Cited by 207Telomeres, Telomerase, and SenescenceDNA Repair MechanismsGenetics, Aging, and Longevity in Model Organisms

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Impact of genomic damage and ageing on stem cell function

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Behrens, Axel, van Deursen, Jan M., Rudolph, K. Lenhard, Schumacher, Björn·2014·Nature Cell Biology

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Abstract

Impairment of stem cell function contributes to the progressive deterioration of tissue maintenance and repair with ageing. Evidence is mounting that age-dependent accumulation of DNA damage in both stem cells and cells that comprise the stem cell microenvironment are partly responsible for stem cell dysfunction with ageing. Here, we review the impact of the various types of DNA damage that accumulate with ageing on stem cell functionality, as well as the development of cancer. We discuss DNA-damage-induced cell intrinsic and extrinsic alterations that influence these processes, and review recent advances in understanding systemic adjustments to DNA damage and how they affect stem cells.

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Authors: Behrens, A., van Deursen, J. M., Rudolph, K. L., & Schumacher, B.
Affiliations: King's College London (GB)
Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) (DE)
University of Cologne (DE)
Corresponding author: Behrens, Axel
Rudolph, K. Lenhard
Schumacher, Björn
ORCID: Behrens, Axel
Rudolph, K. Lenhard
Schumacher, Björn
Venue: Nature Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2014-02-28
Volume: 16
Issue: 3
Pages: 201-207
ISSN: 1465-7392 (ISSN-L)
1476-4679
DOI: 10.1038/ncb2928
PMC: PMC4214082
OpenAlex: W2054525725
Cited by: 207
References: 98
Citations by year: 2026: 7 · 2025: 8 · 2024: 11 · 2023: 12 · 2022: 10 · 2021: 17 · 2020: 19 · 2019: 27 · 2018: 13 · 2017: 18 · 2016: 20 · 2015: 32 · 2014: 13
FWCI: 3.24
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Cell Biology (publishedVersion)
PubMed (publishedVersion)
Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Informationszentrum Lebenswissenschaften (ZB MED) (submittedVersion)
Research Portal (King's College London) (submittedVersion)
Radboud Repository (Radboud University) (submittedVersion)
Funders: Cancer Research UK (15679)
National Cancer Institute (R01CA126828)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords: genomic instability, aging, stem cell function, DNA damage, stem cell niche, tissue maintenance, tissue repair, carcinogenesis
MeSH terms: Aneuploidy, Animals, Cells, Cultured, DNA Damage, DNA Repair, Humans, Neoplasms, Genome, Human, Cellular Senescence, Adult Stem Cells

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