Cited by 251Wound Healing and TreatmentsLiver physiology and pathologyCardiac Fibrosis and Remodeling

The Inflammation–Fibrosis Link? A Jekyll and Hyde Role for Blood Cells during Wound Repair

Open access
Stramer, Brian M., Mori, Ryoichi, Martin, Paul·2007·Journal of Investigative Dermatology

Abstract

The healing of a skin wound is a complex process involving many cell lineages. In adult tissues, repair is always accompanied by a robust inflammatory response, which is necessary to counter the potential for infection at any site where the skin barrier is breached. Unlike embryonic tissues that can repair perfectly without a remnant scar at the wound site, adult tissue repair always leads to formation of a fibrotic scar where the wound has healed. In recent years, it has become clear that the wound inflammatory response may be, at least in part, responsible for fibrosis at sites of tissue repair. In this review, we consider the beneficial vs the detrimental functions of inflammatory cells during the repair response and compare data from other tissues, the lung, and liver, where fibrosis and its resolution may be related to a damage-triggered inflammatory response. We also consider how it may be possible to molecularly disentangle the potentially good from the bad influences of inflammatory cells during tissue repair and how fundamental studies in inflammatory cell biology may prove the way forward for development of drug targets in this respect.

Integrity signals

Registry

Crossref · 10.1038/sj.jid.5700811

Cites

88 of 88 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Excessive ECM deposition by myofibroblasts can lead to fibrosis, scarring, and loss of tissue function if not kept in check.

    “However, if ECM synthesis in myofibroblasts is not kept in check, then excessive matrix deposition can lead to fibrosis, scarring, and loss of tissue function [120–122].”

    From CCN1/CYR61: the very model of a modern matricellular protein (2011) · cites this paper as [121]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Stramer, B. M., Mori, R., & Martin, P.
Affiliations
University of Bristol (GB)
Corresponding author
Stramer, Brian M.
Venue
Journal of Investigative Dermatology
Publisher
Elsevier BV
Published
2007-05
Volume
127
Issue
5
Pages
1009-1017
ISSN
0022-202X (ISSN-L)
OpenAlex
W1996789266
Cited by
251
References
88
Citations by year
2026: 7 · 2025: 7 · 2024: 15 · 2023: 11 · 2022: 7 · 2021: 5 · 2020: 8 · 2019: 8 · 2018: 22 · 2017: 12 · 2016: 19 · 2015: 11 · 2014: 16 · 2013: 16 · 2012: 13
FWCI
2.24
Type
journal article
Language
en
Open access
Locations
  • Journal of Investigative Dermatology (publishedVersion)
  • PubMed (publishedVersion)
  • Bristol Research (University of Bristol) (publishedVersion)
Topics
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Keywords
wound healing, skin fibrosis, inflammation, inflammatory cells, scar formation, tissue repair, pulmonary fibrosis, liver fibrosis, fibrosis resolution, therapeutic target
MeSH terms
Animals, Blood Cells, Cicatrix, Fibrosis, Humans, Inflammation, Liver Cirrhosis, Pulmonary Fibrosis, Skin, Wound Healing

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review