The translational landscape of mTOR signalling steers cancer initiation and metastasis

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Integrative Genomic Profiling of Human Prostate Cancer

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mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

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Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

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Regulation of translation initiation by FRAP/mTOR

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The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

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SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity

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MicroRNA-10a binds the 5’UTR of ribosomal protein mRNAs and enhances their translation

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Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

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mTOR in health and in sickness

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HDAC Inhibitors for the Therapy of Triple Negative Breast Cancer

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Bursting translation on single mRNAs in live cells

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AKT inhibition overcomes rapamycin resistance by enhancing the repressive function of PRAS40 on mTORC1/4E-BP1 axis

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miR-221 regulates CD44 in hepatocellular carcinoma through the PI3K-AKT-mTOR pathway

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Development of a tissue-specific ribosome profiling approach in Drosophila enables genome-wide evaluation of translational adaptations

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HuD Is a Neural Translation Enhancer Acting on mTORC1-Responsive Genes and Counteracted by the Y3 Small Non-coding RNA

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Simple and inexpensive ribosome profiling analysis of mRNA translation

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Transcriptome-wide studies uncover the diversity of modes of mRNA recruitment to eukaryotic ribosomes

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Targeting mTOR for Anti-Aging and Anti-Cancer Therapy

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Signaling crosstalk between the mTOR complexes

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Pten Loss Induces Autocrine FGF Signaling to Promote Skin Tumorigenesis

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Loss of 4E-BP1 function induces EMT and promotes cancer cell migration and invasion via cap-dependent translational activation of snail

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Rac1 modulates the formation of primordial follicles by facilitating STAT3-directed Jagged1, GDF9 and BMP15 transcription in mice

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mTORC1-Mediated Inhibition of 4EBP1 Is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma

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ASC amino acid transporter 2, defined by enzyme‐mediated activation of radical sources, enhances malignancy of GD2‐positive small‐cell lung cancer

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eIF-Three to Tango: emerging functions of translation initiation factor eIF3 in protein synthesis and disease

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uORF-mediated translational control: recently elucidated mechanisms and implications in cancer

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Targeting HER2 Exon 20 Insertion–Mutant Lung Adenocarcinoma with a Novel Tyrosine Kinase Inhibitor Mobocertinib

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Mechanisms of resistance to mTOR inhibitors

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Epstein-Barr Virus-Encoded Latent Membrane Protein 2A Promotes the Epithelial-Mesenchymal Transition in Nasopharyngeal Carcinoma via Metastatic Tumor Antigen 1 and Mechanistic Target of Rapamycin Signaling Induction

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Effect of metformin on prostate cancer outcomes after radical prostatectomy

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Rapamycin-Resistant mTOR Activity Is Required for Sensory Axon Regeneration Induced by a Conditioning Lesion

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Codon usage optimization in pluripotent embryonic stem cells

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Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression

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PP242 suppresses cell proliferation, metastasis, and angiogenesis of gastric cancer through inhibition of the PI3K/AKT/mTOR pathway

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Precise let-7 expression levels balance organ regeneration against tumor suppression

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m‐ TOR inhibitors and their potential role in haematological malignancies

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Ribosome profiling and dynamic regulation of translation in mammals

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Extensive and coordinated control of allele-specific expression by both transcription and translation in Candida albicansPreprint

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Differential Requirement for Translation Initiation Factor Pathways during Ecdysone-Dependent Neuronal Remodeling in Drosophila

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Myc coordinates transcription and translation to enhance transformation and suppress invasiveness

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Parallel measurement of dynamic changes in translation rates in single cells

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Functional evaluation of synthetic flavonoids and chalcones for potential antiviral and anticancer properties

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Overriding TKI resistance of renal cell carcinoma by combination therapy with IL-6 receptor blockade

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Two distinct nodes of translational inhibition in the Integrated Stress Response

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Mammalian EAK-7 activates alternative mTOR signaling to regulate cell proliferation and migration

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Hyperactive mTOR and MNK1 phosphorylation of eIF4E confer tamoxifen resistance and estrogen independence through selective mRNA translation reprogrammingPreprint

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Circular RNA circMBOAT2 promotes prostate cancer progression via a miR-1271-5p/mTOR axis

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Targeting mTORC2/HDAC3 Inhibits Stemness of Liver Cancer Cells Against Glutamine Starvation

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Monitoring the 5′UTR landscape reveals isoform switches to drive translational efficiencies in cancer

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Multifaceted Regulation of Somatic Cell Reprogramming by mRNA Translational Control

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Targeting persistent androgen receptor signaling in castration-resistant prostate cancer

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Resveratrol directly targets DDX5 resulting in suppression of the mTORC1 pathway in prostate cancer

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Changes in global translation elongation or initiation rates shape the proteome via the Kozak sequence

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Cardamonin Inhibits Metastasis of Lewis Lung Carcinoma Cells by Decreasing mTOR Activity

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Translational Control during Cellular Senescence

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Macrophage ERα promoted invasion of endometrial cancer cell by mTOR/KIF5B‐mediated epithelial to mesenchymal transition

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mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism

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The ATP-Competitive mTOR Inhibitor INK128 Enhances In Vitro and In Vivo Radiosensitivity of Pancreatic Carcinoma Cells

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Codon optimality controls differential mRNA translation during amino acid starvation

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Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition

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Zinc enhances the cellular energy supply to improve cell motility and restore impaired energetic metabolism in a toxic environment induced by OTA

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Nutrient Sensing in Cancer

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Contemporary mTOR inhibitor scaffolds to diseases breakdown: A patent review (2015–2021)

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mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway

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Targeted therapy of cancer stem cells: inhibition of mTOR in pre-clinical and clinical research

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Translation regulation gets its ‘omics’ moment

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mTOR Complex 2 Stabilizes Mcl-1 Protein by Suppressing Its Glycogen Synthase Kinase 3-Dependent and SCF-FBXW7-Mediated Degradation

Koo, J., Yue, P., Deng, X., Khuri, F. R., & Sun, S. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.01525-14 · Cited by 53

Beyond control of protein translation: What we have learned about the non-canonical regulation and function of mammalian target of rapamycin (mTOR)

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Global Reprogramming of the Cellular Translational Landscape Facilitates Cytomegalovirus Replication

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Assembly of eIF3 Mediated by Mutually Dependent Subunit Insertion

Smith, M. D., de Tacca, L. A., Nitido, A. D., Montabana, E. A., Park, A., & Cate, J. H. D. (2016) · Structure · doi:10.1016/j.str.2016.02.024 · Cited by 54

The vimentin intermediate filament network restrains regulatory T cell suppression of graft-versus-host disease

McDonald-Hyman, C. S., Muller, J., Loschi, M. L., Thangavelu, G., Saha, A., Kumari, S., Reichenbach, D. K., Smith, M. J., Zhang, G., Koehn, B. H., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci95713 · Cited by 52

Dual-initiation promoters with intertwined canonical and TCT/TOP transcription start sites diversify transcript processing

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Genomic analysis of the molecular neuropathology of tuberous sclerosis using a human stem cell model

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Osteoclast proton pump regulator Atp6v1c1 enhances breast cancer growth by activating the mTORC1 pathway and bone metastasis by increasing V-ATPase activity

McConnell, M., Feng, S., Chen, W., Zhu, G., Shen, D., Ponnazhagan, S., Deng, L., & Li, Y. (2017) · Oncotarget · doi:10.18632/oncotarget.17544 · Cited by 53

Non-immunogenic, low-toxicity and effective glioma targeting MTI-31 liposomes

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Extensive Translational Regulation of Gene Expression in an Allopolyploid (Glycine dolichocarpa)

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Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3

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NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression

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Translation initiation in cancer at a glance

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Roles of RNA-binding proteins in immune diseases and cancer

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Mechanistic Target of Rapamycin Complex 1 (mTORC1) and mTORC2 as Key Signaling Intermediates in Mesenchymal Cell Activation

Walker, N., Belloli, E. A., Stuckey, L. J., Chan, K. M., Lin, J., Lynch, W. R., Chang, A. C., Mazzoni, S. M., Fingar, D. C., & Lama, V. N. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.672170 · Cited by 49

Phosphorylation of eIF4E serine 209 is associated with tumour progression and reduced survival in malignant melanoma

Carter, J. H., Deddens, J. A., Spaulding, N. R., Lucas, D., Colligan, B. M., Lewis, T. G., Hawkins, E., Jones, J., Pemberton, J. O., Douglass, L. E., et al. (2016) · British Journal of Cancer · doi:10.1038/bjc.2015.450 · Cited by 50

Loss of FOXP3 and TSC1 Accelerates Prostate Cancer Progression through Synergistic Transcriptional and Posttranslational Regulation of c-MYC

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Sarcopenia: Tilting the Balance of Protein Homeostasis

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RNA localization mechanisms transcend cell morphology

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mTORC1/C2 and pan-HDAC inhibitors synergistically impair breast cancer growth by convergent AKT and polysome inhibiting mechanisms

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Inflammatory Stress Increases Hepatic CD36 Translational Efficiency via Activation of the mTOR Signalling Pathway

Wang, C., Hu, L. T., Zhao, L., Yang, P., Moorhead, J. F., Varghese, Z., Chen, Y., & Ruan, X. Z. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103071 · Cited by 48

Maintaining Glycogen Synthase Kinase-3 Activity Is Critical for mTOR Kinase Inhibitors to Inhibit Cancer Cell Growth

Koo, J., Yue, P., Gal, A. A., Khuri, F. R., & Sun, S. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2946 · Cited by 49

Overexpressed-eIF3I interacted and activated oncogenic Akt1 is a theranostic target in human hepatocellular carcinoma

Wang, Y.-W., Lin, K., Chen, S., Gu, D.-L., Chen, C., Tu, P., & Jou, Y. (2013) · Hepatology · doi:10.1002/hep.26352 · Cited by 48

The fragile X mental retardation protein regulates tumor invasiveness-related pathways in melanoma cells

Zalfa, F., Panasiti, V., Carotti, S., Zingariello, M., Perrone, G., Sancillo, L., Pacini, L., Luciani, F., Roberti, V., D’Amico, S., et al. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.521 · Cited by 48

Therapeutic potency of mTOR signaling pharmacological inhibitors in the treatment of proinflammatory diseases, current status, and perspectives

Soltani, A., Bahreyni, A., Boroumand, N., Roshan, M. K., Khazaei, M., Ryzhikov, M., Soleimanpour, S., Avan, A., & Hassanian, S. M. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26276 · Cited by 50

Hypoxia-mediated translational activation of ITGB3 in breast cancer cells enhances TGF-β signaling and malignant features in vitro and in vivo

Sesé, M., Fuentes, P. J. B., Esteve‐Codina, A., Béjar, E., McGrail, K., Thomas, G., Aasen, T., & y Cajal, S. R. (2017) · Oncotarget · doi:10.18632/oncotarget.23145 · Cited by 48

MTOR inhibitor-based combination therapies for pancreatic cancer

Hassan, Z., Schneeweis, C., Wirth, M., Veltkamp, C., Dantes, Z., Feuerecker, B., Ceyhan, G. O., Knauer, S. K., Weichert, W., Schmid, R. M., et al. (2018) · British Journal of Cancer · doi:10.1038/bjc.2017.421 · Cited by 48

Scikit-ribo Enables Accurate Estimation and Robust Modeling of Translation Dynamics at Codon Resolution

Fang, H., Huang, Y.-F., Radhakrishnan, A., Siepel, A. C., Lyon, G. J., & Schatz, M. C. (2018) · Cell Systems · doi:10.1016/j.cels.2017.12.007 · Cited by 49

pysradb: A Python package to query next-generation sequencing metadata and data from NCBI Sequence Read Archive

Choudhary, S. (2019) · F1000Research · doi:10.12688/f1000research.18676.1 · Cited by 49

TTPAL promotes gastric tumorigenesis by directly targeting NNMT to activate PI3K/AKT signaling

Liu, W., Gou, H., Wang, X., Li, X., Hu, X., Su, H., Li, S., & Yu, J. Q. (2021) · Oncogene · doi:10.1038/s41388-021-01838-x · Cited by 47

The activation of mTOR signalling modulates DNA methylation by enhancing DNMT1 translation in hepatocellular carcinoma

Chen, M., Fang, Y., Liang, M., Zhang, N., Zhang, X., Xu, L., Ren, X., Zhang, Q., Zhou, Y., Peng, S., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04103-9 · Cited by 47

Microproteins in cancer: identification, biological functions, and clinical implications

Hofman, D. A., Prensner, J. R., & van Heesch, S. (2024) · Trends in Genetics · doi:10.1016/j.tig.2024.09.002 · Cited by 48

Phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin pathway inhibition

Zardavas, D., Fumagalli, D., & Loi, S. (2012) · Current Opinion in Oncology · doi:10.1097/cco.0b013e328358a2b5 · Cited by 47

Assessing the translational landscape of myogenic differentiation by ribosome profiling

de Klerk, E., Fokkema, I. F. A. C., Thiadens, K. A. M. H., Goeman, J. J., Palmblad, M., den Dunnen, J. T., Lindern, M. V., & Hoen, P. A. C. ’. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv281 · Cited by 47

Inhibition of pan-class I phosphatidyl-inositol-3-kinase by NVP-BKM120 effectively blocks proliferation and induces cell death in diffuse large B-cell lymphoma

Zang, C., Eucker, J., Liu, H., Coordes, A., Lenarz, M., Possinger, K., & Scholz, C. W. (2013) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2013.806800 · Cited by 48

Ribosomal stress activates eEF2K–eEF2 pathway causing translation elongation inhibition and recruitment of Terminal Oligopyrimidine (TOP) mRNAs on polysomes

Gismondi, A., Caldarola, S., Lisi, G., Juli, G., Chellini, L., Iadevaia, V., Proud, C. G., & Loreni, F. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku996 · Cited by 50

Genome-Wide Approaches to Dissect the Roles of RNA Binding Proteins in Translational Control: Implications for Neurological Diseases

Kapeli, K., & Yeo, G. W.-M. (2012) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00144 · Cited by 50

Polycystin‐1 and polycystin‐2 are involved in the acquisition of aggressive phenotypes in colorectal cancer

Gargalionis, A. N., Korkolopoulou, P. A., Farmaki, E., Piperi, C., Dalagiorgou, G., Adamopoulos, C., Levidou, G., Saetta, A. A., Fragkou, P., Tsioli, P., et al. (2014) · International Journal of Cancer · doi:10.1002/ijc.29140 · Cited by 48

The initiator methionine tRNA drives cell migration and invasion leading to increased metastatic potential in melanoma

Birch, J. L., Clarke, C. J., Campbell, A. D., Campbell, K. J., Mitchell, L. E., Liko, D., Kalna, G., Strathdee, D., Sansom, O. J., Neilson, M., et al. (2016) · Biology Open · doi:10.1242/bio.019075 · Cited by 47

PTEN deficiency leads to proteasome addiction: a novel vulnerability in glioblastoma

Benítez, J. A., Finlay, D., Castanza, A. S., Parisian, A. D., Ma, J., Longobardi, C., Campos, A. R., Vadla, R., Izurieta, A., Scerra, G., et al. (2021) · Neuro-Oncology · doi:10.1093/neuonc/noab001 · Cited by 47

Irradiated Riboflavin Diminishes the Aggressiveness of Melanoma In Vitro and In Vivo

Machado, D., Shishido, S. M., Queiroz, K. C. S., de Oliveira, D. N., Faria, A. L. C., Catharino, R. R., Spek, C. A., & Ferreira, C. V. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054269 · Cited by 47

Targeting Translation of mRNA as a Therapeutic Strategy in Cancer

Pal, I., Safari, M., Jovanovic, M., Bates, S. E., & Deng, C. (2019) · Current Hematologic Malignancy Reports · doi:10.1007/s11899-019-00530-y · Cited by 46

The director's cut

Gentilella, A., & Thomas, G. (2012) · Nature · doi:10.1038/485050a · Cited by 29

Profiling the translational targets of mTOR signalling

Burgess, D. J. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3216

Translation initiation: a critical signalling node in cancer

Robert, F., & Pelletier, J. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220903241625 · Cited by 48

P39. Rapamycin and the downstream target of mTOR, ribosomal protein L29 (RPL29), regulate prostate cancer cell growth and bone metastatic potential

Schwarting-Opdenaker, L., Carson, D. D., & Farach‐Carson, M. C. (2008) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2008.03.081

Abstract A49: Transcription factor upregulation after mTOR inhibition by Torin1 induces growth factor receptor expression

Yang, T. T., Negri, G. L., Kristensen, A. M., & Sorensen, P. H. B. (2017) · Cancer Research · doi:10.1158/1538-7445.transcontrol16-a49