Cited by 687Monoclonal and Polyclonal Antibodies ResearchT-cell and B-cell ImmunologyGenomics and Phylogenetic Studies

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The promise and challenge of high-throughput sequencing of the antibody repertoire

Open access

Georgiou, George, Ippolito, Gregory C, Beausang, John, Busse, Christian E, Wardemann, Hedda, Quake, Stephen R·2014·Nature Biotechnology

DOI 10.1038/nbt.2782PMC PMC4113560

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Abstract

Efforts to determine the antibody repertoire encoded by B cells in the blood or lymphoid organs using high-throughput DNA sequencing technologies have been advancing at an extremely rapid pace and are transforming our understanding of humoral immune responses. Information gained from high-throughput DNA sequencing of immunoglobulin genes (Ig-seq) can be applied to detect B-cell malignancies with high sensitivity, to discover antibodies specific for antigens of interest, to guide vaccine development and to understand autoimmunity. Rapid progress in the development of experimental protocols and informatics analysis tools is helping to reduce sequencing artifacts, to achieve more precise quantification of clonal diversity and to extract the most pertinent biological information. That said, broader application of Ig-seq, especially in clinical settings, will require the development of a standardized experimental design framework that will enable the sharing and meta-analysis of sequencing data generated by different laboratories.

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Additional file 16 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691664
Additional file 19 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691673
Additional file 35 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691721
Additional file 3 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691622
Additional file 9 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691643
Additional file 11 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691649
Additional file 22 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691682
Additional file 17 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691667
Additional file 36 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691724
Additional file 7 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691637
Additional file 34 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691718
Additional file 23 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691685
Additional file 28 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691700
Additional file 33 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691715
Additional file 29 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691703
Additional file 31 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691709
Additional file 6 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691634
Additional file 27 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691697
Additional file 10 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691646
Additional file 18 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691670
Additional file 37 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691727
Additional file 12 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691652
Additional file 5 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691631
Additional file 1 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25389502
Additional file 2 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25389926
Additional file 24 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691688
Additional file 14 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691658
Additional file 15 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691661
Additional file 26 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691694
Additional file 13 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691655
Additional file 25 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691691
Additional file 39 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691736
Additional file 4 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., Lasanta, M. L., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691625
Additional file 21 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691679
Additional file 8 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691640
Additional file 20 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691676
Additional file 38 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., Lasanta, M. L., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691733
Additional file 30 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691706
Additional file 32 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., Lasanta, M. L., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691712
Additional file 40 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Fernandez, S. S., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691739
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Authors: Georgiou, G., Ippolito, G. C., Beausang, J., Busse, C. E., Wardemann, H., & Quake, S. R.
Affiliations: The University of Texas at Austin (US)
Howard Hughes Medical Institute (US)
Max Planck Institute for Infection Biology (DE)
Corresponding author: Georgiou, George
ORCID: Georgiou, George
Ippolito, Gregory C
Busse, Christian E
Wardemann, Hedda
Quake, Stephen R
Venue: Nature Biotechnology
Publisher: Springer Science and Business Media LLC
Published: 2014-01-19
Volume: 32
Issue: 2
Pages: 158-168
ISSN: 0733-222X (ISSN-L)
1087-0156
1546-1696
DOI: 10.1038/nbt.2782
PMC: PMC4113560
OpenAlex: W1993928780
Cited by: 652
References: 141
Citations by year: 2026: 24 · 2025: 34 · 2024: 50 · 2023: 26 · 2022: 39 · 2021: 49 · 2020: 52 · 2019: 56 · 2018: 74 · 2017: 83 · 2016: 78 · 2015: 54 · 2014: 33
FWCI: 12.91
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Biotechnology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Max Planck Digital Library (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Funders: Howard Hughes Medical Institute
National Institutes of Health
National Institute of Allergy and Infectious Diseases (U54AI057156)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Monoclonal and Polyclonal Antibodies Research
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
Keywords: antibody repertoire, B cells, humoral immune response, B-cell malignancies, antibody discovery, vaccine development, autoimmunity, sequencing artifacts
MeSH terms: Animals, Humans, Immunoglobulins, Immunologic Techniques, Models, Immunological, Biomedical Research, Mice, High-Throughput Nucleotide Sequencing

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The promise and challenge of high-throughput sequencing of the antibody repertoire

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