The translational landscape of mTOR signalling steers cancer initiation and metastasis

Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling

Ingolia, N. T., Ghaemmaghami, S., Newman, J. R. S., & Weissman, J. S. (2009) · Science · doi:10.1126/science.1168978 · Cited by 3,853

Integrative Genomic Profiling of Human Prostate Cancer

Taylor, B. S., Schultz, N. D., Hieronymus, H., Gopalan, A., Xiao, Y., Carver, B. S., Arora, V. K., Kaushik, P., Cerami, E. G., Reva, B. A., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.05.026 · Cited by 3,713

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

Kim, D., Sarbassov, D. D., Ali, S. M., King, J. E., Latek, R. R., Erdjument‐Bromage, H., Tempst, P., & Sabatini, D. M. (2002) · Cell · doi:10.1016/s0092-8674(02)00808-5 · Cited by 3,051

Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

Sarbassov, D. D., Ali, S. M., Kim, D.-H., Guertin, D. A., Latek, R. R., Erdjument-Bromage, H., Tempst, P., & Sabatini, D. M. (2004) · Current Biology · doi:10.1016/j.cub.2004.06.054 · Cited by 2,665

Regulation of translation initiation by FRAP/mTOR

Gingras, A.-C., Raught, B., & Sonenberg, N. (2001) · Genes & Development · doi:10.1101/gad.887201 · Cited by 1,545

The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

Liu, C., Kelnar, K., Liu, B., Chen, X., Calhoun‐Davis, T., Li, H., Patrawala, L., Yan, H., Jeter, C. R., Honorio, S., et al. (2011) · Nature Medicine · doi:10.1038/nm.2284 · Cited by 1,410

SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity

Jacinto, E., Facchinetti, V., Liu, D., Soto, N., Wei, S., Jung, S. Y., Huang, Q., Qin, J., & Su, B. (2006) · Cell · doi:10.1016/j.cell.2006.08.033 · Cited by 1,407

MicroRNA-10a binds the 5’UTR of ribosomal protein mRNAs and enhances their translation

Ørom, U. A., Nielsen, F. C., & Lund, A. H. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.05.001 · Cited by 1,384

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

Feldman, M. E., Apsel, B., Uotila, A., Loewith, R., Knight, Z. A., Ruggero, D., & Shokat, K. M. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000038 · Cited by 1,111

Ribonucleic Acid-Mediated Control of Protein Translation Under Stress

Payea, M. J., Dar, S. A., Malla, S., & Maragkakis, M. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0233 · Cited by 11

The transcription factor DUX4 orchestrates translational reprogramming by broadly suppressing translation efficiency and promoting expression of DUX4-induced mRNAs

Hamm, D. C., Paatela, E., Bennett, S. R., Wong, C.-J., Campbell, A. E., Wladyka, C. L., Smith, A. A., Jagannathan, S., Hsieh, A. C., & Tapscott, S. J. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3002317 · Cited by 11

A drug‐resistant mutation in plant target of rapamycin validates the specificity of ATP ‐competitive TOR inhibitors in vivo

Perdoux, R., Barrada, A., Boulaiz, M., Garau, C., Belbachir, C., Lecampion, C., Montané, M., & Menand, B. (2023) · The Plant Journal · doi:10.1111/tpj.16564 · Cited by 11

Specific PABP effect on translation ofYB-1mRNA is neutralized by polyadenylation through a “mini-loop” at 3′ UTR

Eliseeva, I. A., Ovchinnikov, L. P., & Lyabin, D. N. (2012) · RNA Biology · doi:10.4161/rna.22711 · Cited by 12

In silico motif analysis suggests an interplay of transcriptional and translational control in mTOR response

Eliseeva, I. A., Vorontsov, I. E., Babeyev, K., Buyanova, S., Sysoeva, M., Kondrashov, F. A., & Kulakovskiy, I. V. (2013) · Translation · doi:10.4161/trla.27469 · Cited by 11

High p‐mTOR expression is associated with recurrence and shorter disease‐free survival in atypical meningiomas

Barresi, V., Lionti, S., Rocca, L. L., Caliri, S. L., & Caffo, M. (2018) · Neuropathology · doi:10.1111/neup.12524 · Cited by 11

TCTP protein degradation by targeting mTORC1 and signaling through S6K, Akt, and Plk1 sensitizes lung cancer cells to DNA-damaging drugs

Jeong, M., Jeong, M. H., Kim, J. E., Cho, S., Lee, K. J., Park, S. I., Sohn, J., & Park, Y. G. (2021) · Scientific Reports · doi:10.1038/s41598-021-00247-0 · Cited by 12

A phase II study of sapanisertib (TAK-228) a mTORC1/2 inhibitor in rapalog-resistant advanced pancreatic neuroendocrine tumors (PNET): ECOG-ACRIN EA2161

Rajdev, L. N., Lee, J., Libutti, S. K., Benson, A. B., Fisher, G. A., Kunz, P. L., Hendifar, A. E., Catalano, P. J., & O'Dwyer, P. J. (2022) · Investigational New Drugs · doi:10.1007/s10637-022-01311-w · Cited by 11

mRNA 5′ terminal sequences drive 200-fold differences in expression through effects on synthesis, translation and decay

van den Elzen, A. M. G., Watson, M. J., & Thoreen, C. C. (2022) · PLoS Genetics · doi:10.1371/journal.pgen.1010532 · Cited by 11

Chronic Mechanistic Target of Rapamycin Inhibition: Preventing Cancer to Delay Aging, or Vice Versa?

Sharp, Z. D., Curiel, T. J., & Livi, C. B. (2013) · Interdisciplinary topics in gerontology and geriatrics · doi:10.1159/000343625 · Cited by 11

Synthesis and Biological Evaluation of Novel 8-Morpholinoimidazo[1,2-a]pyrazine Derivatives Bearing Phenylpyridine/Phenylpyrimidine-Carboxamides

Xu, S., Sun, C., Chen, C., Zheng, P., Zhou, Y., Zhou, H., & Zhu, W. (2017) · Molecules · doi:10.3390/molecules22020310 · Cited by 11

Cross-talk between ribosome biogenesis, translation, and mTOR in CD133+ 4/CD44+ prostate cancer stem cells

Binal, Z., Açıkgöz, E., Kızılay, F., Öktem, G., & Altay, B. (2019) · Clinical & Translational Oncology · doi:10.1007/s12094-019-02229-1 · Cited by 11

LARP1 is a major phosphorylation substrate of mTORC1Preprint

Fonseca, B. D., Jia, J.-J., Hollensen, A. K., Pointet, R., Hoang, H., Niklaus, M., Pena, I. A., Lahr, R. M., Smith, E. M., Hearnden, J., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/491274 · Cited by 11

Enhanced translation expands the endo-lysosome size and promotes antigen presentation during phagocyte activationPreprint

Hipolito, V. E. B., Diaz, J. A., Tandoc, K. V., Oertlin, C., Ristau, J., Chauhan, N., Saric, A., Mclaughlan, S., Larsson, O. S., Topisirović, I., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/260257 · Cited by 11

Rapamycin-Induced Feedback Activation of eIF4E-EIF4A Dependent mRNA Translation in Pancreatic Cancer

Nguyen, T. U., Hector, H., Pederson, E. N., Lin, J., Ouyang, Z., Wendel, H., & Singh, K. (2023) · Cancers · doi:10.3390/cancers15051444 · Cited by 10

Crosstalk between the mTOR pathway and primary cilia in human diseases

Prosseda, P. P., Prosseda, S. D., Tran, M., Liton, P. B., & Sun, Y. (2023) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2023.09.004 · Cited by 11

Tenacissoside H repressed the progression of glioblastoma by inhibiting the PI3K/Akt/mTOR signaling pathway

Dong, J., Qian, Y., Zhang, W., Xu, J., Wang, L., Fan, Z., Jia, M., Wei, L., Yang, H., Luo, X., et al. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176401 · Cited by 10

Plasticity and Tumor Microenvironment in Pancreatic Cancer: Genetic, Metabolic, and Immune Perspectives

Hashimoto, A., & Hashimoto, S. (2024) · Cancers · doi:10.3390/cancers16234094 · Cited by 11

Muscle fiber Myc is dispensable for muscle growth and its forced expression severely perturbs homeostasis

Ham, D. J., Semeraro, M., Berger, B. M., McGowan, T. J., Lin, S., Maino, E., Oliveri, F., & Rüegg, M. A. (2025) · Nature Communications · doi:10.1038/s41467-025-58542-7 · Cited by 10

Cell Type‐Specific mTORC1 Signaling and Translational Control in Synaptic Plasticity and Memory

Huang, Z., Mahmood, N., Wiebe, S. A., Khoutorsky, A., Lacaille, J., & Sonenberg, N. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70281 · Cited by 10

Metabolic and transcriptional plasticity supports CD8+ T cell resilience and anti-tumor immunity under nutrient stress

Scaglione, M., Knight, M., Trihemasava, K., Rome, K., Archambault, A., Oh, J., Tanaka, E., Hall, E., Le, T. N. V., Lines, C. L., et al. (2026) · Immunity · doi:10.1016/j.immuni.2026.04.004 · Cited by 10

mTORC1 suppresses PIM3 expression via miR-33 encoded by the SREBP loci

Kelsey, I., Zbinden, M., Byles, V., Torrence, M. E., & Manning, B. D. (2017) · Scientific Reports · doi:10.1038/s41598-017-16398-y · Cited by 10

Regulation of eIF4E guides a unique translational program to control erythroid maturation

Forester, C. M., Osés-Prieto, J. A., Phillips, N. J., Miglani, S., Pang, X., Byeon, G. W., Demarco, R., Burlingame, A. L., Barna, M., & Ruggero, D. (2022) · Science Advances · doi:10.1126/sciadv.add3942 · Cited by 11

EIF3D promotes resistance to 5‐fluorouracil in colorectal cancer through upregulating RUVBL1

Li, C., Lu, K., Yang, C., Du, W., & Liang, Z.-K. (2023) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.24825 · Cited by 11

A novel small-molecule arylsulfonamide causes energetic stress and suppresses breast and lung tumor growth and metastasis

Dai, X., Kaluz, Š., Jiang, Y., Shi, L., Mckinley, D., Wang, Y., Wang, B., Meir, E. G. V., & Tan, C. (2017) · Oncotarget · doi:10.18632/oncotarget.22104 · Cited by 10

Chemoproteomic Profiling Uncovers CDK4-Mediated Phosphorylation of the Translational Suppressor 4E-BP1

Mitchell, D. C., Menon, A., & Garner, A. L. (2019) · Cell chemical biology · doi:10.1016/j.chembiol.2019.03.012 · Cited by 10

mTORC1-Rps15 Axis Contributes to the Mechanisms Underlying Global Translation Reduction During Senescence of Mouse Embryonic Fibroblasts

Wu, S., Xu, S., Li, R., Li, K., Zhong, X., Li, Y., Zhou, Z., Liu, Y., Feng, R., Zheng, J., et al. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00337 · Cited by 12

Targeted inhibition of mRNA translation initiation factors as a novel therapeutic strategy for mature B-cell neoplasms

Taylor, J., Yeomans, A., & Packham, G. (2020) · Exploration of Targeted Anti-tumor Therapy · doi:10.37349/etat.2020.00002 · Cited by 11

Cytotoxicity and changes in gene expression under aluminium potassium sulfate on Spodoptera frugiperda 9 cells

Feng, R., Chen, L., & Chen, K. (2021) · Ecotoxicology · doi:10.1007/s10646-021-02478-3 · Cited by 10

Transcriptional signature induced by a metastasis‐promoting c‐Src mutant in a human breast cell line

Broecker, F., Hardt, C., Herwig, R., Timmermann, B., Kerick, M., Wunderlich, A., Schweiger, M. R., Borsig, L., Heikenwalder, M., Lehrach, H., et al. (2016) · The FEBS Journal · doi:10.1111/febs.13694 · Cited by 9

Ribosome rescue factor PELOTA modulates translation start site choice for C/EBPα protein isoforms

Fernandez, S. G., Ferguson, L., & Ingolia, N. T. (2024) · Life Science Alliance · doi:10.26508/lsa.202302501 · Cited by 9

NRF2 signaling and amino acid metabolism in cancer

Ham, S., Choi, B.-H., & Kwak, M. (2024) · Free Radical Research · doi:10.1080/10715762.2024.2423690 · Cited by 9

Investigation into biased signaling, glycosylation, and drug vulnerability of acute myeloid leukemia

Pienkowski, T., Golonko, A., Bołkuń, Ł., Wawrzak-Pienkowska, K., Szczerbiński, Ł., Kretowski, A. J., Ciborowski, M., Lewandowski, W., Priebe, W., & Świsłocka, R. (2025) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2025.108848 · Cited by 9

Extensive Gene-Specific Translational Reprogramming in a Model of B Cell Differentiation and Abl-Dependent Transformation

Bates, J. G., Salzman, J., May, D., Garcia, P. B., Hogan, G. J., McIntosh, M. W., Schlissel, M. S., & Brown, P. O. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037108 · Cited by 9

Hepatitis C virus core protein targets 4E-BP1 expression and phosphorylation and potentiates Myc-induced liver carcinogenesis in transgenic mice

Abdallah, C., Lejamtel, C., Benzoubir, N., Battaglia, S., Sidahmed‐Adrar, N., Desterke, C., Lemasson, M., Rosenberg, A. R., Samuel, D., Bréchot, C., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.17280 · Cited by 9

Senescence-associated tumor growth is promoted by 12-Lipoxygenase

Patil, S. S., Reedy, J. L., Scroggins, B. T., White, A. O., Kwon, S., Shankavaram, U. T., López-Coral, A., Chung, E. J., & Citrin, D. E. (2022) · Aging · doi:10.18632/aging.203890 · Cited by 10

Orchestration of mesenchymal plasticity and immune evasiveness via rewiring of the metabolic program in pancreatic ductal adenocarcinoma

Hashimoto, A., Handa, H., Hata, S., & Hashimoto, S. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1005566 · Cited by 9

The dark side of mRNA translation and the translation machinery in glioblastoma

Montiel‐Dávalos, A., Ayala, Y., & Hernández, G. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1086964 · Cited by 9

Regulation of mRNA translation by estrogen receptor in breast cancer

Fard, S. S., & Holz, M. K. (2023) · Steroids · doi:10.1016/j.steroids.2023.109316 · Cited by 9

Selective Inhibition of mTORC1 Signaling Supports the Development and Maintenance of Pluripotency

Kim, J. K., Villa-Diaz, L. G., Saunders, T. L., Saul, R. P., Timilsina, S., Liu, F., Mishina, Y. M., & Krebsbach, P. H. (2023) · Stem Cells · doi:10.1093/stmcls/sxad079 · Cited by 10

Targeting protein synthesis pathways in MYC-amplified medulloblastoma

Kumar, D., Kanchan, R. K., & Chaturvedi, N. K. (2025) · Discover Oncology · doi:10.1007/s12672-025-01761-7 · Cited by 9

Automated High-Throughput RNAi Screening in Human Cells Combined with Reporter mRNA Transfection to Identify Novel Regulators of Translation

Casanova, C. M., Sehr, P. A., Putzker, K., Hentze, M. W., Neumann, B., Duncan, K. E., & Thoma, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045943 · Cited by 11

Pivotal role of augmented αB-crystallin in tumor development induced by deficient TSC1/2 complex

Wang, F., Chen, X.-T., Li, C., Sun, Q., Chen, Y., Wang, Y., Peng, H., LIU, Z.-L., Chen, R., Liu, K.-Y., et al. (2013) · Oncogene · doi:10.1038/onc.2013.401 · Cited by 9

Evolution of TOR and Translation Control

Fonseca, B. D., Graber, T. E., Hoang, H., González, A., Soukas, A. A., Hernández, G., Alain, T., Swift, S. L., Weisman, R., Meyer, C., et al. (2016) · Springer eBooks · doi:10.1007/978-3-319-39468-8_15 · Cited by 9

Crk II silencing down-regulates IGF-IR and inhibits migration and invasion of prostate cancer cells

Dhupkar, P. M., Zhao, H., Mujoo, K., An, Z., & Zhang, N. (2016) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2016.10.009 · Cited by 9

Inhibition of Human Class I vs Class III Phosphatidylinositol 3′-Kinases

Hassett, M. R., Sternberg, A. R., & Roepe, P. D. (2017) · Biochemistry · doi:10.1021/acs.biochem.7b00413 · Cited by 9

Scalable, Economical, and Practical Synthesis of 4-(Difluoromethyl)pyridin-2-amine, a Key Intermediate for Lipid Kinase Inhibitors

Rageot, D., Beaufils, F., Borsari, C., Dall’Asen, A., Neuburger, M. A., Hebeisen, P., & Wymann, M. P. (2019) · Organic Process Research & Development · doi:10.1021/acs.oprd.9b00312 · Cited by 9

eIF4G-driven translation initiation of downstream ORFs in mammalian cells

Nobuta, R., Machida, K., Sato, M., Hashimoto, S., Toriumi, Y., Nakajima, S., Suto, D., Imataka, H., & Inada, T. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa728 · Cited by 10

CUDC-101 enhances the chemosensitivity of gemcitabine-treated lymphoma cells

Li, H., Cui, R., Ji, M., & Jin, S. (2021) · Leukemia Research · doi:10.1016/j.leukres.2021.106575 · Cited by 9

High Expression of PAMR1 Predicts Favorable Prognosis and Inhibits Proliferation, Invasion, and Migration in Cervical Cancer

Yang, R., Ma, M., Yu, S., Li, X., Zhang, J., & Wu, S. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.742017 · Cited by 9

Pancreas-specific activation of mTOR and loss of p53 induce tumors reminiscent of acinar cell carcinoma

Kong, B., Cheng, T., Qian, C., Wu, W., Steiger, K., Cao, J., Schlitter, A. M., Regel, I., Raulefs, S., Friess, H., et al. (2015) · Molecular Cancer · doi:10.1186/s12943-015-0483-1 · Cited by 9

Polysome Profiling of a Human Glioblastoma Reveals Intratumoral Heterogeneity

Lupinacci, F. C. S., Kuasne, H., Roffé, M., Vassalakis, J. A., da Silva, F. F., Santos, T. G., de Andrade, V. P., Sanematsu, P., Martins, V. R., Rogatto, S. R., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092177 · Cited by 9

Mechanisms of Immune Evasion in PTEN Loss Prostate Cancer

Esteban-Villarrubia, J., Ballesteros, P. Á., Martín-Serrano, M., Vico, M. R., Funes, J. M., de Velasco, G., Castro, E., Olmos, D., Castellano, D., & González‐Billalabeitia, E. (2024) · Immuno · doi:10.3390/immuno4040028 · Cited by 8

HMGA2 and protein leucine methylation drive pancreatic cancer lineage plasticity

Dobersch, S., Yamamoto, N., Schutter, A., Cavender, S. M., Robertson, T. M., Kartha, N., Samraj, A. N., Doron, B., Poole, L. A., Wladyka, C. L., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60129-1 · Cited by 8

OASL enhances mRNA translation and reprograms lipid metabolism to promote cancer progression

Li, S.-B., Yuan, L., Zhu, Q., Zhang, G., Liu, Y.-T., Gao, M., Han, F., Lin, Z.-R., Zhang, H., Tang, L., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115901 · Cited by 8

Androgen receptor pathway signaling inhibitors in development for prostate cancer therapy

Bleve, S., Nuzzo, P. V., Arham, A. B., Holmes, A. N., & Tagawa, S. T. (2025) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2025.2573647 · Cited by 8

Anoikis resistance and cancer

Frisch, S. M., & Hu, G. (2025) · BMC Cancer · doi:10.1186/s12885-025-15178-6 · Cited by 8

Eukaryotic translation initiation factor 4F: functional properties and physiological role

Shuvalova, E., Sheikh, W. A., Shuvalov, A. V., Terenin, I. M., & Alkalaeva, E. Z. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkaf1351 · Cited by 8

Ribosome transfer via tunnelling nanotubes rescues protein synthesis in pancreatic cancer cells

Martínková, S., Jansová, D., Vorel, J., Lamačová, L. J., Daniel, P., Hudec, M., Boďo, M., Hajer, J., Šušor, A., & Trnka, J. (2026) · Cell Communication and Signaling · doi:10.1186/s12964-026-02763-w · Cited by 8

Upregulation of 5′-terminal oligopyrimidine mRNA translation upon loss of the ARF tumor suppressor

Cottrell, K. A., Chiou, R. C., & Weber, J. D. (2020) · Scientific Reports · doi:10.1038/s41598-020-79379-8 · Cited by 8

Treatment-related adverse events in patients with advanced breast cancer receiving adjuvant AKT inhibitors: a meta-analysis of randomized controlled trials

de Moraes, F. C. A., Sano, V. K. T., Pereira, C. R. M., de Laia, E. A., Stecca, C., Magalhães, M. C. F., & Burbano, R. M. R. (2024) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-024-03713-6 · Cited by 8

Structural Features of 5′ Untranslated Region in Translational Control of Eukaryotes

Razumova, E. A., Makariuk, A., Dontsova, O. А., Shepelev, N. M., & Rubtsova, M. P. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26051979 · Cited by 10

Evaluating the mTOR Pathway in Physiological and Pharmacological Settings

Hong, S., & Inoki, K. (2016) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2016.09.068 · Cited by 8

Genome-wide translational reprogramming of genes important for myocyte functions in overload-induced heart failure

Guo, Q., Zhang, Y., Zhang, S., Jin, J., Pang, S., Wu, X. B., Zhang, W., Bi, X., Zhang, Y., Zhang, Q., et al. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.165649 · Cited by 8

Metastasis-associated protein 1: A potential driver and regulator of the hallmarks of cancer

Vattem, C., & Pakala, S. B. (2022) · Journal of Biosciences · doi:10.1007/s12038-022-00263-w · Cited by 8

Suppression of mTOR Expression by siRNA Leads to Cell Cycle Arrest and Apoptosis Induction in MDA-MB-231 Breast Cancer Cells

Sahu, R., Jha, S., & Pattanayak, S. P. (2023) · Current Gene Therapy · doi:10.2174/1566523223666230329085606 · Cited by 8

Global gene expression of histologically normal primary skin cells from BCNS subjects reveals “single-hit” effects that are influenced by rapamycin

Phatak, A. R., Athar, M., Crowell, J. A., Leffel, D., Herbert, B., Bale, A. E., & Kopelovich, L. (2019) · Oncotarget · doi:10.18632/oncotarget.26640 · Cited by 8

Comprehensive Genome-Wide Approaches to Activity-Dependent Translational Control in Neurons

Choe, H. K., & Cho, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051592 · Cited by 11

Translational Controls in Pain

Loerch, S., de la Peña, J. B., Song, J. J., Pancrazio, J. J., Price, T. J., & Campbell, Z. T. (2019) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190686307.013.22 · Cited by 8

The MYC-Regulated RNA-Binding Proteins hnRNPC and LARP1 Are Drivers of Multiple Myeloma Cell Growth and Disease Progression and Negatively Predict Patient Survival

Seibert, M., Koschade, S. E., Stolp, V., Häupl, B., Wempe, F., Serve, H. L., Kurrle, N., Schnütgen, F., & von Metzler, I. (2023) · Cancers · doi:10.3390/cancers15235508 · Cited by 7

Nutrient-driven TOR signalling controls a chromatin-associated complex for orchestrating plant growth and stress tolerance

Wang, X., Liu, Z.-Z., Yuan, D., Lu, Y., Li, L., Chen, S., & He, X. (2025) · Nature Plants · doi:10.1038/s41477-025-02107-5 · Cited by 7

Harnessing viral strategies to reverse cognitive dysfunction through the integrated stress response

Reineke, L. C., Zhu, P., Dalwadi, U., Dooling, S. W., Liu, Y., Wang, I.-C., Young-Baird, S. K., Okoh, J. T., Kuncha, S. K., Zhou, H., et al. (2026) · Science · doi:10.1126/science.aea8782 · Cited by 7

Diverse Regulation of YB-1 and YB-3 Abundance in Mammals

Eliseeva, I. A., Sogorina, E. M., Smolin, E. A., Kulakovskiy, I. V., & Lyabin, D. N. (2022) · Biochemistry (Moscow) · doi:10.1134/s000629792214005x · Cited by 7

The LARP1 homolog Slr1p controls the stability and expression of proto-5′TOP mRNAs in fission yeast

Farnaz, M., Pircher, A., Bilodeau, D. Y., Siniavskaia, L., Grigull, J., Rissland, O. S., & Bayfield, M. A. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113226 · Cited by 7

Natural isoflavone glabridin targets PI3Kγ as an adjuvant to increase the sensitivity of MDA-MB-231 to tamoxifen and DU145 to paclitaxel

Lin, H., Ai, D., Liu, Q., Xl, W., Chen, Q., Hong, Z., Tao, Y., Gao, J., & Wang, L. (2023) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2023.106426 · Cited by 8

CRISPR loss of function screening to identify genes involved in human primordial germ cell-like cell development

Hwang, Y. S., Seita, Y., Blanco, M. A., & Sasaki, K. (2023) · PLoS Genetics · doi:10.1371/journal.pgen.1011080 · Cited by 7

Requirement for the eIF4E Binding Proteins for the Synergistic Down-Regulation of Protein Synthesis by Hypertonic Conditions and mTOR Inhibition

Clemens, M. J., Elia, A., & Morley, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071138 · Cited by 7

The mTOR Kinase Inhibitor INK128 Blunts Migration of Cultured Retinal Pigment Epithelial Cells

Calton, M. A., & Vollrath, D. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-17121-0_94 · Cited by 7

Androgen receptor activity inversely correlates with immune cell infiltration and immunotherapy response across multiple cancer lineagesPreprint

Hu, Y., Zhao, F., Graff, J. N., Chen, C., Zhao, X., THOMAS, G. V., Wu, H., Kardosh, A., Mills, G. B., Alumkal, J. J., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.08.593181 · Cited by 8

Intra-promoter switch of transcription initiation sites in proliferation signaling-dependent RNA metabolism

Wragg, J. W., White, P.-L., Hadzhiev, Y., Wanigasooriya, K., Stodolna, A., Tee, L. J., Barros-Silva, J. D., Beggs, A. D., & Müller, F. (2023) · Nature Structural & Molecular Biology · doi:10.1038/s41594-023-01156-8 · Cited by 6

GSK-3 kinase a putative therapeutic target in trypanosomatid parasites

Díaz, A. P., Canal, C. A. M., Valdés, A. J., Delgado, J. E. G., & Varela-M, R. E. (2024) · The Brazilian Journal of Infectious Diseases · doi:10.1016/j.bjid.2024.103736 · Cited by 6

Coordinated expression of retained introns and poison exons in renal cell carcinoma

Martínez, J. C., Zhou, M., Giri, G., Tsai, Y., Rowley, M. M., Goda, G. A., Aleman, M. M., Kim, W. Y., & Domínguez, D. J. G. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115985 · Cited by 6

Disruption of Autophagic Flux and Treatment with the PDPK1 Inhibitor GSK2334470 Synergistically Inhibit Renal Cell Carcinoma Pathogenesis

Zhou, W., Huang, J., Huang, C., Wang, G., & Tu, X. (2024) · Journal of Cancer · doi:10.7150/jca.92521 · Cited by 6

TORquing chromatin: the regulatory role of TOR kinase in chromatin function

Dong, Y., Aflaki, F., Mozgová, I., & Berr, A. (2024) · Journal of Experimental Botany · doi:10.1093/jxb/erae474 · Cited by 6

Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function

Sharp, S. Y., Martella, M., D’Agostino, S., Milton, C. I., Ward, G., Woodhead, A., Richardson, C. J., Carr, M. G., Chiarparin, E., Cons, B. D., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-54356-1 · Cited by 6

4EBP1/2 are active under standard cell culture conditions to regulate the translation of specific mRNAs

Alasad, K., Voeltzke, K., Levin, L., Reifenberger, G., Leprivier, G., & Rotblat, B. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03182-6 · Cited by 6

Capture, Release, and Identification of Newly Synthesized Proteins for Improved Profiling of Functional Translatomes

Phillips, N. J., Vinaithirthan, B., Osés-Prieto, J. A., Chalkley, R. J., & Burlingame, A. L. (2023) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2023.100497 · Cited by 7

Translation Rate Prediction and Regulatory Motif Discovery with Multi-task Learning

Zheng, W., Fong, J. H. C., Wan, Y. K., Chu, A. H. Y., Huang, Y., Wong, A. S. L., & Ho, J. W. K. (2023) · Lecture notes in computer science · doi:10.1007/978-3-031-29119-7_9 · Cited by 6

Dichloroacetic acid and rapamycin synergistically inhibit tumor progression

Chen, H., Liang, K., Hou, C., & Piao, H. (2023) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2200356 · Cited by 6

ADP-Ribosylation Factor 6 Pathway Acts as a Key Executor of Mesenchymal Tumor Plasticity

Hashimoto, A., & Hashimoto, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914934 · Cited by 6

ZNL0325, a Pyrazolopyrimidine-Based Covalent Probe, Demonstrates an Alternative Binding Mode for Kinases

Li, Z., Lu, W., Beyett, T. S., Ficarro, S. B., Jiang, J., Tse, J., Kim, A. Y., Marto, J. A., Che, J., Janne, P. A., et al. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c01891 · Cited by 6

Secondary Cancer after Androgen Deprivation Therapy in Prostate Cancer: A Nationwide Study

Kim, J. H., Bae, G. H., Jung, J., & Noh, T. I. (2024) · The World Journal of Men s Health · doi:10.5534/wjmh.230237 · Cited by 6

Investigating Myc-Dependent Translational Regulation in Normal and Cancer Cells

Cunningham, J. T., Pourdehnad, M., Stumpf, C. R., & Ruggero, D. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-429-6_13 · Cited by 6

Alternative Forms of Y-Box Binding Protein 1 and YB-1 mRNA

Lyabin, D. N., Doronin, A. N., Eliseeva, I. A., Guens, G. P., Kulakovskiy, I. V., & Ovchinnikov, L. P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104513 · Cited by 6

The endocrine and epigenetic impact of persistent cow milk consumption on prostate carcinogenesis

Melnik, B. C., John, S. M., Weiskirchen, R., & Schmitz, G. (2022) · Journal of Translational Genetics and Genomics · doi:10.20517/jtgg.2021.37 · Cited by 6

YB-1 Protein in Breast Cancer (Scientific and Personal Meetings with Professor Ovchinnikov)

Guens, G. P. (2022) · Biochemistry (Moscow) · doi:10.1134/s0006297922140073 · Cited by 6

Trans-splicing of mRNAs links gene transcription to translational control regulated by mTOR

Danks, G., Galbiati, H., Raasholm, M., Cleuren, Y. N. T., Valen, E., Navrátilová, P., & Thompson, E. M. (2019) · BMC Genomics · doi:10.1186/s12864-019-6277-x · Cited by 6

90th Anniversary Commentary: The mTORC1 Complex—A Central Player in the Control and Regulation of Amino Acid Sufficiency

Tomé, D. (2018) · Journal of Nutrition · doi:10.1093/jn/nxy172 · Cited by 6

Evaluating Oncogenic Drivers and Therapeutic Potential of the PI3K/AKT/mTOR Pathway in Hepatocellular Carcinoma: An Overview of Clinical Trials

Khorasani, A. B. S., Delshad, M., Sanaei, M., Pourbagheri‐Sigaroodi, A., Pirsalehi, A., & Bashash, D. (2025) · Biocell · doi:10.32604/biocell.2025.059970 · Cited by 5

Elevated Tumor-Associated Androgen Receptor Activity Correlates with Poor Immune Infiltration and Immunotherapy Response across Cancer Types

Hu, Y., Zhao, F., Graff, J. N., Chen, C., Zhang, Y., Stommel, J. M., Lee, J., Zangirolani, G. M., Rose, J., THOMAS, G. V., et al. (2025) · Cancer Research Communications · doi:10.1158/2767-9764.crc-25-0409 · Cited by 5

The director's cut

Gentilella, A., & Thomas, G. (2012) · Nature · doi:10.1038/485050a · Cited by 29

Profiling the translational targets of mTOR signalling

Burgess, D. J. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3216

Translation initiation: a critical signalling node in cancer

Robert, F., & Pelletier, J. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220903241625 · Cited by 48

P39. Rapamycin and the downstream target of mTOR, ribosomal protein L29 (RPL29), regulate prostate cancer cell growth and bone metastatic potential

Schwarting-Opdenaker, L., Carson, D. D., & Farach‐Carson, M. C. (2008) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2008.03.081

Abstract A49: Transcription factor upregulation after mTOR inhibition by Torin1 induces growth factor receptor expression

Yang, T. T., Negri, G. L., Kristensen, A. M., & Sorensen, P. H. B. (2017) · Cancer Research · doi:10.1158/1538-7445.transcontrol16-a49