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Subspecific origin and haplotype diversity in the laboratory mouse
Open accessAbstract
Here we provide a genome-wide, high-resolution map of the phylogenetic origin of the genome of most extant laboratory mouse inbred strains. Our analysis is based on the genotypes of wild-caught mice from three subspecies of Mus musculus. We show that classical laboratory strains are derived from a few fancy mice with limited haplotype diversity. Their genomes are overwhelmingly Mus musculus domesticus in origin, and the remainder is mostly of Japanese origin. We generated genome-wide haplotype maps based on identity by descent from fancy mice and show that classical inbred strains have limited and non-randomly distributed genetic diversity. In contrast, wild-derived laboratory strains represent a broad sampling of diversity within M. musculus. Intersubspecific introgression is pervasive in these strains, and contamination by laboratory stocks has played a role in this process. The subspecific origin, haplotype diversity and identity by descent maps can be visualized using the Mouse Phylogeny Viewer (see URLs).
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Citations
Cites
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Metadata
- Authors
- Yang, H., Wang, J. R., Didion, J. P., Buus, R. J., Bell, T. A., Welsh, C. E., Bonhomme, F., Yu, A. H.-T., Nachman, M. W., Pialek, J., Tucker, P., Boursot, P., McMillan, L., Churchill, G. A., & de Villena, F. P.-M.
- Venue
- Nature Genetics
- Published
- 2011-05-29
- Volume
- 43
- Issue
- 7
- Pages
- 648-655
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2127783517
- Cited by
- 468
- References
- 2
- FWCI
- 25.40
- Type
- journal article
- Language
- en
- Open access
- green
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