The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans
Open accessAbstract
Circular RNAs (circRNAs) are broadly expressed in eukaryotic cells, but their molecular mechanism in human disease remains obscure. Here we show that circular antisense non-coding RNA in the INK4 locus (circANRIL), which is transcribed at a locus of atherosclerotic cardiovascular disease on chromosome 9p21, confers atheroprotection by controlling ribosomal RNA (rRNA) maturation and modulating pathways of atherogenesis. CircANRIL binds to pescadillo homologue 1 (PES1), an essential 60S-preribosomal assembly factor, thereby impairing exonuclease-mediated pre-rRNA processing and ribosome biogenesis in vascular smooth muscle cells and macrophages. As a consequence, circANRIL induces nucleolar stress and p53 activation, resulting in the induction of apoptosis and inhibition of proliferation, which are key cell functions in atherosclerosis. Collectively, these findings identify circANRIL as a prototype of a circRNA regulating ribosome biogenesis and conferring atheroprotection, thereby showing that circularization of long non-coding RNAs may alter RNA function and protect from human disease.
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Self-citationCircular RNAs are a large class of animal RNAs with regulatory potency
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Self-citationCircular RNAs are abundant, conserved, and associated with ALU repeats
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Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed
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Cited by
The biogenesis, biology and characterization of circular RNAs
Kristensen, L. S., Andersen, M. S., Stagsted, L. V. W., Ebbesen, K. K., Hansen, T. B., & Kjems, J. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0158-7 · Cited by 4,823
Circular RNA and its mechanisms in disease: From the bench to the clinic
Han, B., Chao, J., & Yao, H. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.01.010 · Cited by 788
Zang, J., Lu, D., & Xu, A. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24356 · Cited by 641
A decade of genome-wide association studies for coronary artery disease: the challenges ahead
Erdmann, J., Kessler, T., Munoz Venegas, L., & Schunkert, H. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy084 · Cited by 325
Role of circular RNAs in brain development and CNS diseases
Mehta, S. L., Dempsey, R. J., & Vemuganti, R. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101746 · Cited by 281
Metadata
- Authors
- Holdt, L. M., Stahringer, A., Sass, K., Pichler, G., Kulak, N. A., Wilfert, W., Kohlmaier, A., Herbst, A., Northoff, B. H., Nicolaou, A., Gäbel, G., Beutner, F., Scholz, M., Thiery, J., Musunuru, K., Krohn, K., Mann, M., & Teupser, D.
- Venue
- Nature Communications
- Published
- 2016-08-19
- Volume
- 7
- Issue
- 1
- Pages
- 12429-12429
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2511152819
- Cited by
- 1,094
- References
- 18
- FWCI
- 42.43
- Type
- journal article
- Language
- en
- Open access
- gold
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- Holdt, L. M., Stahringer, A., Sass, K., Pichler, G., Kulak, N. A., Wilfert, W., Kohlmaier, A., Herbst, A., Northoff, B. H., Nicolaou, A., Gäbel, G., Beutner, F., Scholz, M., Thiery, J., Musunuru, K., Krohn, K., Mann, M., & Teupser, D. (2016). Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans. Nature Communications. https://doi.org/10.1038/ncomms12429
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