The translational landscape of mTOR signalling steers cancer initiation and metastasis

Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling

Ingolia, N. T., Ghaemmaghami, S., Newman, J. R. S., & Weissman, J. S. (2009) · Science · doi:10.1126/science.1168978 · Cited by 3,853

Integrative Genomic Profiling of Human Prostate Cancer

Taylor, B. S., Schultz, N. D., Hieronymus, H., Gopalan, A., Xiao, Y., Carver, B. S., Arora, V. K., Kaushik, P., Cerami, E. G., Reva, B. A., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.05.026 · Cited by 3,713

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

Kim, D., Sarbassov, D. D., Ali, S. M., King, J. E., Latek, R. R., Erdjument‐Bromage, H., Tempst, P., & Sabatini, D. M. (2002) · Cell · doi:10.1016/s0092-8674(02)00808-5 · Cited by 3,051

Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

Sarbassov, D. D., Ali, S. M., Kim, D.-H., Guertin, D. A., Latek, R. R., Erdjument-Bromage, H., Tempst, P., & Sabatini, D. M. (2004) · Current Biology · doi:10.1016/j.cub.2004.06.054 · Cited by 2,665

Regulation of translation initiation by FRAP/mTOR

Gingras, A.-C., Raught, B., & Sonenberg, N. (2001) · Genes & Development · doi:10.1101/gad.887201 · Cited by 1,545

The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

Liu, C., Kelnar, K., Liu, B., Chen, X., Calhoun‐Davis, T., Li, H., Patrawala, L., Yan, H., Jeter, C. R., Honorio, S., et al. (2011) · Nature Medicine · doi:10.1038/nm.2284 · Cited by 1,410

SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity

Jacinto, E., Facchinetti, V., Liu, D., Soto, N., Wei, S., Jung, S. Y., Huang, Q., Qin, J., & Su, B. (2006) · Cell · doi:10.1016/j.cell.2006.08.033 · Cited by 1,407

MicroRNA-10a binds the 5’UTR of ribosomal protein mRNAs and enhances their translation

Ørom, U. A., Nielsen, F. C., & Lund, A. H. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.05.001 · Cited by 1,384

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

Feldman, M. E., Apsel, B., Uotila, A., Loewith, R., Knight, Z. A., Ruggero, D., & Shokat, K. M. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000038 · Cited by 1,111

Assessment of mTOR-Dependent Translational Regulation of Interferon Stimulated Genes

Livingstone, M., Sikström, K., Robert, P. A., Uzé, G., Larsson, O. S., & Pellegrini, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133482 · Cited by 28

The allosteric mechanism of mTOR activation can inform bitopic inhibitor optimization

Liu, Y., Zhang, M., Jang, H., & Nussinov, R. (2023) · Chemical Science · doi:10.1039/d3sc04690g · Cited by 25

eIF4E Is an Adverse Prognostic Marker of Melanoma Patient Survival by Increasing Melanoma Cell Invasion

Khosravi, S., Tam, K. J., Ardekani, G. S., Martinka, M., McElwee, K. J., & Ong, C. J. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.552 · Cited by 25

Examination of a second node of translational control in the unfolded protein response

Preston, A. M., & Hendershot, L. M. (2013) · Journal of Cell Science · doi:10.1242/jcs.130336 · Cited by 26

LIN28B alters ribosomal dynamics to promote metastasis in MYCN-driven malignancy

Missios, P., da Rocha, E. L., Pearson, D. S., Philipp, J., Aleman, M. M., Pirouz, M., Farache, D., Franses, J. W., Kubaczka, C., Tsanov, K. M., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci145142 · Cited by 24

Epstein-Barr Virus LMP1-Activated mTORC1 and mTORC2 Coordinately Promote Nasopharyngeal Cancer Stem Cell Properties

Zhu, N., Wang, Q. H., Wu, Z., Wang, Y., Zeng, M., & Yuan, Y. (2022) · Journal of Virology · doi:10.1128/jvi.01941-21 · Cited by 25

Master Transcription Factor Reprogramming Unleashes Selective Translation Promoting Castration Resistance and Immune Evasion in Lethal Prostate Cancer

Santasusagna, S., Zhu, S., Jawalagatti, V., Carceles-Cordon, M., Ertel, A., Garcia‐Longarte, S., Song, W., Fujiwara, N., Li, P., Mendizabal, I., et al. (2023) · Cancer Discovery · doi:10.1158/2159-8290.cd-23-0306 · Cited by 24

The ShcA adaptor activates AKT signaling to potentiate breast tumor angiogenesis by stimulating VEGF mRNA translation in a 4E-BP-dependent manner

Im, Y. K., Selva, R. L., Gandin, V., Ha, J. R., Sabourin, V., Sonenberg, N., Pawson, T. J., Topisirović, I., & Ursini‐Siegel, J. (2014) · Oncogene · doi:10.1038/onc.2014.110 · Cited by 24

Elevated expression of HSP90 and the antitumor effect of an HSP90 inhibitor via inactivation of the Akt/mTOR pathway in undifferentiated pleomorphic sarcoma

Bekki, H., Kohashi, K., Maekawa, A., Yamada, Y., Yamamoto, H., Harimaya, K., Hakozaki, M., Nabeshima, K., Iwamoto, Y., & Oda, Y. (2015) · BMC Cancer · doi:10.1186/s12885-015-1830-8 · Cited by 24

Multi-omics Comparative Analysis Reveals Multiple Layers of Host Signaling Pathway Regulation by the Gut Microbiota

Manes, N. P., Shulzhenko, N., Nuccio, A. G., Azeem, S., Morgun, A., & Nita‐Lazar, A. (2017) · mSystems · doi:10.1128/msystems.00107-17 · Cited by 24

HS2ST1‐dependent signaling pathways determine breast cancer cell viability, matrix interactions, and invasive behavior

Kumar, A. V., Brézillon, S., Untereiner, V., Sockalingum, G. D., Katakam, S. K., Mohamed, H. T., Kemper, B., Greve, B., Mohr, B., Ibrahim, S., et al. (2020) · Cancer Science · doi:10.1111/cas.14539 · Cited by 24

Targeted Inhibition of mTOR Signaling Improves Sensitivity of Esophageal Squamous Cell Carcinoma Cells to Cisplatin

Hou, G., Yang, S., Zhou, Y., Wang, C., Zhao, W. H., & Lu, Z. (2014) · Journal of Immunology Research · doi:10.1155/2014/845763 · Cited by 23

Tuberous sclerosis—A model for tumour growth

Dodd, K. M., & Dunlop, E. A. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.01.025 · Cited by 23

PTBP1 promotes hematopoietic stem cell maintenance and red blood cell development by ensuring sufficient availability of ribosomal constituents

Rehn, M., Wenzel, A., Frank, A.-K., Schuster, M. B., Pundhir, S., Jørgensen, N., Vitting‐Seerup, K., Ge, Y. C., Jendholm, J., Michaut, M., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110793 · Cited by 23

Decorin suppresses tumor lymphangiogenesis: A mechanism to curtail cancer progression

Mondal, D. K., Xie, C., Pascal, G. J., Buraschi, S., & Iozzo, R. V. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2317760121 · Cited by 23

Re-annotation of the Saccharopolyspora erythraea genome using a systems biology approach

Marcellin, E., Licona‐Cassani, C., Mercer, T. R., Palfreyman, R. W., & Nielsen, L. K. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-699 · Cited by 23

A novel Bcr-Abl–mTOR–eIF4A axis regulates IRES-mediated translation of LEF-1

Tsai, B. P., Jimenez, J., Lim, S., Fitzgerald, K. D., Zhang, M., Chuah, C. T. H., Axelrod, H. D., Nelson, L. J., Ong, S. T., Semler, B. L., et al. (2014) · Open Biology · doi:10.1098/rsob.140180 · Cited by 23

Emodin inhibits coxsackievirus B3 replication via multiple signalling cascades leading to suppression of translation

Zhang, H. M., Wang, F., Qiu, Y., Ye, X., Hanson, P., Shen, H., & Yang, D. (2015) · Biochemical Journal · doi:10.1042/bj20150419 · Cited by 23

eCF309 : a potent, selective and cell-permeable mTOR inhibitor

Fraser, C., Carragher, N. O., & Unciti‐Broceta, A. (2015) · MedChemComm · doi:10.1039/c5md00493d · Cited by 23

Quantitative Non-canonical Amino Acid Tagging (QuaNCAT) Proteomics Identifies Distinct Patterns of Protein Synthesis Rapidly Induced by Hypertrophic Agents in Cardiomyocytes, Revealing New Aspects of Metabolic Remodeling

Liu, R., Kenney, J. W., Manousopoulou, A., Johnston, H. E., Kamei, M., Woelk, C. H., Xie, J., Schwarzer, M., Garbis, S. D., & Proud, C. G. (2016) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m115.054312 · Cited by 23

p70S6K1 (S6K1)-mediated Phosphorylation Regulates Phosphatidylinositol 4-Phosphate 5-Kinase Type I γ Degradation and Cell Invasion

Jafari, N., Zheng, Q., Li, L., Li, W., Qi, L., Xiao, J., Gao, T., & Huang, C. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.742742 · Cited by 23

The TORC1/2 inhibitor TAK228 sensitizes atypical teratoid rhabdoid tumors to cisplatin-induced cytotoxicity

Rubens, J. A., Wang, S. Z., Price, A. C., Weingart, M., Allen, S. J., Orr, B. A., Eberhart, C. G., & Raabe, E. H. (2017) · Neuro-Oncology · doi:10.1093/neuonc/nox067 · Cited by 23

Unbalanced Growth, Senescence and Aging

Polymenis, M., & Kennedy, B. K. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-57127-0_8 · Cited by 23

RIVET: comprehensive graphic user interface for analysis and exploration of genome-wide translatomics data

Ernlund, A. W., Schneider, R. J., & Ruggles, K. V. (2018) · BMC Genomics · doi:10.1186/s12864-018-5166-z · Cited by 23

Optimization of ribosome profiling using low-input brain tissue from fragile X syndrome model mice

Liu, B., Molinaro, G., Shu, H., Stackpole, E. E., Huber, K. M., & Richter, J. D. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky1292 · Cited by 23

Identification of plicamycin, TG02, panobinostat, lestaurtinib, and GDC-0084 as promising compounds for the treatment of central nervous system infections caused by the free-living amebae Naegleria, Acanthamoeba and Balamuthia

Kangussu-Marcolino, M. M., Ehrenkaufer, G. M., Chen, E., Debnath, A., & Singh, U. (2019) · International Journal for Parasitology Drugs and Drug Resistance · doi:10.1016/j.ijpddr.2019.10.003 · Cited by 23

Cell Fate Control by Translation: mRNA Translation Initiation as a Therapeutic Target for Cancer Development and Stem Cell Fate Control

Kim, H. (2019) · Biomolecules · doi:10.3390/biom9110665 · Cited by 24

mTOR inhibitor INK128 promotes wound healing by regulating MDSCs

Li, Y. Z., Xu, Y., Liu, X., Yan, X., Lin, Y., Tan, Q., & Hou, Y. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02206-y · Cited by 23

Decoupling of mRNA and Protein Expression in Aging Brains Reveals the Age-Dependent Adaptation of Specific Gene Subsets

Khatir, I., Brunet, M. A., Meller, A., Amiot, F., Patel, T., Lapointe, X., Avila Lopez, J., Guilloy, N., Castonguay, A., Husain, M. A., et al. (2023) · Cells · doi:10.3390/cells12040615 · Cited by 22

The significance of lipid metabolism reprogramming of tumor-associated macrophages in hepatocellular carcinoma

Xie, Q.-J., Zeng, Y., Zhang, X., & Yu, F. (2024) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-024-03748-9 · Cited by 24

Mapping of mTOR drug targets: Featured platforms for anti-cancer drug discovery

Shams, R. S., Ito, Y., & Miyatake, H. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.108012 · Cited by 22

Y-box Binding Protein 1: Looking Back to the Future

Evdokimova, V. E. (2022) · Biochemistry (Moscow) · doi:10.1134/s0006297922140024 · Cited by 22

mRNA Translation Is Dynamically Regulated to Instruct Stem Cell Fate

Wang, R., & Amoyel, M. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.863885 · Cited by 23

Bioinformatics Identification of TUBB as Potential Prognostic Biomarker for Worse Prognosis in ERα-Positive and Better Prognosis in ERα-Negative Breast Cancer

Alhammad, R. (2022) · Diagnostics · doi:10.3390/diagnostics12092067 · Cited by 22

Dual contribution of the mTOR pathway and of the metabolism of amino acids in prostate cancer

Schcolnik‐Cabrera, A., & Juárez-López, D. (2022) · Cellular Oncology · doi:10.1007/s13402-022-00706-4 · Cited by 25

Cap-dependent translation initiation monitored in living cells

Gandin, V., English, B. P., Freeman, M., Leroux, L., Preibisch, S., Walpita, D., Jaramillo, M., & Singer, R. H. (2022) · Nature Communications · doi:10.1038/s41467-022-34052-8 · Cited by 24

MNK, mTOR or eIF4E-selecting the best anti-tumor target for blocking translation initiation

Li, S., Chen, J., Li, X., bai, X., & Shi, D. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115781 · Cited by 22

Discovery of regulatory motifs in 5′ untranslated regions using interpretable multi-task learning models

Zheng, W., Fong, J. H. C., Wan, Y. K., Chu, A. H. Y., Huang, Y., Wong, A. S. L., & Ho, J. W. K. (2023) · Cell Systems · doi:10.1016/j.cels.2023.10.011 · Cited by 22

Unveiling the Role of Mechanistic Target of Rapamycin Kinase (MTOR) Signaling in Cancer Progression and the Emergence of MTOR Inhibitors as Therapeutic Strategies

Mehta, D., Rajput, K., Jain, D., Bajaj, A., & Dasgupta, U. (2024) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.4c00530 · Cited by 25

Identification of a Non-Gatekeeper Hot Spot for Drug-Resistant Mutations in mTOR Kinase

Tzung-Ju, W., Wang, X., Zhang, Y., Meng, L., Kerrigan, J. E., Burley, S. K., & Zheng, X. F. S. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.03.040 · Cited by 22

Trilayer micelles for combination delivery of rapamycin and siRNA targeting Y-box binding protein-1 (siYB-1)

Zeng, S., & Xiong, M. P. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.05.010 · Cited by 22

Eukaryotic translation initiation factor 4E as a novel therapeutic target in hematological malignancies and beyond

Pettersson, F., Rincon, S. V. D., & Miller, W. H. (2014) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2014.937426 · Cited by 23

Translational control and autism-like behaviors

Gkogkas, C. G., & Sonenberg, N. (2013) · Cellular Logistics · doi:10.4161/cl.24551 · Cited by 22

Insights into the role and regulation of TCTP in skeletal muscle

Goodman, C. A., Coenen, A. M., Frey, J. W., You, J., Barker, R. G., Frankish, B. P., Murphy, R. M., & Hornberger, T. A. (2016) · Oncotarget · doi:10.18632/oncotarget.13009 · Cited by 22

Embigin Promotes Prostate Cancer Progression by S100A4-Dependent and-Independent Mechanisms

Ruma, I. M. W., Kinoshita, R., Tomonobu, N., Inoue, Y., Kondo, E., 山内, 明., Sato, H., Sumardika, I. W., Chen, Y., Yamamoto, K.-I., et al. (2018) · Cancers · doi:10.3390/cancers10070239 · Cited by 22

By reducing global mRNA translation in several ways, 2-deoxyglucose lowers MCL-1 protein and sensitizes hemopoietic tumor cells to BH3 mimetic ABT737

Tailler, M., Lindqvist, L., Gibson, L., & Adams, J. M. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0244-y · Cited by 22

MicroRNA-1911-3p targets mEAK-7 to suppress mTOR signaling in human lung cancer cells

Mendonça, D. B. S., Nguyen, J. T., Haidar, F., Fox, A. L., Ray, C., Amatullah, H., Liu, F., Kim, J. K., & Krebsbach, P. H. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e05734 · Cited by 22

Antiangiogenic Therapy Using Sunitinib Combined with Rapamycin Retards Tumor Growth But Promotes Metastasis

Yin, T., He, S., Ye, T., Shen, G., Wan, Y., & Wang, Y. (2014) · Translational Oncology · doi:10.1016/j.tranon.2014.02.007 · Cited by 23

GWIPS‐viz as a tool for exploring ribosome profiling evidence supporting the synthesis of alternative proteoforms

Michel, A. M., Ahern, A. M., Donohue, C. A., & Baranov, P. V. (2015) · PROTEOMICS · doi:10.1002/pmic.201400603 · Cited by 21

Randomized Phase II Trial of Sapanisertib ± TAK-117 vs. Everolimus in Patients With Advanced Renal Cell Carcinoma After VEGF-Targeted Therapy

Choueiri, T. K., Porta, C., Suárez, C., Hainsworth, J. D., Voog, É., Durán, I., Reeves, J. A., Czaykowski, P., Castellano, D., Chen, J., et al. (2022) · The Oncologist · doi:10.1093/oncolo/oyac192 · Cited by 21

Functional analogs of mammalian 4E-BPs reveal a role for TOR in global plant translation

Dong, Y., Srour, O., Lukhovitskaya, N. I., Makarian, J., Baumberger, N., Galzitskaya, O. V., Elser, D., Schepetilnikov, M. V., & Ryabova, L. A. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112892 · Cited by 23

Beyond the androgen receptor: New approaches to treating metastatic prostate cancer. Report of the 2013 Prouts Neck Prostate Cancer Meeting

Pienta, K. J., Walia, G., Simons, J. W., & Soule, H. R. (2013) · The Prostate · doi:10.1002/pros.22753 · Cited by 21

AKT signalling is required for ribosomal RNA synthesis and progression of E μ‐Myc B ‐cell lymphoma in vivo

Devlin, J. R., Hannan, K. M., Ng, P. Y., Bywater, M. J., Shortt, J., Cullinane, C. M., McArthur, G. A., Johnstone, R. W., Hannan, R. D., & Pearson, R. B. (2013) · FEBS Journal · doi:10.1111/febs.12135 · Cited by 21

mTORC1 regulates the efficiency and cellular capacity for protein synthesis

Proud, C. G. (2013) · Biochemical Society Transactions · doi:10.1042/bst20130036 · Cited by 24

Fas-associated protein with death domain (FADD) regulates autophagy through promoting the expression of Ras homolog enriched in brain (Rheb) in human breast adenocarcinoma cells

He, L., Ren, Y., Zheng, Q., Wang, L., Lai, Y., Guan, S., Zhang, X., Zhang, R., Wang, J., Chen, D., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8249 · Cited by 21

Synergistically suppressive effects on colorectal cancer cells by combination of mTOR inhibitor and glycolysis inhibitor, Oxamate.

Xing, B.-C., Wang, C., Ji, F., & Zhang, X. (2018) · Europe PMC (PubMed Central) · Cited by 20

Combining the Tyrosine Kinase Inhibitor Cabozantinib and the mTORC1/2 Inhibitor Sapanisertib Blocks ERK Pathway Activity and Suppresses Tumor Growth in Renal Cell Carcinoma

Wu, Y., Chen, S., Yang, X., Sato, K., Lal, P., Wang, Y., Shinkle, A. T., Wendl, M. C., Primeau, T. M., Zhao, Y., et al. (2023) · Cancer Research · doi:10.1158/0008-5472.can-23-0604 · Cited by 20

The nuclear import of ribosomal proteins is regulated by mTOR

Kazyken, D., Kaz, Y., Kiyan, V. S., Zhylkibayev, A. A., Chen, C.-H., Agarwal, N., & Sarbassov, D. D. (2014) · Oncotarget · doi:10.18632/oncotarget.2473 · Cited by 21

Metformin exposure and disseminated disease in patients with colorectal cancer

Spillane, S., Bennett, K., Sharp, L., & Barron, T. I. (2014) · Cancer Epidemiology · doi:10.1016/j.canep.2013.12.003 · Cited by 21

Eukaryotic Translation Initiation Factor 4E Is a Feed-Forward Translational Coactivator of Transforming Growth Factor β Early Protransforming Events in Breast Epithelial Cells

Decarlo, L., Mestel, C., Barcellos-Hoff, M.-H., & Schneider, R. J. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.00324-15 · Cited by 20

Effects of Neddylation and mTOR Inhibition in Acute Myelogenous Leukemia

Guo, N., Azadniv, M., Coppage, M. L., Nemer, M., Mendler, J. H., Becker, M. W., & Liesveld, J. L. (2019) · Translational Oncology · doi:10.1016/j.tranon.2019.01.001 · Cited by 20

The Secret Life of Translation Initiation in Prostate Cancer

Hernández, G., Ramírez, J. L., Pedroza‐Torres, A., Herrera, L. A., & Jiménez-Ríos, M. Á. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00014 · Cited by 22

Total synthesis of griseusins and elucidation of the griseusin mechanism of action

Zhang, Y., Ye, Q., Ponomareva, L. V., Cao, Y., Liu, Y., Cui, Z., Lanen, S. G. V., Voss, S. R., She, Q., & Thorson, J. S. (2019) · Chemical Science · doi:10.1039/c9sc02289a · Cited by 20

Cooperative Blockade of PKCα and JAK2 Drives Apoptosis in Glioblastoma

Wong, R. A., Luo, X., Lu, M., An, Z., Haas-Kogan, D. A., Phillips, J. J., Shokat, K. M., Weiss, W. A., & Fan, Q. W. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-2808 · Cited by 20

Genomic and pathological heterogeneity in clinically diagnosed small cell lung cancer in never/light smokers identifies therapeutically targetable alterations

Ogino, A., Choi, J., Lin, M., Wilkens, M. K., Calles, A., Xu, M., Adeni, A. E., Chambers, E. S., Capelletti, M., Butaney, M., et al. (2020) · Molecular Oncology · doi:10.1002/1878-0261.12673 · Cited by 20

A Novel Combination Approach Targeting an Enhanced Protein Synthesis Pathway in MYC-driven (Group 3) Medulloblastoma

Chaturvedi, N. K., Kling, M. J., Griggs, C. N., Kesherwani, V., Shukla, M., McIntyre, E. M., Ray, S., Liu, Y., McGuire, T. R., Sharp, J. G., et al. (2020) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-19-0996 · Cited by 20

Synergistic efficacy of inhibiting MYCN and mTOR signaling against neuroblastoma

Kling, M. J., Griggs, C. N., McIntyre, E. M., Alexander, G. R., Ray, S., Challagundla, K. B., Joshi, S. S., Coulter, D. W., & Chaturvedi, N. K. (2021) · BMC Cancer · doi:10.1186/s12885-021-08782-9 · Cited by 20

Modulation of the Translational Landscape During Herpesvirus Infection

Glaunsinger, B. A. (2015) · Annual Review of Virology · doi:10.1146/annurev-virology-100114-054839 · Cited by 25

Tuberous sclerosis complex is required for tumor maintenance in MYC‐driven Burkitt's lymphoma

Hartleben, G., Müller, C., Krämer, A., Schimmel, H., Zidek, L. M., Dornblut, C., Winkler, R., Eichwald, S., Kortman, G., Kosan, C., et al. (2018) · The EMBO Journal · doi:10.15252/embj.201798589 · Cited by 20

Increased translation driven by non-canonical EZH2 creates a synthetic vulnerability in enzalutamide-resistant prostate cancer

Chatterjee, S. S., Linares, J. F., Cid-Diaz, T., Durán, Á., Khan, M. I. K., Osrodek, M., Brady, N. J., Reina‐Campos, M., Marzio, A., Venkadakrishnan, V. B., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-53874-2 · Cited by 19

Identification of mTORC2 as a Necessary Component of HRG/ErbB2-Dependent Cellular Transformation

Lin, M.-C. J., Rojas, K. S., Cerione, R. A., & Wilson, K. F. (2014) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-13-0555 · Cited by 19

An unusual mode of baseline translation adjusts cellular protein synthesis capacity to metabolic needs

Schneider, C., Erhard, F., Binotti, B., Buchberger, A., Vogel, J., & Fischer, U. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111467 · Cited by 19

mTOR Signaling Pathway in Bone Diseases Associated with Hyperglycemia

Wang, S., Wang, J., Wang, S., Tao, R., Yi, J., Chen, M., & Zhao, Z. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119198 · Cited by 21

Upstream open reading frames: new players in the landscape of cancer gene regulation

Dasgupta, A., & Prensner, J. R. (2024) · NAR Cancer · doi:10.1093/narcan/zcae023 · Cited by 19

Combination Therapy Approach to Overcome the Resistance to PI3K Pathway Inhibitors in Gynecological Cancers

Ibanez, K. R., Huang, T., & Lee, J.-M. (2024) · Cells · doi:10.3390/cells13121064 · Cited by 19

Role of MTA1 in head and neck cancers

Marzook, H., Sankaran, D., Kumar, R., & Pillai, M. R. (2014) · Cancer and Metastasis Reviews · doi:10.1007/s10555-014-9521-5 · Cited by 19

Metabolic effects of milk protein intake strongly depend on pre-existing metabolic and exercise status

Melnik, B. C., Schmitz, G., John, S. M., Carrera‐Bastos, P., Lindeberg, S., & Cordain, L. (2013) · Nutrition & Metabolism · doi:10.1186/1743-7075-10-60 · Cited by 20

Does HIV-1 mRNA 5'-untranslated region bear an internal ribosome entry site?

Smirnova, V. V., Terenin, I. M., Khutornenko, A. A., Andreev, D. E., Dmitriev, S. E., & Shatsky, I. N. (2015) · Biochimie · doi:10.1016/j.biochi.2015.12.004 · Cited by 20

Unveiling New Chemical Scaffolds as Mnk Inhibitors

Diab, S., Li, P., Basnet, S. K. C., Lu, J., Yu, M., Albrecht, H., Milne, R. W., & Wang, S. (2016) · Future Medicinal Chemistry · doi:10.4155/fmc.15.190 · Cited by 19

Lymphangioleiomyomatosis Biomarkers Linked to Lung Metastatic Potential and Cell Stemness

Ponce, G. R. D. G., Herranz, C., Lope, A. L., Boni, J., Serra-Musach, J., Mateo, F., Aguilar, H., Gómez‐Baldó, L., Petit, A., Vidal, A., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132546 · Cited by 19

The novel mTORC1/2 dual inhibitor INK128 enhances radiosensitivity of breast cancer cell line MCF-7

Liu, Z.-G., Tang, J., Chen, Z., Zhang, H., Wang, H., Yang, J., & Zhang, H. (2016) · International Journal of Oncology · doi:10.3892/ijo.2016.3604 · Cited by 19

Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast cancer

Qian, J., Chen, Y., Meng, T., Ma, L., Meng, L., Wang, X., Yu, T., Zask, A., Shen, J., & Yu, K. (2016) · Oncotarget · doi:10.18632/oncotarget.11490 · Cited by 19

A Mercaptoacetamide‐Based Class II Histone Deacetylase Inhibitor Suppresses Cell Migration and Invasion in Monomorphic Malignant Human Glioma Cells by Inhibiting FAK/STAT3 Signaling

Nam, J. H., Cho, H., Kang, H., Lee, J., Jung, M., Chang, Y., Kim, K., & Hoe, H. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26133 · Cited by 19

Human liver stem cell-derived extracellular vesicles enhance cancer stem cell sensitivity to tyrosine kinase inhibitors through Akt/mTOR/PTEN combined modulation

Fonsato, V., Lena, M. D., Tritta, S., Brossa, A., Calvetti, R., Tetta, C., Camussi, G., & Bussolati, B. (2018) · Oncotarget · doi:10.18632/oncotarget.26319 · Cited by 19

Sapanisertib Plus Exemestane or Fulvestrant in Women with Hormone Receptor–Positive/HER2-Negative Advanced or Metastatic Breast Cancer

Lim, B., Potter, D. A., Salkeni, M. A., Silverman, P., Haddad, T. C., Forget, F., Awada, A. H., Canon, J.-L. R., Danso, M. A., Lortholary, A. H., et al. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-4131 · Cited by 19

mTOR Driven Gene Transcription Is Required for Cholesterol Production in Neurons of the Developing Cerebral Cortex

Schüle, M., Butto, T., Dewi, S., Schlichtholz, L., Strand, S., Gerber, S., Endres, K., Schweiger, S., & Winter, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22116034 · Cited by 19

Muscle-specific Cand2 is translationally upregulated by mTORC1 and promotes adverse cardiac remodeling

Gorska, A. A., Sandmann, C., Riechert, E., Hofmann, C., Malovrh, E., Varma, E., Kmietczyk, V., Ölschläger, J., Jürgensen, L., Kamuf‐Schenk, V., et al. (2021) · EMBO Reports · doi:10.15252/embr.202052170 · Cited by 19

Regulation of mRNA Translation by Hormone Receptors in Breast and Prostate Cancer

Xie, J., Kusnadi, E. P., Furic, L., & Selth, L. A. (2021) · Cancers · doi:10.3390/cancers13133254 · Cited by 18

Clinical Implications of mTOR Expression in Papillary Thyroid Cancer—A Systematic Review

Derwich-Rudowicz, A., Sykutera, M., Bromińska, B., Andrusiewicz, M., Ruchała, M., & Sawicka‐Gutaj, N. (2023) · Cancers · doi:10.3390/cancers15061665 · Cited by 18

The Effects of Deregulated Ribosomal Biogenesis in Cancer

Lu, Y., Wang, S., & Jiao, Y. (2023) · Biomolecules · doi:10.3390/biom13111593 · Cited by 19

Autophagy and cancer: taking the ‘toxic’ out of cytotoxics

Giuliani, C. M., & Dass, C. R. (2013) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12034 · Cited by 18

An investigation of nutrient-dependent mRNA translation in Drosophila larvae

Nagarajan, S., & Grewal, S. (2014) · Biology Open · doi:10.1242/bio.20149407 · Cited by 19

A new generation of mTORC1 inhibitor attenuates alcohol intake and reward in mice

Morisot, N., Novotny, C. J., Shokat, K. M., & Dorit Ron, A. (2017) · Addiction Biology · doi:10.1111/adb.12528 · Cited by 18

Two acute myeloid leukemia patient subsets are identified based on the constitutive PI3K-Akt-mTOR signaling of their leukemic cells; a functional, proteomic, and transcriptomic comparison

Nepstad, I., Hatfield, K. J., Aasebø, E., Hernandez-Valladares, M., Brenner, A. K., Bartaula-Brevik, S., Berven, F. S., Selheim, F., Skavland, J., Gjertsen, B. T., et al. (2018) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2018.1487401 · Cited by 18

Translation of Human β-Actin mRNA is Regulated by mTOR Pathway

Eliseeva, I. A., Vasilieva, M., & Ovchinnikov, L. P. (2019) · Genes · doi:10.3390/genes10020096 · Cited by 18

Novel AU-rich proximal UTR sequences (APS) enhance CXCL8 synthesis upon the induction of rpS6 phosphorylation

Ang, Z., Koean, R. A. G., Er, J. Z., Lee, L. T., Tam, J. K. C., Guo, H., & Ding, J. L. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1008077 · Cited by 20

Crosstalk between Stress Granules, Exosomes, Tumour Antigens, and Immune Cells: Significance for Cancer Immunity

Kothandan, V. K., Sangeetha, K., Kim, D. H., Byun, Y., Lee, Y.-K., Park, I., & Hwang, S. R. (2020) · Vaccines · doi:10.3390/vaccines8020172 · Cited by 19

Optimized rapamycin-loaded PEGylated PLGA nanoparticles: Preparation, characterization and pharmacokinetics study

Cheraga, N., Sun, N., Huang, X., Ye, Z., Xiao, Q., & Huang, N. (2020) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2020.102144 · Cited by 18

The mTORC1‐eIF4F axis controls paused pluripotency

Xu, X., Ahmed, T., Wang, L., Cao, X., Zhang, Z., Wang, M., Lv, Y., Kanwal, S., Tariq, M., Lin, R., et al. (2021) · EMBO Reports · doi:10.15252/embr.202153081 · Cited by 18

Heterogeneity and dynamic of EMT through the plasticity of ribosome and mRNA translation

Morin, C., Moyret‐Lalle, C., Mertani, H. C., Diaz, J., & Marcel, V. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188718 · Cited by 20

The director's cut

Gentilella, A., & Thomas, G. (2012) · Nature · doi:10.1038/485050a · Cited by 29

Profiling the translational targets of mTOR signalling

Burgess, D. J. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3216

Translation initiation: a critical signalling node in cancer

Robert, F., & Pelletier, J. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220903241625 · Cited by 48

P39. Rapamycin and the downstream target of mTOR, ribosomal protein L29 (RPL29), regulate prostate cancer cell growth and bone metastatic potential

Schwarting-Opdenaker, L., Carson, D. D., & Farach‐Carson, M. C. (2008) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2008.03.081

Abstract A49: Transcription factor upregulation after mTOR inhibition by Torin1 induces growth factor receptor expression

Yang, T. T., Negri, G. L., Kristensen, A. M., & Sorensen, P. H. B. (2017) · Cancer Research · doi:10.1158/1538-7445.transcontrol16-a49