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Cited by 287

The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.

Protective vascular and myocardial effects of adiponectin

Open access
Goldstein, Barry J, Scalia, Rosario G, Ma, Xin L·2009·Nature Clinical Practice Cardiovascular Medicine
DOI 10.1038/ncpcardio1398
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Abstract

Adiponectin is an abundant plasma protein secreted from adipocytes that elicits protective effects in the vasculature and myocardium. In obesity and insulin-resistant states, adiponectin levels are reduced and loss of its protective effects might contribute to the excess cardiovascular risk observed in these conditions. Adiponectin ameliorates the progression of macrovascular disease in rodent models, consistent with its correlation with improved vascular outcomes in epidemiological studies. The mechanisms of adiponectin signaling are multiple and vary among its cellular sites of action. In endothelial cells, adiponectin enhances production of nitric oxide, suppresses production of reactive oxygen species, and protects cells from inflammation that results from exposure to high glucose levels or tumor necrosis factor, through activation of AMP-activated protein kinase and cyclic AMP-dependent protein kinase (also known as protein kinase A) signaling cascades. In the myocardium, adiponectin-mediated protection from ischemia–reperfusion injury is linked to cyclo-oxygenase-2-mediated suppression of tumor necrosis factor signaling, inhibition of apoptosis by AMP-activated protein kinase, and inhibition of excess peroxynitrite-induced oxidative and nitrative stress. In this Review, we provide an update of studies of the signaling effects of adiponectin in endothelial cells and cardiomyocytes.

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Metadata

Authors
Goldstein, B. J., Scalia, R. G., & Ma, X. L.
Venue
Nature Clinical Practice Cardiovascular Medicine
Publisher
Springer Science and Business Media LLC
Published
2008-11-25
Volume
6
Issue
1
Pages
27-35
ISSN
  • 1743-4297 (ISSN-L)
  • 1743-4300
DOI
10.1038/ncpcardio1398
OpenAlex
W2095580512
Cited by
287
References
70
FWCI
13.80
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Protective vascular and myocardial effects of adiponectin. https://app.cochat.ai/papers/10.1038/ncpcardio1398
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Goldstein, B. J., Scalia, R. G., & Ma, X. L. (2009). Protective vascular and myocardial effects of adiponectin. Nature Clinical Practice Cardiovascular Medicine. https://doi.org/10.1038/ncpcardio1398

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.