Cited by 4,551Cellular Mechanics and InteractionsHydrogels: synthesis, properties, applicationsTissue Engineering and Regenerative Medicine

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Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering

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Lutolf, M P, Hubbell, J A·2005·Nature Biotechnology

DOI 10.1038/nbt1055

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Abstract

New generations of synthetic biomaterials are being developed at a rapid pace for use as three-dimensional extracellular microenvironments to mimic the regulatory characteristics of natural extracellular matrices (ECMs) and ECM-bound growth factors, both for therapeutic applications and basic biological studies. Recent advances include nanofibrillar networks formed by self-assembly of small building blocks, artificial ECM networks from protein polymers or peptide-conjugated synthetic polymers that present bioactive ligands and respond to cell-secreted signals to enable proteolytic remodeling. These materials have already found application in differentiating stem cells into neurons, repairing bone and inducing angiogenesis. Although modern synthetic biomaterials represent oversimplified mimics of natural ECMs lacking the essential natural temporal and spatial complexity, a growing symbiosis of materials engineering and cell biology may ultimately result in synthetic materials that contain the necessary signals to recapitulate developmental processes in tissue- and organ-specific differentiation and morphogenesis.

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Authors: Lutolf, M. P., & Hubbell, J. A.
Affiliations: École Polytechnique Fédérale de Lausanne (CH)
Corresponding author: Hubbell, J A
ORCID: Hubbell, J A
Venue: Nature Biotechnology
Publisher: Springer Science and Business Media LLC
Published: 2005-01
Volume: 23
Issue: 1
Pages: 47-55
ISSN: 0733-222X (ISSN-L)
1087-0156
1546-1696
DOI: 10.1038/nbt1055
OpenAlex: W2037810763
Cited by: 4,551
References: 113
Citations by year: 2026: 101 · 2025: 126 · 2024: 136 · 2023: 119 · 2022: 124 · 2021: 182 · 2020: 219 · 2019: 231 · 2018: 262 · 2017: 299 · 2016: 302 · 2015: 288 · 2014: 334 · 2013: 290 · 2012: 309
FWCI: 11.77
Type: journal article
Language: en
Open access: green
infoscience.epfl.ch
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Biotechnology (publishedVersion)
PubMed (publishedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords: synthetic biomaterials, extracellular matrix mimics, morphogenesis, tissue engineering, nanofibrillar networks, self-assembly, stem cell differentiation, bone regeneration, angiogenesis, developmental processes
MeSH terms: Animals, Biocompatible Materials, Cell Adhesion, Cell Differentiation, Cells, Cultured, Extracellular Matrix, Humans, Ligands, Models, Biological, Neurons, Peptides, Polymers, Stem Cells, Time Factors, Protein Engineering, Integrins, Cell Lineage, Hydrogels, Tissue Engineering, Endothelial Cells

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Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering

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