Cited by 1,095Genetic Associations and EpidemiologyGenetics, Aging, and Longevity in Model OrganismsParaoxonase enzyme and polymorphisms

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Genetic associations with human longevity at the APOE and ACE loci

Schächter, François, Faure-Delanef, Laurence, Guénot, Frédérique, Rouger, Hervé, Froguel, Philippe, Lesueur-Ginot, Laurence, Cohen, Daniel·1994·Nature Genetics

DOI 10.1038/ng0194-29

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Abstract

In an effort to dissect the genetic components of longevity, we have undertaken case-control studies of populations of centenarians (n = 338) and adults aged 20-70 years at several polymorphic candidate gene loci. Here we report results on two genes, chosen for their impact on cardiovascular risk, encoding apolipoprotein E (ApoE), angiotensin-converting enzyme (ACE). We find that the epsilon 4 allele of APOE, which promotes premature atherosclerosis, is significantly less frequent in centenarians than in controls (p < 0.001), while the frequency of the epsilon 2 allele, associated previously with type III and IV hyperlipidemia, is significantly increased (p < 0.01). A variant of ACE which predisposes to coronary heart disease is surprisingly more frequent in centenarians, with a significant increase of the homozygous genotype (p < 0.01). These associations provide examples of genetic influences on differential survival and may point to pleiotropic age-dependent effects on longevity.

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Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429
Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.
Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268
Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction.
Weber, J. L., & May, P. E. (1989) · Europe PMC (PubMed Central) · Cited by 3,399
Aging, natural death, and the compression of morbidity
Fries, J. F. (1980) · New England Journal of Medicine · doi:10.1056/nejm198007173030304 · Cited by 3,356
Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.
Hixson, J., & Vernier, D. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)43176-1 · Cited by 2,933
Apolipoprotein E polymorphism and atherosclerosis.
Davignon, J., Gregg, R. E., & Sing, C. F. (1988) · Arteriosclerosis: An Official Journal of the American Heart Association, Inc. · doi:10.1161/01.atv.8.1.1 · Cited by 1,981
Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction
Cambien, F., Poirier, O., Lecerf, L., Evans, A., Cambou, J., Arveiler, D., Luc, G., Bard, J., Bara, L., Ricard, S., et al. (1992) · Nature · doi:10.1038/359641a0 · Cited by 1,908
PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1)
Rigat, B. A., Hübert, C., Corvol, P. L., & Soubrier, R. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.6.1433-a · Cited by 1,237
Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels.
Tiret, L., Rigat, B. A., Visvikis‐Siest, S., Breda, C., Corvol, P. L., Cambien, F., & Soubrier, F. (1992) · Europe PMC (PubMed Central) · Cited by 1,174
Evolution of senescence: late survival sacrificed for reproduction
Kirkwood, T. B. L., & Rose, M. R. (1991) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1991.0028 · Cited by 1,127

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Schächter, F. & Cohen, D. Longevity: a new field for human genetics. Lifespan 4, 1–3 (1993).

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Items 201–300 of 1,000

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The APOE Gene and Differences in Life Expectancy in Europe
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Genetics of human longevity within an eco-evolutionary nature-nurture framework
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Gonos, E. S., Derventzi, A., Kveiborg, M., Agiostratidou, G., Kassem, M. S., Clark, B. F. C., Jat, P., & Rattan, S. I. S. (1998) · Experimental Cell Research · doi:10.1006/excr.1998.3948 · Cited by 93
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Zwaan, B. J. (1999) · Heredity · doi:10.1046/j.1365-2540.1999.00544.x · Cited by 89
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Margaglione, M., Seripa, D., Gravina, C., Grandone, E., Vecchione, G., Cappucci, G., Merla, G., Papa, S., Postiglione, A., Minno, G. D., et al. (1998) · Stroke · doi:10.1161/01.str.29.2.399 · Cited by 87
Searching for Human Longevity Genes: The Future History of Gerontology in the Post-genomic Era
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The role of APOE polymorphisms in late-onset dementias
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Methodological problems in genetic association studies of longevity--the apolipoprotein E gene as an example
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Evans, J. G. (1997) · BMJ · doi:10.1136/bmj.315.7115.1075 · Cited by 83
Angiotensin-Converting Enzyme and Angiotensinogen Gene Polymorphisms and Heart Rate Variability in Twins 11This study was supported in part by a grant-in-aid from the BMBF LPD 1995; by a grant-in-aid from the Bundesministerium ü Bildung und Forschung; and by Vo 505/2-1 from the Deutsche Forschungsgemeinschaft, Bonn, Germany.
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Genes and Longevity: Lessons From Studies of Centenarians
Yashin, A. I., BENEDICTIS, G. D., Vaupel, J. W., Tan, Q., Andreev, K. F., Iachine, I. A., Bonafè, M., Valensin, S., Luca, M. D., Carotenuto, L., et al. (2000) · The Journals of Gerontology Series A · doi:10.1093/gerona/55.7.b319 · Cited by 80
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Katzman, R., Zhang, M.-Y., Chen, P. J., Gu, N., Jiang, S., Saitoh, T., Chen, X., Klauber, M. R., Thomas, R. G., Liu, W. T., et al. (1997) · Neurology · doi:10.1212/wnl.49.3.779 · Cited by 78
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Angiotensin-Converting Enzyme Gene Polymorphism
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Salvioli, S., Olivieri, F., Marchegiani, F., Cardelli, M., Santoro, A., Bellavista, E., Mishto, M., Invidia, L., Capri, M., Valensin, S., et al. (2006) · Free Radical Research · doi:10.1080/10715760600917136 · Cited by 77
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Panza, F., Solfrizzi, V., Torres, F., Mastroianni, F., Parigi, A. D., Colacicco, A. M., Basile, A. M., Capurso, C. A., Noya, R., & Capurso, A. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00860-5 · Cited by 78
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Zubenko, G. S., Henderson, R., Stiffler, J. S., Stabler, S. M., Rosen, J., & Kaplan, B. B. (1996) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00046-7 · Cited by 78
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Noble, E. P., Zhang, X., Ritchie, T. L., Lawford, B. R., Grosser, S. C., Young, R. M., & Sparkes, R. S. (1998) · Psychiatry Research · doi:10.1016/s0165-1781(98)00084-5 · Cited by 75
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Liddell, M. B., Lovestone, S., & Owen, M. J. (2001) · The British Journal of Psychiatry · doi:10.1192/bjp.178.1.7 · Cited by 75
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The evolution and expression of virulence
Ebert, D., & Bull, J. J. (2007) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199207466.003.0012 · Cited by 75
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Zweier, C., Temple, I. K., Beemer, F. A., Zackai, E., Lerman‐Sagie, T., Weschke, B., Anderson, C. E., & Rauch, A. M. (2003) · Journal of Medical Genetics · doi:10.1136/jmg.40.8.601 · Cited by 72
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Perls, T. T., & Terry, D. F. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00098-6 · Cited by 73
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Sandholzer, C., Delport, R., Vermaak, H., & Utermann, G. (1995) · Human Genetics · doi:10.1007/bf00225073 · Cited by 70
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Wolters, F. J., Yang, Q., Biggs, M. L., Jakobsdottir, J., Li, S., Evans, D. S., Bis, J. C., Harris, T. B., Vasan, R. S., Zilhao, N. R., et al. (2019) · PLOS ONE · doi:10.1371/journal.pone.0219668 · Cited by 74
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Malovini, A. L., Illario, M., Iaccarino, G., Villa, F., Ferrario, A., Roncarati, R., Anselmi, C. V., Novelli, V., Cipolletta, E., Leggiero, E., et al. (2011) · Rejuvenation Research · doi:10.1089/rej.2010.1114 · Cited by 72
Low prevalence of apolipoprotein E ε4 allele in the neurofibrillary tangle predominant form of senile dementia
Bancher, C., Egensperger, R., Kösel, S., Jellinger, K. A., & Graeber, M. B. (1997) · Acta Neuropathologica · doi:10.1007/s004010050726 · Cited by 71
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Harringtonaa, C. R., Roth, M., Xuereb, J. H., McKenna, P. J., & Wischik, C. M. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)12218-4 · Cited by 71
Paraoxonase polymorphisms PON1 192 and 55 and longevity in Italian centenarians and Irish nonagenarians. A pooled analysis
Rea, I. M., McKeown, P., McMaster, D., Young, I. S., Patterson, C. C., Savage, M., Belton, C., Marchegiani, F., Olivieri, F., Bonafè, M., et al. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2003.11.019 · Cited by 71
Inherited stress resistance and longevity: a stress theory of ageing
Parsons, P. A. (1995) · Heredity · doi:10.1038/hdy.1995.126 · Cited by 71
Angiotensin-Converting Enzyme and Apolipoprotein E Genotypes and Restenosis After Coronary Angioplasty
BOCKXMEER, F. M. V., Mamotte, C. D. S., Gibbons, F. A., Burke, V., & Taylor, R. R. (1995) · Circulation · doi:10.1161/01.cir.92.8.2066 · Cited by 70
Aging and cardiovascular diseases: the role of gene-diet interactions
Corella, D., & Ordovás, J. M. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.08.002 · Cited by 83
Apolipoprotein E polymorphism in patients with different neurodegenerative disorders
Helisalmi, S., Linnaranta, K., Lehtovirta, M., Mannermaa, A., Heinonen, O., Ryynänen, M., Riekkinen, P. J., & Soininen, H. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12373-9 · Cited by 70
The National Institute on Aging/Alzheimer's Association Recommendations on the Application of Apolipoprotein E Genotyping to Alzheimer's Diseasea
Relkin, N. R., Kwon, Y. J., Tsai, J., & Gandy, S. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb32608.x · Cited by 69
Longevity genes: from primitive organisms to humans
Warner, H. R. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.08.015 · Cited by 70
Apolipoprotein E genotype, dementia, and mortality in the oldest old: The 90+ Study
Corrada, M. M., Paganini‐Hill, A., Berlau, D. J., & Kawas, C. H. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2011.12.004 · Cited by 68
Lack of replication of genetic associations with human longevity
Novelli, V., Anselmi, C. V., Roncarati, R., Guffanti, G., Malovini, A. L., Piluso, G., & Puca, A. A. (2007) · Biogerontology · doi:10.1007/s10522-007-9116-4 · Cited by 69
PAI-1 polymorphisms modulate phenotypes associated with the metabolic syndrome in obese and diabetic Caucasian population
Lopes, C., Christian Dina, C., Durand, E., & Froguel, P. (2003) · Diabetologia · doi:10.1007/s00125-003-1170-0 · Cited by 68
Self-citation
Coupling of a DNA piezoelectric biosensor and polymerase chain reaction to detect apolipoprotein E polymorphisms
Tombelli, S., Mascini, M., Braccini, L., Anichini, M., & Turner, A. P. F. (2000) · Biosensors and Bioelectronics · doi:10.1016/s0956-5663(00)00092-0 · Cited by 68
The Renin Angiotensin System and Alzheimer's Disease
Amouyel, P., RICHARD, F., Berr, C., David-Fromentin, I., & Helbecque, N. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06395.x · Cited by 68
Apolipoprotein E allele distribution in parents of Down's syndrome children
Avramopoulos, D., Grigoriadou, M., Petersen, M. B., Mikkelsen, M., Petersen, M. B., & Vassilopoulos, D. (1996) · The Lancet · doi:10.1016/s0140-6736(96)91346-x · Cited by 68
Human Senescence
Crews, D. E. (2003) · Cambridge University Press eBooks · doi:10.1017/cbo9780511542350 · Cited by 69
A prospective study of cognitive health in the elderly (Oregon Brain Aging Study): effects of family history and apolipoprotein E genotype.
Payami, H., Grimslid, H., Oken, B., Camicioli, R. M., Sexton, G. J., Dame, A., Howieson, D. B., & Kaye, J. A. (1997) · PubMed · Cited by 66
HRAS1 and LASS1 with APOE are associated with human longevity and healthy aging
Jazwinski, S. M., Kim, S., Dai, J., Li, L., Bi, X.-H., Jiang, J. C., Arnold, J., Batzer, M. A., Walker, J. A., Welsh, D. A., et al. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00600.x · Cited by 67
Puzzling role of genetic risk factors in human longevity: “risk alleles” as pro-longevity variants
Ukraintseva, S. V., Yashin, A. I., Arbeev, K. G., Kulminski, A. M., Akushevich, I. V., Wu, D., Joshi, G., Land, K. C., & Stallard, E. (2015) · Biogerontology · doi:10.1007/s10522-015-9600-1 · Cited by 68
Disease variants in genomes of 44 centenarians
Freudenberg‐Hua, Y., Freudenberg, J., Vacic, V., Abhyankar, A., Emde, A., Ben‐Avraham, D., Barzilai, N., Oschwald, D. M., Christen, E., Koppel, J. L., et al. (2014) · Molecular Genetics & Genomic Medicine · doi:10.1002/mgg3.86 · Cited by 69
Human senescence evolutionary and biocultural perspectives
Crews, D. E. (2003) · Cited by 67
Neuroinflammation: A Possible Link Between Chronic Vascular Disorders and Neurodegenerative Diseases
Moyse, E., Krantic, S. M., Djellouli, N., Roger, S., Angoulvant, D., Debacq, C., Leroy, V., Fougère, B., & Aïdoud, A. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.827263 · Cited by 72
Apolipoprotein E, an important player in longevity and age-related diseases
Ang, L. S., Cruz, R. P., Hendel, A., & Granville, D. J. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.03.010 · Cited by 70
Angiotensin I converting enzyme (ACE) gene polymorphism in centenarians: Different allele frequencies between the North and South of Europe
Panza, F. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00154-2 · Cited by 65
ApoE genotype and Down's syndrome
Hardy, J., Crook, R., Perry, R., Raghavan, R., & Roberts, G. W. (1994) · The Lancet · doi:10.1016/s0140-6736(94)90106-6 · Cited by 66

Authors: Schächter, F., Faure-Delanef, L., Guénot, F., Rouger, H., Froguel, P., Lesueur-Ginot, L., & Cohen, D.
Affiliations: Fondation Jean Dausset-CEPH (FR)
ORCID: Froguel, Philippe
Cohen, Daniel
Venue: Nature Genetics
Publisher: Springer Science and Business Media LLC
Published: 1994-01
Volume: 6
Issue: 1
Pages: 29-32
ISSN: 1061-4036 (ISSN-L)
1546-1718
DOI: 10.1038/ng0194-29
OpenAlex: W2069863984
Cited by: 1,095
References: 36
Citations by year: 2026: 11 · 2025: 15 · 2024: 17 · 2023: 14 · 2022: 22 · 2021: 18 · 2020: 26 · 2019: 30 · 2018: 22 · 2017: 29 · 2016: 33 · 2015: 28 · 2014: 33 · 2013: 27 · 2012: 33
FWCI: 39.36
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Genetics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
Keywords: human longevity, centenarians, apolipoprotein E, APOE ε4, angiotensin-converting enzyme, ACE I/D polymorphism, genetic association, atherosclerosis, coronary artery disease, cardiovascular risk, hyperlipidemia, pleiotropy, differential survival
MeSH terms: Adult, Aged, Aged, 80 and over, Alleles, Apolipoproteins E, Base Sequence, Female, France, Gene Frequency, Genotype, Humans, Peptidyl-Dipeptidase A, Longevity, Male, Middle Aged, Molecular Sequence Data, Polymorphism, Genetic, Sex Characteristics, Case-Control Studies

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Genetic associations with human longevity at the APOE and ACE loci

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