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Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice
Open accessAbstract
The composite human microbiome of Western populations has probably changed over the past century, brought on by new environmental triggers that often have a negative impact on human health. Here we show that consumption of a diet high in saturated (milk-derived) fat, but not polyunsaturated (safflower oil) fat, changes the conditions for microbial assemblage and promotes the expansion of a low-abundance, sulphite-reducing pathobiont, Bilophila wadsworthia. This was associated with a pro-inflammatory T helper type 1 (T(H)1) immune response and increased incidence of colitis in genetically susceptible Il10(−/−), but not wild-type mice. These effects are mediated by milk-derived-fat-promoted taurine conjugation of hepatic bile acids, which increases the availability of organic sulphur used by sulphite-reducing microorganisms like B. wadsworthia. When mice were fed a low-fat diet supplemented with taurocholic acid, but not with glycocholic acid, for example, a bloom of B. wadsworthia and development of colitis were observed in Il10(−/−) mice. Together these data show that dietary fats, by promoting changes in host bile acid composition, can markedly alter conditions for gut microbial assemblage, resulting in dysbiosis that can perturb immune homeostasis. The data provide a plausible mechanistic basis by which Western-type diets high in certain saturated fats might increase the prevalence of complex immune-mediated diseases like inflammatory bowel disease in genetically susceptible hosts.
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In the citing paper
“Bacteria with BSH activity have benefited from enhanced tolerance against bile and better survival in the gut environment (Begley et al., 2006;Devkota et al., 2012).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Devkota et al., 2012
Experimental — accuracy not yet measuredIn the citing paper
“In Il10−/− mice and mice without disruption of this gene, a diet high in saturated (milk-derived) fat (MF) promoted expansion of the immunogenic sulfite-reducing pathobiont Bilophila wadsworthia, a member of the Deltaproteobacteria.174”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [174]
In the citing paper
“Bilophila wadsworthia, a sulphite-reducing bacteria, has been associated with an increased incidence of colitis [52], and emerges under pathological conditions such as appendicitis and other intestinal inflammatory disorders [52].”
From Intestinal Microbiota Is Influenced by Gender and Body Mass Index (2016) · cites this paper as [52]
In the citing paper
“Consumption of milk fat has been shown to alter bile acid composition, promoting expansion of the sulphite-reducing pathobiont Bilophila wadsworthia and exacerbating colitis in IL10 knockout mice69.”
From Diet and the Intestinal Microbiome: Associations, Functions, and Implications for Health and Disease (2014) · cites this paper as [69]
In the citing paper
“B. wadsworthia increases gut inflammation in mice that lack in the anti-inflammatory cytokine interleukin (IL)-10.”
From Diet–microbiota interactions as moderators of human metabolism (2016) · cites this paper as [111]
In the citing paper
“Levels of the bacterium Bilophila wadsworthia increase when mice are fed a diet rich in milk fat or supplemented with the bile acid taurocholic acid111.”
From Diet–microbiota interactions as moderators of human metabolism (2016) · cites this paper as [111]
In the citing paper
“This is in line with the suggestion that SRB are linked to an inflammatory state of the gut 41, 42.”
From The composition of the gut microbiota shapes the colon mucus barrier (2015) · cites this paper as [42]
In the citing paper
“This pathobiont promotes Th1 type immune responses and increases susceptibility to colitis in IL10–/– mice.137”
From Interaction between microbiota and immunity in health and disease (2020) · cites this paper as [137]
In the citing paper
“The gut microbiota has been shown to differ between mice fed diets that are high or low in fat and between diets that contain equal amounts of fat but from different sources [10–13] (Fig. 1).”
From Dietary lipids, gut microbiota and lipid metabolism (2019) · cites this paper as [13]
In the citing paper
“Milk fat promoted taurine-conjugation of bile acids, which increases the availability of sulfur used by B. wadsworthia.”
From Dietary lipids, gut microbiota and lipid metabolism (2019) · cites this paper as [13]
In the citing paper
“The increased levels of B. wadsworthia were associated with a pro-inflammatory immune response and increased incidence of colitis in genetically susceptible mice.”
From Dietary lipids, gut microbiota and lipid metabolism (2019) · cites this paper as [13]
In the citing paper
“Devkota et al showed that a diet with milk fat, but not diets with lard or safflower oil, increased expansion of Bilophila wadsworthia in mice [13].”
From Dietary lipids, gut microbiota and lipid metabolism (2019) · cites this paper as [13]
In the citing paper
“This phyla has been shown to be intimately tied to a pro-inflammatory state.11,60,61”
From Using Corticosteroids to Reshape the Gut Microbiome: Implications for Inflammatory Bowel Diseases (2015) · cites this paper as [11]
In the citing paper
“For example, high SFA intake has been shown to be associated with reduction in total bacterial abundance in humans (95) and in microbial diversity and richness (95,96), as well as an increase in proinflammatory bacteria (e.g., Bilophila wadsworthia) (96)(97)(98) in mice.”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [96]
In the citing paper
“animals fed with a diet rich in animal-derived saturated fats demonstrated a significant increase in Proteobacteria (Bilophila wadsworthia) abundance (Devkota et al., 2012).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Devkota et al., 2012
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Cites
Molodecky, N. A., Soon, I. S., Rabi, D. M., Ghali, W. A., Ferris, M., Chernoff, G., Benchimol, E. I., Panaccione, R., Ghosh, S., Barkema, H. W., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2011.10.001 · Cited by 4,833
Turnbaugh, P. J., Bäckhed, F., Fulton, L., & Gordon, J. I. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.02.015 · Cited by 2,915
High-Fat Diet Determines the Composition of the Murine Gut Microbiome Independently of Obesity
Hildebrandt, M. A., Hoffmann, C., Sherrill–Mix, S. A., Keilbaugh, S. A., Hamady, M., Chen, Y., Knight, R., Ahima, R. S., Bushman, F., & Wu, G. D. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.08.042 · Cited by 1,576
Diet, gut microbiota and immune responses
Maslowski, K. M., & Mackay, C. R. (2011) · Nature Immunology · doi:10.1038/ni0111-5 · Cited by 1,261
Berg, D., Davidson, N. M., Kühn, R., Müller, W., Menon, S., Holland, G., Thompson-Snipes, L., Leach, M. W., & Rennick, D. M. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118861 · Cited by 1,125
The human gut microbiome: ecology and recent evolutionary changes
Walter, J., & Ley, R. (2011) · Annual Review of Microbiology · doi:10.1146/annurev-micro-090110-102830 · Cited by 720
Wang, Y., Hoenig, J. D., Malin, K. J., Qamar, S., Petrof, E. O., Sun, J., Antonopoulos, D. A., Chang, E. B., & Claud, E. C. (2009) · The ISME Journal · doi:10.1038/ismej.2009.37 · Cited by 600
Sulfate-reducing bacteria in human feces and their association with inflammatory bowel diseases
Loubinoux, J., Bronowicki, J., Pereira, I. A. C., Mougenel, J.-L., & Faou, A. L. (2002) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2002.tb00942.x · Cited by 404
Evidence That Hydrogen Sulfide Is a Genotoxic Agent
Attene‐Ramos, M. S., Wagner, E. D., Plewa, M. J., & Gaskins, H. R. (2006) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-05-0126 · Cited by 367
Dussurget, O., Cabanes, D., Dehoux, P., Lecuit, M., Buchrieser, C., Glaser, P., & Cossart, P. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.03080.x · Cited by 356
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Items 501–600 of 1,001
The microbiome: Composition and locations
Kennedy, M. S., & Chang, E. B. (2020) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.08.013 · Cited by 108
Stable-Isotope Probing of Human and Animal Microbiome Function
Berry, D., & Loy, A. (2018) · Trends in Microbiology · doi:10.1016/j.tim.2018.06.004 · Cited by 99
Gut microbiota and health: connecting actors across the metabolic system
Fava, F., Rizzetto, L., & Tuohy, K. M. (2018) · Proceedings of The Nutrition Society · doi:10.1017/s0029665118002719 · Cited by 99
Mechanisms of Microbe–Host Interaction in Crohn’s Disease: Dysbiosis vs. Pathobiont Selection
Buttó, L. F., Schaubeck, M., & Haller, D. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00555 · Cited by 97
Influence of environmental factors in the development of inflammatory bowel diseases
Legaki, E. (2016) · World Journal of Gastrointestinal Pharmacology and Therapeutics · doi:10.4292/wjgpt.v7.i1.112 · Cited by 94
Interaction between dietary lipids and gut microbiota regulates hepatic cholesterol metabolism
Caesar, R., Nygrén, H., Orešič, M., & Bäckhed, F. (2016) · Journal of Lipid Research · doi:10.1194/jlr.m065847 · Cited by 94
Lin, R., Zhan, M., Yang, L., Wang, H., Shen, H., Huang, S., Huang, X., Xu, S., Zhang, Z., Li, W., et al. (2020) · Oncogene · doi:10.1038/s41388-020-1349-6 · Cited by 93
Meisel, M., Mayassi, T., Fehlner-Peach, H., Koval, J., O'Brien, S. L., Hinterleitner, R., Lesko, K., Kim, S. M., Bouziat, R., Chen, L., et al. (2016) · The ISME Journal · doi:10.1038/ismej.2016.114 · Cited by 95
Gut microbiome-mediated metabolism effects on immunity in rural and urban African populations
Stražar, M., Temba, G. S., Vlamakis, H., Kullaya, V. I., Lyamuya, F., Mmbaga, B. T., Joosten, L. A. B., van der Ven, A. J. A. M., Netea, M. G., de Mast, Q., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25213-2 · Cited by 91
Bioinformatics for the Human Microbiome Project
Gevers, D., Pop, M., Schloss, P. D., & Huttenhower, C. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002779 · Cited by 91
Advances in understanding of bile acid diarrhea
Camilleri, M. (2013) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2014.851599 · Cited by 92
Tindall, A. M., McLimans, C. J., Petersen, K. S., Kris‐Etherton, P. M., & Lamendella, R. (2019) · Journal of Nutrition · doi:10.1093/jn/nxz289 · Cited by 92
Gut : liver : brain axis: the microbial challenge in the hepatic encephalopathy
Mancini, A., Campagna, F., Amodio, P., & Tuohy, K. M. (2018) · Food & Function · doi:10.1039/c7fo01528c · Cited by 89
Dietary fat and gut microbiota: mechanisms involved in obesity control
Coelho, O. G. L., Cândido, F. G., & Alfenas, R. D. C. G. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1481821 · Cited by 90
Zádori, Z., Király, K. P., Al‐Khrasani, M., & Gyires, K. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108327 · Cited by 92
Metabolic functions of the human gut microbiota: the role of metalloenzymes
Rajakovich, L. J., & Balskus, E. P. (2018) · Natural Product Reports · doi:10.1039/c8np00074c · Cited by 91
Terzo, S., Mulè, F., Caldara, G., Baldassano, S., Puleio, R., Vitale, M., Cassata, G., Ferrantelli, V., & Amato, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21010365 · Cited by 89
Fernández, J., Moreno, F. J., Olano, A., Clemente, A., Villar, C. J., & Lombó, F. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02004 · Cited by 88
Goji Berry Modulates Gut Microbiota and Alleviates Colitis in IL‐10‐Deficient Mice
Kang, Y., Yang, G., Zhang, S., Ross, C. F., & Zhu, M. J. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800535 · Cited by 88
Dietary Habits and Intestinal Immunity: From Food Intake to CD4+ TH Cells
Siracusa, F., Schaltenberg, N., Villablanca, E. J., Huber, S., & Gagliani, N. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03177 · Cited by 91
Mefferd, C. C., Bhute, S. S., Phan, J. R., Villarama, J. V., Do, D. M., Alarcia, S., Abel‐Santos, E., & Hedlund, B. P. (2020) · mSystems · doi:10.1128/msystems.00765-19 · Cited by 87
Diet and gut microbiome in gastrointestinal disease
Trakman, G., Fehily, S. R., Basnayake, C., Hamilton, A. L., Russell, E., Wilson-O'Brien, A. L., & Kamm, M. A. (2021) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15728 · Cited by 93
Therapeutic targeting of bile acids
Camilleri, M., & Gores, G. J. (2015) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00121.2015 · Cited by 85
Gut microbiome: a new player in gastrointestinal disease
Gorkiewicz, G., & Moschen, A. R. (2017) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-017-2277-x · Cited by 95
Long term but not short term exposure to obesity related microbiota promotes host insulin resistance
Foley, K. P., Zlitni, S., Denou, E., Duggan, B. M., Chan, R. W., Stearns, J. C., & Schertzer, J. D. (2018) · Nature Communications · doi:10.1038/s41467-018-07146-5 · Cited by 91
The microbiome and ophthalmic disease
Baim, A. D., Movahedan, A., Farooq, A. V., & Skondra, D. (2018) · Experimental Biology and Medicine · doi:10.1177/1535370218813616 · Cited by 87
Bile acid-based therapies for non-alcoholic steatohepatitis and alcoholic liver disease
Li, T., & Chiang, J. Y. L. (2020) · HepatoBiliary Surgery and Nutrition · doi:10.21037/hbsn.2019.09.03 · Cited by 87
Fujiya, M., Ueno, N., & Kohgo, Y. (2013) · Clinical Journal of Gastroenterology · doi:10.1007/s12328-013-0440-8 · Cited by 90
Martoni, C. J., Labbé, A., Ganopolsky, J. G., Prakash, S., & Jones, M. L. (2015) · Gut Microbes · doi:10.1080/19490976.2015.1005474 · Cited by 87
The Link between Obesity, Microbiota Dysbiosis, and Neurodegenerative Pathogenesis
Vamanu, E., & Nand, S. (2021) · Diseases · doi:10.3390/diseases9030045 · Cited by 91
Anto, L., & Blesso, C. N. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.108991 · Cited by 90
Ye, Z., Xu, Y., & Liu, Y. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.05.001 · Cited by 86
Mitochondrial function in intestinal epithelium homeostasis and modulation in diet-induced obesity
Guerbette, T., Boudry, G., & Lan, A. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101546 · Cited by 100
Endotoxicity of Lipopolysaccharide as a Determinant of T-Cell−Mediated Colitis Induction in Mice
Gronbach, K., Flade, I., Holst, O., Lindner, B., Ruscheweyh, H., Wittmann, A., Menz, S., Schwiertz, A., Adam, P., Stecher, B., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.11.033 · Cited by 83
Obesity and Asthma: Microbiome–Metabolome Interactions
Shore, S. A., & Cho, Y. (2016) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2016-0052ps · Cited by 86
Review article: fungal alterations in inflammatory bowel diseases
Lam, S., Zuo, T., Ho, M., Chan, F. K. L., Chan, P. K. S., & Ng, S. C. (2019) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15523 · Cited by 87
Immunology of bile acids regulated receptors
Fiorucci, S., Marchianò, S., Urbani, G., Giorgio, C. D., Distrutti, E., Zampella, A., & Biagioli, M. (2024) · Progress in Lipid Research · doi:10.1016/j.plipres.2024.101291 · Cited by 88
Microbiota in the Throat and Risk Factors for Laryngeal Carcinoma
Gong, H., Shi, Y., Zhou, X., Wu, C., Cao, P., Xu, C., Hou, D., Wang, Y., & Zhou, L. F. (2014) · Applied and Environmental Microbiology · doi:10.1128/aem.02329-14 · Cited by 84
Inflammatory bowel disease pathogenesis: Where are we?
Fiocchi, C. (2015) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12751 · Cited by 85
Microbiome-driven carcinogenesis in colorectal cancer: Models and mechanisms
Wang, X., Yang, Y., & Huycke, M. M. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.10.504 · Cited by 86
Ocvirk, S., Wilson, A. S., Posma, J. M., Li, J. V., Koller, K. R., Day, G. M., Flanagan, C. A., Otto, E., Sacco, P. E., Sacco, F. D., et al. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz301 · Cited by 84
Bile Acids, Their Receptors, and the Gut Microbiota
Poland, J. C., & Flynn, C. R. (2021) · Physiology · doi:10.1152/physiol.00028.2020 · Cited by 93
Macroecological dynamics of gut microbiota
Ji, B. W., Sheth, R. U., Dixit, P. D., Tchourine, K., & Vitkup, D. (2020) · Nature Microbiology · doi:10.1038/s41564-020-0685-1 · Cited by 83
Brown, H. M., & Esterházy, D. (2021) · Mucosal Immunology · doi:10.1038/s41385-021-00420-8 · Cited by 88
Molecular and Pathophysiological Links between Metabolic Disorders and Inflammatory Bowel Diseases
Hyun, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179139 · Cited by 87
The functional impact of the intestinal microbiome on mucosal immunity and systemic autoimmunity
Longman, R., & Littman, D. R. (2015) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000190 · Cited by 82
Paola, M. D., Cavalieri, D., Albanese, D., Sordo, M., Pindo, M., Donati, C., Pagnini, I., Giani, T., Simonini, G., Paladini, A., et al. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01703 · Cited by 82
Mokkala, K., Houttu, N., Cansev, T., & Laitinen, K. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.05.003 · Cited by 82
Diet-Microbe-Host Interactions That Affect Gut Mucosal Integrity and Infection Resistance
Forgie, A. J., Fouhse, J. M., & Willing, B. P. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01802 · Cited by 88
Filippis, A. D., Ullah, H., Baldi, A., Dacrema, M., Esposito, C., Garzarella, E. U., Santarcangelo, C., Tantipongpiradet, A., & Daglia, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144929 · Cited by 87
Vandeputte, D., & Joossens, M. (2020) · Microorganisms · doi:10.3390/microorganisms8111638 · Cited by 86
Effector and memory T cell responses to commensal bacteria
Belkaid, Y., Bouladoux, N. J., & Hand, T. W. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.03.003 · Cited by 83
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Cevallos, S. A., Lee, J., Tiffany, C. R., Byndloss, A. J., Johnston, L., Byndloss, M. X., & Bäumler, A. J. (2019) · mBio · doi:10.1128/mbio.02244-19 · Cited by 89
Mesnage, R., Grundler, F., Schwiertz, A., Maho, Y. L., & de Toledo, F. W. (2019) · Journal of Nutritional Science · doi:10.1017/jns.2019.33 · Cited by 79
Dynamic Changes in Gut Microbiome of Ulcerative Colitis: Initial Study from Animal Model
Gu, W., Zhang, L., Tao, H., Huang, H., & Chen, J. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s358807 · Cited by 80
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Sipka, S., & Bruckner, G. G. (2014) · International Archives of Allergy and Immunology · doi:10.1159/000366100 · Cited by 83
Mikkelsen, S. U., Allin, K. H., & Knop, F. K. (2016) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12637 · Cited by 85
Hale, V. L., Jeraldo, P., Mundy, M. B., Yao, J. Z., Keeney, G., Scott, N. E., Cheek, E. H., Davidson, J., Greene, M., Martinez, C., et al. (2018) · Methods · doi:10.1016/j.ymeth.2018.04.024 · Cited by 80
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Arnone, D., Chabot, C., Heba, A.-C., Kökten, T., Caron, B., Hansmannel, F., Dreumont, N., Ananthakrishnan, A. N., Quilliot, D., & Peyrin‐Biroulet, L. (2021) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2021.12.011 · Cited by 91
Cao, C., Wang, L., Ai, C., Gong, G., Wang, Z., Huang, L., Song, S., & Zhu, B. (2022) · Food & Function · doi:10.1039/d2fo01283a · Cited by 81
The mouse gut microbiome revisited: From complex diversity to model ecosystems
Clavel, T., Lagkouvardos, I., Blaut, M., & Stecher, B. (2016) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2016.03.002 · Cited by 84
Chen, L., Brar, M. S., Leung, F. C.-C., & Hsiao, W. L. W. (2016) · Oncotarget · doi:10.18632/oncotarget.8886 · Cited by 81
Bongers, G., Pacer, M. E., Geraldino, T. H., Chen, L., He, Z., Hashimoto, D., Furtado, G. C., Ochando, J., Kelley, K. A., Clemente, J. C., et al. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20131587 · Cited by 79
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Teigen, L. M., Geng, Z., Sadowsky, M. J., Vaughn, B. P., Hamilton, M. J., & Khoruts, A. (2019) · Nutrients · doi:10.3390/nu11040931 · Cited by 82
Thomas, C. E., Luu, H. N., Wang, R., Xie, G., Adams‐Haduch, J. M., Jin, A., Koh, W., Jia, W. P., Behari, J., & Yuan, J. (2021) · Cancers · doi:10.3390/cancers13112648 · Cited by 78
Xu, S., Yang, Q., Wang, R., Tian, C., Ji, Y., Tan, H., Zhao, P., Kaplan, D. L., Wang, F., & Xia, Q. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.03.012 · Cited by 78
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Zeybel, M., Arif, M., Li, X., Altay, Ö., Yang, H., Shi, M., Akyıldız, M., Sağlam, B., Gönenli, M. G., Yiğit, B., et al. (2022) · Advanced Science · doi:10.1002/advs.202104373 · Cited by 77
Yang, L., Bian, G., Su, Y., & Zhu, W. (2014) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.2013.13621 · Cited by 78
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Thompson, S. V., Bailey, M. A., Taylor, A. M., Kaczmarek, J. L., Mysonhimer, A. R., Edwards, C., Reeser, G. E., Burd, N. A., Khan, N. A., & Holscher, H. D. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa219 · Cited by 82
Rolig, A. S., Cech, C., Ahler, E., Carter, J. E., & Ottemann, K. M. (2013) · Infection and Immunity · doi:10.1128/iai.00044-13 · Cited by 77
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McCarville, J. L., Caminero, A., & Verdu, E. F. (2016) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x16637819 · Cited by 78
Role of Bile Acids in Bariatric Surgery
Wang, W., Cheng, Z., Wang, Y., Dai, Y., Zhang, X., & Hu, S. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00374 · Cited by 80
Neto, H. A. P., Ausina, P., Gomez, L. S., Leandro, J. G. B., Zancan, P., & Sola‐Penna, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01478 · Cited by 81
Hanson, B. T., Kits, K. D., Löffler, J., Burrichter, A. G., Fiedler, A. W., Denger, K., Frommeyer, B., Herbold, C. W., Rattei, T., Karcher, N., et al. (2021) · The ISME Journal · doi:10.1038/s41396-021-00968-0 · Cited by 70
Sun, J., Qiao, Y., Qi, C., Jiang, W., Xiao, H., Shi, Y., & Le, G. (2015) · Nutrition · doi:10.1016/j.nut.2015.08.020 · Cited by 76
Rosa, V. D., Galgani, M., Santopaolo, M., Colamatteo, A., Laccetti, R., & Matarese, G. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2015.10.001 · Cited by 77
Shen, W., Wolf, P. G., Carbonero, F. G., Wei, Z., Reid, T., Gaskins, H. R., & McIntosh, M. (2014) · Journal of Nutrition · doi:10.3945/jn.114.194332 · Cited by 80
Impact of dietary fiber and fat on gut microbiota re-modeling and metabolic health
Benítez‐Páez, A., del Pulgar, E. M. G., Kjølbæk, L., Brahe, L. K., Astrup, A. V., Larsen, L. H., & Sanz, Y. (2016) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2016.11.001 · Cited by 80
Neyrinck, A. M., Taminiau, B., Walgrave, H., Daube, G., Cani, P. D., Bindels, L. B., & Delzenne, N. M. (2017) · Nutrients · doi:10.3390/nu9060633 · Cited by 81
Jové, M., Ayala, V., Ramírez‐Núñez, O., Serrano, J. C. E., Cassanyé, A., Arola, L., Caimari, A., Bas-Prior, J. M. D., Crescenti, A., Pamplona, R., et al. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvs368 · Cited by 75
Chung, B. K., Karlsen, T. H., & Folseraas, T. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.08.020 · Cited by 76
Implication of Obesity and Gut Microbiome Dysbiosis in the Etiology of Colorectal Cancer
Singh, S., Sharma, P., Sarma, D. K., Kumawat, M., Tiwari, R. R., Verma, V., Nagpal, R., & Kumar, M. (2023) · Cancers · doi:10.3390/cancers15061913 · Cited by 83
Ovadia, C., Perdones-Montero, Á., Spagou, K., Smith, A., Sarafian, M. H., Gómez‐Romero, M., Bellafante, E., Clarke, L. C. D., Sadiq, F., Nikolova, V., et al. (2019) · Hepatology · doi:10.1002/hep.30661 · Cited by 73
Dysbiotic gut microbiome: A key element of Crohn's disease
Øyri, S. F., Műzes, G., & Sípos, F. (2015) · Comparative Immunology Microbiology and Infectious Diseases · doi:10.1016/j.cimid.2015.10.005 · Cited by 78
Gnotobiotics: Past, present and future
Basic, M., & Bleich, A. (2019) · Laboratory Animals · doi:10.1177/0023677219836715 · Cited by 73
Influence of Environmental Factors in the Development and Outcomes of Inflammatory Bowel Disease.
Vedamurthy, A., & Ananthakrishnan, A. N. (2019) · Europe PMC (PubMed Central) · Cited by 73
Polyphenols and Intestinal Health
Martinez, K., Mackert, J. D., & McIntosh, M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805376-8.00018-6 · Cited by 85
Chen, D., Chen, G., Chen, C., Zeng, X., & Ye, H. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.04.248 · Cited by 72
Gut mycobiome: The probable determinative role of fungi in IBD patients
Maal, A. B., Shahrokh, S., Ansari, S., Mirsamadi, E. S., Yadegar, A., Mirjalali, H., & Zali, M. R. (2021) · Mycoses · doi:10.1111/myc.13238 · Cited by 75
Gut microbiome and Clostridioides difficile infection: a closer look at the microscopic interface
Sehgal, K., & Khanna, S. (2021) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756284821994736 · Cited by 74
Dietary Influences on the Microbiota–Gut–Brain Axis
Barber, T. M., Valsamakis, G., Mastorakos, G. P., Hanson, P., Kyrou, I., Randeva, H. S., & Weickert, M. O. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073502 · Cited by 78
The roles of dietary lipids and lipidomics in gut-brain axis in type 2 diabetes mellitus
Ağagündüz, D., İçer, M. A., Yeşildemir, Ö., Koçak, T., Koçyiğit, E., & Capasso, R. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04088-5 · Cited by 85
New therapeutic avenues in ulcerative colitis: thinking out of the box
Torres, J., Danese, S., & Colombel, J. (2013) · Gut · doi:10.1136/gutjnl-2012-303959 · Cited by 74
Modulating Composition and Metabolic Activity of the Gut Microbiota in IBD Patients
Matijašić, M., Meštrović, T., Perić, M., Paljetak, H. Č., Panek, M., Bender, D. V., Kelečić, D. L., Krznarić, Ž., & Verbanac, D. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17040578 · Cited by 71
Maintenance of gut homeostasis by the mucosal immune system
Okumura, R., & Takeda, K. (2016) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.92.423 · Cited by 77
Circular RNAs in colorectal cancer: Possible roles in regulation of cancer cells
Taborda, M. I., Ramírez, S., & Bernal, G. (2017) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v9.i2.62 · Cited by 68
Digesting the complex metabolic effects of diet on the host and microbiome
Carmody, R. N., Varady, K. A., & Turnbaugh, P. J. (2024) · Cell · doi:10.1016/j.cell.2024.06.032 · Cited by 76
Metadata
- Authors
- Devkota, S., Wang, Y., Musch, M. W., Leone, V., Fehlner-Peach, H., Nadimpalli, A., Antonopoulos, D. A., Jabri, B., & Chang, E. B.
- Affiliations
- University of Chicago (US)
- Argonne National Laboratory (US)
- Corresponding author
- Chang, Eugene B.
- ORCID
- Venue
- Nature
- Published
- 2012-06-13
- Volume
- 487
- Issue
- 7405
- Pages
- 104-108
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3393783
- OpenAlex
- W2151798187
- Cited by
- 1,904
- References
- 27
- Citations by year
- 2026: 106 · 2025: 137 · 2024: 144 · 2023: 140 · 2022: 164 · 2021: 162 · 2020: 139 · 2019: 144 · 2018: 133 · 2017: 144 · 2016: 125 · 2015: 115 · 2014: 118 · 2013: 103 · 2012: 26
- FWCI
- 46.57
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK047722, DK-47722, R37DK047722, R01DK097268, T32DK007074, UH3DK083993, DK42086, P30DK042086)
- National Center for Complementary and Integrative Health (F31AT006073)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Medicine › Gastroenterology › Microscopic Colitis
- Keywords
- taurocholate, milk fat, saturated fatty acids, Bilophila wadsworthia, colitis, IL-10-deficient mice, bile acid conjugation, taurine, gut dysbiosis, inflammatory bowel disease, Th1 response, Western diet, unsaturated fatty acids, safflower oil, gut microbiota
- MeSH terms
- Animals, Bile Acids and Salts, Colitis, Dietary Fats, Inflammation, Mice, Inbred C57BL, Milk, Molecular Sequence Data, Safflower Oil, Sulfites, Taurine, Taurocholic Acid, Inflammatory Bowel Diseases, Interleukin-10, Th1 Cells, Diet, Fat-Restricted, Bilophila, Mice, Metagenome
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