology · doi:10.1007/s12185-012-1181-z · Cited by 59

Application of ChIP-Seq and Related Techniques to the Study of Immune Function

Northrup, D. L., & Zhao, K. (2011) · Immunity · doi:10.1016/j.immuni.2011.06.002 · Cited by 57

Association of H3K9me3 and H3K27me3 repressive histone marks with breast cancer subtypes in the Nurses’ Health Study

Healey, M. A., Hu, R., Beck, A. H., Collins, L. C., Schnitt, S. J., Tamimi, R. M., & Hazra, A. (2014) · Breast Cancer Research and Treatment · doi:10.1007/s10549-014-3089-1 · Cited by 59

The methyltransferases enhancer of zeste homolog (EZH) 1 and EZH2 control hepatocyte homeostasis and regeneration

Bae, W. K., Kang, K., Yu, J. H., Yoo, K. H., Factor, V. M., Kaji, K., Matter, M. S., Thorgeirsson, S. S., & Hennighausen, L. G. (2014) · The FASEB Journal · doi:10.1096/fj.14-261537 · Cited by 64

Role of the EZH2 histone methyltransferase as a therapeutic target in cancer

Italiano, A. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.05.003 · Cited by 60

Polycomb Repressive Complex 2 Methylates Elongin A to Regulate Transcription

Ardehali, M. B., Anselmo, A. N., Cochrane, J. C., Kundu, S., Sadreyev, R. I., & Kingston, R. E. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.10.025 · Cited by 63

Ezh2 Regulates Activation-Induced CD8+ T Cell Cycle Progression via Repressing Cdkn2a and Cdkn1c Expression

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MicroRNA-26a is a key regulon that inhibits progression and metastasis of c-Myc/EZH2 double high advanced hepatocellular carcinoma

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Histones and Their Modifications in Ovarian Cancer – Drivers of Disease and Therapeutic Targets

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Suz12 inactivation cooperates with JAK3 mutant signaling in the development of T-cell acute lymphoblastic leukemia

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The PRT6 N‐degron pathway restricts VERNALIZATION 2 to endogenous hypoxic niches to modulate plant development

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Ybx1 fine-tunes PRC2 activities to control embryonic brain development

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Dynamics of H3K27me3 Modification on Plant Adaptation to Environmental Cues

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Myristoylation-mediated phase separation of EZH2 compartmentalizes STAT3 to promote lung cancer growth

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Exploiting epigenetic dependencies in ovarian cancer therapy

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Functions and Interactions of Mammalian KDM5 Demethylases

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Hepatitis B virus X protein induces EpCAM expression via active DNA demethylation directed by RelA in complex with EZH2 and TET2

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Histone Methyltransferase Inhibitors: Novel Epigenetic Agents for Cancer Treatment

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Arabidopsis Retinoblastoma-related and Polycomb group proteins: cooperation during plant cell differentiation and development

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The epigenetic regulation of embryonic myogenesis and adult muscle regeneration by histone methylation modification

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Prognostic Significance of EZH2 Expression in Non-Small Cell Lung Cancer: A Meta-analysis

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Ezh2 Acts as a Tumor Suppressor in Kras-driven Lung Adenocarcinoma

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Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors

Booth, C. A. G., Barkas, N., Neo, W. H., Boukarabila, H., Soilleux, E. J., Giotopoulos, G., Farnoud, N., Giustacchini, A., Ashley, N., Carrelha, J., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.01.006 · Cited by 57

Steroidogenic differentiation and PKA signaling are programmed by histone methyltransferase EZH2 in the adrenal cortex

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Mechanisms of chromatin-based epigenetic inheritance

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Epigenetic dosage identifies two major and functionally distinct β cell subtypes

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Over-expression of XIST, the Master Gene for X Chromosome Inactivation, in Females With Major Affective Disorders

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Signaling epigenetics: Novel insights on cell signaling and epigenetic regulation

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Role of PRC 2‐associated factors in stem cells and disease

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Polycomb Repressive Complex 2 Structure and Function

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A Structural Perspective on Gene Repression by Polycomb Repressive Complex 2

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Structural and Mechanistic Insights into Polycomb Repressive Complex 2 Regulation in Gene Silencing

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PRC2 activity, recruitment, and silencing: a comparative perspective

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