Cited by 4,106RNA modifications and cancerEpigenetics and DNA MethylationRNA regulation and disease

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N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

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Jia, Guifang, Fu, Ye, Zhao, Xu, Dai, Qing, Zheng, Guanqun, Yang, Ying, Yi, Chengqi, Lindahl, Tomas, Pan, Tao, Yang, Yun-Gui, He, Chuan·2011·Nature Chemical Biology

DOI 10.1038/nchembio.687PMC PMC3218240

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Abstract

We report here that fat mass and obesity-associated protein (FTO) has efficient oxidative demethylation activity targeting the abundant N6-methyladenosine (m(6)A) residues in RNA in vitro. FTO knockdown with siRNA led to increased amounts of m(6)A in mRNA, whereas overexpression of FTO resulted in decreased amounts of m(6)A in human cells. We further show the partial colocalization of FTO with nuclear speckles, which supports the notion that m(6)A in nuclear RNA is a major physiological substrate of FTO.

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Background
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Authors: Jia, G., Fu, Y., Zhao, X., Dai, Q., Zheng, G., Yang, Y., Yi, C., Lindahl, T., Pan, T., Yang, Y.-G., & He, C.
Affiliations: University of Chicago (US)
Chinese Academy of Sciences (CN)
Cancer Research UK (GB)
Corresponding author: He, Chuan
ORCID: Jia, Guifang
Fu, Ye
Dai, Qing
Yang, Ying
Yi, Chengqi
Lindahl, Tomas
Pan, Tao
Yang, Yun-Gui
He, Chuan
Venue: Nature Chemical Biology
Publisher: Springer Science and Business Media LLC
Published: 2011-10-16
Volume: 7
Issue: 12
Pages: 885-887
ISSN: 1552-4450 (ISSN-L)
1552-4469
DOI: 10.1038/nchembio.687
PMC: PMC3218240
OpenAlex: W2071930821
Cited by: 4,106
References: 27
Citations by year: 2026: 272 · 2025: 416 · 2024: 473 · 2023: 489 · 2022: 546 · 2021: 544 · 2020: 341 · 2019: 217 · 2018: 218 · 2017: 159 · 2016: 109 · 2015: 107 · 2014: 94 · 2013: 67 · 2012: 45
FWCI: 26.98
Type: journal article
Language: en
Update notices: erratum (2012-11-26)
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Chemical Biology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of General Medical Sciences (GM071440, R01GM071440, R01GM088599, GM088599)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Keywords: N6-methyladenosine, m6A demethylation, FTO, nuclear RNA, RNA modification, oxidative demethylation, nuclear speckles, obesity, RNA metabolism
MeSH terms: Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Adenosine, Cell Nucleus, HeLa Cells, Humans, Methylation, Obesity, Oxidation-Reduction, Proteins, RNA, Messenger, Substrate Specificity

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N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

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