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Understanding the common themes and diverse roles of the second extracellular loop (ECL2) of the GPCR super-family

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Nanobodies to study protein conformational states

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Cryo-electron microscopy analysis of small membrane proteins

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G PROTEIN‐COUPLED RECEPTORS

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Bitter taste TAS2R14 activation by intracellular tastants and cholesterol

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Second Extracellular Loop of Human Glucagon-like Peptide-1 Receptor (GLP-1R) Has a Critical Role in GLP-1 Peptide Binding and Receptor Activation

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Gonadotropin-Releasing Hormone (GnRH) Receptor Structure and GnRH Binding

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Sequential Inter- and Intrasubunit Rearrangements During Activation of Dimeric Metabotropic Glutamate Receptor 1

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Diversity and functional properties of bistable pigments

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Recent advances in magic angle spinning solid state NMR of membrane proteins

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Targeting recognition surfaces on natural proteins with peptidic foldamers

Checco, J. W., & Gellman, S. H. (2016) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2016.06.014 · Cited by 88

Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor

Kahsai, A. W., Wisler, J. W., Lee, J., Ahn, S., Cahill, T. J., Dennison, S. M., Staus, D. P., Thomsen, A. R. B., Anasti, K. M., Pani, B., et al. (2016) · Nature Chemical Biology · doi:10.1038/nchembio.2126 · Cited by 88

Rules and mechanisms governing G protein coupling selectivity of GPCRs

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The Chemokine Receptor CCR1 Is Constitutively Active, Which Leads to G Protein-independent, β-Arrestin-mediated Internalization

Gilliland, C. T., Salanga, C. L., Kawamura, T., Trejo, J., & Handel, T. M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.503797 · Cited by 88

Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour

Doi, M., Murai, I., Kunisue, S., Setsu, G., Uchio, N., Tanaka, R., Kobayashi, S., Shimatani, H., Hayashi, H., Chao, H., et al. (2016) · Nature Communications · doi:10.1038/ncomms10583 · Cited by 87

Mapping the Functional Binding Sites of Cholesterol in β2-Adrenergic Receptor by Long-Time Molecular Dynamics Simulations

Cang, X., Du, Y., Mao, Y., Wang, Y., Yang, H., & Jiang, H. (2013) · The Journal of Physical Chemistry B · doi:10.1021/jp3118192 · Cited by 87

Development and Characterization of Pepducins as Gs-biased Allosteric Agonists*

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Identifying ligands at orphan GPCRs: current status using structure‐based approaches

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Macrophage Migration Inhibitory Factor-CXCR4 Receptor Interactions

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The nuclear actin-containing Arp8 module is a linker DNA sensor driving INO80 chromatin remodeling

Knoll, K. R., Eustermann, S., Niebauer, V., Oberbeckmann, E., Stoehr, G., Schall, K., Tosi, A., Schwarz, M., Buchfellner, A., Korber, P., et al. (2018) · Nature Structural & Molecular Biology · doi:10.1038/s41594-018-0115-8 · Cited by 92

In brief

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Conformational changes in the G protein Gs induced by the β2 adrenergic receptor

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Activation of G Protein-Coupled Receptors and Heterotrimeric G Proteins.

DeVree, B. T. (2013) · Deep Blue (University of Michigan)

Structure and function of an irreversible agonist-β2 adrenoceptor complex

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Snapshot of a signalling complex

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