The Polycomb complex PRC2 and its mark in life

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Items 101–200 of 1,009

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2. The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors
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3. The chromatin-modifying enzyme Ezh2 is critical for the maintenance of regulatory T cell identity after activation
   DuPage, Michel, Chopra, Gaurav, Quiros, Jason, Rosenthal, Wendy L., Morar, Malika M., Holohan, Dan, Zhang, Ruan, Turka, Laurence, Marson, Alexander, Bluestone, Jeffrey A. · 2015 · Immunity
4. The Role of DNA Methylation and Histone Modifications in Transcriptional Regulation in Humans
   Jaime L. Miller, Patrick A. Grant · 2012 · Sub-cellular biochemistry/Subcellular biochemistry
5. What are memories made of? How Polycomb and Trithorax proteins mediate epigenetic memory
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6. Polycomb Repressive Complex 2 Regulates Normal Hematopoietic Stem Cell Function in a Developmental-Stage-Specific Manner
   Huafeng Xie, Jian Xu, Jessie Hao-Ru Hsu, Minh Nguyen, Yuko Fujiwara, Cong Peng, Stuart H. Orkin · 2013 · Cell stem cell
7. Single-cell chromatin modification profiling reveals increased epigenetic variations with aging
   Cheung, Peggie, Vallania, Francesco, Warsinske, Hayley C., Donato, Michele, Schaffert, Steven, Chang, Sarah E., Dvorak, Mai, Dekker, Cornelia L., Davis, Mark M., Utz, Paul J. et al. · 2018 · Cell
8. An AUTS2–Polycomb complex activates gene expression in the CNS
   Zhonghua Gao, Pedro Lee, James M. Stafford, Melanie J. von Schimmelmann, Anne Schaefer, Danny Reinberg · 2014 · Nature
9. Multifunctional role of the transcription factor Blimp-1 in coordinating plasma cell differentiation
   Martina Minnich, Hiromi Tagoh, Peter Bönelt, Elin Axelsson, Maria Fischer, Beatriz Cebolla, Alexander Tarakhovsky, Stephen L. Nutt, Markus Jaritz, Meinrad Busslinger · 2016 · Nature Immunology
10. H3K27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interactions
    Cai, Yichao, Zhang, Ying, Loh, Yan Ping, Tng, Jia Qi, Lim, Mei Chee, Cao, Zhendong, Raju, Anandhkumar, Lieberman Aiden, Erez, Li, Shang, Manikandan, Lakshmanan et al. · 2021 · Nature Communications
11. Inhibitors of Protein Methyltransferases and Demethylases
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12. The Fusarium graminearum Histone H3 K27 Methyltransferase KMT6 Regulates Development and Expression of Secondary Metabolite Gene Clusters
    Lanelle Connolly, Kristina Smith, Michael Freitag · 2013 · PLoS Genetics
13. Long noncoding RNAs: an emerging link between gene regulation and nuclear organization
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14. SET for life: biochemical activities and biological functions of SET domain-containing proteins
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15. Long noncoding RNA PVT1 indicates a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically regulating p15 and p16
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16. Polycomb complexes in stem cells and embryonic development
    Luigi Aloia, Bruno Di Stefano, Luciano Di Croce · 2013 · Development
17. Chemistries of bifunctional PROTAC degraders
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18. Role of H3K9me3 heterochromatin in cell identity establishment and maintenance
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19. UTX and UTY Demonstrate Histone Demethylase-Independent Function in Mouse Embryonic Development
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20. PRC2 binds active promoters and contacts nascent RNAs in embryonic stem cells
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21. The NF1 somatic mutational landscape in sporadic human cancers
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22. An epigenetic switch ensures transposon repression upon dynamic loss of DNA methylation in embryonic stem cells
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23. Mechanisms of T cell tolerance towards the allogeneic fetus
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24. Histone H3.3 K27M Accelerates Spontaneous Brainstem Glioma and Drives Restricted Changes in Bivalent Gene Expression
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25. The long noncoding RNA SNHG1 regulates colorectal cancer cell growth through interactions with EZH2 and miR-154-5p
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26. Unique genetic and epigenetic mechanisms driving paediatric diffuse high-grade glioma
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27. Dynamics of BAF–Polycomb complex opposition on heterochromatin in normal and oncogenic states
    Cigall Kadoch, Robert T Williams, Joseph P. Calarco, Erik L. Miller, Christopher M. Weber, Simon M. G. Braun, John L. Pulice, Emma J. Chory, Gerald R. Crabtree · 2016 · Nature Genetics
28. Genomic and Epigenomic Profiling of High-Risk Intestinal Metaplasia Reveals Molecular Determinants of Progression to Gastric Cancer
    Kie Kyon Huang, Kalpana Ramnarayanan, Feng Zhu, Supriya Srivastava, Chang Xu, Angie Lay Keng Tan, Ming‐Hui Lee, Su Ting Tay, Kakoli Das, Manjie Xing et al. · 2017 · Cancer Cell
29. PROTAC: An Effective Targeted Protein Degradation Strategy for Cancer Therapy
    Simin Qi, Jinyun Dong, Zhiyuan Xu, Xiangdong Cheng, Weidong Zhang, Jiang‐Jiang Qin · 2021 · Frontiers in Pharmacology
30. A Histone Mutant Reproduces the Phenotype Caused by Loss of Histone-Modifying Factor Polycomb
    Pengelly, Ana Raquel, Copur, Ömer, Jäckle, Herbert, Herzig, Alf, Müller, Jürg · 2013 · Science
31. The recruitment of chromatin modifiers by long noncoding RNAs: lessons from PRC2
    Chen Davidovich, Thomas R. Cech · 2015 · RNA
32. PRDM14 Ensures Naive Pluripotency through Dual Regulation of Signaling and Epigenetic Pathways in Mouse Embryonic Stem Cells
    Masashi Yamaji, Jun Ueda, Katsuhiko Hayashi, Hiroshi Ohta, Yukihiro Yabuta, Kazuki Kurimoto, Ryuichiro Nakato, Yasuhiro Yamada, Katsuhiko Shirahige, Mitinori Saitou · 2013 · Cell stem cell
33. The Molecular Balancing Act of p16INK4a in Cancer and Aging
    Kyle M. LaPak, Christin Elizabeth Burd · 2013 · Molecular Cancer Research
34. Loss of H3K27me3 Expression Is a Highly Sensitive Marker for Sporadic and Radiation-induced MPNST
    Carlos N. Prieto Granada, Thomas Wiesner, Jane L. Messina, Achim A. Jungbluth, Ping Chi, Cristina R. Antonescu · 2015 · The American Journal of Surgical Pathology
35. Molecular mechanisms of long noncoding RNAs on gastric cancer
    Tianwen Li, Xiaoyan Mo, Liyun Fu, Bingxiu Xiao, Junming Guo · 2016 · Oncotarget
36. Polycomb-like proteins link the PRC2 complex to CpG islands
    Haojie Li, Robert Liefke, Junyi Jiang, Jesse V. Kurland, Wei Tian, Pujuan Deng, Weidi Zhang, Qian He, Dinshaw J. Patel, Martha L. Bulyk et al. · 2017 · Nature
37. Epigenetic Silencing of HIV-1 by the Histone H3 Lysine 27 Methyltransferase Enhancer of Zeste 2
    Julia H. Friedman, Won-Kyung Cho, Chung K. Chu, Kara S. Keedy, Nancie M. Archin, David M. Margolis, Jonathan Karn · 2011 · Journal of Virology
38. Regulatory Interactions between RNA and Polycomb Repressive Complex 2
    Catherine Cifuentes‐Rojas, Alfredo J. Hernandez, Kavitha Sarma, Jeannie T. Lee · 2014 · Molecular Cell
39. Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation
    Serena Sanulli, Neil Justin, Aurélie Teissandier, Katia Ancelin, Manuela Portoso, Matthieu J. Caron, Audrey Michaud, Bérangère Lombard, Simão Teixeira da Rocha, John Offer et al. · 2015 · Molecular Cell
40. Long Noncoding RNAs: Emerging Stars in Gene Regulation, Epigenetics and Human Disease
    Arunoday Bhan, Subhrangsu S. Mandal · 2014 · ChemMedChem
41. A High-Density Map for Navigating the Human Polycomb Complexome
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42. Hira-Dependent Histone H3.3 Deposition Facilitates PRC2 Recruitment at Developmental Loci in ES Cells
    Laura A. Banaszynski, Duancheng Wen, Scott B. Dewell, Sarah J. Whitcomb, Mingyan Lin, Nichole S. Diaz, Simon J. Elsässer, Ariane L. A. Chapgier, Aaron D. Goldberg, Eli Canaani et al. · 2013 · Cell
43. The Histone H3 Lysine 9 Methyltransferases G9a and GLP Regulate Polycomb Repressive Complex 2-Mediated Gene Silencing
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44. An interactive environment for agile analysis and visualization of ChIP-sequencing data
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45. A transcriptional view on somatic embryogenesis
    Anneke Horstman, Marian Bemer, Kim Boutilier · 2017 · Regeneration
46. PRC2 Epigenetically Silences Th1-Type Chemokines to Suppress Effector T-Cell Trafficking in Colon Cancer
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47. Capturing the Onset of PRC2-Mediated Repressive Domain Formation
    Ozgur Oksuz, Varun K. Narendra, Chul‐Hwan Lee, Nicolas Descostes, Gary LeRoy, Ramya Raviram, Lili M. Blumenberg, Kelly R. Karch, Pedro P. Rocha, Benjamin Aaron Garcia et al. · 2018 · Molecular Cell
48. Transcriptional Silencing by Polycomb-Group Proteins
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49. A key role for <i>EZH2</i> and associated genes in mouse and human adult T-cell acute leukemia
    Simon, Camille, Chagraoui, Jalila, Krosl, Jana, Gendron, Patrick, Wilhelm, Brian, Lemieux, Sébastien, Boucher, Geneviève, Chagnon, Pierre, Drouin, Simon, Lambert, Raphaëlle et al. · 2012 · Genes &amp; Development
50. Jarid2 Is Implicated in the Initial Xist-Induced Targeting of PRC2 to the Inactive X Chromosome
    Simão Teixeira da Rocha, Valentina Boeva, Martín Escamilla-Del-Arenal, Katia Ancelin, Camille Granier, Neuza R. Matias, Serena Sanulli, Jen Y. Chow, Edda G. Schulz, Christel Picard et al. · 2014 · Molecular Cell
51. Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation
    Gerard L. Brien, Guillermo Gambero, David J O’Connell, Emilia Jerman, Siobhán A. Turner, Chris M Egan, Eiseart J. Dunne, Maike C. Jürgens, Kieran J. Wynne, Lianhua Piao et al. · 2012 · Nature Structural & Molecular Biology
52. Long noncoding RNAs in development and cancer: potential biomarkers and therapeutic targets
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53. Proteolysis targeting chimera (PROTAC) in drug discovery paradigm: Recent progress and future challenges
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54. Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis
    Paul Delgado-Olguı́n, Yu Huang, Xue Li, Danos C. Christodoulou, Christine E. Seidman, Jonathan G. Seidman, Alexander Tarakhovsky, Benoit G. Bruneau · 2012 · Nature Genetics
55. Long Noncoding RNAs in Cancer: From Function to Translation
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56. PRC2 is high maintenance
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57. EZH2 Methyltransferase and H3K27 Methylation in Breast Cancer
    Kyung Hyun Yoo, Lothar G. Hennighausen · 2012 · International Journal of Biological Sciences
58. Stoichiometry of chromatin-associated protein complexes revealed by label-free quantitative mass spectrometry-based proteomics
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59. Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis
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60. Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia
    Stefanie Göllner, Thomas Oellerich, Shuchi Agrawal Singh, Tino Schenk, Hans‐Ulrich Klein, Christian Rohde, Caroline Pabst, Tim Sauer, Mads Lerdrup, Sigal Tavor et al. · 2016 · Nature Medicine
61. Genomic Imprinting: A Mammalian Epigenetic Discovery Model
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62. An H3K36 Methylation-Engaging Tudor Motif of Polycomb-like Proteins Mediates PRC2 Complex Targeting
    Ling Cai, Scott B. Rothbart, Rui Lu, Bowen Xu, Wei‐Yi Chen, Ashutosh Tripathy, Shira Rockowitz, Deyou Zheng, Dinshaw J. Patel, C. David Allis et al. · 2012 · Molecular Cell
63. TCF1 in T cell immunity: a broadened frontier
    Xudong Zhao, Qiang Shan, Hai‐Hui Xue · 2021 · Nature reviews. Immunology
64. Functional Long Non-coding RNAs Evolve from Junk Transcripts
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65. Common stemness regulators of embryonic and cancer stem cells
    Christiana Hadjimichael · 2015 · World Journal of Stem Cells
66. EZH2-Targeted Therapies in Cancer: Hype or a Reality
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67. Histones: At the Crossroads of Peptide and Protein Chemistry
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68. Molecular architecture of human polycomb repressive complex 2
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69. Epigenetic encoding, heritability and plasticity of glioma transcriptional cell states
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70. PRC2 mediated H3K27 methylations in cellular identity and cancer
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71. Polycomb Repressive Complex 2-Mediated Chromatin Repression Guides Effector CD8 + T Cell Terminal Differentiation and Loss of Multipotency
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72. Modulation of EZH2 expression in T cells improves efficacy of anti-CTLA-4 therapy
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73. Roles of the Polycomb group proteins in stem cells and cancer
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74. Inflammation-induced repression of chromatin bound by the transcription factor Foxp3 in regulatory T cells
    Aaron J. Arvey, Joris van der Veeken, Robert M. Samstein, Yongqiang Feng, John A. Stamatoyannopoulos, Alexander Yu Rudensky · 2014 · Nature Immunology
75. JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications
    Vignesh Kasinath, Curtis Beck, Paul Victor Sauer, Simon Poepsel, Jennifer Kosmatka, Marco Faini, Daniel B. Toso, Ruedi H. Aebersold, Eva Nogales · 2021 · Science
76. Environmental perception and epigenetic memory: mechanistic insight through FLC
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77. EZH2-mediated epigenetic suppression of long noncoding RNA SPRY4-IT1 promote s NSCLC cell proliferation and metastasis by affecting the epithelial–mesenchymal transition
    Ming Sun, X-H Liu, K-H Lu, F.F. Nie, R Xia, Renyi Kong, JS Yang, T-p Xu, Y-W Liu, Y-F Zou et al. · 2014 · Cell Death and Disease
78. Redistribution of H3K27me3 upon DNA hypomethylation results in de-repression of Polycomb target genes
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79. Discovery of a first-in-class EZH2 selective degrader
    Anqi Ma, Ηλίας Στρατικόπουλος, Kwang‐Su Park, Jieli Wei, Tiphaine C. Martin, Xiaobao Yang, Megan Catherine Schwarz, Violetta V. Leshchenko, Alexander Rialdi, Brandon Dale et al. · 2019 · Nature Chemical Biology
80. Chromatin-associated RNAs as facilitators of functional genomic interactions
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81. Arabidopsis MSI1 connects LHP1 to PRC2 complexes
    Maria Derkacheva, Yvonne Steinbach, Thomas Wildhaber, Iva Mozgová, Walid Mahrez, Paolo Nanni, Sylvain Bischof, Wilhelm Gruissem, Lars Hennig · 2013 · The EMBO Journal
82. Lysine methylation: beyond histones
    Xi Zhang, Hong Wen, Xiaobing Shi · 2011 · Acta Biochimica et Biophysica Sinica
83. Long non-coding RNA HOTAIR promotes glioblastoma cell cycle progression in an EZH2 dependent manner
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84. Polycomb Protein EZH2 Regulates Tumor Invasion via the Transcriptional Repression of the Metastasis Suppressor RKIP in Breast and Prostate Cancer
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85. PARTICLE, a Triplex-Forming Long ncRNA, Regulates Locus-Specific Methylation in Response to Low-Dose Irradiation
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86. The interaction of PRC2 with RNA or chromatin is mutually antagonistic
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87. Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia
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88. The never-ending story: from pluripotency to plant developmental plasticity
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89. Targeting of Polycomb Repressive Complex 2 to RNA by Short Repeats of Consecutive Guanines
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90. Identification of ( R )- N -((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1 H -indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas
    Rishi G. Vaswani, Victor S. Gehling, Les A. Dakin, Andrew S. Cook, Christopher G. Nasveschuk, Martin Duplessis, Priyadarshini Iyer, Srividya Balasubramanian, Feng Zhao, Andrew C. Good et al. · 2016 · Journal of Medicinal Chemistry
91. Long non-coding RNA TUG1 is involved in cell growth and chemoresistance of small cell lung cancer by regulating LIMK2b via EZH2
    Yuchun Niu, Feng Ma, Weimei Huang, Shun Fang, Man Li, Ting Wei, Linlang Guo · 2017 · Molecular Cancer
92. Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration
    von Schimmelmann, Melanie, Feinberg, Philip A, Sullivan, Josefa M, Ku, Stacy M, Badimon, Ana, Duff, Mary Kaye, Wang, Zichen, Lachmann, Alexander, Dewell, Scott, Ma'ayan, Avi et al. · 2016 · Nature Neuroscience
93. Disentangling the Many Layers of Eukaryotic Transcriptional Regulation
    Katherine M. Lelli, Matthew G. Slattery, Richard S. Mann · 2012 · Annual Review of Genetics
94. Targeting EZH2 in cancer therapy
    Makoto Yamagishi, Kaoru Uchimaru · 2017 · Current Opinion in Oncology
95. The EED protein–protein interaction inhibitor A-395 inactivates the PRC2 complex
    He, Yupeng, Selvaraju, Sujatha, Curtin, Michael L, Jakob, Clarissa G, Zhu, Haizhong, Comess, Kenneth M, Shaw, Bailin, The, Juliana, Lima-Fernandes, Evelyne, Szewczyk, Magdalena M et al. · 2017 · Nature Chemical Biology
96. Epigenome in Early Mammalian Development: Inheritance, Reprogramming and Establishment
    Qianhua Xu, Wei Xie · 2017 · Trends in Cell Biology
97. Ezh1 Is Required for Hematopoietic Stem Cell Maintenance and Prevents Senescence-like Cell Cycle Arrest
    Hidalgo, Isabel, Herrera-Merchan, Antonio, Ligos, Jose Manuel, Carramolino, Laura, Nuñez, Javier, Martinez, Fernando, Dominguez, Orlando, Torres, Miguel, Gonzalez, Susana · 2012 · Cell Stem Cell
98. Causal role for inheritance of H3K27me3 in maintaining the OFF state of a <i>Drosophila</i> HOX gene
    Coleman, Rory T., Struhl, Gary · 2017 · Science
99. RETRACTED: The Noncoding RNA Mistral Activates Hoxa6 and Hoxa7 Expression and Stem Cell Differentiation by Recruiting MLL1 to Chromatin
    Stéphane Bertani, Silvia Sauer, Eugene Bolotin, Frank Sauer · 2011 · Molecular Cell · Retracted
100. The human lncRNA LINC-PINT inhibits tumor cell invasion through a highly conserved sequence element
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