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N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
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We report here that fat mass and obesity-associated protein (FTO) has efficient oxidative demethylation activity targeting the abundant N6-methyladenosine (m(6)A) residues in RNA in vitro. FTO knockdown with siRNA led to increased amounts of m(6)A in mRNA, whereas overexpression of FTO resulted in decreased amounts of m(6)A in human cells. We further show the partial colocalization of FTO with nuclear speckles, which supports the notion that m(6)A in nuclear RNA is a major physiological substrate of FTO.
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“The m6A modification can be removed by erasers, mainly FTO and ALKBH5 [24,25].”
From IMPlications of IMP2 in RNA Biology and Disease (2025) · cites this paper as [24]
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“Although evidence points to an oncogenic role of FTO in AML 15 ,”
From The roles of DNA, RNA and histone methylation in ageing and cancer (2019) · cites this paper as [15]
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“In addition to TET enzymes, D2HG can inhibit the N6-methyladenosine (m6A) RNA demethylase fat mass and obesity associated protein (FTO), another α -KG-dependent dioxygenase 15 .”
From The roles of DNA, RNA and histone methylation in ageing and cancer (2019) · cites this paper as [15]
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Cites
Genetics of Food Intake Self-Regulation in Childhood: Literature Review and Research Opportunities
Faith, M. S., Carnell, S., & Kral, T. V. E. (2013) · Human Heredity · doi:10.1159/000353879 · Cited by 7,633
Lippa, N. C., & Sanderson, S. C. (2013) · Human Heredity · doi:10.1159/000353712 · Cited by 6,095
Frayling, T. M., Timpson, N. J., Weedon, M. N., Zeggini, E., Freathy, R. M., Lindgren, C. M., Perry, J. R. B., Elliott, K. S., Lango, H., Rayner, N. W., et al. (2007) · Science · doi:10.1126/science.1141634 · Cited by 4,531
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
Scott, L. J., Mohlke, K. L., Bonnycastle, L. L., Willer, C. J., Li, Y., Duren, W. L., Erdos, M. R., Stringham, H. M., Chines, P. S., Jackson, A. U., et al. (2007) · Science · doi:10.1126/science.1142382 · Cited by 2,753
Variation in FTO contributes to childhood obesity and severe adult obesity
Dina, C., Meyre, D., Gallina, S., Durand, E., Körner, A., Jacobson, P., Carlsson, L. M. S., Kieß, W., Vatin, V., Lecœur, C., et al. (2007) · Nature Genetics · doi:10.1038/ng2048 · Cited by 1,648
The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase
Gerken, T., Girard, C. A. J., Tung, Y. L., Webby, C. J., Saudek, V., Hewitson, K. S., Yeo, G. S. H., McDonough, M. A., Cunliffe, S. L., McNeill, L. A., et al. (2007) · Science · doi:10.1126/science.1151710 · Cited by 1,541
Self-citationThorleifsson, G., Walters, G. B., Gudbjartsson, D. F., Steinthorsdottir, V., Sulem, P., Helgadottir, A., Styrkarsdottir, U., Gretarsdottir, S., Thorlacius, S., Jonsdottir, I., et al. (2009) · Nature Genetics · doi:10.1038/ng.274 · Cited by 1,375
Nuclear speckles: a model for nuclear organelles
Lamond, A. I., & Spector, D. L. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1172 · Cited by 1,002
Inactivation of the Fto gene protects from obesity
Fischer, J., Koch, L., Emmerling, C., Vierkotten, J., Peters, T., Brüning, J. C., & Rüther, U. (2009) · Nature · doi:10.1038/nature07848 · Cited by 964
Bokar, J. A., Shambaugh, M. E., Polayes, D. A., Matera, A. G., & ROTTMAN, F. M. (1997) · PubMed Central · Cited by 955
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Research works printed but not linked: 1
- Bokar, J.A., Shambaugh, M.E., Polayes, D., Matera, A.G. & Rottman, F.M. RNA 3, 1233–1247 (1997).
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Sorted by citations
Items 501–600 of 1,011
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Tang, J., Chen, S., & Jia, G. (2023) · Plant Communications · doi:10.1016/j.xplc.2023.100546 · Cited by 127
Self-citationNovel positioning from obesity to cancer: FTO, an m6A RNA demethylase, regulates tumour progression
Chen, J., & Du, B. (2018) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-018-2796-0 · Cited by 126
m6A RNA Methylation in Cardiovascular Diseases
Wu, S., Zhang, S., Wu, X., & Zhou, X. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2020.08.010 · Cited by 125
Xia, Z., Tang, M., Ma, J., Zhang, H., Gimple, R. C., Prager, B. C., Tang, H., Sun, C., Liu, F., Lin, P., et al. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab517 · Cited by 122
The roles and mechanism of m6A RNA methylation regulators in cancer immunity
Chen, L., He, Y., Zhu, J., Zhao, S., Qi, S., Chen, X., Zhang, H., Ni, Z., Zhou, Y., Chen, G., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114839 · Cited by 128
Toh, J. D. W., Sun, L., Lau, L. Z. M., Tan, J., Low, J. J. A., Tang, C. W. Q., Cheong, E. J. Y., Tan, M. J. H., Chen, Y., Hong, W., et al. (2014) · Chemical Science · doi:10.1039/c4sc02554g · Cited by 125
METTL3-mediated m6A is required for murine oocyte maturation and maternal-to-zygotic transition
Sui, X., Hu, Y., Ren, C., Cao, Q., Zhou, S. F., Cao, Y. M., Li, M., Shu, W., & Huo, R. (2020) · Cell Cycle · doi:10.1080/15384101.2019.1711324 · Cited by 122
Imam, H., Kim, G., Mir, S. A., Khan, M. A., & Siddiqui, A. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008338 · Cited by 123
NADP modulates RNA m6A methylation and adipogenesis via enhancing FTO activity
Wang, L., Song, C., Wang, N., Li, S., Liu, Q., Sun, Z., Wang, K., Yu, S., & Yang, Q. (2020) · Nature Chemical Biology · doi:10.1038/s41589-020-0601-2 · Cited by 123
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Zhang, B., Jiang, H., Dong, Z., Sun, A., & Ge, J. (2020) · Genes & Diseases · doi:10.1016/j.gendis.2020.07.011 · Cited by 125
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Song, P., Tayier, S., Cai, Z., & Jia, G. (2021) · Cell Biology and Toxicology · doi:10.1007/s10565-021-09627-8 · Cited by 125
Self-citationA dynamic reversible RNA N6‐methyladenosine modification: current status and perspectives
Bi, Z., Liu, Y., Zhao, Y., Yao, Y., Wu, R., Liu, Q., Wang, Y., & Wang, X. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28014 · Cited by 121
Zhang, Q., Riddle, R. C., Yang, Q., Rosen, C. J., Guttridge, D. C., Dirckx, N., Monier‐Faugere, M., Farber, C. R., & Clemens, T. L. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1905489116 · Cited by 123
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Wang, Y., Gao, M., Zhu, F., Li, X., Yang, Y., Yan, Q., Jia, L., Xie, L., & Chen, Z. (2020) · Nature Communications · doi:10.1038/s41467-020-15488-2 · Cited by 126
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Lu, Y., Li, Z., Chen, L., Zhang, J., & Shen, Z. (2021) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.23866 · Cited by 122
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Chen, D., Gu, X., Nurzat, Y., Xu, L., Li, X., Wu, L., Jiao, H., Gao, P., Zhu, X., Yan, D., et al. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02089-6 · Cited by 127
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Wu, C., Chen, W., He, J., Jin, S., Liu, Y., Yang, Y., Gao, Z., Yang, J., Yang, J., Cui, J., et al. (2020) · Science Advances · doi:10.1126/sciadv.aba0647 · Cited by 121
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Self-citationYin, R., Chang, J.-W., Li, Y., Gao, Z., Qiu, Q., Wang, Q., Han, G., Chai, J., Feng, M., Wang, P., et al. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.09.014 · Cited by 123
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Zhong, Z.-D., Xie, Y.-Y., Chen, H.-X., Lan, Y.-L., Liu, X., Ji, J.-Y., Wu, F., Jin, L., Chen, J., Mak, D. W., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37596-5 · Cited by 119
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Liu, S., Xiu, J., Zhu, C., Meng, K., Li, C., Han, R., Du, T., Li, L., Xu, L., Liu, R., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27044-7 · Cited by 118
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Xue, M., Zhao, B. S., Zhang, Z. S., Lu, M., Harder, O. E., Chen, P., Lu, Z., Li, A., Ma, Y., Xu, Y., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12504-y · Cited by 111
Self-citationXiao, Y., Thakkar, K. N., Zhao, H., Broughton, J. P., Li, Y., Seoane, J. A., Diep, A. N., Metzner, T. J., von Eyben, R., Dill, D. L., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2000516117 · Cited by 118
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Zong, X., Zhao, J. C., Wang, H., Lu, Z., Wang, F., Du, H., & Wang, Y. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1801151 · Cited by 106
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Cho, S., Lee, G., Pickering, B. F., Jang, C., Park, J. H., He, L., Mathur, L., Kim, S.-S., Jung, S., Tang, H.-W., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.03.010 · Cited by 113
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Chen, Y., Zitello, E., Guo, R., & Deng, Y. (2021) · Clinical and Translational Medicine · doi:10.1002/ctm2.367 · Cited by 108
Zhang, M., Zhang, Y., Ma, J., Guo, F., Cao, Q., Zhang, Y., Zhou, B., Chai, J., Zhao, W., & Zhao, R. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133788 · Cited by 115
Fate by RNA methylation: m6A steers stem cell pluripotency
Zhao, B. S., & He, C. (2015) · Genome biology · doi:10.1186/s13059-015-0609-1 · Cited by 109
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Dinescu, S., Ignat, S.-R., Lazăr, A. D., Constantin, C., Neagu, M. T., & Costache, M. (2019) · Genes · doi:10.3390/genes10010052 · Cited by 110
Huong, T. T., Ngoc, L. N. T., & Kang, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186707 · Cited by 109
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Sun, K., Du, Y., Hou, Y., Zhao, M., Li, J., Du, Y., Zhang, L., Chen, C., Yang, H., Yan, F., et al. (2021) · Theranostics · doi:10.7150/thno.55574 · Cited by 109
Luo, G., Wang, F., Weng, X., Chen, K., Hao, Z., Yu, M., Deng, X., Liu, J., & He, C. (2016) · Nature Communications · doi:10.1038/ncomms11301 · Cited by 106
Self-citationBetaine increases mitochondrial content and improves hepatic lipid metabolism
Zhang, L., Qi, Y., Aluo, Z., Liu, S., Zhang, Z., & Zhou, L. (2018) · Food & Function · doi:10.1039/c8fo02004c · Cited by 108
Zheng, H., Sun, X. H., Li, J., Song, Y., Song, J., Wang, F., Liu, L., Zhang, X., & Sui, N. (2020) · Plant Science · doi:10.1016/j.plantsci.2020.110801 · Cited by 108
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“Interestingly, even though ALKBH5 is only moderately expressed in the brain, it has been associated with mental disorders.”
BackgroundInfluentialHuang, W., Li, Z., Wu, Y.-H., Shi, Z., Mi, J., Hu, K., & Wang, R. (2022) · Translational Oncology · doi:10.1016/j.tranon.2022.101576 · Cited by 106
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Liu, J., Sun, G., Pan, S., Qin, M., Ouyang, R., Li, Z., & Huang, J. (2020) · Bioengineered · doi:10.1080/21655979.2020.1787764 · Cited by 105
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Metadata
- Authors
- Jia, G., Fu, Y., Zhao, X., Dai, Q., Zheng, G., Yang, Y., Yi, C., Lindahl, T., Pan, T., Yang, Y.-G., & He, C.
- Affiliations
- University of Chicago (US)
- Chinese Academy of Sciences (CN)
- Cancer Research UK (GB)
- Corresponding author
- He, Chuan
- Venue
- Nature Chemical Biology
- Published
- 2011-10-16
- Volume
- 7
- Issue
- 12
- Pages
- 885-887
- ISSN
- 1552-4450 (ISSN-L)
- 1552-4469
- PMC
- PMC3218240
- OpenAlex
- W2071930821
- Cited by
- 4,106
- References
- 27
- Citations by year
- 2026: 272 · 2025: 416 · 2024: 473 · 2023: 489 · 2022: 546 · 2021: 544 · 2020: 341 · 2019: 217 · 2018: 218 · 2017: 159 · 2016: 109 · 2015: 107 · 2014: 94 · 2013: 67 · 2012: 45
- FWCI
- 26.98
- Type
- journal article
- Language
- en
- Update notices
- erratum (2012-11-26)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Chemical Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (GM071440, R01GM071440, R01GM088599, GM088599)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Keywords
- N6-methyladenosine, m6A demethylation, FTO, nuclear RNA, RNA modification, oxidative demethylation, nuclear speckles, obesity, RNA metabolism
- MeSH terms
- Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Adenosine, Cell Nucleus, HeLa Cells, Humans, Methylation, Obesity, Oxidation-Reduction, Proteins, RNA, Messenger, Substrate Specificity
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