The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Transcriptional regulation of autophagy by an FXR–CREB axis
Open accessAbstract
Lysosomal degradation of cytoplasmic components by autophagy is essential for cellular survival and homeostasis under nutrient-deprived conditions. Acute regulation of autophagy by nutrient-sensing kinases is well defined, but longer-term transcriptional regulation is relatively unknown. Here we show that the fed-state sensing nuclear receptor farnesoid X receptor (FXR) and the fasting transcriptional activator cAMP response element-binding protein (CREB) coordinately regulate the hepatic autophagy gene network. Pharmacological activation of FXR repressed many autophagy genes and inhibited autophagy even in fasted mice, and feeding-mediated inhibition of macroautophagy was attenuated in FXR-knockout mice. From mouse liver chromatin immunoprecipitation and high-throughput sequencing data, FXR and CREB binding peaks were detected at 178 and 112 genes, respectively, out of 230 autophagy-related genes, and 78 genes showed shared binding, mostly in their promoter regions. CREB promoted autophagic degradation of lipids, or lipophagy, under nutrient-deprived conditions, and FXR inhibited this response. Mechanistically, CREB upregulated autophagy genes, including Atg7, Ulk1 and Tfeb, by recruiting the coactivator CRTC2. After feeding or pharmacological activation, FXR trans-repressed these genes by disrupting the functional CREB–CRTC2 complex. This study identifies the new FXR–CREB axis as a key physiological switch regulating autophagy, resulting in sustained nutrient regulation of autophagy during feeding/fasting cycles.
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Metadata
- Authors
- Seok, S., Fu, T., Choi, S.-E., Li, Y., Zhu, R., Kumar, S., Sun, X., Yoon, G., Kang, Y., Zhong, W., Ma, J., Kemper, B., & Kemper, J. K.
- Venue
- Nature
- Published
- 2014-11-12
- Volume
- 516
- Issue
- 7529
- Pages
- 108-111
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2066662062
- Cited by
- 429
- References
- 11
- FWCI
- 26.07
- Type
- journal article
- Language
- en
- Open access
- green
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