Cited by 191IL-33, ST2, and ILC PathwaysT-cell and B-cell ImmunologyImmune Response and Inflammation

The Stromal Intervention: Regulation of Immunity and Inflammation at the Epithelial-Mesenchymal Barrier

Open access
Nowarski, Roni, Jackson, Ruaidhrí, Flavell, Richard A.·2017·Cell

Abstract

The immune system safeguards organ integrity by employing a balancing act of inflammatory and immunosuppressive mechanisms designed to neutralize foreign invaders and resolve injury. Maintaining or restoring a state of immune homeostasis is particularly challenging at barrier sites where constant exposure to immunogenic environmental agents may induce destructive inflammation. Recent studies underscore the role of epithelial and mesenchymal barrier cells in regulating immune cell function and local homeostatic and inflammatory responses. Here, we highlight immunoregulatory circuits engaging epithelial and mesenchymal cells in the intestine, airways, and skin and discuss how immune communications with hematopoietic cells and the microbiota orchestrate local immune homeostasis and inflammation.

Integrity signals

Registry

Crossref · 10.1016/j.cell.2016.11.040

Cites

128 of 128 references verified0 citation errors · 0 not checkable

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  • Structural cells (epithelium, endothelium, and fibroblasts) have been shown to contribute in important ways to mammalian immunity.

    “These three cell types, which we refer to as “structural cells”, have been shown to contribute in important ways to mammalian immunity7–11.”

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Authors
Nowarski, R., Jackson, R., & Flavell, R. A.
Affiliations
  • Yale University (US)
  • Howard Hughes Medical Institute (US)
Corresponding author
Flavell, Richard A.
Venue
Cell
Publisher
Elsevier BV
Published
2017-01
Volume
168
Issue
3
Pages
362-375
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2580798654
Cited by
191
References
129
Citations by year
2026: 16 · 2025: 13 · 2024: 21 · 2023: 18 · 2022: 19 · 2021: 33 · 2020: 33 · 2019: 14 · 2018: 14 · 2017: 10
FWCI
1.99
Type
journal article
Language
en
Open access
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
immune regulation, inflammation, immune homeostasis, epithelial cells, mesenchymal cells, hematopoietic cells, microbiota, intestinal immunity, airway immunity, skin immunity
MeSH terms
Animals, Epithelial Cells, Epithelium, Homeostasis, Humans, Infections, Inflammation, Intestines, Mesoderm, Respiratory System

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