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N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
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We report here that fat mass and obesity-associated protein (FTO) has efficient oxidative demethylation activity targeting the abundant N6-methyladenosine (m(6)A) residues in RNA in vitro. FTO knockdown with siRNA led to increased amounts of m(6)A in mRNA, whereas overexpression of FTO resulted in decreased amounts of m(6)A in human cells. We further show the partial colocalization of FTO with nuclear speckles, which supports the notion that m(6)A in nuclear RNA is a major physiological substrate of FTO.
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“The m6A modification can be removed by erasers, mainly FTO and ALKBH5 [24,25].”
From IMPlications of IMP2 in RNA Biology and Disease (2025) · cites this paper as [24]
In the citing paper
“Although evidence points to an oncogenic role of FTO in AML 15 ,”
From The roles of DNA, RNA and histone methylation in ageing and cancer (2019) · cites this paper as [15]
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“In addition to TET enzymes, D2HG can inhibit the N6-methyladenosine (m6A) RNA demethylase fat mass and obesity associated protein (FTO), another α -KG-dependent dioxygenase 15 .”
From The roles of DNA, RNA and histone methylation in ageing and cancer (2019) · cites this paper as [15]
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Self-citationLoss of Endothelial FTO Antagonizes Obesity-Induced Metabolic and Vascular Dysfunction
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“Wild type FTO and the variant used for structural studies have been shown to be active against 6mA in ssDNA, although the available evidence is that mRNA is likely to be a more physiologically relevant substrate (16,22).”
Inducible and reversible RNA N6-methyladenosine editing
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“2), as well as the Jumonjic (JmjC)-domain-containing histone demethylase and the m 6 A demethylase (FTO, AlkBs) are NHFe/ α -KG-dependent dioxygenases (Shi, 2007; Jia et al., 2011; Markolovic et al., 2016).”
The YTHDF proteins display distinct cellular functions on m6A-modified RNA
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N6-methyladenosine (m6A) methylation in ischemia–reperfusion injury
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Metadata
- Authors
- Jia, G., Fu, Y., Zhao, X., Dai, Q., Zheng, G., Yang, Y., Yi, C., Lindahl, T., Pan, T., Yang, Y.-G., & He, C.
- Affiliations
- University of Chicago (US)
- Chinese Academy of Sciences (CN)
- Cancer Research UK (GB)
- Corresponding author
- He, Chuan
- Venue
- Nature Chemical Biology
- Published
- 2011-10-16
- Volume
- 7
- Issue
- 12
- Pages
- 885-887
- ISSN
- 1552-4450 (ISSN-L)
- 1552-4469
- PMC
- PMC3218240
- OpenAlex
- W2071930821
- Cited by
- 4,106
- References
- 27
- Citations by year
- 2026: 272 · 2025: 416 · 2024: 473 · 2023: 489 · 2022: 546 · 2021: 544 · 2020: 341 · 2019: 217 · 2018: 218 · 2017: 159 · 2016: 109 · 2015: 107 · 2014: 94 · 2013: 67 · 2012: 45
- FWCI
- 26.98
- Type
- journal article
- Language
- en
- Update notices
- erratum (2012-11-26)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Chemical Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (GM071440, R01GM071440, R01GM088599, GM088599)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Keywords
- N6-methyladenosine, m6A demethylation, FTO, nuclear RNA, RNA modification, oxidative demethylation, nuclear speckles, obesity, RNA metabolism
- MeSH terms
- Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Adenosine, Cell Nucleus, HeLa Cells, Humans, Methylation, Obesity, Oxidation-Reduction, Proteins, RNA, Messenger, Substrate Specificity
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