Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

Oka, Takafumi, Hikoso, Shungo, Yamaguchi, Osamu, Taneike, Manabu, Takeda, Toshihiro, Tamai, Takahito, Oyabu, Jota, Murakawa, Tomokazu, Nakayama, Hiroyuki, Nishida, Kazuhiko, Akira, Shizuo, Yamamoto, Akitsugu, Komuro, Issei, Otsu, Kinya·2012·Nature

DOI 10.1038/nature10992

Cited by (997)

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Barrera, María-José, Aguilera, Sergio, Castro, Isabel, Carvajal, Patricia, Jara, Daniela, Molina, Claudio, González, Sergio, González, María-Julieta · 2021 · Autoimmunity Reviews
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Lian Lam, Sophia Murphy, Dimitra Kokkinaki, Alessandro Venosa, Scott A. Sherrill-Mix, Carla Casu, Stefano Rivella, Aaron I. Weiner, Jeongho Park, Sunny Shin et al. · 2021 · Science Translational Medicine
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Theodoros Eleftheriadis, Georgios Pissas, Vassilios Liakopoulos, Ioannis Stefanidis · 2016 · Frontiers in Immunology
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Zufeng Ding, Shijie Liu, Xianwei Wang, Magomed Khaidakov, Yao Dai, Jawahar L. Mehta · 2013 · Scientific Reports
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Angel López‐Candales, Paula M. Hernández Burgos, Dagmar F. Hernández-Suárez, David A. Harris · 2017 · PubMed
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Dare, Anna J., Bolton, Eleanor A., Pettigrew, Gavin J., Bradley, J. Andrew, Saeb-Parsy, Kourosh, Murphy, Michael P. · 2015 · Redox Biology
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Nikolaos Georgios Frangogiannis · 2015 · Current Opinion in Cardiology
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Xiaojing Liu, Zhihong Chen · 2017 · Journal of Translational Medicine
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Jiali Nie, Ling Zhou, Weiwei Tian, Xiansheng Liu, Liping Yang, Xingcheng Yang, Yicheng Zhang, Shuang Wei, Dao Wen Wang, Jia Wei · 2025 · Signal Transduction and Targeted Therapy
Beneficial effects of exercise on age‐related mitochondrial dysfunction and oxidative stress in skeletal muscle
Joseph, Anna‐Maria, Adhihetty, Peter J., Leeuwenburgh, Christiaan · 2016 · The Journal of Physiology
T cell costimulation blockade blunts pressure overload-induced heart failure
Marinos Kallikourdis, Elisa Martini, Pierluigi Carullo, Claudia Sardi, Giuliana Roselli, Carolina M. Greco, Debora Vignali, Federica Riva, Anne Marie Ormbostad Berre, Tomas Stølen et al. · 2017 · Nature Communications
Mitochondrial dysfunction as a trigger of innate immune responses and inflammation
Andrew Phillip West · 2017 · Toxicology
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Anna Picca, Riccardo Calvani, Hélio José Coelho‐Júnior, Emanuele Marzetti · 2021 · Cells
Mitochondria as Cellular and Organismal Signaling Hubs
Koning Shen, Corinne L. Pender, Raz Bar‐Ziv, Hanlin Zhang, Kevin Wickham, Elizabeth Willey, Jenni Durieux, Qazi Ahmad, Andrew G. Dillin · 2022 · Annual Review of Cell and Developmental Biology
The Autophagy Lysosomal Pathway and Neurodegeneration
Finkbeiner, Steven · 2020 · Cold Spring Harbor Perspectives in Biology
Innate Immunity and Neuroinflammation
Abhishek Shastri, Domenico Marco Bonifati, Uday Kishore · 2013 · Mediators of Inflammation
Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: from mechanisms to therapeutics
Emanuele Marzetti, Anna Csiszár, Debapriya Dutta, Gauthami Balagopal, Riccardo Calvani, Christiaan Leeuwenburgh · 2013 · American Journal of Physiology-Heart and Circulatory Physiology
New signal transduction paradigms in anthracycline-induced cardiotoxicity
Alessandra Ghigo, Mingchuan Li, Emilio Hirsch · 2016 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Mitochondria-Striking a balance between host and endosymbiont
Youle, Richard J. · 2019 · Science
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Paul T. Schumacker, Mark N. Gillespie, Kiichi Nakahira, Augustine M.K. Choi, Elliott D. Crouser, Claude A. Piantadosi, Jahar Bhattacharya · 2014 · American Journal of Physiology-Lung Cellular and Molecular Physiology
Circulating mitochondrial DNA and Toll-like receptor 9 are associated with vascular dysfunction in spontaneously hypertensive rats
Cameron G. McCarthy, Camilla Ferreira Wenceslau, Styliani Goulopoulou, Safia N. Ogbi, Babak Baban, Jennifer C. Sullivan, Takayuki Matsumoto, Robert Clinton Webb · 2015 · Cardiovascular Research
Mitochondria: hub of injury responses in the developing brain
Henrik Hagberg, Carina E. Mallard, Catherine I. Rousset, Claire Thornton · 2014 · The Lancet Neurology
Mitophagy Is Required for Acute Cardioprotection by Simvastatin
Allen M. Andres, Genaro Hernandez, Pamela Lee, Chengqun Huang, Eric P. Ratliff, Jon Sin, Christine A Thornton, Marichris V. Damasco, Roberta A. Gottlieb · 2013 · Antioxidants and Redox Signaling
TLRs: Linking inflammation and breast cancer
Khyati Bhatelia, Kritarth Singh, Rajesh Kumar Singh · 2014 · Cellular Signalling
Molecular Mechanisms of Mitochondrial Quality Control in Ischemic Cardiomyopathy
Xing Chang, Ruxiu Liu, Ruibin Li, Youyou Peng, Pingjun Zhu, Hao Zhou · 2022 · International Journal of Biological Sciences
Pharmacological modulation of nucleic acid sensors - therapeutic potential and persisting obstacles
Vanpouille-Box, Claire, Hoffmann, Jules A., Galluzzi, Lorenzo · 2019 · Nature Reviews Drug Discovery
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Anna Czajka, Saima Ajaz, Luigi Gnudi, Chandani Kiran Parsade, Peter M. Jones, Fiona Reid, Afshan N. Malik · 2015 · EBioMedicine
Toll-like receptors and damage-associated molecular patterns: novel links between inflammation and hypertension
Cameron G. McCarthy, Styliani Goulopoulou, Camilla Ferreira Wenceslau, Kathryn M. Spitler, Takayuki Matsumoto, Robert Clinton Webb · 2013 · American Journal of Physiology-Heart and Circulatory Physiology
The Role of Oxidative Stress, Mitochondrial Function, and Autophagy in Diabetic Polyneuropathy
Sonia Sifuentes-Franco, Fermín Paúl Pacheco-Moisés, Adolfo Daniel Rodríguez-Carrizález, Alejandra Guillermina Miranda‐Díaz · 2017 · Journal of Diabetes Research
Mitochondrial metabolism in pulmonary hypertension: beyond mountains there are mountains
Miranda K. Culley, Stephen Y. Chan · 2018 · Journal of Clinical Investigation
A heart–brain–kidney network controls adaptation to cardiac stress through tissue macrophage activation
Katsuhito Fujiu, Munehiko Shibata, Yukiteru Nakayama, Fusa Ogata, Sahohime Matsumoto, Koji Noshita, Shingo Iwami, Susumu Nakae, Issei Komuro, Ryozo Nagai et al. · 2017 · Nature Medicine
Emerging role of mitophagy in cardiovascular physiology and pathology
Pablo Esteban Morales, Carla Arias-Durán, Yáreni Ávalos-Guajardo, Geraldine Aedo, Hugo Verdejo, Valentina Parra, Sergio Lavandero · 2019 · Molecular Aspects of Medicine
Extracellular Mitochondrial DNA Is Generated by Fibroblasts and Predicts Death in Idiopathic Pulmonary Fibrosis
Ryu, Changwan, Sun, Huanxing, Gulati, Mridu, Herazo-Maya, Jose D., Chen, Yonglin, Osafo-Addo, Awo, Brandsdorfer, Caitlin, Winkler, Julia, Blaul, Christina, Faunce, Jaden et al. · 2017 · American Journal of Respiratory and Critical Care Medicine
Myocardial stress and autophagy: mechanisms and potential therapies
Lea M.D. Delbridge, Kimberley M. Mellor, DAVID J. TAYLOR, Roberta A. Gottlieb · 2017 · Nature Reviews Cardiology
Mitochondrial DNMT3A and DNA methylation in skeletal muscle and CNS of transgenic mouse models of ALS
Margaret Wong, Barry Gertz, Barry A. Chestnut, Lee J. Martin · 2013 · Frontiers in Cellular Neuroscience
Mitophagy and age-related pathologies: Development of new therapeutics by targeting mitochondrial turnover
Konstantinos Palikaras, Ioanna Daskalaki, Maria Markaki, Nektarios Tavernarakis · 2017 · Pharmacology & Therapeutics
Cardiovascular autophagy
Sergio Lavandero, Rodrigo Troncoso, Beverly A. Rothermel, Wim Martinet, Junichi Sadoshima, Joseph A. Hill · 2013 · Autophagy
Hepatic DNA deposition drives drug‐induced liver injury and inflammation in mice
Pedro Elias Marques, A. G. de Oliveira, Rafaela Vaz Sousa Pereira, Bruna Araújo David, Lindisley Ferreira Gomides, Adriana Machado Saraiva, Daniele Araújo Pires, Júlia Tosta Novaes, Daniel de Oliveira Patricio, Daniel Cisalpino et al. · 2014 · Hepatology
Proteasomal and lysosomal protein degradation and heart disease
Xuejun Wang, Jeffrey M. Robbins · 2013 · Journal of Molecular and Cellular Cardiology
Advances in the understanding of mitochondrial DNA as a pathogenic factor in inflammatory diseases
Ray Kiran Boyapati, Arina Tamborska, David A. Dorward, Gwo‐Tzer Ho · 2017 · F1000Research
Cellular pyrimidine imbalance triggers mitochondrial DNA–dependent innate immunity
Hans‐Georg Sprenger, Thomas MacVicar, Amir Bahat, Kai Uwe Fiedler, Steffen Hermans, Denise Ehrentraut, Katharina Ried, Dusanka Milenkovic, Nina A. Bonekamp, Nils‐Göran Larsson et al. · 2021 · Nature Metabolism
Mitochondrial DNA in the regulation of innate immune responses
Chunju Fang, Xiawei Wei, Yuquan Wei · 2015 · Protein & Cell
Autophagosome–lysosome fusion triggers a lysosomal response mediated by TLR9 and controlled by OCRL
De Leo, Maria Giovanna, Staiano, Leopoldo, Vicinanza, Mariella, Luciani, Alessandro, Carissimo, Annamaria, Mutarelli, Margherita, Di Campli, Antonella, Polishchuk, Elena, Di Tullio, Giuseppe, Morra, Valentina et al. · 2016 · Nature Cell Biology
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Xiaoxiang Yan, Takashi Shichita, Yoshinori Katsumata, Tomohiro Matsuhashi, Hideyuki Ito, Kentaro Ito, Atsushi Anzai, Jin Endo, Yuichi Tamura, Kensuke Kimura et al. · 2012 · Journal of the American Heart Association
Heart-resident CCR2+ macrophages promote neutrophil extravasation through TLR9/MyD88/CXCL5 signaling
Wenjun Li, Hsi-Min Hsiao, Ryuji Higashikubo, Brian T. Saunders, Ankit Bharat, Daniel R. Goldstein, Alexander Sasha Krupnick, Andrew E. Gelman, Kory J. Lavine, Daniel Kreisel · 2016 · JCI Insight
Gasdermin D-dependent platelet pyroptosis exacerbates NET formation and inflammation in severe sepsis
Meiling Su, Chaofei Chen, Shaoying Li, Musheng Li, Zhi Zeng, Yuan Zhang, Luoxing Xia, Xiuzhen Li, Dezhong Zheng, Qiqi Lin et al. · 2022 · Nature Cardiovascular Research
Irisin alleviates pressure overload-induced cardiac hypertrophy by inducing protective autophagy via mTOR-independent activation of the AMPK-ULK1 pathway
Ruli Li, Sisi Wu, Wu Yao, Xiaoxiao Wang, Hongying Chen, Juan-juan Xin, He Li, Jie Lan, Kunyue Xue, Xue Li et al. · 2018 · Journal of Molecular and Cellular Cardiology
Mitochondrial DNA in liver inflammation and oxidative stress
Xufei Zhang, Xiuwen Wu, Qiongyuan Hu, Jie Wu, Gefei Wang, Zhiwu Hong, Jianan Ren · 2019 · Life Sciences
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Gwo‐Tzer Ho, Arianne L. Theiss · 2021 · Annual Review of Physiology
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Fucikova, Jitka, Moserova, Irena, Urbanova, Linda, Bezu, Lucillia, Kepp, Oliver, Cremer, Isabelle, Salek, Cyril, Strnad, Pavel, Kroemer, Guido, Galluzzi, Lorenzo et al. · 2015 · Frontiers in Immunology
The Inflammasome in Myocardial Injury and Cardiac Remodeling
Stefano A Toldo, Eleonora Mezzaroma, Adolfo Gabriele Mauro, Fadi N. Salloum, Benjamin Wallace Van Tassell, Antonio Abbate · 2014 · Antioxidants and Redox Signaling
Mitochondrial damage: An important mechanism of ambient PM2.5 exposure-induced acute heart injury in rats
Ruijin Li, Xiaojing Kou, Hong Geng, Jingfang Xie, Jingjing Tian, Zongwei Cai, Chuan Dong · 2015 · Journal of Hazardous Materials
Mitochondrial DNA as an inflammatory mediator in cardiovascular diseases
Nakayama, Hiroyuki, Otsu, Kinya · 2018 · Biochemical Journal
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Xiaoxiao Liu, Minghui Li, Zhiwei Chen, Yong Qiang Yu, Hui Shi, Ying Yu, Yucheng Wang, Ruizhen Chen, Junbo Ge · 2022 · Basic Research in Cardiology
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Lili Yu, Zhiwei Feng · 2018 · Mediators of Inflammation
Mitochondria: the indispensable players in innate immunity and guardians of the inflammatory response
Abhishek Mohanty, Rashmi Tiwari-Pandey, Nihar R. Pandey · 2019 · Journal of Cell Communication and Signaling
STING, a cytosolic DNA sensor, plays a critical role in atherogenesis: a link between innate immunity and chronic inflammation caused by lifestyle-related diseases
Phuong Tran Pham, Daiju Fukuda, Sachiko Nishimoto, Joo‐ri Kim‐Kaneyama, Xiao‐Feng Lei, Yutaka Takahashi, Tomohito Sato, Kimie Tanaka, Kumiko Suto, Yutaka Kawabata et al. · 2021 · European Heart Journal
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Toshiyuki Ko, Seitaro Nomura, Shintaro Yamada, Kanna Fujita, Takanori Fujita, Masahiro Satoh, Chio Oka, Manami Katoh, Masamichi Ito, Mikako Katagiri et al. · 2022 · Nature Communications
Mitochondria-derived cell-to-cell communication
Zahra Al Amir Dache, Alain Roger Thierry · 2023 · Cell Reports
Organellar homeostasis and innate immune sensing
Cassandra R. Harapas, Elina Idiiatullina, Mahmoud Al‐Azab, Katja Hrovat-Schaale, Thomas Reygaerts, Annemarie Steiner, Pawat Laohamonthonkul, Sophia Davidson, Chien‐Hsiung Yu, Lee M. Booty et al. · 2022 · Nature reviews. Immunology
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Campos, Juliane C., Queliconi, Bruno B., Bozi, Luiz H. M., Bechara, Luiz R. G., Dourado, Paulo M. M., Andres, Allen M., Jannig, Paulo R., Gomes, Kátia M. S., Zambelli, Vanessa O., Rocha-Resende, Cibele et al. · 2017 · Autophagy
Gut mucosal DAMPs in IBD: from mechanisms to therapeutic implications
Ray Kiran Boyapati, Adriano Giorgio Rossi, Jack Satsangi, Gwo‐Tzer Ho · 2016 · Mucosal Immunology
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Ray Kiran Boyapati, David A. Dorward, Arina Tamborska, Rahul Kalla, Nicholas T. Ventham, Mary K. Doherty, Phillip D. Whitfield, Mohini Gray, Joseph Loane, Adriano Giorgio Rossi et al. · 2018 · Inflammatory Bowel Diseases
Innate immunity as a target for acute cardioprotection
Coert Jozef Zuurbier, Antonio Abbate, Héctor A. Cabrera-Fuentes, Michael V. Cohen, Massimo Collino, Dominique P.V. de Kleijn, James M. Downey, Pasquale Pagliaro, Klaus T. Preissner, Masafumi Takahashi et al. · 2018 · Cardiovascular Research
TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus
Matsuda, Taito, Murao, Naoya, Katano, Yuki, Juliandi, Berry, Kohyama, Jun, Akira, Shizuo, Kawai, Taro, Nakashima, Kinichi · 2015 · Nature Communications
Mitochondrial ROS Induces Cardiac Inflammation via a Pathway through mtDNA Damage in a Pneumonia-Related Sepsis Model
Xiao Yao, Deborah Carlson, Yuxiao Sun, Lisha Ma, Steven E. Wolf, Joseph P. Minei, Qun Sophia Zang · 2015 · PLoS ONE
Chronology of mitochondrial and cellular events during skeletal muscle ischemia-reperfusion
Stéphanie Paradis, Anne‐Laure Charles, Alain Meyer, Anne Lejay, James William Scholey, Nabil Chakfé, Joffrey Zoll, Bernard Gény · 2016 · American Journal of Physiology-Cell Physiology
The Role of Epithelial Damage in the Pulmonary Immune Response
Rachel A. Burgoyne, Andrew John Fisher, Lee Anthony Borthwick · 2021 · Cells
LOX-1, mtDNA damage, and NLRP3 inflammasome activation in macrophages: implications in atherogenesis
Z. Ding, S. Liu, Xianwei Wang, Y. Dai, Magomed Khaidakov, Xiaoyan Deng, Yubo Fan, D. Xiang, Jawahar Lal Mehta · 2014 · Cardiovascular Research
Direct uptake and degradation of DNA by lysosomes
Yuuki Fujiwara, Hisae Kikuchi, Shu Aizawa, Akiko Furuta, Yusuke Hatanaka, Chiho Konya, Kenko Uchida, Keiji Wada, Tomohiro Kabuta · 2013 · Autophagy
Iron derived from autophagy-mediated ferritin degradation induces cardiomyocyte death and heart failure in mice
Jumpei Ito, Shigemiki Omiya, Mara-Camelia Rusu, Hiromichi Ueda, Tomokazu Murakawa, Yohei Tanada, Hajime Abe, Kazuki Nakahara, Michio Asahi, Manabu Taneike et al. · 2021 · eLife
DAMPs and autophagy
Qiuhong Zhang, Rui Kang, Herbert J. Zeh, Michael T. Lotze, Daolin Tang · 2013 · Autophagy
Inflammaging: The ground for sarcopenia?
Zejun Liang, Tianxiao Zhang, Honghong Liu, Zhenlin Li, Lihong Peng, Changyi Wang, Tiantian Wang · 2022 · Experimental Gerontology
Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis
Xudong Liao, Rongli Zhang, Yuan Lu, Domenick A. Prosdocimo, Panjamaporn Sangwung, Lilei Zhang, Guangjin Zhou, Puneet Anand, Ling Lai, Teresa C. Leone et al. · 2015 · Journal of Clinical Investigation
Mitochondrial dysfunction in inflammatory responses and cellular senescence: pathogenesis and pharmacological targets for chronic lung diseases
Yue Li, Hongwei Yao · 2016 · British Journal of Pharmacology
Mechanisms of mitochondrial DNA escape and its relationship with different metabolic diseases
Perla Pérez-Treviño, Mónica M. Velasquez-Esparza, Noemı́ Garcı́a · 2020 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Emerging Role of Mitochondrial DNA as a Major Driver of Inflammation and Disease Progression
Fei Zhong, Shuang Liang, Zhenyu Zhong · 2019 · Trends in Immunology
Mitochondrial damage-associated molecular patterns and vascular function
Wenceslau, C. F., McCarthy, C. G., Szasz, T., Spitler, K., Goulopoulou, S., Webb, R. C., Working Group on DAMPs in Cardiovascular Disease · 2014 · European Heart Journal
Mitophagy mechanisms and role in human diseases
Matthew Redmann, Matthew B. Dodson, Michaël Boyer‐Guittaut, Victor M. Darley-Usmar, Jianhua Zhang · 2014 · The International Journal of Biochemistry & Cell Biology
IFNα Impairs Autophagic Degradation of mtDNA Promoting Autoreactivity of SLE Monocytes in a STING-Dependent Fashion
Katerina Gkirtzimanaki, Eleni Kabrani, Dimitra Nikoleri, Alexander Polyzos, Athanasios Blanas, Prodromos I. Sidiropoulos, Antonis Makrigiannakis, George K Bertsias, Dimitrios T. Boumpas, Panayotis Verginis · 2018 · Cell Reports
Systemic activation of NLRP3 inflammasome in patients with severe primary Sjögren's syndrome fueled by inflammagenic DNA accumulations
Aigli G. Vakrakou, Sorina Boiu, Panayiotis D. Ziakas, Evangelia Xingi, Haralabia Boleti, Menelaos N. Manoussakis · 2018 · Journal of Autoimmunity
IL-1β Inhibition in Cardiovascular Complications Associated to Diabetes Mellitus
Concepción Peiró, Óscar Lorenzo, Raffaele Carraro, Carlos F. Sánchez‐Ferrer · 2017 · Frontiers in Pharmacology
The mitochondrial DNA polymerase gamma degrades linear DNA fragments precluding the formation of deletions
Nadee Nissanka, Sandra R. Bacman, Melanie J. Plastini, Carlos Torres Moraes · 2018 · Nature Communications
Increased neutrophil extracellular traps activate NLRP3 and inflammatory macrophages in adult-onset Still’s disease
Qiongyi Hu, Hui Shi, Ting Zeng, Honglei Liu, Yutong Su, Xiaobing Cheng, Junna Ye, Yufeng Yin, Mengru Liu, Hui Wen Zheng et al. · 2019 · Arthritis Research & Therapy
Decreased mitochondrial DNA copy number in the hippocampus and peripheral blood during opiate addiction is mediated by autophagy and can be salvaged by melatonin
Yuemei Feng, Yun‐Fang Jia, Ling‐Yan Su, Dong Wang, Li Lv, Lin Xu, Yong‐Gang Yao · 2013 · Autophagy