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Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia
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“…occur in 8% of MDS patients and in 23% of newly diagnosed AML patients, and have been implicated in disease pathogenesis, and as prognostic parameters for worse overall survival (Hopfer et al., 2009; Ley et al., 2010; Ribeiro et al., 2012; Thol et al., 2011a; Walter et al., 2011; Yan et al., 2011).”
BackgroundConditional knockin of Dnmt3a R878H initiates acute myeloid leukemia with mTOR pathway involvement
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Clonal hematopoiesis and hematological malignancy
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Metadata
- Authors
- Yan, X.-J., Xu, J., Gu, Z.-H., Pan, C.-M., Lu, G., Shen, Y., Shi, J.-Y., Zhu, Y.-M., Tang, L., Zhang, X.-W., Liang, W.-X., Mi, J.-Q., Song, H.-D., Li, K.-Q., Chen, Z., & Chen, S.-J.
- Venue
- Nature Genetics
- Published
- 2011-03-13
- Volume
- 43
- Issue
- 4
- Pages
- 309-315
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2140929811
- Cited by
- 813
- References
- 10
- FWCI
- 65.27
- Type
- journal article
- Language
- en
- Open access
- closed
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