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N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
Open accessAbstract
We report here that fat mass and obesity-associated protein (FTO) has efficient oxidative demethylation activity targeting the abundant N6-methyladenosine (m(6)A) residues in RNA in vitro. FTO knockdown with siRNA led to increased amounts of m(6)A in mRNA, whereas overexpression of FTO resulted in decreased amounts of m(6)A in human cells. We further show the partial colocalization of FTO with nuclear speckles, which supports the notion that m(6)A in nuclear RNA is a major physiological substrate of FTO.
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“The m6A modification can be removed by erasers, mainly FTO and ALKBH5 [24,25].”
From IMPlications of IMP2 in RNA Biology and Disease (2025) · cites this paper as [24]
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“Although evidence points to an oncogenic role of FTO in AML 15 ,”
From The roles of DNA, RNA and histone methylation in ageing and cancer (2019) · cites this paper as [15]
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“In addition to TET enzymes, D2HG can inhibit the N6-methyladenosine (m6A) RNA demethylase fat mass and obesity associated protein (FTO), another α -KG-dependent dioxygenase 15 .”
From The roles of DNA, RNA and histone methylation in ageing and cancer (2019) · cites this paper as [15]
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“This study proposed that FTO, an enzyme previously associated with human obesity, is an m6A demethylase (Jia et al. 2011).”
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InfluentialSelf-citationRNA m6A methylation regulates the ultraviolet-induced DNA damage response
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A majority of m6A residues are in the last exons, allowing the potential for 3′ UTR regulationPreprint
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“Furthermore, mutations in one of the human demethylase genes is associated with a phenotype (overweight) (Jia et al. 2011; Zheng et al. 2013).”
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Self-citation
Metadata
- Authors
- Jia, G., Fu, Y., Zhao, X., Dai, Q., Zheng, G., Yang, Y., Yi, C., Lindahl, T., Pan, T., Yang, Y.-G., & He, C.
- Affiliations
- University of Chicago (US)
- Chinese Academy of Sciences (CN)
- Cancer Research UK (GB)
- Corresponding author
- He, Chuan
- Venue
- Nature Chemical Biology
- Published
- 2011-10-16
- Volume
- 7
- Issue
- 12
- Pages
- 885-887
- ISSN
- 1552-4450 (ISSN-L)
- 1552-4469
- PMC
- PMC3218240
- OpenAlex
- W2071930821
- Cited by
- 4,106
- References
- 27
- Citations by year
- 2026: 272 · 2025: 416 · 2024: 473 · 2023: 489 · 2022: 546 · 2021: 544 · 2020: 341 · 2019: 217 · 2018: 218 · 2017: 159 · 2016: 109 · 2015: 107 · 2014: 94 · 2013: 67 · 2012: 45
- FWCI
- 26.98
- Type
- journal article
- Language
- en
- Update notices
- erratum (2012-11-26)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Chemical Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (GM071440, R01GM071440, R01GM088599, GM088599)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Keywords
- N6-methyladenosine, m6A demethylation, FTO, nuclear RNA, RNA modification, oxidative demethylation, nuclear speckles, obesity, RNA metabolism
- MeSH terms
- Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Adenosine, Cell Nucleus, HeLa Cells, Humans, Methylation, Obesity, Oxidation-Reduction, Proteins, RNA, Messenger, Substrate Specificity
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