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Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure
Open accessAbstract
Heart failure is a leading cause of morbidity and mortality in industrialized countries. Although infection with microorganisms is not involved in the development of heart failure in most cases, inflammation has been implicated in the pathogenesis of heart failure. However, the mechanisms responsible for initiating and integrating inflammatory responses within the heart remain poorly defined. Mitochondria are evolutionary endosymbionts derived from bacteria and contain DNA similar to bacterial DNA. Mitochondria damaged by external haemodynamic stress are degraded by the autophagy/lysosome system in cardiomyocytes. Here we show that mitochondrial DNA that escapes from autophagy cell-autonomously leads to Toll-like receptor (TLR) 9-mediated inflammatory responses in cardiomyocytes and is capable of inducing myocarditis and dilated cardiomyopathy. Cardiac-specific deletion of lysosomal deoxyribonuclease (DNase) II showed no cardiac phenotypes under baseline conditions, but increased mortality and caused severe myocarditis and dilated cardiomyopathy 10 days after treatment with pressure overload. Early in the pathogenesis, DNase II-deficient hearts showed infiltration of inflammatory cells and increased messenger RNA expression of inflammatory cytokines, with accumulation of mitochondrial DNA deposits in autolysosomes in the myocardium. Administration of inhibitory oligodeoxynucleotides against TLR9, which is known to be activated by bacterial DNA, or ablation of Tlr9 attenuated the development of cardiomyopathy in DNase II-deficient mice. Furthermore, Tlr9 ablation improved pressure overload-induced cardiac dysfunction and inflammation even in mice with wild-type Dnase2a alleles. These data provide new perspectives on the mechanism of genesis of chronic inflammation in failing hearts.
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“APS patients met the 2006 revised Sapporo Criteria (3)”
From Identification of Mitofusin 1 and Complement Component 1q Subcomponent Binding Protein as Mitochondrial Targets in Systemic Lupus Erythematosus (2022) · cites this paper as [3]
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“Extracellular mitochondria have been identified in damaged tissues (8, 18–20); diverse inflammatory conditions (11, 12, 14, 21–24); and in the blood of critical care patients (22).”
From Autoantibodies in Systemic Lupus Erythematosus Target Mitochondrial RNA (2019) · cites this paper as [20]
Experimental — accuracy not yet measuredIn the citing paper
“Mitochondria are a source of damage-associated molecular patterns (DAMPs), and among others, mtDNA has been shown to induce a pro-inflammatory state (Zhang et al, 2010;Oka et al, 2012;Wenceslau et al, 2014).”
From Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency (2018) · cites this paper as Oka et al, 2012
In the citing paper
“MtDNA has been reported to activate immunity through two distinct pathways, namely Toll-like receptor 9 (TLR9; Zhang et al, 2010;Oka et al, 2012;Liu et al, 2015), and cGAS activation (White et al, 2014;West et al, 2015).”
From Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency (2018) · cites this paper as Oka et al, 2012
In the citing paper
“Recent data have established a relationship between autophagy malfunction and presence of undegraded mtDNA, which is recognized by TLR9 and results in inflammation (Nakahira et al, 2011;Oka et al, 2012).”
From Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency (2018) · cites this paper as Oka et al, 2012
In the citing paper
“Based on data indicating that autophagy malfunction caused mtDNA-mediated inflammation (Nakahira et al, 2011;Oka et al, 2012)”
From Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency (2018) · cites this paper as Oka et al, 2012
In the citing paper
“| Cardiomyopathies | Cardiomyocyte‐specific deletion of Dnase2a | Left ventricular dilatation, severe contractile dysfunction, inflammation and premature death from sustained PO, linked to mitochondrial misalignment and aggregation | Oka et al (2012) |”
From Autophagy in major human diseases (2021) · cites this paper as Oka et al (2012)
In the citing paper
“Accumulating evidence suggests that mitophagy impairment can induce cardiomyocyte death and HF [206,207,208,209].”
From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [209]
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Cites
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351
Pattern Recognition Receptors and Inflammation
Takeuchi, O., & Akira, S. (2010) · Cell · doi:10.1016/j.cell.2010.01.022 · Cited by 8,895
Self-citationLC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.
Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605
Self-citationA Toll-like receptor recognizes bacterial DNA
Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491 · cited 3×
“To identify the source of IL-1b and IL-6, we performed in situ hybridization analysis in heart sections.”
MethodSelf-citationAutophagy fights disease through cellular self-digestion
Mizushima, N., Levine, B., Cuervo, A. M., & Klionsky, D. J. (2008) · Nature · doi:10.1038/nature06639 · Cited by 6,452
Cui, C., Cui, J., Jin, F., Cui, Y., Li, R., Jiang, X., Tian, Y., Wang, R. C., Jiang, P., & Gao, J. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479571 · Cited by 5,214
Circulating mitochondrial DAMPs cause inflammatory responses to injury
Zhang, Q., Raoof, M., Chen, Y., Sumi, Y., Sursal, T., Junger, W., Brohi, K., Itagaki, K., & Hauser, C. J. (2010) · Nature · doi:10.1038/nature08780 · Cited by 3,812
Yang, Y., Li, S., Yang, Q., Shi, Y., Zheng, M., Liu, Y., Chen, F., Song, G., Xu, H., Wan, T., et al. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000358696 · Cited by 3,263
Nakahira, K., Haspel, J. A., Rathinam, V. A. K., Lee, S.-J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., et al. (2011) · Nature Immunology · doi:10.1038/ni.1980 · Cited by 3,049
DAMPs, PAMPs and alarmins: all we need to know about danger
Bianchi, M. E. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0306164 · Cited by 2,794
Flagged first, then by citations
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Items 401–500 of 997
Thomas, R. L., & Gustafsson, Å. B. (2013) · Circulation Journal · doi:10.1253/circj.cj-13-0835 · Cited by 58
Parkhitko, A. A., Priolo, C., Coloff, J. L., Yun, J., Wu, J. J., Mizumura, K., Xu, W., Malinowska, I. A., Yu, J. J., Kwiatkowski, D. J., et al. (2013) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-13-0258-t · Cited by 58
Lin, J., Jing, R., Lin, F., Ge, W., Dai, H., & Pan, L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01477 · Cited by 58
Mitochondrial transcription factor A promotes DNA strand cleavage at abasic sites
Xu, W., Boyd, R. M., Tree, M. O., Samkari, F., & Zhao, L. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1911252116 · Cited by 61
Cell-Free Circulating Mitochondrial DNA: A Potential Blood-Based Marker for Atrial Fibrillation
Wiersma, M., van Marion, D. M. S., Bouman, E. J., Li, J., Zhang, D., Ramos, K. S., Lanters, E. A. H., de Groot, N. M. S., & Brundel, B. J. J. M. (2020) · Cells · doi:10.3390/cells9051159 · Cited by 57
Macromolecular Degradation Systems and Cardiovascular Aging
Nakayama, H., Nishida, K., & Otsu, K. (2016) · Circulation Research · doi:10.1161/circresaha.115.307495 · Cited by 56
Self-citationPanickar, K. S., & Jewell, D. E. (2015) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2015-0017 · Cited by 58
Mitophagy as a Protective Mechanism against Myocardial Stress
Nah, J., Miyamoto, S., & Sadoshima, J. (2017) · Comprehensive physiology · doi:10.1002/cphy.c170005 · Cited by 60
Circulatory Mitochondrial DNA Is a Pro-Inflammatory Agent in Maintenance Hemodialysis Patients
Cao, H., Ye, H., Sun, Z., Shen, X., Song, Z., Wu, X., He, W., Dai, C., & Yang, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113179 · Cited by 56
Tang, Y., Liu, J., & Long, J. (2014) · Journal of Diabetes Investigation · doi:10.1111/jdi.12302 · Cited by 54
TLR2 Regulates Allergic Airway Inflammation and Autophagy Through PI3K/Akt Signaling Pathway
Jiang, X., Fang, L., Wu, H., Mei, X., He, F., Ding, P., & Liu, R. (2017) · Inflammation · doi:10.1007/s10753-017-0581-x · Cited by 56
Mitochondrial fidelity and metabolic agility control immune cell fate and function
Sack, M. N. (2018) · Journal of Clinical Investigation · doi:10.1172/jci120845 · Cited by 54
Inflammation in myocardial injury: mesenchymal stem cells as potential immunomodulators
Yan, W., Abu‐El‐Rub, E., Sekaran, S., Kirshenbaum, L. A., Arora, R. C., & Dhingra, S. (2019) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00065.2019 · Cited by 55
Mitochondrial DNA, oxidants, and innate immunity
Piantadosi, C. A. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.01.013 · Cited by 61
A Dual Role of Type I Interferons in Antitumor Immunity
Zhou, L., Zhang, Y., Wang, Y., Zhang, M., Sun, W., Dai, T., Wang, A., Wu, X., Zhang, S., Wang, S., et al. (2020) · Advanced Biosystems · doi:10.1002/adbi.201900237 · Cited by 62
Mitochondrial DNA as inflammatory DAMP: a warning of an aging immune system?
Zanini, G., Selleri, V., Doménech, S. L., Malerba, M., Nasi, M., Mattioli, A. V., & Pinti, M. (2023) · Biochemical Society Transactions · doi:10.1042/bst20221010 · Cited by 56
Liu, Y., Zhang, B., Duan, R., & Liu, Y. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.04.009 · Cited by 58
Immunosurveillance as a regulator of tissue homeostasis
Senovilla, L., Galluzzi, L., Zitvogel, L., & Kroemer, G. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.06.005 · Cited by 57
Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging
(2017) · Elsevier eBooks · doi:10.1016/c2016-0-02189-7 · Cited by 55
The role of autophagic degradation in the heart
Nishida, K., Taneike, M., & Otsu, K. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.09.029 · Cited by 53
Self-citationBeyond starvation: An update on the autophagic machinery and its functions
Kawabata, T., & Yoshimori, T. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.12.005 · Cited by 56
Macrophages, Metabolism and Heterophagy in the Heart
Nicolás-Ávila, J. Á., Pena-Couso, L., Muñoz‐Cánoves, P., & Hidalgo, A. (2022) · Circulation Research · doi:10.1161/circresaha.121.319812 · Cited by 52
LOX-1, oxidant stress, mtDNA damage, autophagy, and immune response in atherosclerosis
Ding, Z., Liu, S., Wang, X., Dai, Y., Khaidakov, M., Romeo, F., & Mehta, J. L. (2014) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2013-0420 · Cited by 53
Parousis, A., Carter, H. N., Tran, C., Erlich, A. T., Moosavi, Z. S. M., Pauly, M., & Hood, D. A. (2018) · Autophagy · doi:10.1080/15548627.2018.1491488 · Cited by 57
Haraguchi, R., Kohara, Y., Matsubayashi, K., Kitazawa, R., & Kitazawa, S. (2020) · ACTA HISTOCHEMICA ET CYTOCHEMICA · doi:10.1267/ahc.20008 · Cited by 53
Halloran, P. F., & Madill-Thomsen, K. S. (2022) · Transplantation · doi:10.1097/tp.0000000000004323 · Cited by 52
Status of Mitochondrial Oxidative Phosphorylation during the Development of Heart Failure
Bhullar, S. K., & Dhalla, N. S. (2023) · Antioxidants · doi:10.3390/antiox12111941 · Cited by 59
Metformin increases degradation of phospholamban via autophagy in cardiomyocytes
Teng, A. C. T., Miyake, T., Yokoe, S., Zhang, L., Rezende, L. M., Sharma, P., MacLennan, D. H., Liu, P. P., & Gramolini, A. O. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1508815112 · Cited by 51
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Crump, K. E., & Sahingur, S. E. (2015) · Journal of Dental Research · doi:10.1177/0022034515609062 · Cited by 52
NLRP3 inflammasome activation in COVID-19: an interlink between risk factors and disease severity
Amin, S., Aktar, S., Rahman, M. M., & Chowdhury, M. M. H. (2022) · Microbes and Infection · doi:10.1016/j.micinf.2021.104913 · Cited by 51
Torp, M., Vaage, J., & Stensløkken, K. (2023) · Acta Physiologica · doi:10.1111/apha.13920 · Cited by 54
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Nishida, Y., Ohtsuki, S., Araie, Y., Umeki, Y., Endo, M., Emura, T., Hidaka, K., Sugiyama, H., Takahashi, Y., Takakura, Y., et al. (2015) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2015.08.004 · Cited by 51
Mitochondria: Metabolic regulators of innate immune responses to pathogens and cell stress
Lartigue, L., & Faustin, B. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.06.014 · Cited by 52
Emerging roles of Toll-like receptor 9 in cardiometabolic disorders
Nishimoto, S., Fukuda, D., & Sata, M. (2020) · Inflammation and Regeneration · doi:10.1186/s41232-020-00118-7 · Cited by 56
Tsuji, N., & Agbor-Enoh, S. T. (2021) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2021.03.007 · Cited by 50
Mitochondria as the Essence of Yang Qi in the Human Body
Luo, J., Shiwei, S., Xia, J., Wang, J., & Gu, Z. (2022) · Phenomics · doi:10.1007/s43657-022-00060-3 · Cited by 52
Evidence to support mitochondrial neuroprotection, in severe traumatic brain injury
Gajavelli, S., Sinha, V. K., Mazzeo, A. T., Spurlock, M. S., Lee, S. W., Ahmed, A. I., Yokobori, S., & Bullock, R. M. (2014) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-014-9589-1 · Cited by 51
Lu, X., He, Y., Tang, C., Wang, X., Que, L., Zhu, G., Liu, L., Ha, T., Chen, Q., Li, C., et al. (2020) · Basic Research in Cardiology · doi:10.1007/s00395-020-0779-1 · Cited by 51
Santa, P., Garreau, A., Serpas, L., Ferrière, A., Blanco, P., Soni, C., & Sisirak, V. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.629922 · Cited by 56
Secretion of mitochondrial DNA via exosomes promotes inflammation in Behçet's syndrome
Konaka, H., Kato, Y., Hirano, T., Tsujimoto, K., Park, J., Koba, T., Aoki, W., Matsuzaki, Y., Taki, M., Koyama, S., et al. (2023) · The EMBO Journal · doi:10.15252/embj.2022112573 · Cited by 49
Self-citationChlorogenic acid prevents isoproterenol-induced hypertrophy in neonatal rat myocytes
Li, Y., Shen, D., Tang, X., Li, X., Wo, D., Yan, H., Song, R., Feng, J., Li, P., Zhang, J., et al. (2014) · Toxicology Letters · doi:10.1016/j.toxlet.2014.02.016 · Cited by 49
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Wilkins, H., Carl, S. M., Greenlief, A. C. S., Festoff, B. W., & Swerdlow, R. H. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00311 · Cited by 51
Targeting Mitochondria and Metabolism in Acute Kidney Injury
Li, Y., Hepokoski, M., Gu, W., Simonson, T. S., & Singh, P. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10173991 · Cited by 47
Mekers, V. E., Kho, V. M., Ansems, M., & Adema, G. J. (2022) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2022.07.014 · Cited by 47
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Trinchese, G., Cimmino, F., Catapano, A., Cavaliere, G., & Mollica, M. P. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1334006 · Cited by 57
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Kirillov, V., Siler, J. T., Ramadass, M., Ge, L., Davis, J. E., Grant, G. M., Nathan, S. D., Járai, G., & Trujillo, G. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.12.011 · Cited by 48
Singh, B., Modica-Napolitano, J. S., & Singh, K. K. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.05.004 · Cited by 49
Chu, Q., Zhang, S., Yu, L., Li, Y., Liu, Y., Ye, X., & Zheng, X. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.03.012 · Cited by 48
Ge, C., Hu, L., Lou, D., Li, Q., Feng, J., Wu, Y., Tan, J., & Xu, M. (2020) · Aging · doi:10.18632/aging.102906 · Cited by 48
Omiya, S., Omori, Y., Taneike, M., Protti, A., Yamaguchi, O., Akira, S., Shah, A. M., Nishida, K., & Otsu, K. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00481.2016 · Cited by 47
Self-citationSTING modulators: Predictive significance in drug discovery
Cui, X., Zhang, R., Cen, S., & Zhou, J. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.111591 · Cited by 48
Koller, A., Fazzini, F., Lamina, C., Rantner, B., Kollerits, B., Stadler, M., Klein-Weigel, P. F., Fraedrich, G., & Kronenberg, F. (2020) · Journal of Internal Medicine · doi:10.1111/joim.13027 · Cited by 47
Rhee, A. J., & Lavine, K. J. (2020) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021119-034412 · Cited by 46
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Zanini, G., De Gaetano, A., Selleri, V., Savino, G., Cossarizza, A., Pinti, M., Mattioli, A. V., & Nasi, M. (2021) · Cells · doi:10.3390/cells10102575 · Cited by 46
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Pang, Y., Zhang, C., & Gao, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.747377 · Cited by 47
Werbner, B., Tavakoli‐Rouzbehani, O. M., Fatahian, A. N., & Boudina, S. (2023) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2022.42 · Cited by 44
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Li, R., Jen, N., Wu, L., Lee, J., Fang, K., Quigley, K., Lee, K. J., Wang, S., Zhou, B., Vergnes, L., et al. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.5896 · Cited by 46
Kawai, Y. (2014) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.14-9 · Cited by 48
Association of telomere shortening in myocardium with heart weight gain and cause of death
Terai, M., Izumiyama‐Shimomura, N., Aida, J., Ishikawa, N., Sawabe, M., Arai, T., Fujiwara, M., Ishii, A., Nakamura, K., & Takubo, K. (2013) · Scientific Reports · doi:10.1038/srep02401 · Cited by 46
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Suspène, R., Mußil, B., Laude, H., Caval, V., Berry, N., Bouzidi, M. S., Thiers, V., Wain–Hobson, S., & Vartanian, J. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx001 · Cited by 45
Tjahjono, E., & Kirienko, N. V. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006876 · Cited by 46
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Misaka, T., Murakawa, T., Nishida, K., Omori, Y., Taneike, M., Omiya, S., Molenaar, C., Uno, Y., Yamaguchi, O., Takeda, J., et al. (2017) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2017.11.004 · Cited by 45
Self-citationPro‐inflammatory role of cell‐free mitochondrial DNA in cardiovascular diseases
Nie, S., Lu, J., Wang, L., & Gao, M. (2020) · IUBMB Life · doi:10.1002/iub.2339 · Cited by 50
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Sun, Y., Xiao, Q., Luo, C., Zhao, Y., Pu, D., Zhao, K., Chen, J., Wang, M., & Liao, Z. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.07.032 · Cited by 45
Tripathi, A., Bartosh, A., Whitehead, C., & Pillai, A. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02189-7 · Cited by 47
Li, L., Liu, X., Xu, J., Weng, L., Ren, J. T., Ge, J., & Zou, Y. (2015) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12567 · Cited by 45
Sudakov, N. P., Апарцин, К. А., Lepekhova, S. A., Nikiforov, S. B., Katyshev, A. I., Израйлевна, Л. Г., Vybivantseva, A. V., & Konstantinov, Y. M. (2017) · European journal of medical research · doi:10.1186/s40001-016-0241-x · Cited by 45
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Kitazume-Taneike, R., Taneike, M., Omiya, S., Misaka, T., Nishida, K., Yamaguchi, O., Akira, S., Shattock, M. J., Sakata, Y., & Otsu, K. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.05.150 · Cited by 45
Self-citationMonoamine oxidases: A missing link between mitochondria and inflammation in chronic diseases ?
Beucher, L., Gabillard-Lefort, C., Baris, O. R., & Mialet‐Perez, J. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103393 · Cited by 45
Activated protein C modulates cardiac metabolism and augments autophagy in the ischemic heart
COSTA, R., MORRISON, A., Wang, J., Manithody, C., LI, J., & Rezaie, A. R. (2012) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2012.04833.x · Cited by 43
Saadat, K. A. S. M., Murakami, Y., Tan, X., Nomura, Y., Yasukawa, T., Okada, E., Ikeda, Y., & Yanagi, Y. (2014) · FEBS Open Bio · doi:10.1016/j.fob.2014.11.003 · Cited by 44
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Ichimura, S., Misaka, T., Ogawara, R., Tomita, Y., Anzai, F., Sato, Y., Miura, S., Yokokawa, T., Sato, T., Oikawa, M., et al. (2024) · Circulation Heart Failure · doi:10.1161/circheartfailure.123.011057 · Cited by 45
Xie, L., Liu, S., Cheng, J., Wang, L., Liu, J., & Gong, J. (2017) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2017.07.028 · Cited by 45
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Metadata
- Authors
- Oka, T., Hikoso, S., Yamaguchi, O., Taneike, M., Takeda, T., Tamai, T., Oyabu, J., Murakawa, T., Nakayama, H., Nishida, K., Akira, S., Yamamoto, A., Komuro, I., & Otsu, K.
- Affiliations
- The University of Osaka (JP)
- King's College London (GB)
- Immunology Frontier Research Center, The University of Osaka (JP)
- Nagahama Institute of Bio-Science and Technology (JP)
- Corresponding author
- Otsu, Kinya
- ORCID
- Venue
- Nature
- Published
- 2012-04-25
- Volume
- 485
- Issue
- 7397
- Pages
- 251-255
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3378041
- OpenAlex
- W2092943609
- Cited by
- 1,201
- References
- 30
- Citations by year
- 2026: 75 · 2025: 71 · 2024: 85 · 2023: 80 · 2022: 98 · 2021: 97 · 2020: 85 · 2019: 79 · 2018: 77 · 2017: 107 · 2016: 75 · 2015: 83 · 2014: 80 · 2013: 74 · 2012: 34
- FWCI
- 64.37
- Type
- journal article
- Language
- en
- Update notices
- erratum (2012-09-19)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- British Heart Foundation (CH/11/3/29051, RG/11/12/29052)
- Japan Society for the Promotion of Science (21390240, 21229010)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- mitochondrial DNA, autophagy, heart failure, inflammation, TLR9, cardiomyocytes, DNase II, myocarditis, dilated cardiomyopathy, pressure overload, autolysosomes, oligodeoxynucleotides, cardiac dysfunction
- MeSH terms
- Alleles, Animals, Aorta, Autophagy, Constriction, Pathologic, DNA, Mitochondrial, Endodeoxyribonucleases, Heart, Cardiomegaly, Heart Failure, Lysosomes, Male, Mitochondria, Myocarditis, Myocardium, Pressure, RNA, Messenger, Signal Transduction, Cytokines, Myocytes, Cardiac, Toll-Like Receptor 9, Mice
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