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Integrative Genomic Profiling of Human Prostate Cancer

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mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

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Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

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Regulation of translation initiation by FRAP/mTOR

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The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

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SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity

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MicroRNA-10a binds the 5’UTR of ribosomal protein mRNAs and enhances their translation

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Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

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New insights into 4E-BP1-regulated translation in cancer progression and metastasis

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Inhibition of protein translation as a novel mechanism for prostaglandin E 2 regulation of cell functions

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Detecting Förster resonance energy transfer in living cells by conventional and spectral flow cytometry

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Reanalysis of ribosome profiling datasets reveals a function of rocaglamide A in perturbing the dynamics of translation elongation via eIF4A

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Review: The PI3K-AKT-mTOR signal transduction pathway in canine cancer

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eIF4A1 enhances LARP1-mediated translational repression during mTORC1 inhibition

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A cellular basis for the mammalian nocturnal-diurnal switch

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Leucine Differentially Regulates Gene-Specific Translation in Mouse Skeletal Muscle

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Isolation and evaluation of phytoconstituents from red alga Acanthophora spicifera as potential apoptotic agents towards A549 and HeLa cancer cells lines

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Emerging Roles of Translational Control in Circadian Timekeeping

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Establishment and characterization of a docetaxel‑resistant human prostate cancer cell line

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Translation elongation factor 2 depletion by siRNA in mouse liver leads to mTOR-independent translational upregulation of ribosomal protein genes

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Targeting mTOR and eIF4E: a feasible scenario in ovarian cancer therapy

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Isoform-resolved mRNA profiling of ribosome load defines interplay of HIF and mTOR dysregulation in kidney cancer

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CD40L/IL-4–stimulated CLL demonstrates variation in translational regulation of DNA damage response genes including ATM

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Fabrication and evaluation of a γ-PGA-based self-assembly transferrin receptor-targeting anticancer drug carrier

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Mg 2+ influx mediated by TRPM7 triggers the initiation of muscle stem cell activation

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Cardiac aging: Molecular mechanisms and therapeutic interventions

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Palladin Is a Neuron-Specific Translational Target of mTOR Signaling That Regulates Axon Morphogenesis

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Dairy Products: Is There an Impact on Promotion of Prostate Cancer? A Review of the Literature

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A translational program that suppresses metabolism to shield the genome

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The Anti-Cancer Effects of a Zotarolimus and 5-Fluorouracil Combination Treatment on A549 Cell-Derived Tumors in BALB/c Nude Mice

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Involvement of mTOR Pathways in Recovery from Spinal Cord Injury by Modulation of Autophagy and Immune Response

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mRNA translation is a therapeutic vulnerability necessary for bladder epithelial transformation

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Revealing molecular pathways for cancer cell fitness through a genetic screen of the cancer translatome

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Therapeutic silencing of mTOR by systemically administered siRNA-loaded neutral liposomal nanoparticles inhibits DMBA-induced mammary carcinogenesis

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Study of breast cancer incidence in patients of lymphangioleiomyomatosis

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PUNCH-P for global translatome profiling

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Phosphorylated Mammalian Target of Rapamycin p-mTOR Is a Favorable Prognostic Factor than mTOR in Gastric Cancer

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Translation efficiency covariation identifies conserved coordination patterns across cell types

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Impact of immune suppressive agents on the BK-Polyomavirus non coding control region

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Over-expressed RHEB promotes the progression of pancreatic adenocarcinoma

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A Rapid Translational Immune Response Program in CD8 Memory T Lymphocytes

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NaP-TRAP reveals the regulatory grammar in 5’UTR-mediated translation regulation during zebrafish development

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Molecular portraits: the evolution of the concept of transcriptome-based cancer signatures

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Computational challenges, tools, and resources for analyzing co‐ and post‐transcriptional events in high throughput

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Rictor ablation in BMSCs inhibits bone metastasis of TM40D cells by attenuating osteolytic destruction and CAF formation

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mTOR-coordinated Post-Transcriptional Gene Regulations: from Fundamental to Pathogenic Insights

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Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity

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Hepatocellular carcinoma (HCC): the most promising therapeutic targets in the preclinical arena based on tumor biology characteristics

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Cancer Metabolism and Ischemia-Reperfusion Injury: Two Sides of the Same Coin

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Chloride intracellular channel 1 promotes esophageal squamous cell carcinoma proliferation via mTOR signalling

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Rab5a-mediated autophagy regulates the phenotype and behavior of vascular smooth muscle cells

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mTORC1 Inhibition Induces Resistance to Methotrexate and 6-Mercaptopurine in Ph+ and Ph-like B-ALL

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Oncogenic kinases and perturbations in protein synthesis machinery and energetics in neoplasia

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UFMylation regulates translational homeostasis and cell cycle progressionPreprint

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Mechanistic insights into cancer drug resistance through optogenetic PI3K signaling hyperactivation

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Assessments of prostate cancer cell functions highlight differences between a pan‐ PI 3 K /m TOR inhibitor, gedatolisib, and single‐node inhibitors of the PI 3 K / AKT /m TOR pathway

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eIF4A controls translation of estrogen receptor alpha and is a therapeutic target in advanced breast cancer

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Competitive but Not Allosteric mTOR Kinase Inhibition Enhances Tumor Cell Radiosensitivity

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Knockdown of Y-box-binding protein-1 inhibits the malignant progression of HT-29 colorectal adenocarcinoma cells by reversing epithelial-mesenchymal transition

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Controllability Analysis and Control Synthesis for the Ribosome Flow Model

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Enhanced efficacy of JAK1 inhibitor with mTORC1/C2 targeting in smoldering/chronic adult T cell leukemia

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Ponatinib, Lestaurtinib, and mTOR/PI3K Inhibitors Are Promising Repurposing Candidates against Entamoeba histolytica

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Ribosome profiling: a powerful tool in oncological research

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Gene expression measurements normalized to cell number reveal large scale differences due to cell size changes, transcriptional amplification and transcriptional repression in CHO cells

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mTORC1 alters the expression of glycolytic genes by regulating KPNA2 abundances

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Individualized analysis of differentially expressed miRNAs with application to the identification of miRNAs deregulated commonly in lung cancer tissues

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Shoelaces: an interactive tool for ribosome profiling processing and visualization

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A Functional Network Model of the Metastasis Suppressor PEBP1/RKIP and Its Regulators in Breast Cancer Cells

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Activation of the Akt-mTOR and MAPK pathways in dedifferentiated liposarcomas

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S-adenosylmethionine biosynthesis is a targetable metabolic vulnerability in multiple myeloma

Wang, Y., Muylaert, C., Wyns, A., Vlummens, P., Veirman, K. D., Vanderkerken, K., Zaal, E. A., Berkers, C. R., Moreaux, J., Bruyne, E. D., et al. (2023) · Haematologica · doi:10.3324/haematol.2023.282866 · Cited by 13

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

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Phase 1 Study to Evaluate the Effect of the Investigational Anticancer Agent Sapanisertib on the QTc Interval in Patients With Advanced Solid Tumors

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Targeting “undruggable” c-Myc protein by synthetic lethality

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Fragile X mental retardation protein in intrahepatic cholangiocarcinoma: regulating the cancer cell behavior plasticity at the leading edge

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Significant impact of mTORC1 and ATF4 pathways in CHO cell recombinant protein production induced by CDK4/6 inhibitor

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N-myc–Mediated Translation Control Is a Therapeutic Vulnerability in Medulloblastoma

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Ribosome changes reprogram translation for chemosurvival in G0 leukemic cells

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Molecular recognition of some novel mTOR kinase inhibitors to develop anticancer leads by drug-likeness, molecular docking and molecular dynamics based virtual screening strategy

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The Important Role of Protein Kinases in the p53 Sestrin Signaling Pathway

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Found in translation of mTOR signaling

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PIP5K1α inhibition as a therapeutic strategy for prostate cancer

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Selective regulation of YB-1 mRNA translation by the mTOR signaling pathway is not mediated by 4E-binding protein

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4EBP-Dependent Signaling Supports West Nile Virus Growth and Protein Expression

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mTOR Kinase Inhibition Effectively Decreases Progression of a Subset of Neuroendocrine Tumors that Progress on Rapalog Therapy and Delays Cardiac Impairment

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