The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Sepsis induces long-term metabolic and mitochondrial muscle stem cell dysfunction amenable by mesenchymal stem cell therapy
Open accessAbstract
Sepsis, or systemic inflammatory response syndrome, is the major cause of critical illness resulting in admission to intensive care units. Sepsis is caused by severe infection and is associated with mortality in 60% of cases. Morbidity due to sepsis is complicated by neuromyopathy, and patients face long-term disability due to muscle weakness, energetic dysfunction, proteolysis and muscle wasting. These processes are triggered by pro-inflammatory cytokines and metabolic imbalances and are aggravated by malnutrition and drugs. Skeletal muscle regeneration depends on stem (satellite) cells. Herein we show that mitochondrial and metabolic alterations underlie the sepsis-induced long-term impairment of satellite cells and lead to inefficient muscle regeneration. Engrafting mesenchymal stem cells improves the septic status by decreasing cytokine levels, restoring mitochondrial and metabolic function in satellite cells, and improving muscle strength. These findings indicate that sepsis affects quiescent muscle stem cells and that mesenchymal stem cells might act as a preventive therapeutic approach for sepsis-related morbidity.
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Cites
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The role of exercise and PGC1α in inflammation and chronic disease
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Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration
Sambasivan, R., Yao, R., Kissenpfennig, A., Van Wittenberghe, L., Paldi, A., Gayraud-Morel, B., Guenou, H., Malissen, B., Tajbakhsh, S., & Galy, A. (2011) · Development · doi:10.1242/dev.067587 · Cited by 939
Skeletal muscle stem cells adopt a dormant cell state post mortem and retain regenerative capacity
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Self-citationInflammation-Induced Acute Phase Response in Skeletal Muscle and Critical Illness Myopathy
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Cited by
The Pathogenesis of Sepsis and Potential Therapeutic Targets
Huang, M., Cai, S., & Su, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215376 · Cited by 776
Vanhorebeek, I., Latronico, N., & Van den Berghe, G. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-05944-4 · Cited by 717
Self-citationSepsis therapies: learning from 30 years of failure of translational research to propose new leads
Cavaillon, J., Singer, M., & Skirecki, T. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.201810128 · Cited by 319
A metabolic handbook for the COVID-19 pandemic
Ayres, J. S. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0237-2 · Cited by 292
The ICM research agenda on intensive care unit-acquired weakness
Latronico, N., Herridge, M., Hopkins, R. O., Angus, D., Hart, N., Hermans, G., Iwashyna, T., Arabi, Y., Citerio, G., Wesley Ely, E., et al. (2017) · Intensive Care Medicine · doi:10.1007/s00134-017-4757-5 · Cited by 256
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Metadata
- Authors
- Rocheteau, P., Chatre, L., Briand, D., Mebarki, M., Jouvion, G., Bardon, J., Crochemore, C., Serrani, P., Lecci, P. P., Latil, M., Matot, B., Carlier, P. G., Latronico, N., Huchet, C., Lafoux, A., Sharshar, T., Ricchetti, M., & Chrétien, F.
- Venue
- Nature Communications
- Published
- 2015-12-15
- Volume
- 6
- Issue
- 1
- Pages
- 10145-10145
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2205181912
- Cited by
- 234
- References
- 9
- FWCI
- 5.53
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
