The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Nox2 redox signaling maintains essential cell populations in the brain
Open accessAbstract
Reactive oxygen species (ROS) are conventionally classified as toxic consequences of aerobic life, and the brain is particularly susceptible to ROS-induced oxidative stress and damage owing to its high energy and oxygen demands. In this context, NAPDH oxidases (Nox) are a widespread source of brain ROS implicated in seizures, stroke, and neurodegeneration. A physiological role for ROS generation in normal brain function has not been established, despite the fact that mice and humans lacking functional Nox proteins exhibit cognitive deficits. Using molecular imaging with Peroxyfluor-6 (PF6), a new selective fluorescent indicator for hydrogen peroxide (H2O2), we show that adult hippocampal stem/progenitor cells (AHPs) generate H2O2 through Nox2 to regulate intracellular growth signaling pathways, which in turn maintains their normal proliferation in vitro and in vivo. Our results challenge the traditional view that brain ROS are solely deleterious by demonstrating that controlled ROS chemistry is needed for maintaining specific cell populations.
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Cites
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Cited by
Cellular mechanisms and physiological consequences of redox-dependent signalling
Holmström, K. M., & Finkel, T. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3801 · Cited by 2,093
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Self-citation13 reasons why the brain is susceptible to oxidative stress
Cobley, J. N., Fiorello, M. L., & Bailey, D. M. (2018) · Redox Biology · doi:10.1016/j.redox.2018.01.008 · Cited by 1,215
NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential
Xie, N., Zhang, L., Gao, W., Huang, C., Huber, P. E., Zhou, X., Li, C., Shen, G., & Zou, B. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00311-7 · Cited by 1,052
Unraveling the biological roles of reactive oxygen species
Murphy, M. P., Holmgren, A., Larsson, N.-G., Halliwell, B., Chang, C. J., Kalyanaraman, B., Rhee, S. G., Thornalley, P. J., Partridge, L., Gems, D., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.010 · Cited by 836
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Metadata
- Authors
- Dickinson, B. C., Peltier, J., Stone, D., Schaffer, D. V., & Chang, C. J.
- Venue
- Nature Chemical Biology
- Published
- 2010-12-26
- Volume
- 7
- Issue
- 2
- Pages
- 106-112
- ISSN
- 1552-4450 (ISSN-L)
- 1552-4469
- OpenAlex
- W2129482408
- Cited by
- 273
- References
- 14
- FWCI
- 8.39
- Type
- journal article
- Language
- en
- Open access
- green
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- Dickinson, B. C., Peltier, J., Stone, D., Schaffer, D. V., & Chang, C. J. (2011). Nox2 redox signaling maintains essential cell populations in the brain. Nature Chemical Biology. https://doi.org/10.1038/nchembio.497
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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