Cited by 102Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Glutamate receptor dysfunction and drug targets across models of autism spectrum disorders

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Carlson, Greg C.·2012·Pharmacology Biochemistry and Behavior

Abstract

There is strong evidence that metabotropic and ionotropic glutamate receptors are affected in autism spectrum disorders (ASD), but there are few candidate genes indicating involvement of these receptors. This suggests that glutamate receptor dysregulation may primarily be involved in the expression of ASD, but is an uncommon etiology. Directly implicated in models of fragile-X with ASD phenotypes is metabotropic glutamate receptor type 5 (mGluR5), which appears to be an effective pharmacologic target in a number of models of ASD. The review of other ASD models demonstrates that there is also evidence of a role for kainate, NMDA, and AMPA receptors in the neuropathophysiology of ASD, though the relationship between dysfunction in those receptors and ASD-associated phenotypes is not well understood. Current models indicate a way forward to delineate the role of glutamate receptors in ASD. Further development of preclinical models focusing on glutamate receptors may provide tools to target a clinically important subset of ASD symptoms.

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Crossref · 10.1016/j.pbb.2011.02.003

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  • The therapeutic armamentarium aimed at autism derives specificity from neurotransmitter systems broadly, or receptor subtypes like mGluR5, known or believed likely to influence development or expression of core or related autism symptoms.

    “Indeed, to the extent that the therapeutic armamentarium is aimed in a specific way at autism, the specificity derives from neurotransmitter systems broadly, or in some cases receptor subtypes, such as metabotropic glutamate receptors like mGluR5 [255], that are known or believed likely to influence the development or expression of core or related autism symptoms.”

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Authors
Carlson, G. C.
Affiliations
University of Pennsylvania (US)
Corresponding author
Carlson, Greg C.
Venue
Pharmacology Biochemistry and Behavior
Publisher
Elsevier BV
Published
2012-02
Volume
100
Issue
4
Pages
850-854
ISSN
0091-3057 (ISSN-L)
OpenAlex
W2054063927
Cited by
102
References
82
Citations by year
2026: 1 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 16 · 2021: 5 · 2020: 9 · 2019: 2 · 2018: 9 · 2017: 2 · 2016: 2 · 2015: 10 · 2014: 16 · 2013: 10 · 2012: 9
FWCI
1.00
Type
journal article
Language
en
Open access
Locations
  • Pharmacology Biochemistry and Behavior (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD062577, HD062577-02)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
autism spectrum disorder, glutamate receptors, metabotropic glutamate receptor 5, mGluR5, fragile X syndrome, ionotropic glutamate receptors, kainate receptors, NMDA receptor, AMPA receptors, preclinical animal models, therapeutic target, neuropathophysiology
MeSH terms
Child, Child Development Disorders, Pervasive, Humans, Receptors, Glutamate

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