The translational landscape of mTOR signalling steers cancer initiation and metastasis

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Integrative Genomic Profiling of Human Prostate Cancer

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mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

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Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

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Regulation of translation initiation by FRAP/mTOR

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The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

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SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity

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MicroRNA-10a binds the 5’UTR of ribosomal protein mRNAs and enhances their translation

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Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

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Role of mTORC1 in mechanically induced increases in translation and skeletal muscle mass

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Translational control of cell growth and malignancy by the CPEBs

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Tonic Signals: Why Do Lymphocytes Bother?

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The Fragile X Protein binds mRNAs involved in cancer progression and modulates metastasis formation

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mTOR-Mediated Regulation of Dendritic Cell Differentiation and Function

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Muscle-specific 4E-BP1 signaling activation improves metabolic parameters during aging and obesity

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N-terminal Proteomics and Ribosome Profiling Provide a Comprehensive View of the Alternative Translation Initiation Landscape in Mice and Men

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Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain

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Metabolic Control over mTOR-Dependent Diapause-like State

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Translation Initiation Factors: Reprogramming Protein Synthesis in Cancer

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Cap-Independent Translation: What’s in a Name?

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Translatome profiling: methods for genome-scale analysis of mRNA translation

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Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment

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The translational landscape of the splicing factor SRSF1 and its role in mitosis

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The Multifaceted Role of Nutrient Sensing and mTORC1 Signaling in Physiology and Aging

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Drugging the PI3K/AKT/mTOR Pathway in ER+ Breast Cancer

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In Search of Lost Small Peptides

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Tumor cell-intrinsic PD-L1 promotes tumor-initiating cell generation and functions in melanoma and ovarian cancer

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Autogenous Control of 5′TOP mRNA Stability by 40S Ribosomes

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Role of the Mammalian Target of Rapamycin Pathway in Liver Cancer: From Molecular Genetics to Targeted Therapies

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KIF2C: a novel link between Wnt/β-catenin and mTORC1 signaling in the pathogenesis of hepatocellular carcinoma

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Phosphorylation and Signal Transduction Pathways in Translational ControlPreprint

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SLFN11 inhibits hepatocellular carcinoma tumorigenesis and metastasis by targeting RPS4X via mTOR pathway

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Protein synthesis control in cancer: selectivity and therapeutic targeting

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PM2.5 promotes NSCLC carcinogenesis through translationally and transcriptionally activating DLAT-mediated glycolysis reprograming

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TET2 repression by androgen hormone regulates global hydroxymethylation status and prostate cancer progression

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Drosophila tsRNAs preferentially suppress general translation machinery via antisense pairing and participate in cellular starvation response

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The ribosome, (slow) beating heart of cancer (stem) cell

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The Transcription and Translation Landscapes during Human Cytomegalovirus Infection Reveal Novel Host-Pathogen Interactions

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La-related protein 1 (LARP1) repression of TOP mRNA translation is mediated through its cap-binding domain and controlled by an adjacent regulatory region

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Translational control of breast cancer plasticity

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Ribosome Profiling Reveals a Cell-Type-Specific Translational Landscape in Brain Tumors

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Diverse diseases from a ubiquitous process: The ribosomopathy paradox

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mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation

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METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer

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A liaison between mTOR signaling, ribosome biogenesis and cancer

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p53 induces transcriptional and translational programs to suppress cell proliferation and growth

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Extensive stage-regulation of translation revealed by ribosome profiling of Trypanosoma brucei

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Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR

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mTOR, cardiomyocytes and inflammation in cardiac hypertrophy

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The Lysosome at the Intersection of Cellular Growth and Destruction

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Oxygen and glucose deprivation induces widespread alterations in mRNA translation within 20 minutes

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AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation

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Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease

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Chemotherapeutic drugs: Cell death- and resistance-related signaling pathways. Are they really as smart as the tumor cells?

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Y-box binding protein 1 – A prognostic marker and target in tumour therapy

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Inducible Nitric Oxide Synthase Drives mTOR Pathway Activation and Proliferation of Human Melanoma by Reversible Nitrosylation of TSC2

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Efficacy of the investigational mTOR kinase inhibitor MLN0128/INK128 in models of B-cell acute lymphoblastic leukemia

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The Role and Mechanism of Epithelial-to-Mesenchymal Transition in Prostate Cancer Progression

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Milk—A Nutrient System of Mammalian Evolution Promoting mTORC1-Dependent Translation

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Comparative survey of the relative impact of mRNA features on local ribosome profiling read density

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Silencing c-Myc translation as a therapeutic strategy through targeting PI3Kδ and CK1ε in hematological malignancies

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Musashi2 sustains the mixed-lineage leukemia–driven stem cell regulatory program

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Baicalein ameliorates pristane-induced lupus nephritis via activating Nrf2/HO-1 in myeloid-derived suppressor cells

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Generally applicable transcriptome-wide analysis of translation using anota2seq

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eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma

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Growth control and ribosomopathies

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Cellular and molecular effects of the mTOR inhibitor everolimus

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The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation

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Baicalein inhibits prostate cancer cell growth and metastasis via the caveolin-1/AKT/mTOR pathway

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The ever-evolving role of mTOR in translation

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Next-generation analysis of gene expression regulation – comparing the roles of synthesis and degradation

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Advances in targeted therapy mainly based on signal pathways for nasopharyngeal carcinoma

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The mTORC1/mTORC2 inhibitor AZD2014 enhances the radiosensitivity of glioblastoma stem-like cells

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Targeting of mTOR catalytic site inhibits multiple steps of the HIV-1 lifecycle and suppresses HIV-1 viremia in humanized mice

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Regulatory discrimination of mRNAs by FMRP controls mouse adult neural stem cell differentiation

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mTORC1 and CK2 coordinate ternary and eIF4F complex assembly

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TAK ‐228 (formerly MLN 0128), an investigational oral dual TORC 1/2 inhibitor: A phase I dose escalation study in patients with relapsed or refractory multiple myeloma, non‐Hodgkin lymphoma, or Waldenström's macroglobulinemia

Ghobrial, I. M., Siegel, D. S. D., Vij, R., Berdeja, J. G., Richardson, P. G. G., Neuwirth, R. B., Patel, C. G., Zohren, F., & Wolf, J. L. (2016) · American Journal of Hematology · doi:10.1002/ajh.24300 · Cited by 100

Optimizing 5’UTRs for mRNA-delivered gene editing using deep learning

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MLN0128, an ATP-Competitive mTOR Kinase Inhibitor with Potent In Vitro and In Vivo Antitumor Activity, as Potential Therapy for Bone and Soft-Tissue Sarcoma

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Transcriptional regulation of the stress response by mTOR

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The splicing factor U2AF1 contributes to cancer progression through a noncanonical role in translation regulationPreprint

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mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1

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Molecular mechanisms of mTOR regulation by stress

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Subcellular mRNA Localization Regulates Ribosome Biogenesis in Migrating Cells

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Functional Translatome Proteomics Reveal Converging and Dose-Dependent Regulation by mTORC1 and eIF2α

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Post-Transcriptional Regulation of Homeostatic, Stressed, and Malignant Stem Cells

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The Logic and Design of Analog-Sensitive Kinases and Their Small Molecule Inhibitors

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