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The Polycomb complex PRC2 and its mark in life
Open accessAbstract
Polycomb group proteins maintain the gene-expression pattern of different cells that is set during early development by regulating chromatin structure. In mammals, two main Polycomb group complexes exist - Polycomb repressive complex 1 (PRC1) and 2 (PRC2). PRC1 compacts chromatin and catalyses the monoubiquitylation of histone H2A. PRC2 also contributes to chromatin compaction, and catalyses the methylation of histone H3 at lysine 27. PRC2 is involved in various biological processes, including differentiation, maintaining cell identity and proliferation, and stem-cell plasticity. Recent studies of PRC2 have expanded our perspectives on its function and regulation, and uncovered a role for non-coding RNA in the recruitment of PRC2 to target genes.
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“That said, we do not wish to imply that DNA methylation is the only epigenetic mark involved in this process. It likely involves other transcription factors and epigenetic modifications, such as the PRC2 complex and H3K27me3, both of which are involved in maintaining stem cell plasticity and are associated with DNAm clock sites4,49,50.”
From Reprogramming to recover youthful epigenetic information and restore vision (2020) · cites this paper as [49]
Experimental — accuracy not yet measuredIn the citing paper
“EZH2 catalyzes nucleosome compaction via H3K27 trimethylation11”
From Profiling the genetic determinants of chromatin accessibility with scalable single-cell CRISPR screens (2021) · cites this paper as [11]
In the citing paper
“The suppression of clearance genes in striatal microglia is governed by Polycomb repressive complex 2 (PRC2), which catalyzes the repressive chromatin modification histone H3 lysine 27 tri-methylation (H3K27me3)16.”
From Epigenetic regulation of brain region-specific microglia clearance activity (2018) · cites this paper as [16]
In the citing paper
“H3K27me3 is mediated by PRC2, which has a well-established role in the regulation of cell differentiation during development16.”
From Epigenetic regulation of brain region-specific microglia clearance activity (2018) · cites this paper as [16]
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Metadata
- Authors
- Margueron, R., & Reinberg, D.
- Affiliations
- Institut Curie (FR)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Reinberg, Danny
- Venue
- Nature
- Published
- 2011-01-19
- Volume
- 469
- Issue
- 7330
- Pages
- 343-349
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3760771
- OpenAlex
- W2060608189
- Cited by
- 3,347
- References
- 97
- Citations by year
- 2026: 145 · 2025: 188 · 2024: 231 · 2023: 211 · 2022: 236 · 2021: 274 · 2020: 260 · 2019: 260 · 2018: 214 · 2017: 236 · 2016: 221 · 2015: 220 · 2014: 202 · 2013: 207 · 2012: 177
- FWCI
- 18.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- National Institute of General Medical Sciences (R37GM037120, R01GM064844)
- Institute of Cancer Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- polycomb repressive complex 2, Polycomb group proteins, histone H3 lysine 27 methylation, chromatin condensation, gene expression regulation, cell identity, stem cell plasticity, non-coding RNA, chromatin structure
- MeSH terms
- Animals, Cell Differentiation, Chromatin, Histones, Humans, Methylation, Neoplasms, Histone-Lysine N-Methyltransferase, Repressor Proteins, Genome, Evolution, Molecular, Polycomb-Group Proteins
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