The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Injectable bioadhesive hydrogels with innate antibacterial properties
Open accessAbstract
Surgical site infections cause significant postoperative morbidity and increased healthcare costs. Bioadhesives used to fill surgical voids and support wound healing are typically devoid of antibacterial activity. Here we report novel syringe-injectable bioadhesive hydrogels with inherent antibacterial properties prepared from mixing polydextran aldehyde and branched polyethylenimine. These adhesives kill both Gram-negative and Gram-positive bacteria, while sparing human erythrocytes. An optimal composition of 2.5 wt% oxidized dextran and 6.9 wt% polyethylenimine sets within seconds forming a mechanically rigid (~\n1,700 Pa) gel offering a maximum adhesive stress of ~\n2.8 kPa. A murine infection model showed that the adhesive is capable of killing Streptococcus pyogenes introduced subcutaneously at the bioadhesive’s surface, with minimal inflammatory response. The adhesive was also effective in a cecal ligation and puncture model, preventing sepsis and significantly improving survival. These bioadhesives represent novel, inherently antibacterial materials for wound-filling applications. Bioadhesives are materials frequently used as surgical sealants, though to date, these typically possess limited antibacterial properties. Here, the authors present a novel injectable and antibacterial bioadhesive hydrogel and demonstrate its performance in vivo.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Guideline for Prevention of Surgical Site Infection, 1999
Mangram, A. J., Horan, T. C., Pearson, M. L., Silver, L. C., Jarvis, W. R., & The Hospital Infection Control Practices Advisory Committee (1999) · Infection Control & Hospital Epidemiology · doi:10.1086/501620 · Cited by 4,595
Mechanisms of Antimicrobial Peptide Action and Resistance
Yeaman, M. R., & Yount, N. Y. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.1.2 · Cited by 3,001
A reversible wet/dry adhesive inspired by mussels and geckos
Lee, H., Lee, B. P., & Messersmith, P. B. (2007) · Nature · doi:10.1038/nature05968 · Cited by 2,043
Mechanisms of polymer degradation and erosion
Göpferich, A. (1996) · Biomaterials · doi:10.1016/0142-9612(96)85755-3 · Cited by 1,781
A two-stage poly(ethylenimine)-mediated cytotoxicity: implications for gene transfer/therapy
Moghimi, S. M., Symonds, P., Murray, J. C., Hunter, A. C., Debska, G., & Szewczyk, A. (2005) · Molecular Therapy · doi:10.1016/j.ymthe.2005.02.010 · Cited by 1,092
Host interactions of probiotic bacterial surface molecules: comparison with commensals and pathogens
Lebeer, S., Vanderleyden, J., & De Keersmaecker, S. C. J. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2297 · Cited by 1,062
Surgical site infections: epidemiology, microbiology and prevention
Owens, C. D., & Stoessel, K. (2008) · Journal of Hospital Infection · doi:10.1016/s0195-6701(08)60017-1 · Cited by 987
Multifunctional chondroitin sulphate for cartilage tissue–biomaterial integration
Wang, D.-A., Varghese, S., Sharma, B., Strehin, I., Fermanian, S., Gorham, J., Fairbrother, D. H., Cascio, B., & Elisseeff, J. H. (2007) · Nature Materials · doi:10.1038/nmat1890 · Cited by 693
A biodegradable and biocompatible gecko-inspired tissue adhesive
Mahdavi, A., Ferreira, L., Sundback, C., Nichol, J. W., Chan, E. P., Carter, D. J. D., Bettinger, C. J., Patanavanich, S., Chignozha, L., Ben-Joseph, E., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712117105 · Cited by 554
Design Strategies and Applications of Tissue Bioadhesives
Mehdizadeh, M., & Yang, J. (2013) · Macromolecular Bioscience · doi:10.1002/mabi.201200332 · Cited by 448
A bio-inspired swellable microneedle adhesive for mechanical interlocking with tissue
Yang, S. Y., O'Cearbhaill, E. D., Sisk, G. C., Park, K. M., Cho, W. K., Villiger, M., Bouma, B. E., Pomahac, B., & Karp, J. M. (2013) · Nature Communications · doi:10.1038/ncomms2715 · Cited by 448
SMITH, A. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2005.04.007 · Cited by 443
Fibrin Sealant: Scientific Rationale, Production Methods, Properties, and Current Clinical Use
Radosevich, M., Goubran, H. A., & Burnouf, T. (1997) · Vox Sanguinis · doi:10.1046/j.1423-0410.1997.7230133.x · Cited by 389
A Degradable Polyethylenimine Derivative with Low Toxicity for Highly Efficient Gene Delivery
Forrest, M. L., Koerber, J. T., & Pack, D. W. (2003) · Bioconjugate Chemistry · doi:10.1021/bc034014g · Cited by 387
The index of microbial air contamination
Pasquarella, C., Pitzurra, O., & Savino, A. (2000) · Journal of Hospital Infection · doi:10.1053/jhin.2000.0820 · Cited by 380
Fibrin Sealant: Past, Present, and Future: A Brief Review
Spotnitz, W. D. (2010) · World Journal of Surgery · doi:10.1007/s00268-009-0252-7 · Cited by 338
Milović, N. M., Wang, J., Lewis, K., & Klibanov, A. M. (2005) · Biotechnology and Bioengineering · doi:10.1002/bit.20454 · Cited by 315
Polyethyleneimine is an effective permeabilizer of Gram negative bacteria
Helander, I. M., Alakomi, H.-L., Latva-Kala, K., & Koski, P. (1997) · Microbiology · doi:10.1099/00221287-143-10-3193 · Cited by 237
Cen, L., Neoh, K. G., & Kang, E. T. (2003) · Langmuir · doi:10.1021/la035104c · Cited by 200
Gao, G., Yu, K., Kindrachuk, J., Brooks, D. E., Hancock, R. E. W., & Kizhakkedathu, J. N. (2011) · Biomacromolecules · doi:10.1021/bm2009697 · Cited by 156
Antimicrobial Properties of a Chitosan Dextran-Based Hydrogel for Surgical Use
Aziz, M. A., Cabral, J. D., Brooks, H. J. L., Moratti, S. C., & Hanton, L. R. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.05463-11 · Cited by 149
Polyethylenimine In Medicinal Chemistry
Vicennati, P., Giuliano, A., Ortaggi, G., & Masotti, A. (2008) · Current Medicinal Chemistry · doi:10.2174/092986708786242778 · Cited by 124
Metters, A. T., Anseth, K. S., & Bowman, C. N. (2001) · The Journal of Physical Chemistry B · doi:10.1021/jp004083h · Cited by 115
Tiller, J. C. (2010) · Advances in polymer science · doi:10.1007/12_2010_101 · Cited by 115
Xiong, M. P., Forrest, M. L., Ton, G. N., Zhao, A., Davies, N. M., & Kwon, G. S. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.07.043 · Cited by 114
Ignatova, M., Voccia, S., Gilbert, B., Markova, N., Mercuri, P. S., Galleni, M., Sciannamea, V., Lenoir, S., Cossement, D., Gouttebaron, R., et al. (2004) · Langmuir · doi:10.1021/la048347t · Cited by 95
Poly(ethyleneimines) in dermal applications: Biocompatibility and antimicrobial effects
Wiegand, C., Bauer, M., Hipler, U., & Fischer, D. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.08.001 · Cited by 88
Viscoelastic adhesive mechanics of aldehyde-mediated soft tissue sealants
Shazly, T. M., Artzi, N., Boehning, F., & Edelman, E. R. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.08.032 · Cited by 73
Why and how are peptide-lipid interactions utilized for self defence?
Matsuzaki, K. (2001) · Biochemical Society Transactions · doi:10.1042/bst0290598 · Cited by 73
Making thin polymeric materials, including fabrics, microbicidal and also water-repellent
Lin, J., Murthy, S. K., Olsen, B. D., Gleason, K. K., & Klibanov, A. M. (2003) · Biotechnology Letters · doi:10.1023/a:1025613814588 · Cited by 65
Implant contamination during spine surgery
Bible, J. E., O’Neill, K. R., Crosby, C. G., Schoenecker, J. G., McGirt, M. J., & Devin, C. J. (2013) · The Spine Journal · doi:10.1016/j.spinee.2012.11.053 · Cited by 52
Johnson, K. E., Sherman, M. E., Ssempijja, V., Tobian, A. A. R., Zenilman, J. M., Duggan, M. A., Kigozi, G., Serwadda, D. M., Wawer, M. J., Quinn, T. C., et al. (2009) · AIDS · doi:10.1097/qad.0b013e32832efdf1 · Cited by 46
Tuning adhesion failure strength for tissue-specific applications
Artzi, N., Zeiger, A. S., Boehning, F., Ramos, A. B., Vliet, K. J. V., & Edelman, E. R. (2010) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.07.008 · Cited by 43
Murine Model of Polymicrobial Septic Peritonitis Using Cecal Ligation and Puncture (CLP)
Medina, E. (2009) · Methods in molecular biology · doi:10.1007/978-1-60761-058-8_23 · Cited by 35
Cited by
Liang, Y., Li, Z., Huang, Y., Yu, R., & Guo, B. (2021) · ACS Nano · doi:10.1021/acsnano.1c00204 · Cited by 1,083
Mao, C., Xiang, Y., Liu, X., Cui, Z., Yang, X., Yeung, K. W. K., Pan, H., Wang, X., Chu, P. K., & Wu, S. (2017) · ACS Nano · doi:10.1021/acsnano.7b03513 · Cited by 756
Mussel‐Inspired Hydrogels for Self‐Adhesive Bioelectronics
Xie, C., Wang, X., He, H., Ding, Y., & Lu, X. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201909954 · Cited by 482
Gan, D., Xu, T., Xing, W., Ge, X., Fang, L., Wang, K., Ren, F., & Lu, X. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201805964 · Cited by 425
Zhu, J., Li, F., Wang, X., Yu, J., & Wu, D. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b18927 · Cited by 373
Metadata
- Authors
- Giano, M. C., Ibrahim, Z., Medina, S. H., Sarhane, K. A., Christensen, J. M., Yamada, Y., Brandacher, G., & Schneider, J. P.
- Venue
- Nature Communications
- Published
- 2014-06-24
- Volume
- 5
- Issue
- 1
- Pages
- 4095-4095
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2130728966
- Cited by
- 355
- References
- 34
- FWCI
- 6.95
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
