The translational landscape of mTOR signalling steers cancer initiation and metastasis

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Integrative Genomic Profiling of Human Prostate Cancer

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mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

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Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

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Regulation of translation initiation by FRAP/mTOR

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The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

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SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity

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MicroRNA-10a binds the 5’UTR of ribosomal protein mRNAs and enhances their translation

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Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

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Heightening Energetic Stress Selectively Targets LKB1-Deficient Non–Small Cell Lung Cancers

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Estrogen receptor alpha controls gene expression via translational offsetting

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The role of metabolic ecosystem in cancer progression — metabolic plasticity and mTOR hyperactivity in tumor tissues

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Dual roles of mTORC1-dependent activation of the ubiquitin-proteasome system in muscle proteostasis

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Global and cell-type specific properties of lincRNAs with ribosome occupancy

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Eukaryotic Translation Initiation Factor 4 Gamma 1 (EIF4G1): a target for cancer therapeutic intervention?

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Translational Regulation of Cancer Metastasis

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Stress Granules Involved in Formation, Progression and Metastasis of Cancer: A Scoping Review

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Translational offsetting as a mode of estrogen receptor α‐dependent regulation of gene expression

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Links between the Oncoprotein YB-1 and Small Non-Coding RNAs in Breast Cancer

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hnRNP A1-mediated translational regulation of the G quadruplex-containing RON receptor tyrosine kinase mRNA linked to tumor progression

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TAK-228 (formerly MLN0128), an investigational dual TORC1/2 inhibitor plus paclitaxel, with/without trastuzumab, in patients with advanced solid malignancies

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Ribosome elongating footprints denoised by wavelet transform comprehensively characterize dynamic cellular translation events

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A Patient-derived Xenograft Model of Pancreatic Neuroendocrine Tumors Identifies Sapanisertib as a Possible New Treatment for Everolimus-resistant Tumors

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mTOR signaling and transcriptional regulation in T lymphocytes

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Connecting Metabolic Rewiring With Phenotype Switching in Melanoma

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A Dual-Target and Dual-Mechanism Design Strategy by Combining Inhibition and Degradation Together

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Preclinical trial of a new dual mTOR inhibitor, MLN0128, using renal cell carcinoma tumorgrafts

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RPL24: a potential therapeutic target whose depletion or acetylation inhibits polysome assembly and cancer cell growth

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Association of Aminoacyl-tRNA Synthetases with Cancer

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Real-time 2-5A kinetics suggest that interferons β and λ evade global arrest of translation by RNase L

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Survey of the translation shifts in hepatocellular carcinoma with ribosome profiling

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Distinct roles of LARP1 and 4EBP1/2 in regulating translation and stability of 5′TOP mRNAs

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eIF4EBP3L Acts as a Gatekeeper of TORC1 In Activity-Dependent Muscle Growth by Specifically Regulating Mef2ca Translational Initiation

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mTORC1 and -2 Coordinate Transcriptional and Translational Reprogramming in Resistance to DNA Damage and Replicative Stress in Breast Cancer Cells

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Computational resources for ribosome profiling: from database to Web server and software

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Dysregulation of cotranscriptional alternative splicing underlies CHARGE syndrome

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In vivo screening identifies GATAD2B as a metastasis driver in KRAS-driven lung cancer

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TRIBE editing reveals specific mRNA targets of eIF4E-BP in Drosophila and in mammals

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Emerging Roles for Mammalian Target of Rapamycin (mTOR) Complexes in Bladder Cancer Progression and Therapy

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The DHX33 RNA Helicase Promotes mRNA Translation Initiation

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Trespassing cancer cells: ‘fingerprinting’ invasive protrusions reveals metastatic culprits

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Resistance to mTOR Kinase Inhibitors in Lymphoma Cells Lacking 4EBP1

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Cell type–specific abundance of 4EBP1 primes prostate cancer sensitivity or resistance to PI3K pathway inhibitors

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Active Tonic mTORC1 Signals Shape Baseline Translation in Naive T Cells

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c-MYC regulates mRNA translation efficiency and start-site selection in lymphoma

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eIF4A inhibition circumvents uncontrolled DNA replication mediated by 4E-BP1 loss in pancreatic cancer

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The mTOR regulated RNA-binding protein LARP1 requires PABPC1 for guided mRNA interaction

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Lifetime Impact of Cow’s Milk on Overactivation of mTORC1: From Fetal to Childhood Overgrowth, Acne, Diabetes, Cancers, and Neurodegeneration

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Emerging therapies for autosomal dominant polycystic kidney disease with a focus on cAMP signaling

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Growth-factor dependent expression of the translationally controlled tumour protein TCTP is regulated through the PI3-K/Akt/mTORC1 signalling pathway

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A Transcriptome-proteome Integrated Network Identifies Endoplasmic Reticulum thiol oxidoreductase (ERp57) as a Hub that Mediates Bone Metastasis

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Dual mTOR inhibitor MLN0128 suppresses Merkel cell carcinoma (MCC) xenograft tumor growth

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Inhibition of mTOR kinase as a therapeutic target for acute myeloid leukemia

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Eukaryotic elongation factor 2 kinase upregulates the expression of proteins implicated in cell migration and cancer cell metastasis

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Filling the Gap after CDK4/6 Inhibitors: Novel Endocrine and Biologic Treatment Options for Metastatic Hormone Receptor Positive Breast Cancer

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The Role of Activation of PI3K/AKT/mTOR and RAF/MEK/ERK Pathways in Aggressive Pituitary Adenomas—New Potential Therapeutic Approach—A Systematic Review

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Improved transcription and translation with L-leucine stimulation of mTORC1 in Roberts syndrome

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Systematic genomic and translational efficiency studies of uveal melanoma

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Cooperation and competition by RNA-binding proteins in cancer

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The role of LARP1 in translation and beyond

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Non-coding RNA mediated regulation of PI3K/Akt pathway in hepatocellular carcinoma: Therapeutic perspectives

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Control of the translational machinery by amino acids

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Metformin: An Inhibitor of mTORC1 Signaling

Melnik, B. C., & Schmitz, G. (2014) · Cited by 39

Migration and epithelial-to-mesenchymal transition of lung cancer can be targeted via translation initiation factors eIF4E and eIF4GI

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Nutrient Control of mRNA Translation

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The role of eIF4F-driven mRNA translation in regulating the tumour microenvironment

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Loss of fatty acid synthase suppresses the malignant phenotype of colorectal cancer cells by down-regulating energy metabolism and mTOR signaling pathway

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MYC the oncogene from hell: Novel opportunities for cancer therapy

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Isoform-level ribosome occupancy estimation guided by transcript abundance with Ribomap

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Requirement of Mammalian Target of Rapamycin Complex 1 Downstream Effectors in Cued Fear Memory Reconsolidation and Its Persistence

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Combined therapy with RAD001 e BEZ235 overcomes resistance of PET immortalized cell lines to mTOR inhibition

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The novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression

Harada, M., Benito, J., Yamamoto, S., Kaur, S., Arslan, D., Ramírez, S., Jacamo, R. O., Platanias, L. C., Matsushita, H., Fujimura, T., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.6122 · Cited by 38

A Legume TOR Protein Kinase Regulates Rhizobium Symbiosis and Is Essential for Infection and Nodule Development

Nanjareddy, K., Blanco, L., Arthikala, M., Alvarado-Affantranger, X., Quinto, C., Sánchez, F., & Lara, M. (2016) · PLANT PHYSIOLOGY · doi:10.1104/pp.16.00844 · Cited by 38

Central role of mTORC1 downstream of YAP/TAZ in hepatoblastoma development

Pin, L., Calvisi, D. F., Kiss, A., Cigliano, A., Schaff, Z., Che, L., Ribback, S., Dombrowski, F., Zhao, D., & Chen, X. (2017) · Oncotarget · doi:10.18632/oncotarget.20622 · Cited by 39

Methods for monitoring and measurement of protein translation in time and space

Dermit, M., Dodel, M., & Mardakheh, F. K. (2017) · Molecular BioSystems · doi:10.1039/c7mb00476a · Cited by 44

The role of mTOR-mediated signaling in the regulation of cellular migration

Holroyd, A. K., & Michie, A. M. (2018) · Immunology Letters · doi:10.1016/j.imlet.2018.01.015 · Cited by 40

A Ribonucleoprotein Complex Protects the Interleukin-6 mRNA from Degradation by Distinct Herpesviral Endonucleases

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A reconstituted cell-free assay for the evaluation of the intrinsic activity of purified human ribosomes

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Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1

Wang, J., Ye, Q., Cao, Y., Guo, Y., Huang, X., Mi, W., Liu, S., Wang, C., Yang, H., Zhou, B. P., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-02243-3 · Cited by 38

CD44 positive and sorafenib insensitive hepatocellular carcinomas respond to the ATP-competitive mTOR inhibitor INK128

Badawi, M. A., Kim, J., Dauki, A. M., Sutaria, D. S., Motiwala, T., Reyes, R., Wani, N. A., Kolli, S., Jiang, J., Coss, C. C., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.25430 · Cited by 38

New Emerging Targets in Cancer Immunotherapy: The Role of B7-H3

Koumprentziotis, I., Theocharopoulos, C., Foteinou, D., Angeli, E., Anastasopoulou, A. N., Gogas, H. J., & Ziogas, D. C. (2024) · Vaccines · doi:10.3390/vaccines12010054 · Cited by 38

mTOR inactivation by ROS-JNK-p53 pathway plays an essential role in Psedolaric acid B induced autophagy-dependent senescence in murine fibrosarcoma L929 cells

Qi, M., Zhou, H., Fan, S., Li, Z., Yao, G., Tashiro, S., Onodera, S., Xia, M., & Ikejima, T. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.05.051 · Cited by 38

Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition

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Molecular mechanisms controlling protein synthesis in memory reconsolidation

Roesler, R. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.04.015 · Cited by 37

An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis

Smith, H. W., Hirukawa, A., Sanguin‐Gendreau, V., Nandi, I., Dufour, C. R., Zuo, D., Tandoc, K. V., Leibovitch, M., Singh, S., Rennhack, J. P., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10681-4 · Cited by 37

Control of Translation at the Initiation Phase During Glucose Starvation in Yeast

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PI3K/AKT/p53 pathway inhibits infectious spleen and kidney necrosis virus infection by regulating autophagy and immune responses

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Non-canonical mRNA translation initiation in cell stress and cancer

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Accumulation of Polyribosomes in Dendritic Spine Heads, But Not Bases and Necks, during Memory Consolidation Depends on Cap-Dependent Translation Initiation

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A Systems Biology Roadmap to Decode mTOR Control System in Cancer

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mTORC1 signalling is not essential for the maintenance of muscle mass and function in adult sedentary mice

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How can we turn the PI3K/AKT/mTOR pathway down? Insights into inhibition and treatment of cancer

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Oncogenic SNORD12B activates the AKT-mTOR-4EBP1 signaling in esophageal squamous cell carcinoma via nucleus partitioning of PP-1α

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mTORC1 controls Golgi architecture and vesicle secretion by phosphorylation of SCYL1

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eIF4E-independent translation is largely eIF3d-dependent

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Concurrent inhibition of PI3-Kinase and mTOR induces cell death in diffuse large B cell lymphomas, a mechanism involving down regulation of Mcl-1

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Prostate cancer invasion and metastasis: insights from mining genomic data

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Targeted profiling of RNA translation reveals mTOR-4EBP1/2-independent translation regulation of mRNAs encoding ribosomal proteins

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The mTORC1/4E-BP/eIF4E Axis Promotes Antibody Class Switching in B Lymphocytes

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Catabolic degradation of endothelial VEGFA via autophagy

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In Vitro and in Vivo Activity of mTOR Kinase and PI3K Inhibitors Against Leishmania donovani and Trypanosoma brucei

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Synthetic lethality by targeting the RUVBL1/2-TTT complex in mTORC1-hyperactive cancer cells

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eIF4E-binding proteins: new factors, new locations, new roles

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Differential Regulation of the Melanoma Proteome by eIF4A1 and eIF4E

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Suppression of ABCE1-Mediated mRNA Translation Limits N-MYC–Driven Cancer Progression

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SPIDR enables multiplexed mapping of RNA-protein interactions and uncovers a mechanism for selective translational suppression upon cell stress

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Many roads from mTOR to eIF4F

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The director's cut

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Profiling the translational targets of mTOR signalling

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Translation initiation: a critical signalling node in cancer

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P39. Rapamycin and the downstream target of mTOR, ribosomal protein L29 (RPL29), regulate prostate cancer cell growth and bone metastatic potential

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Abstract A49: Transcription factor upregulation after mTOR inhibition by Torin1 induces growth factor receptor expression

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