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Genetic associations with human longevity at the APOE and ACE loci
Abstract
In an effort to dissect the genetic components of longevity, we have undertaken case-control studies of populations of centenarians (n = 338) and adults aged 20-70 years at several polymorphic candidate gene loci. Here we report results on two genes, chosen for their impact on cardiovascular risk, encoding apolipoprotein E (ApoE), angiotensin-converting enzyme (ACE). We find that the epsilon 4 allele of APOE, which promotes premature atherosclerosis, is significantly less frequent in centenarians than in controls (p < 0.001), while the frequency of the epsilon 2 allele, associated previously with type III and IV hyperlipidemia, is significantly increased (p < 0.01). A variant of ACE which predisposes to coronary heart disease is surprisingly more frequent in centenarians, with a significant increase of the homozygous genotype (p < 0.01). These associations provide examples of genetic influences on differential survival and may point to pleiotropic age-dependent effects on longevity.
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“The ε4 allele of the apolipoprotein E (APOE) gene is the major genetic risk factor for AD and dementia with Lewy bodies (DLB) (1, 5, 6), whereas APOE2, a well-established longevity determinant, affords protection against the disease (7, 8).”
From APOE3 -Jacksonville (V236E) variant reduces self-aggregation and risk of dementia (2021) · cites this paper as [7]
In the citing paper
“ApoE4 was the first genetic variation to be associated with decreased longevity [72].”
From Apoe4 and Alzheimer’s Disease Pathogenesis—Mitochondrial Deregulation and Targeted Therapeutic Strategies (2023) · cites this paper as [72]
In the citing paper
“and decreased longevity. 41,44,45”
From Preclinical Evidence of Alzheimer's Disease in Persons Homozygous for the ε4 Allele for Apolipoprotein E (1996) · cites this paper as [45]
In the citing paper
“and increased longevity.41,44,45”
From Preclinical Evidence of Alzheimer's Disease in Persons Homozygous for the ε4 Allele for Apolipoprotein E (1996) · cites this paper as [45]
Citations
Cites
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429
Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268
Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction.
Weber, J. L., & May, P. E. (1989) · Europe PMC (PubMed Central) · Cited by 3,399
Aging, natural death, and the compression of morbidity
Fries, J. F. (1980) · New England Journal of Medicine · doi:10.1056/nejm198007173030304 · Cited by 3,356
Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.
Hixson, J., & Vernier, D. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)43176-1 · Cited by 2,933
Apolipoprotein E polymorphism and atherosclerosis.
Davignon, J., Gregg, R. E., & Sing, C. F. (1988) · Arteriosclerosis: An Official Journal of the American Heart Association, Inc. · doi:10.1161/01.atv.8.1.1 · Cited by 1,981
Cambien, F., Poirier, O., Lecerf, L., Evans, A., Cambou, J., Arveiler, D., Luc, G., Bard, J., Bara, L., Ricard, S., et al. (1992) · Nature · doi:10.1038/359641a0 · Cited by 1,908
Rigat, B. A., Hübert, C., Corvol, P. L., & Soubrier, R. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.6.1433-a · Cited by 1,237
Tiret, L., Rigat, B. A., Visvikis‐Siest, S., Breda, C., Corvol, P. L., Cambien, F., & Soubrier, F. (1992) · Europe PMC (PubMed Central) · Cited by 1,174
Evolution of senescence: late survival sacrificed for reproduction
Kirkwood, T. B. L., & Rose, M. R. (1991) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1991.0028 · Cited by 1,127
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- Schächter, F. & Cohen, D. Longevity: a new field for human genetics. Lifespan 4, 1–3 (1993).
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Items 601–700 of 1,000
Immunochip analysis identifies association of the RAD 50/ IL 13 region with human longevity
Flachsbart, F., Ellinghaus, D., Gentschew, L., Heinsen, F., Caliebe, A., Christiansen, L., Nygaard, M., Christensen, K., Blanché, H., Deleuze, J., et al. (2016) · Aging Cell · doi:10.1111/acel.12471 · Cited by 23
Shadyab, A. H., Kooperberg, C. L., Reiner, A. P., Jain, S., Manson, J. E., Hohensee, C., Macera, C. A., Shaffer, R. A., Gallo, L. C., & LaCroix, A. Z. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw198 · Cited by 23
A centenarian-only approach for assessing gene–gene interaction in human longevity
Tan, Q., Benedictis, G. D., Ukraintseva, S. V., Franceschi, C., Vaupel, J. W., & Yashin, A. I. (2002) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200770 · Cited by 23
Vormfelde, S. V., Burckhardt, G., Zirk, A., Wojnowski, L., & Brockmöller, J. (2003) · Pharmacogenomics · doi:10.1517/phgs.4.6.701.22817 · Cited by 23
Diagnosis of Alzheimer's disease: defining genetic profiles (genotype vs phenotype)
Cacabelos, R. (1996) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1996.tb05875.x · Cited by 23
Risk factors for ill‐health in a remote desert‐dwelling Aboriginal community in Western Australia
Gracey, M. S., Burke, V., Spargo, R. M., Beilin, L. J., Smith, P. M., Beilby, J. P., Smith, R. M., & Chin, C. (1996) · Australian and New Zealand Journal of Medicine · doi:10.1111/j.1445-5994.1996.tb00881.x · Cited by 23
Tan, Q., Yashin, A. I., Bladbjerg, E., de Maat, M. P. M., Andersen‐Ranberg, K., Jeune, B., Christensen, K., & Vaupel, J. W. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00102-4 · Cited by 23
Molecular Genetics and Psychology
Plomin, R. J. (1995) · Current Directions in Psychological Science · doi:10.1111/1467-8721.ep10772416 · Cited by 23
Gambaro, G., & Baggio, B. (1996) · Nephrology Dialysis Transplantation · doi:10.1093/oxfordjournals.ndt.a027392 · Cited by 23
Zhang, Y., Murata, S., Schmidt‐Mende, K., Ebeling, M., & Modig, K. (2024) · GeroScience · doi:10.1007/s11357-024-01330-w · Cited by 22
Flachsbart, F., Franke, A., Kleindorp, R., Caliebe, A., Blanché, H., Schreiber, S., & Nebel, A. (2010) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2010.08.006 · Cited by 22
Torres, G. G., Dose, J., Hasenbein, T. P., Nygaard, M., Krause‐Kyora, B., Mengel‐From, J., Christensen, K., Andersen‐Ranberg, K., Kolbe, D., Lieb, W., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810949 · Cited by 20
Amygdala subnuclei and healthy cognitive aging
Aghamohammadi‐Sereshki, A., Hrybouski, S., Travis, S. G., Huang, Y., Olsen, F., Carter, R., Camicioli, R. M., & Malykhin, N. V. (2018) · Human Brain Mapping · doi:10.1002/hbm.24353 · Cited by 23
Wang, J., Shi, L., Zou, Y., Tang, J., Cai, J., Wei, Y., Qin, J., & Zhang, Z. (2018) · Aging · doi:10.18632/aging.101663 · Cited by 22
Apolipoprotein E gene in physiological and pathological aging
Ferri, E., Gussago, C., Casati, M., Mari, D., Rossi, P. D., Ciccone, S., Cesari, M., & Arosio, B. (2019) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2019.01.005 · Cited by 22
Accardi, G., Aprile, S., Candore, G., Caruso, C., Cusimano, R., Cristaldi, L., Bona, D. D., Duro, G., Galimberti, D., Gambino, C. M., et al. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190313115233 · Cited by 22
Yang, F., Sun, L., Zhu, X., Han, J., Zeng, Y., Nie, C., Yuan, H., Li, X., Shi, X., Yang, Y., et al. (2017) · Aging · doi:10.18632/aging.101323 · Cited by 22
Angiotensin converting enzyme gene, smoking and mortality in a population‐based study
Arias‐Vásquez, A., Sayed‐Tabatabaei, F. A., Schut, A. F., Hofman, A., Bertolli‐Avella, A. M., Vergeer, J. M., Aulchenko, Y. S., Witteman, J. C. M., & van Duijn, C. M. (2005) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2005.01515.x · Cited by 22
The ACE Deletion Polymorphism Is Not Associated with Parkinson’s Disease
Mellick, G. D., Buchanan, D. D., McCann, S. J., Davis, D. R., Couteur, D. G. L., Chan, D. K. Y., & Johnson, A. G. (1999) · European Neurology · doi:10.1159/000008012 · Cited by 22
Thibonnier, M., & Schork, N. J. (1995) · Current Opinion in Genetics & Development · doi:10.1016/0959-437x(95)80052-2 · Cited by 22
Is Apolipoprotein E4 an Important Risk Factor for Dementia in Persons with Down Syndrome?
Rohn, T. T., McCarty, K. L., Love, J. E., & Head, E. (2014) · Journal of Parkinson’s Disease and Alzheimer’s Disease · doi:10.13188/2376-922x.1000004 · Cited by 22
Role of CLU, PICALM, and TNK1 Genotypes in Aging With and Without Alzheimer’s Disease
Seripa, D., Panza, F., Paroni, G., D’Onofrio, G., Bisceglia, P., Gravina, C., Urbano, M., Lozupone, M., Solfrizzi, V., Bizzarro, A., et al. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0547-x · Cited by 21
Ferrario, A., Villa, F., Malovini, A. L., Araniti, F., & Puca, A. A. (2012) · Immunity & Ageing · doi:10.1186/1742-4933-9-7 · Cited by 21
Parental Longevity and Diabetes Risk in the Diabetes Prevention Program
Florez, H. J., Ma, Y., Crandall, J. P., Perreault, L., Marcovina, S. M., Bray, G. A., Saudek, C. D., Barrett-Connor, E. L., & Knowler, W. C. (2011) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr114 · Cited by 21
Graeser, A.-C., Huebbe, P., Storm, N., Höppner, W., Döring, F., Wagner, A. E., & Rimbach, G. H. (2012) · Genes & Nutrition · doi:10.1007/s12263-012-0282-x · Cited by 21
Influence of Apolipoprotein E Genotype on Progression of Diabetic Nephropathy
Joss, N., Jardine, A. G., Gaffney, D. F., & Boulton‐Jones, J. M. (2005) · Nephron Experimental Nephrology · doi:10.1159/000087577 · Cited by 21
Evidence that the gene encoding insulin degrading enzyme influences human lifespan
Hong, M., Reynolds, C. A., Gatz, M., Johansson, B. E. A., Palmer, J. C., Gu, H. F., Blennow, K., Kehoe, P. G., Fairé, U. D., Pedersen, N. L., et al. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn137 · Cited by 21
ApoE2 Allele, Down's Syndrome, and Dementiaa
Royston, M. C., Mann, D. M. A., Pickering-Brown, S. M., Owen, F., Perry, R., RAGBHAVAN, R., Khin-Nu, C., Tyner, S., DAY, K., Crook, R., et al. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb34428.x · Cited by 20
ACE Gene Polymorphism and Insulin Action in Older Subjects and Healthy Centenarians
Paolisso, G., Tagliamonte, M. R., Lucia, D. D., Palmieri, F., Manzella, D., Rinaldi, C., Bossone, A., Colaizzo, D., Margaglione, M., & Varricchio, M. (2001) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2001.49122.x · Cited by 21
Rahmutula, D., Nakayama, T., Izumi, Y., Ozawa, Y., Shimabukuro, H., Kawamura, H., Zhen-Wang, S., Xiong-Wang, J., Aisa, M., Run-Yang, C., et al. (2002) · The Journals of Gerontology Series A · doi:10.1093/gerona/57.1.m57 · Cited by 21
Analysis of the APOE alleles impact in Down's syndrome
Lambert, J., Pérez‐Tur, J., Dupire, M.-J., Delacourte, A., Frigard, B., & Chartier‐Harlin, M. (1996) · Neuroscience Letters · doi:10.1016/s0304-3940(96)13244-4 · Cited by 21
Apolipoprotein e genotype and late paraphrenia
Howard, R. J., Dennehey, J., Lovestone, S., Birkett, J., Sham, P. C., Powell, J. F., Castle, D. J., Murray, R. M., & Levy, R. (1995) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.930100210 · Cited by 21
Increase of homozygosity in centenarians revealed by a new inter-Alu PCR technique
Bonafè, M. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00112-7 · Cited by 21
Genetic Determinants of Endurance Performance
Bouchard, C., Wolfarth, B., Rivera, M. A., Gagnon, J., & Simoneau, J. (2000) · Wiley eBooks · doi:10.1002/9780470694930.ch15 · Cited by 20
Longitudinal machine learning uncouples healthy aging factors from chronic disease risks
Cohen, N. M., Lifshitz, A., Jaschek, R., Rinott, E., Balicer, R. D., Shlush, L. I., Barbash, G. I., & Tanay, A. (2023) · Nature Aging · doi:10.1038/s43587-023-00536-5 · Cited by 20
Druley, T. E., Wang, L., Lin, S. J., Lee, J. H., Zhang, Q., Daw, E. W., Abel, H., Chasnoff, S. E., Ramos, E., Levinson, B. T., et al. (2016) · BMC Geriatrics · doi:10.1186/s12877-016-0253-y · Cited by 21
Kerber, R. A., O’Brien, E., Boucher, K. M., Smith, K. R., & Cawthon, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034746 · Cited by 20
Rana, G., Yadav, S., Joshi, S., & Saraswathy, K. N. (2017) · Journal of Community Genetics · doi:10.1007/s12687-017-0321-9 · Cited by 20
Ataxia-telangiectasia mutated (ATM) genetic variant in Italian centenarians
Piaceri, I., Bagnoli, S., Tedde, A., Sorbi, S., & Nacmias, B. (2012) · Neurological Sciences · doi:10.1007/s10072-012-1188-5 · Cited by 19
Low level of the mtDNA4977 deletion in blood of exceptionally old individuals
von Wurmb‐Schwark, N., Schwark, T., Caliebe, A., Drenske, C., Nikolaus, S., Schreiber, S., & Nebel, A. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.01.005 · Cited by 20
Is the ACE I/D polymorphism associated with extreme longevity? A study on a Spanish cohort
Fiuza‐Luces, C., Ruiz, J. R., Rodríguez‐Romo, G., Santiago, C., Gómez‐Gallego, F., Cano-Nieto, A., Garatachea, N., Rodríguez-Moreno, I., Morán, M., & Lucía, A. (2011) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320310391505 · Cited by 19
Bias in Association Studies Resulting from Gene-Environment Interactions and Competing Risks
Elbaz, A. (2002) · American Journal of Epidemiology · doi:10.1093/aje/155.3.265 · Cited by 20
Hibberd, M. L., Millward, B. A., & Demaine, A. G. (1997) · Journal of Diabetes and its Complications · doi:10.1016/1056-8727(95)00114-x · Cited by 20
Apo E and Apo CI Loci Are Associated with Dementia in Younger But Not Older Late-Onset Cases
Tysoe, C. J., Galinsky, D., Robinson, D., Brayne, C., Huppert, F. A., Dening, T., Paykel, E. S., Easton, D. F., & Rubinsztein, D. C. (1998) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000017046 · Cited by 20
Azar, S. T., Zalloua, P., Medlej, R., & Halabi, G. (2001) · Endocrine Research · doi:10.1081/erc-100107173 · Cited by 20
Hirose, N., Homma, S., Arai, Y., Kawamura, M., Hasegawa, H., Ishida, H., Shimizu, K., Osono, Y., Homma, A., & Nakamura, Y. (1997) · Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics · doi:10.3143/geriatrics.34.267 · Cited by 20
Kamboh, M. I., Sanghera, D. K., Aston, C. E., Bunker, C. H., Hamman, R. F., Ferrell, R. E., & DeKosky, S. T. (1997) · Genetic Epidemiology · doi:10.1002/(sici)1098-2272(1997)14:2 · Cited by 16
Evolutionary Theories of Aging Can Explain Why We Age
Bourg, É. L. (2014) · Interdisciplinary topics in gerontology and geriatrics · doi:10.1159/000358897 · Cited by 19
Dietary beta‐carotene and lutein metabolism is modulated by the APOE genotype
Huebbe, P., Lange, J., Lietz, G., & Rimbach, G. H. (2016) · BioFactors · doi:10.1002/biof.1284 · Cited by 21
Apolipoprotein E Polymorphisms and Age at First Coronary Artery Bypass Graft
Newman, M. F., Laskowitz, D. T., White, W. D., Kirchner, J., Grocott, H. P., Stafford‐Smith, M., Mh, S., Jones, R. H., Reves, J. G., & Saunders, A. M. (2001) · Anesthesia & Analgesia · doi:10.1097/00000539-200104000-00006 · Cited by 19
Emergence of new infectious diseases
Woolhouse, M. E. J., & Antia, R. (2007) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199207466.003.0016 · Cited by 19
Mammalian longevity under the protection of PARP-1’s multi-facets
Muiras, M.-L. (2003) · Ageing Research Reviews · doi:10.1016/s1568-1637(02)00062-4 · Cited by 19
Apolipoprotein E genotype in elderly nondemented subjects without senile changes in the brain
Yamada, M., Itoh, Y., Otomo, E., Suematsu, N., & Matsushita, M. (1996) · Annals of Neurology · doi:10.1002/ana.410400217 · Cited by 19
Yliopisto, K., & Helisalmi, S. (1998) · Cited by 19
Genetic Factors Associated With the Absence of Atherosclerosis in Octogenarians
Zuliani, G., Cherubini, A., Volpato, S., Palmieri, E., Mecocci, P., Rango, P. D., Cao, P., Costantini, F., Mezzetti, A., Mascoli, F., et al. (2002) · The Journals of Gerontology Series A · doi:10.1093/gerona/57.9.m611 · Cited by 19
Miller, B., Kim, S., Cao, K., Mehta, H. H., Thumaty, N., Kumagai, H., Iida, T., McGill, C. J., Pike, C. J., Nurmakova, K., et al. (2024) · Aging Cell · doi:10.1111/acel.14153 · Cited by 19
Familial Mortality in the Utah Population Database: Characterizing a Human Aging Phenotype
O’Brien, E. A., Kerber, R. A., Smith, K. R., Mineau, G., Boucher, K. M., & Reed, D. L. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.8.803 · Cited by 18
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Duarte, P. D. O., Duarte, M. G. F., Pelichek, A., Pfrimer, K., Ferriolli, E., Moriguti, J. C., & Lima, N. K. C. (2016) · Aging Clinical and Experimental Research · doi:10.1007/s40520-016-0603-9 · Cited by 18
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Tan, Q., Christiansen, L., Christensen, K., Kruse, T. A., & Bathum, L. (2004) · European Journal of Epidemiology · doi:10.1023/b:ejep.0000036784.64143.26 · Cited by 18
Tanisawa, K., Arai, Y., Hirose, N., Shimokata, H., Yamada, Y., Kawai, H., Kojima, M., Obuchi, S. P., Hirano, H., Yoshida, H., et al. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw074 · Cited by 19
Yoshida, K., Ishigami, T., Nakazawa, I., Ohno, A., Tamura, K., Fukuoka, M., Mizushima, S., & Umemura, S. (2000) · Journal of Human Genetics · doi:10.1007/s100380070019 · Cited by 18
Zhang, J., Li, X., Zhang, Z., Chen, D., Zhao, H.-L., Wu, Y., & Qu, Q.-M. (2005) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000085075 · Cited by 18
Gondo, Y., Hirose, N., Arai, Y., Yamamura, K., Shimizu, K.-I., Takayama, M., Ebihara, Y., Nakazawa, S., Inagaki, H., Masui, Y., et al. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.06.006 · Cited by 18
Trougakos, I. P., Petropoulou, C., Franceschi, C., & Gonos, E. S. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1354.039 · Cited by 18
Reed, T., Carmelli, D., Robinson, T. S., Rinehart, S. A., & Williams, C. J. (2003) · The Journals of Gerontology Series A · doi:10.1093/gerona/58.4.m367 · Cited by 18
Usmani, B. A., Janeczko, M., Shen, R., Mazumdar, M., Papandreou, C. N., & Nanus, D. M. (2000) · British Journal of Cancer · doi:10.1054/bjoc.1999.0962 · Cited by 18
Ballerini, S., Bellincampi, L., Bernardini, S., Casciani, S., Motti, C., Cortese, C., & Federici, G. (2002) · Clinica Chimica Acta · doi:10.1016/s0009-8981(01)00769-0 · Cited by 18
How frequent is altered gene expression among susceptibility genes to human complex disorders?
Jais, P. H. (2005) · Genetics in Medicine · doi:10.1097/01.gim.0000153665.55420.c3 · Cited by 18
Apolipoprotein E and Alzheimer's disease
Poirier, J., Nalbantoglu, J. N., Guillaume, D., & Bertrand, P. (1995) · Elsevier eBooks · doi:10.1016/b978-012286965-5/50014-5 · Cited by 18
Winkler, T. W., Wiegrebe, S., Herold, J. M., Stark, K. J., Küchenhoff, H., & Heid, I. M. (2024) · Genome biology · doi:10.1186/s13059-024-03439-9 · Cited by 18
Carriers of Heterozygous Loss-of-Function ACE Mutations Are at Risk for Alzheimer’s Disease
Danilov, S. M., Adzhubei, I. A., Kozuch, A. J., Petukhov, P. A., Popova, I. A., Choudhury, A., Sengupta, D., & Dudek, S. M. (2024) · Biomedicines · doi:10.3390/biomedicines12010162 · Cited by 17
Genetic variation and human longevity.
Soerensen, M. (2012) · PubMed · Cited by 17
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Soeiro‐de‐Souza, M. G., Bio, D. S., Dias, V. V., do Prado, C. M., Campos, R. N., Costa, L. F. D. O., Moreno, D. H., Ojopi, E. P. B., Gattaz, W. F., & Moreno, R. A. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00153.x · Cited by 17
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Bo, R. D., Ghezzi, S., Scarlato, M., Albani, D., Galimberti, D., Lucca, U., Tettamanti, M., Scarpini, E. A., Forloni, G., Bresolin, N., et al. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.05.003 · Cited by 17
Global spatial patterns of infectious diseases and human evolution
Guégan, J., Prugnolle, F., & Frédéric Thomas, A. (2007) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199207466.003.0002 · Cited by 16
Genetic interplay between human longevity and metabolic pathways — a large‐scale eQTL study
Häsler, R., Venkatesh, G., Tan, Q., Flachsbart, F., Sinha, A. N., Rosenstiel, P. C., Lieb, W., Schreiber, S., Christensen, K., Christiansen, L., et al. (2017) · Aging Cell · doi:10.1111/acel.12598 · Cited by 17
Eco-Aging: stem cells and microbes are controlled by aging antagonist FoxO
Mortzfeld, B. M., & Bosch, T. C. G. (2017) · Current Opinion in Microbiology · doi:10.1016/j.mib.2017.06.009 · Cited by 17
Iacono, D., Zandi, P. P., Gross, M. D., Markesbery, W. R., Pletniková, O., Rudow, G. L., & Troncoso, J. C. (2015) · Oncotarget · doi:10.18632/oncotarget.4118 · Cited by 18
Koella, J. C., & Turner, P. E. (2007) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199207466.003.0017 · Cited by 17
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Williams, T. A., Villard, E., Prigent, Y., Dadoune, J., & Soubrier, F. (1995) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(94)03446-z · Cited by 17
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Vijg, J., Perls, T. T., Franceschi, C., & van Orsouw, N. J. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb05639.x · Cited by 17
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Haig, D. (2007) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199207466.003.0006 · Cited by 17
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Morris, B. J. (1996) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1996.tb03054.x · Cited by 17
Effect of six candidate genes on early aging in a French population
Xia, Y., Gueguen, R., Vincent‐Viry, M., Siest, G., & Visvikis‐Siest, S. (2003) · Aging Clinical and Experimental Research · doi:10.1007/bf03324487 · Cited by 17
Effects of the ApoE Polymorphism on Plasma Lipoproteins in Mexican Americans
Hsueh, W., Mitchell, B. D., Hixson, J. E., & Rainwater, D. L. (2000) · Annals of Epidemiology · doi:10.1016/s1047-2797(00)00074-0 · Cited by 17
Molecular biology's impact on our understanding of aging
Mann, D. M. A. (1997) · BMJ · doi:10.1136/bmj.315.7115.1078 · Cited by 16
Searching for genetic determinants of human aging and longevity: opportunities and challenges
Vijg, J., & van Orsouw, N. J. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00346-3 · Cited by 18
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Rossi, G. P., Taddei, S., Virdis, A., Ghiadoni, L., Albertin, G., Favilla, S., Sudano, I., Pessina, A. C., & Salvetti, A. (2001) · Hypertension · doi:10.1161/01.hyp.37.2.293 · Cited by 17
Santamaria, J. C., & Irla, M. (2026) · Science Advances · doi:10.1126/sciadv.aeb2970 · Cited by 20
Liu, W., Zhu, X., Tang, L. Y., Shen, N., Cheng, F., Zou, P., You, Y., Yuan, G., Li, Q., & Zhu, X. (2022) · Scientific Reports · doi:10.1038/s41598-022-21009-6 · Cited by 17
Genetic evidence of heterogeneity in intrahepatic cholestasis of pregnancy
Savander, M. (2003) · Journal of Medical Genetics · doi:10.1136/jmg.40.8.640 · Cited by 16
Yokoyama, S., Oguro, R., Yamamoto, K. I., Akasaka, H., Ito, N., Kawai, T., Kusunoki, H., Takeya, Y., Onishi‐Takeya, M., Yamamoto‐Hanasaki, H., et al. (2018) · Aging · doi:10.18632/aging.101728 · Cited by 16
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Samokhodskaya, L. M., Jain, M. S., Kurilova, O. V., Bobkov, A. P., Kamalov, A. A., Dudek, S. M., & Danilov, S. M. (2021) · The Journal of Applied Laboratory Medicine · doi:10.1093/jalm/jfab032 · Cited by 16
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Lanni, C., Racchi, M., Uberti, D. L., Mazzini, G., Stanga, S., Sinforiani, E., Memo, M., & Govoni, S. M. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208786264133 · Cited by 16
Petrovič, D., Zorc, M., & Peterlin, B. (2000) · Folia Biologica · doi:10.14712/fb2000046050181 · Cited by 16
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Robine, J. (2007) · Springer eBooks · doi:10.1007/978-1-4020-4848-7_1 · Cited by 16
MTHFR thermolabile genotype frequencies and longevity in Northern Ireland
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Riol, H., Jeune, B., Moskovic, A., Bathum, L., & Wang, E. (1999) · Analytical Biochemistry · doi:10.1006/abio.1999.4328 · Cited by 16
Metadata
- Authors
- Schächter, F., Faure-Delanef, L., Guénot, F., Rouger, H., Froguel, P., Lesueur-Ginot, L., & Cohen, D.
- Affiliations
- Fondation Jean Dausset-CEPH (FR)
- Venue
- Nature Genetics
- Published
- 1994-01
- Volume
- 6
- Issue
- 1
- Pages
- 29-32
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2069863984
- Cited by
- 1,095
- References
- 36
- Citations by year
- 2026: 11 · 2025: 15 · 2024: 17 · 2023: 14 · 2022: 22 · 2021: 18 · 2020: 26 · 2019: 30 · 2018: 22 · 2017: 29 · 2016: 33 · 2015: 28 · 2014: 33 · 2013: 27 · 2012: 33
- FWCI
- 39.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
- Keywords
- human longevity, centenarians, apolipoprotein E, APOE ε4, angiotensin-converting enzyme, ACE I/D polymorphism, genetic association, atherosclerosis, coronary artery disease, cardiovascular risk, hyperlipidemia, pleiotropy, differential survival
- MeSH terms
- Adult, Aged, Aged, 80 and over, Alleles, Apolipoproteins E, Base Sequence, Female, France, Gene Frequency, Genotype, Humans, Peptidyl-Dipeptidase A, Longevity, Male, Middle Aged, Molecular Sequence Data, Polymorphism, Genetic, Sex Characteristics, Case-Control Studies
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