The promise and challenge of high-throughput sequencing of the antibody repertoire

Antibody therapy of cancer

Scott, A. M., Wolchok, J. D., & Old, L. J. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3236 · Cited by 2,244

Predominant Autoantibody Production by Early Human B Cell Precursors

Wardemann, H., Yurasov, S., Schaefer, A., Young, J. W., Meffre, E., & Nussenzweig, M. C. (2003) · Science · doi:10.1126/science.1086907 · Cited by 2,088

Germinal Centers

Victora, G. D., & Nussenzweig, M. C. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075032 · Cited by 1,878

Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target

Walker, L., Phogat, S., Chan-hui, P., Wagner, D., Pham, P., Goss, J. L., Wrin, T., Simek, M., Fling, S., Mitcham, J., et al. (2009) · Science · doi:10.1126/science.1178746 · Cited by 1,849

Prevalence of monoclonal gammopathy of undetermined significance

Kyle, R. A., Therneau, T. M., Rajkumar, S. V., Larson, D. R., Plevak, M. F., Offord, J. R., Dispenzieri, A., Katzmann, J. A., & Melton, L. J. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa054494 · Cited by 1,423

Performance comparison of benchtop high-throughput sequencing platforms

Loman, N. J., Misra, R., Dallman, T. J., Constantinidou, C., Gharbia, S. E., Wain, J. R., & Pallen, M. J. (2012) · Nature Biotechnology · doi:10.1038/nbt.2198 · Cited by 1,383

A Neutralizing Antibody Selected from Plasma Cells That Binds to Group 1 and Group 2 Influenza A Hemagglutinins

Corti, D., Voss, J., Gamblin, S. J., Codoni, G., Macagno, A., Jarrossay, D., Vachieri, S. G., Pinna, D., Minola, A., Vanzetta, F., et al. (2011) · Science · doi:10.1126/science.1205669 · Cited by 1,203

Human Immunoglobulin (Ig)M+IgD+ Peripheral Blood B Cells Expressing the CD27 Cell Surface Antigen Carry Somatically Mutated Variable Region Genes: CD27 as a General Marker for Somatically Mutated (Memory) B Cells

Klein, U., Rajewsky, K., & Küppers, R. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.9.1679 · Cited by 1,161

Detection and quantification of rare mutations with massively parallel sequencing

Kinde, I., Wu, J., Papadopoulos, N., Kinzler, K. W., & Vogelstein, B. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105422108 · Cited by 1,144

Comparative analysis of the feline immunoglobulin repertoire

Steiniger, S. C. J., Glanville, J., Harris, D. W., Wilson, T. L., Ippolito, G. C., & Dunham, S. A. (2017) · Biologicals · doi:10.1016/j.biologicals.2017.01.004 · Cited by 9

Unraveling the Repertoire in Wiskott–Aldrich Syndrome

Petersen, S. H., Sendel, A., van der Burg, M., & Westerberg, L. S. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00539 · Cited by 8

Selection of therapeutic H5N1 monoclonal antibodies following IgVH repertoire analysis in mice

Gray, S. A., Moore, M. D., VandenEkart, E., Roque, R., Bowen, R. A., Hoeven, N. V., Wiley, S. R., & Clegg, C. H. (2016) · Antiviral Research · doi:10.1016/j.antiviral.2016.04.001 · Cited by 8

Unbiased RACE-Based Massive Parallel Surveys of Human IgA Antibody Repertoires

Bannoudi, H. E., Anquetil, C., Braunstein, M. J., Pond, S. L. K., & Silverman, G. J. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7180-0_5 · Cited by 8

A High-Throughput Magnetic Nanoparticle-Based Semi-Automated Antibody Phage Display Biopanning

Ch’ng, A. C. W., Ahmad, A., Konthur, Z., & Lim, T. S. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8958-4_18 · Cited by 8

Deep phenotypic characterization of immunization-induced antibacterial IgG repertoires in mice using a single-antibody bioassay

Heo, M., Chenon, G., Castrillon, C. E., Bibette, J., Bruhns, P., Griffiths, A. D., Baudry, J., & Eyer, K. (2020) · Communications Biology · doi:10.1038/s42003-020-01296-3 · Cited by 8

A scalable model for simulating multi-round antibody evolution and benchmarking of clonal tree reconstruction methods

Zhang, C., Bzikadze, A. V., Safonova, Y., & Mirarab, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1014439 · Cited by 9

Complete variable domain sequences of monoclonal antibody light chains identified from untargeted RNA sequencing data

Nau, A. N., Shen, Y., Sanchorawala, V., Prokaeva, T. B., & Morgan, G. J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1167235 · Cited by 8

In situproduction of therapeutic monoclonal antibodies

Suscovich, T. J., & Alter, G. (2015) · Expert Review of Vaccines · doi:10.1586/14760584.2015.1001375 · Cited by 9

Mapping serum antibody repertoires using peptide libraries

Paull, M. L., & Daugherty, P. S. (2018) · Current Opinion in Chemical Engineering · doi:10.1016/j.coche.2017.12.001 · Cited by 8

Cross-Reactive Bactericidal Antimeningococcal Antibodies Can Be Isolated From Convalescing Invasive Meningococcal Disease Patients Using Reverse Vaccinology 2.0

Bidmos, F. A., Nadel, S., Screaton, G. R., Kroll, J. S., & Langford, P. R. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01621 · Cited by 8

Simultaneous polyclonal antibody sequencing and epitope mapping by cryo electron microscopy and mass spectrometryPreprint

Schulte, D., Šiborová, M., Käll, L., & Snijder, J. (2025) · eLife · doi:10.7554/elife.101322 · Cited by 7

Studying Antibody Repertoires with Next-Generation Sequencing

Lees, W., & Shepherd, A. J. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6613-4_15 · Cited by 7

Applications of High-Throughput DNA Sequencing to Single-Domain Antibody Discovery and Engineering

Lowden, M. J., Lei, E. K., Hussack, G., & Henry, K. A. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-3381-6_26 · Cited by 7

A transplant “immunome” screening platform defines a targetable epitope fingerprint of multiple myeloma

Schieferdecker, A., Oberle, A., Thiele, B., Hofmann, F., Göthel, M., Miethe, S., Hust, M., Braig, F., Voigt, M., von Pein, U., et al. (2016) · Blood · doi:10.1182/blood-2015-10-676536 · Cited by 7

A comparison of unamplified and massively multiplexed PCR amplification for murine antibody repertoire sequencing

Rettig, T. A., Pecaut, M. J., & Chapes, S. K. (2018) · FASEB BioAdvances · doi:10.1096/fba.1017 · Cited by 7

Exploiting next-generation sequencing in antibody selections – a simple PCR method to recover binders

Ferrara, F., Teixeira, A. A. R., Naranjo, L. A., Erasmus, M. F., D’Angelo, S., & Bradbury, A. M. (2019) · mAbs · doi:10.1080/19420862.2019.1701792 · Cited by 7

Deep Mining of Human Antibody Repertoires: Concepts, Methodologies, and Applications

Tian, X., Li, C., Wu, Y., & Ying, T. (2020) · Small Methods · doi:10.1002/smtd.202000451 · Cited by 6

RAPID: A Rep-Seq Dataset Analysis Platform With an Integrated Antibody Database

Zhang, Y., Chen, T., Zeng, H., Yang, X., Xu, Q., Zhang, Y., Chen, Y., Wang, M., Zhu, Y., Lan, C., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.717496 · Cited by 7

THE MAJOR ROLE OF JUNCTIONAL DIVERSITY IN THE HORSE ANTIBODY REPERTOIRE

Navas, C., Manso, T., Martins, F., Minto, L., Moreira, R., Minozzo, J. C., Antunes, B. C., Vale, A. M., McDaniel, J. R., Ippolito, G. C., et al. (2022) · Molecular Immunology · doi:10.1016/j.molimm.2022.09.011 · Cited by 7

The Impact of “Omic” and Imaging Technologies on Assessing the Host Immune Response to Biodefence Agents

Tree, J. A., Flick-Smith, H. C., Elmore, M. J., & Rowland, C. A. (2014) · Journal of Immunology Research · doi:10.1155/2014/237043 · Cited by 7

Oxford Nanopore Sequencing Enables Rapid Discovery of Single-Domain Antibodies from Phage Display Libraries

Lowden, M. J., & Henry, K. A. (2018) · BioTechniques · doi:10.2144/btn-2018-0123 · Cited by 7

Analysis by Flow Cytometry of B-Cell Activation and Antibody Responses Induced by Toll-Like Receptors

Pone, E. J. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3335-8_15 · Cited by 7

Omics-driven startups challenge healthcare model

Sheridan, C. (2015) · Nature Biotechnology · doi:10.1038/nbt0915-887 · Cited by 7

Large-scale integrative analysis of juvenile idiopathic arthritis for new insight into its pathogenesis

Kim, D., Song, J., Mancuso, N., Mangul, S., Ahn, C. W., Jang, W., & Jang, W. (2024) · Arthritis Research & Therapy · doi:10.1186/s13075-024-03280-2 · Cited by 7

Local and Global Variability in Developing Human T-Cell Repertoires

Isacchini, G., Quiniou, V., Barennes, P., Mhanna, V., Vantomme, H., Stys, P., Mariotti‐Ferrandiz, E., Klatzmann, D., Walczak, A. M., Mora, T., et al. (2024) · PRX Life · doi:10.1103/prxlife.2.013011 · Cited by 6

AntiRef: reference clusters of human antibody sequences

Briney, B. S. (2023) · Bioinformatics Advances · doi:10.1093/bioadv/vbad109 · Cited by 6

Structural insights into the unique recognition module between α‐synuclein peptide and nanobody

Islam, Z., Vaikath, N. N., Hmila, I., El‐Agnaf, O. M. A., & Kolatkar, P. R. (2023) · Protein Science · doi:10.1002/pro.4875 · Cited by 6

Immunoglobulin and T cell receptor repertoire changes induced by a prototype vaccine against Chagas disease in naïve rhesus macaques

Dumonteil, E., Tu, W., Desale, H., Goff, K. A., Marx, P. A., Ortega‐López, J., & Herrera, C. P. (2024) · Journal of Biomedical Science · doi:10.1186/s12929-024-01050-5 · Cited by 6

Immunisation of chickens with inactivated and/or infectious H9N2 avian influenza virus leads to differential immune B-cell repertoire development

Dascalu, S., Sealy, J. E., Sadeyen, J.-R., Flammer, P. G., Fiddaman, S. R., Preston, S. G., Dixon, R. J., Bonsall, M. B., Smith, A. L., & Iqbal, M. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1461678 · Cited by 6

Data Integration for Immunology

Pineda, S., Bunis, D. G., Kosti, I., & Sirota, M. (2020) · Annual Review of Biomedical Data Science · doi:10.1146/annurev-biodatasci-012420-122454 · Cited by 6

AbCellera's success is unprecedented: what have we learned?

Sinton, D. A., & Kelley, S. O. (2021) · Lab on a Chip · doi:10.1039/d1lc00155h · Cited by 6

Counting is almost all you need

Akerman, O., Isakov, H., Levi, R., Psevkin, V., & Louzoun, Y. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1031011 · Cited by 6

Exploring the sheep (Ovis aries) immunoglobulin repertoire by next generation sequencing

Park, M., de Villavicencio-Díaz, T. N., Lange, V., Wu, L., Bihan, T. L., & Ma, B. (2023) · Molecular Immunology · doi:10.1016/j.molimm.2023.02.008 · Cited by 6

Antibodies, repertoires and microdevices in antibody discovery and characterization

Schlotheuber, L. J., Lüchtefeld, I., & Eyer, K. (2024) · Lab on a Chip · doi:10.1039/d3lc00887h · Cited by 6

A phosphorylation pattern-recognizing antibody specifically reacts to RNA polymerase II bound to exons

Han, J., Lee, J., Park, S., Yoon, S., Yoon, A., Hwang, D., Lee, H. K., Kim, M. S., Lee, Y., Yang, W. J., et al. (2016) · Experimental & Molecular Medicine · doi:10.1038/emm.2016.101 · Cited by 6

VDJ Gene Usage of B Cell Receptors in Peripheral Blood of ABO-incompatible Kidney Transplantation Patients

Jeon, H. J., Fang, T., Lee, J.-G., Jang, J. Y., Kim, K., Choi, S., Yan, J.-J., Ryu, J.-H., Koo, T. Y., Ahn, C., et al. (2018) · Transplantation Proceedings · doi:10.1016/j.transproceed.2018.01.047 · Cited by 6

Inter- and intraspecies comparison of phylogenetic fingerprints and sequence diversity of immunoglobulin variable genes

Yermanos, A., Dounas, A., Greiff, V., Stadler, T., Oxenius, A., & Reddy, S. T. (2020) · Immunogenetics · doi:10.1007/s00251-020-01164-8 · Cited by 7

FcRn Overexpression Expands Diversity of the Humoral Immune Response in bFcRn Transgenic Mice

Szikora, B., Marx, A., Jani, P. K., Pipek, O., Müller, V., Csabai, I., & Kacskovıcs, I. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01887 · Cited by 6

Immune Human Antibody Libraries for Infectious Diseases

Chan, S. K., & Lim, T. S. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-72077-7_4 · Cited by 6

Molecular Hematopathology

He, R. Q., Oliveira, J. L., Hoyer, J. D., & Viswanatha, D. S. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-47913-4.00024-0 · Cited by 6

Rationalizing Random Walks: Replicating Protective Antibody Trajectories

Remmel, J. L., & Ackerman, M. E. (2021) · Trends in Immunology · doi:10.1016/j.it.2021.01.001 · Cited by 6

Editorial: Next-Generation Sequencing of Human Antibody Repertoires for Exploring B-cell Landscape, Antibody Discovery and Vaccine Development

Prabakaran, P., Glanville, J., & Ippolito, G. C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01344 · Cited by 6

Accurate Prediction of Antibody Function and Structure Using Bio-Inspired Antibody Language ModelPreprint

Jing, H., Gao, Z., Xu, S. Y., Shen, T., Peng, Z., He, S., You, T., Ye, S., Lin, W., & Sun, S. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.30.555473 · Cited by 6

PRecision Medicine: Beyond Genomics to Targeted Therapies

D, R. S. M., & Spellmeyer, D. C. (2016) · Personalized Medicine · doi:10.2217/pme.15.48 · Cited by 5

Characterization of the B cell receptor repertoire of patients with acute coronary syndrome

Weng, R., Liu, S., Gu, X., & Zhong, Z. (2021) · Genes & Genomics · doi:10.1007/s13258-021-01110-2 · Cited by 5

Dual UMIs and Dual Barcodes With Minimal PCR Amplification Removes Artifacts and Acquires Accurate Antibody Repertoire

Wang, Q., Zeng, H., Zhu, Y., Wang, M., Zhang, Y., Yang, X., Tang, H., Li, H., Chen, Y., Ma, C., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.778298 · Cited by 5

Bioinformatic Analysis of Natively Paired VH:VL Antibody Repertoires for Antibody Discovery

Fahad, A. S., Madan, B., & DeKosky, B. J. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2609-2_25 · Cited by 5

Specificity of immunoglobulin high-throughput sequencing minimal residual disease monitoring in non-Hodgkin lymphomas

Shukla, N., Schroers‐Martin, J. G., Sworder, B. J., Kathuria, K. R., Alig, S., Frank, M. J., Miklos, D. B., Coutre, S. E., Diehn, M., Khodadoust, M. S., et al. (2023) · Blood Advances · doi:10.1182/bloodadvances.2023011997 · Cited by 5

Single-cell 5′ RNA sequencing of camelid peripheral B cells provides insights into cellular basis of heavy-chain antibody production

Yi, L., Guo, X., Liu, Y., Jirimutu, & Wang, Z. (2024) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2024.04.041 · Cited by 5

Analysis of immunoglobulin organization and complexity in mink (Neovison vison)

Yi, X., Qiu, Y., Wang, S.-H., & Sun, X. (2024) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2024.105234 · Cited by 5

Identification of antigen-specific human monoclonal antibodies using high-throughput sequencing of the antibody repertoire

Liu, J., Li, R., Liu, K., Li, L., Zai, X., Chi, X., Fu, L. L., Xu, J., & Chen, W. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.03.038 · Cited by 5

Accurate estimation of microbial sequence diversity with Distanced

Hackmann, T. J. (2019) · Bioinformatics · doi:10.1093/bioinformatics/btz668 · Cited by 5

Study on the diversity of denitrification bacteria treating with wastewater by using PPGC filler on SBMBBR at low temperature

Fu, J., Zhang, Z., & Zhu, J. (2020) · E3S Web of Conferences · doi:10.1051/e3sconf/202015804002 · Cited by 5

CRIS: complete reconstruction of immunoglobulin V-D-J sequences from RNA-seq data

Islam, R., Bilenky, M., Weng, A. P., Connors, J. M., & Hirst, M. (2021) · Bioinformatics Advances · doi:10.1093/bioadv/vbab021 · Cited by 5

Exploring the Diversity of the B-Cell Receptor Repertoire Through High-Throughput Sequencing

Hom, J., Tomar, D., & Tipton, C. M. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1944-5_16 · Cited by 5

Echidna: integrated simulations of single-cell immune receptor repertoires and transcriptomes

Han, J., Masserey, S., Shlesinger, D., Kuhn, R., Papadopoulou, C., Agrafiotis, A., Kreiner, V., Dizerens, R., Hong, K., Weber, C. R., et al. (2022) · Bioinformatics Advances · doi:10.1093/bioadv/vbac062 · Cited by 5

Homology Modeling of Antibody Variable Regions: Methods and Applications

Bansia, H., & Ramakumar, S. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-2974-1_16 · Cited by 5

simAIRR: simulation of adaptive immune repertoires with realistic receptor sequence sharing for benchmarking of immune state prediction methods

Kanduri, C., Scheffer, L., Pavlović, M., Rand, K. D., Chernigovskaya, M., Pirvandy, O., Yaari, G., Greiff, V., & Sandve, G. K. (2022) · GigaScience · doi:10.1093/gigascience/giad074 · Cited by 5

Progress and open problems in evolutionary dynamicsPreprint

Neher, R. A., & Walczak, A. M. (2018) · arXiv (Cornell University) · doi:10.48550/arxiv.1804.07720 · Cited by 7

A Generative Foundation Model for Antibody DesignPreprint

Wang, R., Wu, F., Shi, J., Song, Y., Kong, Y., Ma, J., He, B., Yan, Q., Ying, T., Zhao, P., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.12.675771 · Cited by 7

Gene discovery and expression analysis of the B cell receptor repertoire in the domestic ferret model

Hebert, L. S., Pickens, W., Satterwhite, E., Soto, G. B., Pflaum, F. M., Zhan, M., Moody, M. A., Kain, J., Kirchenbaum, G. A., Ferguson, J. A., et al. (2025) · Vaccine · doi:10.1016/j.vaccine.2025.127725 · Cited by 4

Biologics developability data analysis using hierarchical clustering accelerates candidate lead selection, optimization, and preformulation screening

Metcalf, K. J., Wo, G., Zaragoza, J. P. T., Raoufi, F., Baker, J., Chen, D., Derebe, M. G., Hogan, J. M., Hsu, A. H.-M., Kofman, E., et al. (2025) · mAbs · doi:10.1080/19420862.2025.2502127 · Cited by 4

Annotation of gene loci and analysis of expression diversity in sheep immunoglobulin

Wu, M., Chen, F., Tang, X., Li, J., Zhao, H., & Zhang, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1643380 · Cited by 4

Characterizing adjuvants’ effects at murine immunoglobulin repertoire level

Feng, F., Yuen, R. R., Wang, Y., Hua, A., Kepler, T. B., & Wetzler, L. M. (2023) · iScience · doi:10.1016/j.isci.2023.108749 · Cited by 4

Combined techniques for antigen-specific nanobody discovery in the white-spotted bamboo shark (Chiloscyllium plagiosum)

Zhong, B., Yang, J., Zheng, K., Tang, W., Jia, L., Gu, M., Hu, J., Jiang, X., Chen, J., Lyu, Z., et al. (2025) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2025.110411 · Cited by 4

The role of idiotypic interactions in the adaptive immune system: a belief-propagation approach

Bartolucci, S., Mozeika, A., & Annibale, A. (2016) · Journal of Statistical Mechanics Theory and Experiment · doi:10.1088/1742-5468/2016/08/083402 · Cited by 4

Deep targeted sequencing reveals the diversity of TRB-CDR3 repertoire in patients with preeclampsia

Guo, C., Cai, R., Cao, X., Yang, Y., Wang, Q., He, R., An, L., Peng, Z., Chen, Y., Ni, S., et al. (2019) · Human Immunology · doi:10.1016/j.humimm.2019.04.003 · Cited by 4

SOS: online probability estimation and generation of T-and B-cell receptors

Isacchini, G., Olivares, C., Nourmohammad, A., Walczak, A. M., & Mora, T. (2020) · Bioinformatics · doi:10.1093/bioinformatics/btaa574 · Cited by 4

Therapeutic antibody discovery

Hoover, J. M., Prinslow, E. G., Teigler, J. E., Truppo, M. D., & LaPorte, S. L. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-820007-0.00023-4 · Cited by 4

In-Depth Determination and Analysis of the Human Paired Heavy and Light Chain Antibody Repertoire

DeKosky, B. J. (2017) · Springer theses · doi:10.1007/978-3-319-58518-5_3 · Cited by 4

Rapid generation of human recombinant monoclonal antibodies from antibody-secreting cells using ferrofluid-based technology

Strazza, V., Rossi, M., Avati, A., Tiseo, G., Falcone, M., Cusi, M. G., Menichetti, F., Ricciardi‐Castagnoli, P., Tinti, C., & Pileri, P. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1341389 · Cited by 4

High-titer antibody depletion enhances discovery of diverse serum antibody specificities

Bozekowski, J. D., Graham, A. J., & Daugherty, P. S. (2018) · Journal of Immunological Methods · doi:10.1016/j.jim.2018.01.003 · Cited by 4

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

Sun, L., Kono, N., Toh, H., Xue, H., Sano, K., Suzuki, T., Ainai, A., Orba, Y., Yamagishi, J., Hasegawa, H., et al. (2019) · Journal of Visualized Experiments · doi:10.3791/58804 · Cited by 4

RNase H-dependent PCR enables highly specific amplification of antibody variable domains from single B-cells

Crissman, J. W., Lin, Y., Separa, K., Duquette, M., Cohen, M., Velasquez, C., & Cujec, T. P. (2020) · PLoS ONE · doi:10.1371/journal.pone.0241803 · Cited by 4

Primer Design and Inverse PCR on Yeast Display Antibody Selection Outputs

Ferrara, F., Bradbury, A. M., & D’Angelo, S. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7546-4_4 · Cited by 4

Building Representation Learning Models for Antibody ComprehensionPreprint

Barton, J., Gaspariunas, A., Galson, J. D., & Leem, J. (2023) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041462 · Cited by 4

De novo antibody identification in human blood from full-length single B cell transcriptomics and matching haplotype-resolved germline assembliesPreprint

Beaulaurier, J., Ly, L., Duty, J. A., Tyer, C., Stevens, C. S., Hung, C.-T., Sookdeo, A., Drong, A. W., Kowdle, S., Guzmán-Solís, A. A., et al. (2025) · Genome Research · doi:10.1101/gr.279392.124 · Cited by 4

Profiling the broad antibody diversity of lymphatic filariasis immune antibody repertoire by deep sequencing

Lim, C. C., & Lim, T. S. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.140037 · Cited by 3

Navigating the landscape: A comprehensive overview of computational approaches in therapeutic antibody design and analysis

Yadav, A. J., Bhagat, K., Sharma, A., & Padhi, A. K. (2025) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2024.10.011 · Cited by 3

Optimizing the breadth of SARS-CoV-2-neutralizing antibodies in vivo and in silico

Kuroda, D., Moriyama, S., Sasaki, H., & Takahashi, Y. (2025) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2025.2526873 · Cited by 3

Artificial immunoglobulin light chain with potential to associate with a wide variety of immunoglobulin heavy chains

Xue, H., Sun, L., Fujimoto, H., Suzuki, T., Takahashi, Y., & Ohnishi, K. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.05.149 · Cited by 3

IgGeneUsage: differential gene usage in immune repertoires

Kitanovski, S., & Hoffmann, D. E. (2020) · Bioinformatics · doi:10.1093/bioinformatics/btaa174 · Cited by 3

Activation-Induced Cytidine Deaminase Impacts the Primary Antibody Repertoire in Naive Mice

Bao, K., Zhang, J., Scherl, A., Ziai, J. M., Hadadianpour, A., Xu, D., Cruz, C. D., Liu, J., Liang, Y., Tam, L., et al. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2101193 · Cited by 3

Conference Proceedings – 6th International Conference on Molecular Diagnostics and Biomarker Discovery (MDBD 2022): Building Resilience in Biomedical Research

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