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Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice
Open accessAbstract
The composite human microbiome of Western populations has probably changed over the past century, brought on by new environmental triggers that often have a negative impact on human health. Here we show that consumption of a diet high in saturated (milk-derived) fat, but not polyunsaturated (safflower oil) fat, changes the conditions for microbial assemblage and promotes the expansion of a low-abundance, sulphite-reducing pathobiont, Bilophila wadsworthia. This was associated with a pro-inflammatory T helper type 1 (T(H)1) immune response and increased incidence of colitis in genetically susceptible Il10(−/−), but not wild-type mice. These effects are mediated by milk-derived-fat-promoted taurine conjugation of hepatic bile acids, which increases the availability of organic sulphur used by sulphite-reducing microorganisms like B. wadsworthia. When mice were fed a low-fat diet supplemented with taurocholic acid, but not with glycocholic acid, for example, a bloom of B. wadsworthia and development of colitis were observed in Il10(−/−) mice. Together these data show that dietary fats, by promoting changes in host bile acid composition, can markedly alter conditions for gut microbial assemblage, resulting in dysbiosis that can perturb immune homeostasis. The data provide a plausible mechanistic basis by which Western-type diets high in certain saturated fats might increase the prevalence of complex immune-mediated diseases like inflammatory bowel disease in genetically susceptible hosts.
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In the citing paper
“Bacteria with BSH activity have benefited from enhanced tolerance against bile and better survival in the gut environment (Begley et al., 2006;Devkota et al., 2012).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Devkota et al., 2012
Experimental — accuracy not yet measuredIn the citing paper
“In Il10−/− mice and mice without disruption of this gene, a diet high in saturated (milk-derived) fat (MF) promoted expansion of the immunogenic sulfite-reducing pathobiont Bilophila wadsworthia, a member of the Deltaproteobacteria.174”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [174]
In the citing paper
“Bilophila wadsworthia, a sulphite-reducing bacteria, has been associated with an increased incidence of colitis [52], and emerges under pathological conditions such as appendicitis and other intestinal inflammatory disorders [52].”
From Intestinal Microbiota Is Influenced by Gender and Body Mass Index (2016) · cites this paper as [52]
In the citing paper
“Consumption of milk fat has been shown to alter bile acid composition, promoting expansion of the sulphite-reducing pathobiont Bilophila wadsworthia and exacerbating colitis in IL10 knockout mice69.”
From Diet and the Intestinal Microbiome: Associations, Functions, and Implications for Health and Disease (2014) · cites this paper as [69]
In the citing paper
“B. wadsworthia increases gut inflammation in mice that lack in the anti-inflammatory cytokine interleukin (IL)-10.”
From Diet–microbiota interactions as moderators of human metabolism (2016) · cites this paper as [111]
In the citing paper
“Levels of the bacterium Bilophila wadsworthia increase when mice are fed a diet rich in milk fat or supplemented with the bile acid taurocholic acid111.”
From Diet–microbiota interactions as moderators of human metabolism (2016) · cites this paper as [111]
In the citing paper
“This is in line with the suggestion that SRB are linked to an inflammatory state of the gut 41, 42.”
From The composition of the gut microbiota shapes the colon mucus barrier (2015) · cites this paper as [42]
In the citing paper
“This pathobiont promotes Th1 type immune responses and increases susceptibility to colitis in IL10–/– mice.137”
From Interaction between microbiota and immunity in health and disease (2020) · cites this paper as [137]
In the citing paper
“The gut microbiota has been shown to differ between mice fed diets that are high or low in fat and between diets that contain equal amounts of fat but from different sources [10–13] (Fig. 1).”
From Dietary lipids, gut microbiota and lipid metabolism (2019) · cites this paper as [13]
In the citing paper
“Milk fat promoted taurine-conjugation of bile acids, which increases the availability of sulfur used by B. wadsworthia.”
From Dietary lipids, gut microbiota and lipid metabolism (2019) · cites this paper as [13]
In the citing paper
“The increased levels of B. wadsworthia were associated with a pro-inflammatory immune response and increased incidence of colitis in genetically susceptible mice.”
From Dietary lipids, gut microbiota and lipid metabolism (2019) · cites this paper as [13]
In the citing paper
“Devkota et al showed that a diet with milk fat, but not diets with lard or safflower oil, increased expansion of Bilophila wadsworthia in mice [13].”
From Dietary lipids, gut microbiota and lipid metabolism (2019) · cites this paper as [13]
In the citing paper
“This phyla has been shown to be intimately tied to a pro-inflammatory state.11,60,61”
From Using Corticosteroids to Reshape the Gut Microbiome: Implications for Inflammatory Bowel Diseases (2015) · cites this paper as [11]
In the citing paper
“For example, high SFA intake has been shown to be associated with reduction in total bacterial abundance in humans (95) and in microbial diversity and richness (95,96), as well as an increase in proinflammatory bacteria (e.g., Bilophila wadsworthia) (96)(97)(98) in mice.”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [96]
In the citing paper
“animals fed with a diet rich in animal-derived saturated fats demonstrated a significant increase in Proteobacteria (Bilophila wadsworthia) abundance (Devkota et al., 2012).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Devkota et al., 2012
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Cites
Molodecky, N. A., Soon, I. S., Rabi, D. M., Ghali, W. A., Ferris, M., Chernoff, G., Benchimol, E. I., Panaccione, R., Ghosh, S., Barkema, H. W., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2011.10.001 · Cited by 4,833
Turnbaugh, P. J., Bäckhed, F., Fulton, L., & Gordon, J. I. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.02.015 · Cited by 2,915
High-Fat Diet Determines the Composition of the Murine Gut Microbiome Independently of Obesity
Hildebrandt, M. A., Hoffmann, C., Sherrill–Mix, S. A., Keilbaugh, S. A., Hamady, M., Chen, Y., Knight, R., Ahima, R. S., Bushman, F., & Wu, G. D. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.08.042 · Cited by 1,576
Diet, gut microbiota and immune responses
Maslowski, K. M., & Mackay, C. R. (2011) · Nature Immunology · doi:10.1038/ni0111-5 · Cited by 1,261
Berg, D., Davidson, N. M., Kühn, R., Müller, W., Menon, S., Holland, G., Thompson-Snipes, L., Leach, M. W., & Rennick, D. M. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118861 · Cited by 1,125
The human gut microbiome: ecology and recent evolutionary changes
Walter, J., & Ley, R. (2011) · Annual Review of Microbiology · doi:10.1146/annurev-micro-090110-102830 · Cited by 720
Wang, Y., Hoenig, J. D., Malin, K. J., Qamar, S., Petrof, E. O., Sun, J., Antonopoulos, D. A., Chang, E. B., & Claud, E. C. (2009) · The ISME Journal · doi:10.1038/ismej.2009.37 · Cited by 600
Sulfate-reducing bacteria in human feces and their association with inflammatory bowel diseases
Loubinoux, J., Bronowicki, J., Pereira, I. A. C., Mougenel, J.-L., & Faou, A. L. (2002) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2002.tb00942.x · Cited by 404
Evidence That Hydrogen Sulfide Is a Genotoxic Agent
Attene‐Ramos, M. S., Wagner, E. D., Plewa, M. J., & Gaskins, H. R. (2006) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-05-0126 · Cited by 367
Dussurget, O., Cabanes, D., Dehoux, P., Lecuit, M., Buchrieser, C., Glaser, P., & Cossart, P. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.03080.x · Cited by 356
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Items 301–400 of 1,001
Bakiri, L., & Wagner, E. F. (2013) · Molecular Oncology · doi:10.1016/j.molonc.2013.01.005 · Cited by 173
Microbial Activities and Intestinal Homeostasis: A Delicate Balance Between Health and Disease
Ohland, C., & Jobin, C. (2014) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2014.11.004 · Cited by 177
The Role of Diet in Multiple Sclerosis: Mechanistic Connections and Current Evidence
Sand, I. K. (2018) · Current Nutrition Reports · doi:10.1007/s13668-018-0236-z · Cited by 181
Méndez-Salazar, E. O., Ortiz‐López, M. G., Granados‐Silvestre, M. D. L. Á., Palacios‐González, B., & Menjívar, M. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02494 · Cited by 187
Gerasimidis, K., Bryden, K., Chen, X., Papachristou, E., Verney, A., Roig, M. J., Hansen, R., Nichols, B., Papadopoulou, R., & Parrett, A. (2019) · European Journal of Nutrition · doi:10.1007/s00394-019-02161-8 · Cited by 179
Role of gut microbiota in identification of novel TCM-derived active metabolites
Lin, T., Lu, C., Lai, W.-F., Wu, T., Lu, J., Chen, Y.-M., Tzeng, C., Liu, H., Wei, H., & Lai, H. (2020) · Protein & Cell · doi:10.1007/s13238-020-00784-w · Cited by 175
Hu, Y. C., Leu, R. K. L., Christophersen, C. T., Somashekar, R., Conlon, M. A., Meng, X. Q., Winter, J. M., Woodman, R. J., McKinnon, R. A., & Young, G. P. (2016) · Carcinogenesis · doi:10.1093/carcin/bgw019 · Cited by 170
Seishima, J., Iida, N., Kitamura, K., Yutani, M., Wang, Z., Seki, A., Yamashita, T., Sakai, Y., Honda, M., Yamashita, T., et al. (2019) · Genome biology · doi:10.1186/s13059-019-1879-9 · Cited by 169
The role of gut microbiota in bone homeostasis
Behera, J., Ison, J., Tyagi, S. C., & Tyagi, N. (2020) · Bone · doi:10.1016/j.bone.2020.115317 · Cited by 162
Aleksandrova, K., Romero-Mosquera, B., & Hernández, V. (2017) · Nutrients · doi:10.3390/nu9090962 · Cited by 176
Aron, R. A. C., Abid, A., Vesa, C. M., Nechifor, A. C., Behl, T., Ghitea, T. C., Munteanu, M. A., Frățilă, O., Andronie-Cioară, F. L., Toma, M. M., et al. (2021) · Microorganisms · doi:10.3390/microorganisms9030618 · Cited by 174
Gut microbiome in modulating immune checkpoint inhibitors
Li, X., Zhang, S., Guo, G., Han, J., & Yu, J. Q. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104163 · Cited by 177
The "Gut Feeling": Breaking Down the Role of Gut Microbiome in Multiple Sclerosis
Freedman, S. N., Shahi, S. K., & Mangalam, A. K. (2018) · Neurotherapeutics · doi:10.1007/s13311-017-0588-x · Cited by 168
Gut dysbiosis in acute‐on‐chronic liver failure and its predictive value for mortality
Chen, Y., Guo, J., Qian, G., Fang, D., Shi, D., Guo, L., & Li, L. (2015) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12932 · Cited by 168
How Diet and Physical Activity Modulate Gut Microbiota: Evidence, and Perspectives
Campaniello, D., Corbo, M. R., Sinigaglia, M., Speranza, B., Racioppo, A., Altieri, C., & Bevilacqua, A. (2022) · Nutrients · doi:10.3390/nu14122456 · Cited by 178
Interactions between Diet, Bile Acid Metabolism, Gut Microbiota, and Inflammatory Bowel Diseases
Devkota, S., & Chang, E. B. (2015) · Digestive Diseases · doi:10.1159/000371687 · Cited by 167
Self-citationThe Fire Within: Microbes Inflame Tumors
Gagliani, N., Hu, B., Huber, S., Elinav, E., & Flavell, R. A. (2014) · Cell · doi:10.1016/j.cell.2014.03.006 · Cited by 168
Co-evolution in context: The importance of studying gut microbiomes in wild animals
Amato, K. R. (2013) · Microbiome Science and Medicine · doi:10.2478/micsm-2013-0002 · Cited by 168
The Role of Dietary Nutrients in Inflammatory Bowel Disease
Sugihara, K., Morhardt, T. L., & Kamada, N. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03183 · Cited by 172
Chen, W., Wei, Y., Xiong, A., Li, Y., Guan, H., Wang, Q., Miao, Q., Bian, Z., Xiao, X., Lian, M., et al. (2020) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-019-08731-2 · Cited by 166
Zhou, X., Cao, L., Jiang, C., Xie, Y., Cheng, X., Krausz, K. W., Qi, Y., Sun, L., Shah, Y. M., Gonzalez, F. J., et al. (2014) · Nature Communications · doi:10.1038/ncomms5573 · Cited by 162
The gut microbiota in mouse models of inflammatory bowel disease
Gkouskou, K. K., Deligianni, C., Tsatsanis, C., & Eliopoulos, A. G. (2014) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2014.00028 · Cited by 164
Pathophysiology, Evaluation, and Management of Chronic Watery Diarrhea
Camilleri, M., Sellin, J. H., & Barrett, K. E. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.10.014 · Cited by 165
Constante, M., Fragoso, G., Calvé, A., Samba-Mondonga, M., & Santos, M. M. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01809 · Cited by 161
The dynamic biliary epithelia: Molecules, pathways, and disease
O’Hara, S. P., Tabibian, J. H., Splinter, P. L., & LaRusso, N. F. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.10.011 · Cited by 168
A Guide to Diet-Microbiome Study Design
Johnson, A. J., Zheng, J. J., Kang, J. W., Saboe, A., Knights, D., & Zivkovic, A. M. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2020.00079 · Cited by 168
Hertel, J., Harms, A. C., Heinken, A., Baldini, F., Thinnes, C. C., Glaab, E., Vasco, D. A., Pietzner, M., Stewart, I. D., Wareham, N. J., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.10.035 · Cited by 162
Rodrigues, R. R., Gurung, M., Li, Z., García‐Jaramillo, M., Greer, R. L., Gaulke, C. A., Bauchinger, F., You, H., Pederson, J. W., Vasquez‐Perez, S., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20313-x · Cited by 163
New insights into the mechanisms of high‐fat diet mediated gut microbiota in chronic diseases
Chen, J., Xiao, Y., Li, D., Zhang, S., Wu, Y., Zhang, Q., & Bai, W. (2023) · iMeta · doi:10.1002/imt2.69 · Cited by 178
Shen, W., Gaskins, H. R., & McIntosh, M. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.09.009 · Cited by 166
Cytokine Networks and T-Cell Subsets in Inflammatory Bowel Diseases
Chen, M. L., & Sundrud, M. S. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000714 · Cited by 162
Diet and microbiota in inflammatory bowel disease: The gut in disharmony
Rapozo, D. C. M., Bernardazzi, C., & de Souza, H. S. P. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i12.2124 · Cited by 169
High-fat or high-sugar diets as trigger inflammation in the microbiota-gut-brain axis
Jamar, G., Ribeiro, D. A., & Pisani, L. P. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1747046 · Cited by 172
Metabolic Influences of Gut Microbiota Dysbiosis on Inflammatory Bowel Disease
Sultan, S., El‐Mowafy, M., Elgaml, A., Ahmed, T. A., Hassan, H., & Mottawea, W. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.715506 · Cited by 170
Adipose-Tissue and Intestinal Inflammation – Visceral Obesity and Creeping Fat
Kredel, L. I., & Siegmund, B. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00462 · Cited by 166
Kienesberger, S., Cox, L. M., Livanos, A. E., Zhang, X., Chung, J., Perez-Perez, G. I., Gorkiewicz, G., Zechner, E. L., & Blaser, M. J. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.01.017 · Cited by 159
Olesen, S. W., & Alm, E. J. (2016) · Nature Microbiology · doi:10.1038/nmicrobiol.2016.228 · Cited by 154
D’Argenio, V., Casaburi, G., Precone, V., Pagliuca, C., Colicchio, R., Sarnataro, D., Discepolo, V., Kim, S. M., Russo, I., Blanco, G. D. V., et al. (2016) · The American Journal of Gastroenterology · doi:10.1038/ajg.2016.95 · Cited by 154
Host-microbiota interaction-mediated resistance to inflammatory bowel disease in pigs
Zhao, X., Jiang, L., Fang, X., Guo, Z., Wang, X., Shi, B., & Meng, Q. (2022) · Microbiome · doi:10.1186/s40168-022-01303-1 · Cited by 159
Zhu, C., Sawrey-Kubicek, L., Beals, E., Rhodes, C. H., Houts, H. E., Sacchi, R., & Zivkovic, A. M. (2020) · Nutrition Research · doi:10.1016/j.nutres.2020.03.005 · Cited by 153
Functional Impacts of the Intestinal Microbiome in the Pathogenesis of Inflammatory Bowel Disease
Li, J. S. Y., Butcher, J., Mack, D. R., & Stintzi, A. (2014) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000215 · Cited by 152
Vijay-Kumar, M., Chassaing, B., Kumar, M., Baker, M. T., & Singh, V. K. (2014) · Biomedical Journal · doi:10.4103/2319-4170.130922 · Cited by 166
Medical comorbidity in bipolar disorder: The link with metabolic-inflammatory systems
SayuriYamagata, A., Brietzke, E. M., Rosenblat, J. D., Kakar, R., & McIntyre, R. S. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.12.059 · Cited by 160
Miyoshi, J., Bobe, A. M., Miyoshi, S., Huang, Y., Hubert, N., Delmont, T. O., Eren, A. M., Leone, V., & Chang, E. B. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.06.060 · Cited by 156
Lv, L., Li, S., Li, S.-C., Zhong, Z.-C., Duan, H., Cheng, T., Li, H., He, W., Chen, M.-C., He, T., et al. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00224 · Cited by 156
Deconstructing Mechanisms of Diet-Microbiome-Immune Interactions
Alexander, M., & Turnbaugh, P. J. (2020) · Immunity · doi:10.1016/j.immuni.2020.07.015 · Cited by 151
Nutritional regulation of microbiota-derived metabolites: Implications for immunity and inflammation
Arifuzzaman, M., Collins, N., Guo, C., & Artis, D. (2024) · Immunity · doi:10.1016/j.immuni.2023.12.009 · Cited by 159
The Gordian Knot of dysbiosis, obesity and NAFLD
Mehal, W. Z. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.146 · Cited by 156
The role of bile acids in metabolic regulation
Vítek, L., & Haluzík, M. (2016) · Journal of Endocrinology · doi:10.1530/joe-15-0469 · Cited by 157
Diet as a Therapeutic Option for Adult Inflammatory Bowel Disease
Kakodkar, S., & Mutlu, E. (2017) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2017.08.016 · Cited by 158
Diet, Microbiota, and Metabolic Health: Trade-Off Between Saccharolytic and Proteolytic Fermentation
Korpela, K. (2018) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-030117-012830 · Cited by 161
Liver–Microbiome Axis in Health and Disease
Adolph, T. E., Grander, C., Moschen, A. R., & Tilg, H. (2018) · Trends in Immunology · doi:10.1016/j.it.2018.05.002 · Cited by 167
Sulfur Cycling and the Intestinal Microbiome
Barton, L. L., Ritz, N. L., Fauque, G. D., & Lin, H. C. (2017) · Digestive Diseases and Sciences · doi:10.1007/s10620-017-4689-5 · Cited by 149
Chen, J., Thomsen, M., & Vitetta, L. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27635 · Cited by 155
Emerging roles of hydrogen sulfide in inflammatory and neoplastic colonic diseases
Guo, F.-F., Yu, T.-C., Hong, J., & Fang, J.-Y. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00156 · Cited by 146
The gut microbiota and the metabolic health of the host
Joyce, S. A., & Gahan, C. G. M. (2014) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000039 · Cited by 147
Wong, C. B., Odamaki, T., & Xiao, J. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.02.002 · Cited by 151
Wotzka, S. Y., Kreuzer, M., Maier, L., Arnoldini, M., Nguyen, B. D., Brachmann, A. O., Berthold, D. L., Zünd, M., Hausmann, A., Bakkeren, E., et al. (2019) · Nature Microbiology · doi:10.1038/s41564-019-0568-5 · Cited by 141
den Bossche, L. V., Hindryckx, P., Devisscher, L., Devriese, S., Welden, S. V., Holvoet, T., Vilchez‐Vargas, R., Vital, M., Pieper, D. H., Bussche, J. V., et al. (2017) · Applied and Environmental Microbiology · doi:10.1128/aem.02766-16 · Cited by 146
Shankar, V., Gouda, M., Moncivaiz, J. D., Gordon, A., Reo, N. V., Hussein, L., & Paliy, O. (2017) · mSystems · doi:10.1128/msystems.00169-16 · Cited by 152
Microbiota Features Associated With a High-Fat/Low-Fiber Diet in Healthy Adults
Bailén, M., Bressa, C., Martínez‐López, S., González-Soltero, R., Montalvo-Lominchar, M. G., Juan, C. S., & Larrosa, M. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2020.583608 · Cited by 152
The gut microbiota and inflammatory bowel diseases
Miyoshi, J., & Chang, E. B. (2016) · Translational research · doi:10.1016/j.trsl.2016.06.002 · Cited by 151
Yu, J. S., Youn, G. S., Choi, J., Kim, C., Kim, B., Yang, S., Lee, J., Park, T., Kim, B. K., Kim, Y. B., et al. (2021) · Clinical and Translational Medicine · doi:10.1002/ctm2.634 · Cited by 147
Diet, microbes, and host genetics: the perfect storm in inflammatory bowel diseases
Leone, V., Chang, E. B., & Devkota, S. (2013) · Journal of Gastroenterology · doi:10.1007/s00535-013-0777-2 · Cited by 147
Self-citationMicrobiota, NASH, HCC and the potential role of probiotics
Brandi, G., Lorenzo, S. D., Candela, M., Pantaleo, M. A., Bellentani, S., Tovoli, F., Saccoccio, G., & Biasco, G. (2017) · Carcinogenesis · doi:10.1093/carcin/bgx007 · Cited by 141
Diet, the human gut microbiota, and IBD
Wu, G. D., Bushmanc, F. D., & Lewis, J. D. (2013) · Anaerobe · doi:10.1016/j.anaerobe.2013.03.011 · Cited by 144
Kang, M., & Martín, A. (2017) · Seminars in Immunology · doi:10.1016/j.smim.2017.04.003 · Cited by 143
Yang, T., Shu, T., Liu, G., Mei, H., Zhu, X., Huang, X., Zhang, L., & Jiang, Z. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2017.05.015 · Cited by 143
Plieskatt, J. L., Deenonpoe, R., Mulvenna, J. P., Krause, L., Sripa, B., Bethony, J. M., & Brindley, P. J. (2013) · The FASEB Journal · doi:10.1096/fj.13-232751 · Cited by 141
Roy, U., Gálvez, E. J. C., Iljazović, A., Lesker, T. R., Błażejewski, A. J., Pils, M. C., Heise, U., Huber, S., Flavell, R. A., & Strowig, T. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.097 · Cited by 140
Understanding bile acid signaling in diabetes: From pathophysiology to therapeutic targets
Ferrell, J. M., & Chiang, J. Y. L. (2019) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2019.0043 · Cited by 139
Lymphotoxin signalling in immune homeostasis and the control of microorganisms
Upadhyay, V., & Fu, Y. (2013) · Nature reviews. Immunology · doi:10.1038/nri3406 · Cited by 136
Exploring and Understanding the Biochemical Diversity of the Human Microbiota
Koppel, N., & Balskus, E. P. (2016) · Cell chemical biology · doi:10.1016/j.chembiol.2015.12.008 · Cited by 140
Bacteriophages and their potential for treatment of gastrointestinal diseases
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Forster, S. C., Clare, S., Beresford-Jones, B. S., Harcourt, K., Notley, G., Stares, M., Kumar, N., Soderholm, A. T., Adoum, A., Wong, H. E., et al. (2022) · Nature Microbiology · doi:10.1038/s41564-022-01094-z · Cited by 153
Diet fuelling inflammatory bowel diseases: preclinical and clinical concepts
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Ha, C. W. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i44.16498 · Cited by 137
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Ridlon, J. M., Devendran, S., Alves, J. M. P., Doden, H. L., Wolf, P. G., Pereira, G. V., Ly, L. K., Volland, A., Takei, H., Nittono, H., et al. (2019) · Gut Microbes · doi:10.1080/19490976.2019.1618173 · Cited by 141
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Sheng, L., Jena, P. K., Hu, Y. C., Liu, H., Nagar, N., Kalanetra, K. M., French, S. W., French, S. W., Mills, D. A., & Wan, Y. Y. (2017) · The Journal of Pathology · doi:10.1002/path.4983 · Cited by 133
Huang, E. Y., Leone, V. A., Devkota, S., Wang, Y., Brady, M. J., & Chang, E. B. (2013) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607113486931 · Cited by 133
Self-citationPavlidis, P., Powell, N., Vincent, R. P., Ehrlich, S. D., Bjarnason, I., & Hayee, B. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13333 · Cited by 135
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Olson, C. A., Iñiguez, A. J., Yang, G. E., Fang, P., Pronovost, G. N., Jameson, K. G., Rendon, T. K., Paramo, J., Barlow, J. T., Ismagilov, R. F., et al. (2021) · Cell Host & Microbe · doi:10.1016/j.chom.2021.07.004 · Cited by 126
Clavel, T., Lepage, P., & Charrier, C. (2014) · Springer eBooks · doi:10.1007/978-3-642-30138-4_343 · Cited by 128
Metadata
- Authors
- Devkota, S., Wang, Y., Musch, M. W., Leone, V., Fehlner-Peach, H., Nadimpalli, A., Antonopoulos, D. A., Jabri, B., & Chang, E. B.
- Affiliations
- University of Chicago (US)
- Argonne National Laboratory (US)
- Corresponding author
- Chang, Eugene B.
- ORCID
- Venue
- Nature
- Published
- 2012-06-13
- Volume
- 487
- Issue
- 7405
- Pages
- 104-108
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3393783
- OpenAlex
- W2151798187
- Cited by
- 1,904
- References
- 27
- Citations by year
- 2026: 106 · 2025: 137 · 2024: 144 · 2023: 140 · 2022: 164 · 2021: 162 · 2020: 139 · 2019: 144 · 2018: 133 · 2017: 144 · 2016: 125 · 2015: 115 · 2014: 118 · 2013: 103 · 2012: 26
- FWCI
- 46.57
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK047722, DK-47722, R37DK047722, R01DK097268, T32DK007074, UH3DK083993, DK42086, P30DK042086)
- National Center for Complementary and Integrative Health (F31AT006073)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Medicine › Gastroenterology › Microscopic Colitis
- Keywords
- taurocholate, milk fat, saturated fatty acids, Bilophila wadsworthia, colitis, IL-10-deficient mice, bile acid conjugation, taurine, gut dysbiosis, inflammatory bowel disease, Th1 response, Western diet, unsaturated fatty acids, safflower oil, gut microbiota
- MeSH terms
- Animals, Bile Acids and Salts, Colitis, Dietary Fats, Inflammation, Mice, Inbred C57BL, Milk, Molecular Sequence Data, Safflower Oil, Sulfites, Taurine, Taurocholic Acid, Inflammatory Bowel Diseases, Interleukin-10, Th1 Cells, Diet, Fat-Restricted, Bilophila, Mice, Metagenome
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