Cited by 1,095Genetic Associations and EpidemiologyGenetics, Aging, and Longevity in Model OrganismsParaoxonase enzyme and polymorphisms

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Genetic associations with human longevity at the APOE and ACE loci

Schächter, François, Faure-Delanef, Laurence, Guénot, Frédérique, Rouger, Hervé, Froguel, Philippe, Lesueur-Ginot, Laurence, Cohen, Daniel·1994·Nature Genetics

DOI 10.1038/ng0194-29

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Abstract

In an effort to dissect the genetic components of longevity, we have undertaken case-control studies of populations of centenarians (n = 338) and adults aged 20-70 years at several polymorphic candidate gene loci. Here we report results on two genes, chosen for their impact on cardiovascular risk, encoding apolipoprotein E (ApoE), angiotensin-converting enzyme (ACE). We find that the epsilon 4 allele of APOE, which promotes premature atherosclerosis, is significantly less frequent in centenarians than in controls (p < 0.001), while the frequency of the epsilon 2 allele, associated previously with type III and IV hyperlipidemia, is significantly increased (p < 0.01). A variant of ACE which predisposes to coronary heart disease is surprisingly more frequent in centenarians, with a significant increase of the homozygous genotype (p < 0.01). These associations provide examples of genetic influences on differential survival and may point to pleiotropic age-dependent effects on longevity.

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Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429
Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.
Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268
Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction.
Weber, J. L., & May, P. E. (1989) · Europe PMC (PubMed Central) · Cited by 3,399
Aging, natural death, and the compression of morbidity
Fries, J. F. (1980) · New England Journal of Medicine · doi:10.1056/nejm198007173030304 · Cited by 3,356
Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.
Hixson, J., & Vernier, D. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)43176-1 · Cited by 2,933
Apolipoprotein E polymorphism and atherosclerosis.
Davignon, J., Gregg, R. E., & Sing, C. F. (1988) · Arteriosclerosis: An Official Journal of the American Heart Association, Inc. · doi:10.1161/01.atv.8.1.1 · Cited by 1,981
Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction
Cambien, F., Poirier, O., Lecerf, L., Evans, A., Cambou, J., Arveiler, D., Luc, G., Bard, J., Bara, L., Ricard, S., et al. (1992) · Nature · doi:10.1038/359641a0 · Cited by 1,908
PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1)
Rigat, B. A., Hübert, C., Corvol, P. L., & Soubrier, R. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.6.1433-a · Cited by 1,237
Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels.
Tiret, L., Rigat, B. A., Visvikis‐Siest, S., Breda, C., Corvol, P. L., Cambien, F., & Soubrier, F. (1992) · Europe PMC (PubMed Central) · Cited by 1,174
Evolution of senescence: late survival sacrificed for reproduction
Kirkwood, T. B. L., & Rose, M. R. (1991) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1991.0028 · Cited by 1,127

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Schächter, F. & Cohen, D. Longevity: a new field for human genetics. Lifespan 4, 1–3 (1993).

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Items 901–1,000 of 1,000

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Wülfert, E. (1996) · CNS Drug Reviews · doi:10.1111/j.1527-3458.1996.tb00300.x · Cited by 3
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Hamaguchi, K., Arikawa, M., Yasunaga, S., Kakuma, T., Fukagawa, K., Yanase, T., Nawata, H., & Sakata, T. (1998) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19980226)76:1 · Cited by 18
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Gu, Y., Lee, J. H., & Mayeux, R. P. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813955-4.00050-7 · Cited by 2
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Ronnacker, J., Grau, M., Klasmeier, M., Klesse, C., Baldauf, H., Abert, S., Berdel, A. F., Füsser, F. T., Sandmann, S., Albring, J. C., et al. (2025) · Blood · doi:10.1182/blood.2024026886 · Cited by 3
Associations between STR autosomal markers and longevity
Bediaga, N. G., Aznar, J. M., Elcoroaristizabal, X., Albóniga, O. E., Gómez-Busto, F., Artabe, I. A., Rocandio, A. M., & de Pancorbo, M. M. (2015) · AGE · doi:10.1007/s11357-015-9818-5 · Cited by 3
Genes and Centenarians
Perls, T. T., Fretts, R. C., Daly, M. J., Brewster, S. J., Kunkel, L. M., & Puca, A. A. (2001) · Springer eBooks · doi:10.1007/978-3-642-59558-5_4 · Cited by 2
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Thévoz, J.-M. (1998) · Laval théologique et philosophique · doi:10.7202/401158ar · Cited by 2
Serum high sensitivity C-reactive protein levels in obese middle school boys
Jeong, J.-H., Lim, J.-W., Cheon, E.-J., Ko, K.-O., & Lee, Y.-H. (2006) · Korean Journal of Pediatrics · doi:10.3345/kjp.2006.49.6.617 · Cited by 2
Metabolic aging and predicted longevity: Results of a cross-sectional study in post-menopausal women
Hays, N. P., Bathalon, G. P., Meydani, S. N., Leka, L. S., Lipman, R. D., Roubenoff, R., Schaefer, E. J., & Roberts, S. B. (2002) · Aging Clinical and Experimental Research · doi:10.1007/bf03327346 · Cited by 2
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Tyrovolas, S., Polychronopoulos, E., Mariolis, A. D., Piscopo, S., Valacchi, G., Makri, K., Zeimbekis, A., Tyrovola, D., Bountziouka, V., Gotsis, E., et al. (2016) · Angiology · doi:10.1177/0003319716642140 · Cited by 3
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Vargas‐Alarcón, G., & Flores-Domı́nguez, C. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-556-9_16 · Cited by 2
Health consequences of ecogenetic variation
Bamshad, M. J., & Motulsky, A. G. (2007) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199207466.003.0004 · Cited by 2
Dietary Patterns Associated with Alzheimer's Disease and Related Chronic Disease Risk: A Review
Gardener, S. L., Rainey‐Smith, S. R., Keogh, J. B., Mathieson, S., & Martins, R. N. (2013) · Murdoch University Research Portal · Cited by 2
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Ordovás, J. M. (2015) · CRC Press eBooks · doi:10.1201/b18563-5 · Cited by 2
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Raji, M. A., & Goodwin, J. (2006) · CRC Press eBooks · doi:10.3109/9780849374487-3 · Cited by 2
Decoupling of DNA Methylation Status and Gene Expression Levels in Aging Individuals
Wierczeiko, A., Fournier, D., Todorov, H., Klingenberg, S., Endres, K., & Gerber, S. (2018) · Genomics and Computational Biology · doi:10.18547/gcb.2018.vol4.iss2.e100040 · Cited by 2
Cell and Molecular Aging
Troen, B. R., & Cristofalo, V. J. (2001) · Springer eBooks · doi:10.1007/978-1-4757-3432-4_1 · Cited by 2
Japanese centenarians
Ota, T. (2003) · Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics · doi:10.3143/geriatrics.40.466 · Cited by 2
The Biological Basis of Aging
Oshima, J., Martin, G. M., & Hisama, F. M. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-383834-6.00022-7 · Cited by 2
Cellular and Molecular Mechanisms Underlying Synaptic Degeneration and Neuronal Death in Alzheimer's Disease
Mattson, M. P., Pedersen, W. A., & Culmsee, C. (2001) · Humana Press eBooks · doi:10.1007/978-1-59259-106-0_6 · Cited by 2
The apolipoprotein E connection One particular variant of the polymorphic protein apolipoprotein E appears to be a risk factor for Alzheimer's disease, possibly because it directly promotes amyloid formation.
Utermann, G. (1994) · Cited by 2
To eat or not to eat – Anti‐ageing effects of energy restriction
Neves, D., Martins, M. J., Passos, E., & Tomada, I. (2015) · Wiley eBooks · doi:10.1002/9781118823408.ch2 · Cited by 2
Genetics of Aging
Schächter, F. (1997) · Springer eBooks · doi:10.1007/978-3-642-60813-1_10 · Cited by 2
Self-citation
Human ageing, a biological view
Almeida, H., & Matos, L. (2015) · Wiley eBooks · doi:10.1002/9781118823408.ch1 · Cited by 2
Molecular Determinants of Human Longevity
Panza, F., D’Introno, A., Colacicco, A. M., Capurso, C. A., Palasciano, R., Capurso, S. A., Gadaleta, A., Capurso, A., Kehoe, P. G., & Solfrizzi, V. (2005) · Advances in clinical chemistry · doi:10.1016/s0065-2423(04)39007-4 · Cited by 2
Langlebigkeit und Altern: Gene oder Umwelt?
Höhn, H. (2002) · Zeitschrift für die gesamte Versicherungswissenschaft · doi:10.1007/bf03190765 · Cited by 2
Elevated frequency of the C2 allele of the ETS-I oncogene in elderly subjects
Crossen, P. E., & Morrison, M. J. (1996) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(96)01721-6 · Cited by 2
Family History and the Frequency of Human Leukocyte Antigen (HLA-DR) in Centenarians.
Akisaka, M., Nohara, Y., & Suzuki, M. (1996) · Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics · doi:10.3143/geriatrics.33.180 · Cited by 2
Genetic Control of the Aging Process: A Review and Interpretation
Enesco, H. E. (1996) · Canadian Journal on Aging / La Revue canadienne du vieillissement · doi:10.1017/s0714980800013258 · Cited by 2
Does Apolipoprotein E Polymorphism Determine the Survivability of Vascular Accidents at Advanced Ages? Implications for Mortality Differentials
Corder, E. H., Lannfelt, L., Viitanen, M. H., Corder, L. S., & Winblad, B. G. (2006) · Springer eBooks · doi:10.1007/1-4020-4032-6_10 · Cited by 2
Evolutionary origins of diversity in human viruses
Sharp, P. M., Bailes, E., & Wain, L. V. (2007) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199207466.003.0013 · Cited by 2
Exome-wide association studies in general and long-lived populations identify genetic variants related to human agePreprint
Sin‐Chan, P., Gosalia, N., Gao, C., Hout, C. V. V., Ye, B., Marcketta, A., Li, A. H., O’Dushlaine, C. T., Li, D., Overton, J. D., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.19.188789 · Cited by 2
Alzheimer's Disease
Mayeux, R. P., & Gandy, S. (2000) · Elsevier eBooks · doi:10.1016/b978-012288145-9/50112-1 · Cited by 3
Genetic Control of Aging
Baghdadi, M., Karasik, D., & Deelen, J. (2019) · Springer eBooks · doi:10.1007/978-3-319-69892-2_726-1 · Cited by 2
Mass Spectrometry for Lipidomics: Methods and Applications – Aging and A lzheimer's Disease
Huynh, K., Beyene, H. B., Wang, T., Giles, C., & Meikle, P. J. (2023) · Wiley eBooks · doi:10.1002/9783527836512.ch25 · Cited by 2
Polygenic scores for estimated glomerular filtration rate in a population of general adults and elderly – comparative results from the KORA and AugUR study
Herold, J. M., Nano, J., Gorski, M., Winkler, T. W., Stanzick, K. J., Zimmermann, M. E., Brandl, C., Peters, A., Köenig, W., Burkhardt, R., et al. (2023) · BMC Genomic Data · doi:10.1186/s12863-023-01130-9 · Cited by 1
Exploring the intersection of Alzheimer's disease and comorbidities: a review of the interplay between multiple chronic conditions
Khan, S., Imam, A., Singh, S., Ahmed, A., Hassan, M. I., Shahid, M., Athar, F., & Islam, A. (2026) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2026.168190 · Cited by 2
Apolipoprotein E in Alzheimer's disease: A review of APOE receptors, signalling pathways and therapeutic opportunities
Saravanan, J., Easwaran, V., Selvaraj, D., Gunasekaran, V., Soumya, V., Thiruselvi, M., Prasanth, M. L., Singh, S., Ellaiyarasu, C., Rai, P. K., et al. (2026) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2026.104108 · Cited by 1
ApoE polymorphism in Polish patients with Alzheimer's disease
Lalowski, M. M., Czyźewski, K., Pfeffer, A., Barcikowska, M., & Kwieciński, H. (1998) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-1998-1260 · Cited by 1
Does FVL have an effect on longevity?
Akın, D. F., Eğin, Y., & Akar, N. (2014) · Egyptian Journal of Medical Human Genetics · doi:10.1016/j.ejmhg.2014.02.009 · Cited by 1
The Biological Basis of Aging: Implications for Medical Genetics
Oshima, J., Martin, G. M., & Hisama, F. M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.05491-x · Cited by 1
Mitochondrial DNA variation in extremely selected traits: longevity and elite athletic performance
Niemi, A. (2005) · Cited by 1
Centenarian Study: Present Status and Perspectives.
Hirose, N., & Suzuki, M. (1999) · Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics · doi:10.3143/geriatrics.36.219 · Cited by 1
Growing up in ageing
Kirkwood, T. B. L. (2011) · Clinical Medicine · doi:10.7861/clinmedicine.11-2-169 · Cited by 1
Chapter 18 – The Biological Basis of Aging: Implications for Medical Genetics
Oshima, J., Martin, G. M., & Hisama, F. M. (2013) · Cited by 1
Role of Phytochemicals in Eliciting Longevity Genes
Kalaiselvi, P., & Velusamy, P. (2018) · Springer eBooks · doi:10.1007/978-981-13-1699-9_17 · Cited by 1
Genetics, Alzheimer’s disease and Down syndrome
Schupf, N. (2018) · CRC Press eBooks · doi:10.1201/9781315376875-3 · Cited by 1
Longevity as an Artifact of Civilization
Vaupel, J. W. (2000) · Springer eBooks · doi:10.1007/978-1-4615-4249-0_8 · Cited by 1
Death gene as it is understood by theology and genetics
Ciocan, T.-C., & Martinescu, A. (2014) · Dialogo · doi:10.51917/dialogo.2014.1.1.5 · Cited by 1
Overview of Older People, Ageing and Diabetes, the Disease
Dunning, T. L. (2018) · Springer eBooks · doi:10.1007/978-3-319-74360-8_1 · Cited by 1
Cohort Differences in the Associations of Selected Candidate Genes With Risk of All-Cause Mortality at Advanced Ages
Tan, Q., Lindahl‐Jacobsen, R., Nygaard, M., Soerensen, M., Mengel‐From, J., Christiansen, L., & Christensen, K. (2020) · American Journal of Epidemiology · doi:10.1093/aje/kwaa007 · Cited by 1
Genetic and Dietary Influences on Lifespan
Gu, Y., Schupf, N., & Mayeux, R. P. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-410529-4.00046-2 · Cited by 1
Surgery in Centenarians
Katlic, M. R., & Coleman, J. (2020) · Springer eBooks · doi:10.1007/978-3-319-47771-8_4 · Cited by 1
The Biological Basis of Aging
Oshima, J., Hisama, F. M., & Martin, G. M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-812537-3.00015-9 · Cited by 1
Post-Genomic View of Aging: Definitions, Theories and Observations
Marı́n-Garcı́a, J., Goldenthal, M. J., & Moe, G. W. P. L. (2007) · Springer eBooks · doi:10.1007/978-0-387-74072-0_1 · Cited by 1
Evolutionary and biological theories of senescence
Crews, D. E. (2003) · Cambridge University Press eBooks · doi:10.1017/cbo9780511542350.003 · Cited by 1
Overview of cardiovascular aging
Wolk, R. A., & Somers, V. K. (2002) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(02)11025-x · Cited by 1
Apolipoprotein E ϵ4 allele, skin vessel reactivity and vascular risk factors in Alzheimer's disease
Algotsson, A., Nordberg, A. K., Lannfelt, L., Almkvist, O., & Winblad, B. G. (1996) · Archives of Gerontology and Geriatrics · doi:10.1016/0167-4943(96)00695-4 · Cited by 1
Enfermedad de Alzheimer: deterioro cognitivo y funcional asociado a polimorfismos de APOE y A2M
Fariñas, M. T. F., Gregório, P. G., Sastre, I., & Bullido, M. J. (2002) · Revista Española de Geriatría y Gerontología · doi:10.1016/s0211-139x(02)74786-0 · Cited by 1
Genes and Age-Related Macular Degeneration
Guymer, R. H., Narendran, N., & Baird, P. N. (2005) · Springer eBooks · doi:10.1007/3-540-26977-0_4 · Cited by 1
EVALUATION OF HIGH-THROUGHPUT METHODOLOGY FOR MULTI-GENE SCREENING IN PATIENTS WITH NON- ALCOHOLIC FATTY LIVER DISEASE (NAFLD)
Fisher, L. R. (2011) · SUNScholar (Stellenbosch University) · Cited by 1
Zukunftsperspektiven der Forschung in Psychiatrie und Psychotherapie
Aldenhoff, J. (1998) · Springer eBooks · doi:10.1007/978-3-7091-6472-3_19 · Cited by 1
From Molecular Gerontology to Healthy Old Age
Toussaint, O., & Rattan, S. I. S. (1996) · Springer eBooks · doi:10.1007/978-1-4615-5889-7_13 · Cited by 1
: Measuring Functional Decline in Population Aging in a Changing World and an Evolving Biology
Mor, V., & Perls, T. T. (2004) · The Journals of Gerontology Series A · doi:10.1093/gerona/59.6.m609 · Cited by 1
[Apolipoprotein E4 and Alzheimer's disease].
Mori, S. (2001) · PubMed · Cited by 1
Cancer as a microevolutionary process
Komarova, N. L., & Wodarz, D. (2007) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199207466.003.0022 · Cited by 1
Whole-genome analysis of pathogen evolution
Parkhill, J. (2007) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199207466.003.0015 · Cited by 1
Genetic Control of Aging
Baghdadi, M., Karasik, D., & Deelen, J. (2021) · Springer eBooks · doi:10.1007/978-3-030-22009-9_726 · Cited by 1
Artificial intelligence-assisted meta-analysis of the frequency of ACE I/D polymorphisms in centenarians and other long-lived individualsPreprint
Li, L., & Murakami, S. (2022) · medRxiv · doi:10.1101/2022.12.10.22283306 · Cited by 1
Association of Genetic Polymorphisms with Longevity in the population of the Sardinian Blue ZonePreprint
Errigo, A., Dore, M. P., & Pes, G. M. (2023) · Preprints.org · doi:10.20944/preprints202309.1070.v1
Suppressing APOE4-induced mortality and cellular damage by targeting VHLPreprint
Jiang, W. I., Cao, Y., Xue, Y., Ji, Y., Winer, B. Y., Zhang, M., Singhal, N. S., Pierce-Shimomura, J. T., Chen, S., & Dengke, K. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.28.582664 · Cited by 1
A mathematical model that predicts human biological age from physiological traits identifies environmental and genetic factors that influence agingPreprint
Libert, S., Chekholko, A., & Kenyon, C. J. (2025) · eLife · doi:10.7554/elife.92092.2 · Cited by 1
Utility of Polygenic Risk Scores in Families with Exceptional LongevityPreprint
Xicota, L., Cheng, R., Barral, S., Honig, L. S., Schupf, N., Gu, Y., Andersen, S. L., Cosentino, S., Zmuda, J. M., Perls, T. T., et al. (2025) · medRxiv · doi:10.1101/2025.07.21.25331660 · Cited by 1
Interactive Effects of Telomere Length and Genetic Variants on Alzheimer Disease Risk Across Multiple Ancestral PopulationsPreprint
Khurshid, Z., Tong, T., Olayinka, O. A., Farrell, J. J., Zhu, C., Alzheimer’s Disease Sequencing Project, Martin, E. R., Bush, W. S., Pericak‐Vance, M. A., Wang, L.-S., et al. (2025) · medRxiv · doi:10.64898/2025.12.15.25342309 · Cited by 1
Ethnic Variation in the Association Between APOE-ε4 and Alzheimer’s Disease: A Follow-up Study
Maestre, G. E., Schofield, P. W., Chun, M. R., Tang, M. ‐., Tycko, B., & Mayeux, R. P. (1996) · Springer eBooks · doi:10.1007/978-3-642-80109-9_15 · Cited by 1
Bedeutung peptiderger Systeme bei der Genese kardiovaskulärer Erkrankungen
Stula, M., Schott, E., & Paul, M. (1998) · Springer eBooks · doi:10.1007/978-3-642-80360-4_11
Longevity and Brain Aging: The Paradigm of Centenarians
Bouras, C., Vallet, P. G., Kövari, E., Michel, J., Herrmann, F. R., Hof, P. R., & Giannakopoulos, P. (2001) · Elsevier eBooks · doi:10.1016/b978-012351830-9/50010-x
Prospective Genetic Epidemiology of Dementia in the Very Old
Altstiel, L., Greenberg, D. A., Lantz, M., Lebow, L., Marin, D. B., Zhou, G. L., Keddache, M. A., Yang, X.-P., & Mohs, R. C. (1997) · KARGER eBooks · doi:10.1159/000059505
Ageing – Future Directions for Research in the Biology of Ageing
Kirkwood, T. B. L. (2003) · Encyclopedia of Life Sciences · doi:10.1038/npg.els.0003394
Preface
Crews, D. E. (2003) · Cambridge University Press eBooks · doi:10.1017/cbo9780511542350.001
Human variation: chronic diseases, risk factors, and senescence
Crews, D. E. (2003) · Cambridge University Press eBooks · doi:10.1017/cbo9780511542350.005
Age, Sex, and Genetic Architecture of Human Gene Expression in EBV Transformed Cell LinesPreprint
Rivas, M. A., Daly, M. J., & Pe’er, I. (2009) · arXiv (Cornell University) · doi:10.48550/arxiv.0911.0215
References
(2003) · Cambridge University Press eBooks · doi:10.1017/cbo9780511542350.008
Human Models of Longevity
Perls, T. T. (2006) · Elsevier eBooks · doi:10.1016/b978-012369391-4/50048-5
Genetics and Genomics of Human Longevity
Wu, Y., Chung, W., & Chung, W. (2014) · Wiley eBooks · doi:10.1002/9780470015902.a0024643

Authors: Schächter, F., Faure-Delanef, L., Guénot, F., Rouger, H., Froguel, P., Lesueur-Ginot, L., & Cohen, D.
Affiliations: Fondation Jean Dausset-CEPH (FR)
ORCID: Froguel, Philippe
Cohen, Daniel
Venue: Nature Genetics
Publisher: Springer Science and Business Media LLC
Published: 1994-01
Volume: 6
Issue: 1
Pages: 29-32
ISSN: 1061-4036 (ISSN-L)
1546-1718
DOI: 10.1038/ng0194-29
OpenAlex: W2069863984
Cited by: 1,095
References: 36
Citations by year: 2026: 11 · 2025: 15 · 2024: 17 · 2023: 14 · 2022: 22 · 2021: 18 · 2020: 26 · 2019: 30 · 2018: 22 · 2017: 29 · 2016: 33 · 2015: 28 · 2014: 33 · 2013: 27 · 2012: 33
FWCI: 39.36
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Genetics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
Keywords: human longevity, centenarians, apolipoprotein E, APOE ε4, angiotensin-converting enzyme, ACE I/D polymorphism, genetic association, atherosclerosis, coronary artery disease, cardiovascular risk, hyperlipidemia, pleiotropy, differential survival
MeSH terms: Adult, Aged, Aged, 80 and over, Alleles, Apolipoproteins E, Base Sequence, Female, France, Gene Frequency, Genotype, Humans, Peptidyl-Dipeptidase A, Longevity, Male, Middle Aged, Molecular Sequence Data, Polymorphism, Genetic, Sex Characteristics, Case-Control Studies

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Genetic associations with human longevity at the APOE and ACE loci

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