Cited by 1,095Genetic Associations and EpidemiologyGenetics, Aging, and Longevity in Model OrganismsParaoxonase enzyme and polymorphisms

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Genetic associations with human longevity at the APOE and ACE loci

Schächter, François, Faure-Delanef, Laurence, Guénot, Frédérique, Rouger, Hervé, Froguel, Philippe, Lesueur-Ginot, Laurence, Cohen, Daniel·1994·Nature Genetics

DOI 10.1038/ng0194-29

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Abstract

In an effort to dissect the genetic components of longevity, we have undertaken case-control studies of populations of centenarians (n = 338) and adults aged 20-70 years at several polymorphic candidate gene loci. Here we report results on two genes, chosen for their impact on cardiovascular risk, encoding apolipoprotein E (ApoE), angiotensin-converting enzyme (ACE). We find that the epsilon 4 allele of APOE, which promotes premature atherosclerosis, is significantly less frequent in centenarians than in controls (p < 0.001), while the frequency of the epsilon 2 allele, associated previously with type III and IV hyperlipidemia, is significantly increased (p < 0.01). A variant of ACE which predisposes to coronary heart disease is surprisingly more frequent in centenarians, with a significant increase of the homozygous genotype (p < 0.01). These associations provide examples of genetic influences on differential survival and may point to pleiotropic age-dependent effects on longevity.

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Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429
Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.
Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268
Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction.
Weber, J. L., & May, P. E. (1989) · Europe PMC (PubMed Central) · Cited by 3,399
Aging, natural death, and the compression of morbidity
Fries, J. F. (1980) · New England Journal of Medicine · doi:10.1056/nejm198007173030304 · Cited by 3,356
Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.
Hixson, J., & Vernier, D. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)43176-1 · Cited by 2,933
Apolipoprotein E polymorphism and atherosclerosis.
Davignon, J., Gregg, R. E., & Sing, C. F. (1988) · Arteriosclerosis: An Official Journal of the American Heart Association, Inc. · doi:10.1161/01.atv.8.1.1 · Cited by 1,981
Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction
Cambien, F., Poirier, O., Lecerf, L., Evans, A., Cambou, J., Arveiler, D., Luc, G., Bard, J., Bara, L., Ricard, S., et al. (1992) · Nature · doi:10.1038/359641a0 · Cited by 1,908
PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1)
Rigat, B. A., Hübert, C., Corvol, P. L., & Soubrier, R. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.6.1433-a · Cited by 1,237
Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels.
Tiret, L., Rigat, B. A., Visvikis‐Siest, S., Breda, C., Corvol, P. L., Cambien, F., & Soubrier, F. (1992) · Europe PMC (PubMed Central) · Cited by 1,174
Evolution of senescence: late survival sacrificed for reproduction
Kirkwood, T. B. L., & Rose, M. R. (1991) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1991.0028 · Cited by 1,127

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Schächter, F. & Cohen, D. Longevity: a new field for human genetics. Lifespan 4, 1–3 (1993).

Sorted by citations

Items 101–200 of 1,000

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The Genetics of the Amyloidoses
Buxbaum, J. N., & Tagoe, C. E. (2000) · Annual Review of Medicine · doi:10.1146/annurev.med.51.1.543 · Cited by 153
Apolipoprotein E Genetic Variation and Alzheimer’s Disease
Rubinsztein, D. C., & Easton, D. F. (1999) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000017120 · Cited by 151
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Baghai, T. C., Binder, E. B., Schüle, C., Salyakina, D., Eser, D., Lucae, S., Zwanzger, P., Haberger, C., Zill, P., Ising, M., et al. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001884 · Cited by 151
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Geesaman, B. J., Benson, E. K., Brewster, S. J., Kunkel, L. M., Blanché, H., Thomas, G. D., Perls, T. T., Daly, M. J., & Puca, A. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1936249100 · Cited by 149
Pathophysiology of apolipoprotein E deficiency in mice: relevance to apo E‐related disorders in humans
Moghadasian, M. H., McManus, B. M., Nguyen, L. B., Shefer, S., Nadji, M., Godin, D. V., Green, T. J., Hill, J. S., Yang, Y., Scudamore, C. H., et al. (2001) · The FASEB Journal · doi:10.1096/fj.01-0463com · Cited by 150
Gene dose of the ε4 allele of apolipoprotein E and disease progression in sporadic late‐onset alzheimer's disease
Frisoni, G. B., Govoni, S., Geroldi, C., Bianchetti, A., Calabresi, L., Franceschini, G., & Trabucchi, M. (1995) · Annals of Neurology · doi:10.1002/ana.410370509 · Cited by 149
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Martínez-Martínez, A. B., Torres-Perez, E., Devanney, N., Del Moral, R., Johnson, L. A., & Arbones-Mainar, J. M. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104809 · Cited by 149
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Retracted
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Morris, B. J., Willcox, B. J., & Donlon, T. A. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.08.039 · Cited by 140
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RPGR mutation associated with retinitis pigmentosa, impaired hearing, and sinorespiratory infections
Zito, I., Downes, S. M., Patel, R. J., Cheetham, M. E., Ebenezer, N. D., Jenkins, S. A., Bhattacharya, S. S., Webster, A. R., Holder, G. E., Bird, A. C., et al. (2003) · Journal of Medical Genetics · doi:10.1136/jmg.40.8.609 · Cited by 145
Lower Cognitive Performance in Normal Older Adult Male Twins Carrying the Apolipoprotein E 4 Allele
Reed, T., Carmelli, D., Swan, G. E., Breitner, J. C. S., Welsh-Bohmer, K. A., Jarvik, G. P., Deeb, S., & Auwerx, J. H. (1994) · Archives of Neurology · doi:10.1001/archneur.1994.00540240033012 · Cited by 143
A population study of apoE genotype at the age of 85: relation to dementia, cerebrovascular disease, and mortality
Skoog, I. G., Hesse, C., Aevarsson, Ó., Landahl, S., Wahlström, J., Fredman, P., & Blennow, K. (1998) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.64.1.37 · Cited by 143
Genome-environment interactions that modulate aging: powerful targets for drug discovery
de Magalhães, J. P., Wuttke, D., Wood, S. H., Plank, M., & Vora, C. (2012) · Pharmacological Reviews · doi:10.1124/pr.110.004499 · Cited by 136
Disentangling the Genetic Determinants of Human Aging: Biological Age as an Alternative to the Use of Survival Measures
Karasik, D., Demissie, S., Cupples, L. A., & Kiel, D. P. (2005) · The Journals of Gerontology Series A · doi:10.1093/gerona/60.5.574 · Cited by 141
ApoE allele frequencies in Italian sporadic and familial Alzheimer's disease
Sorbi, S., Nacmias, B., Forleo, P., Latorraca, S., Gobbini, M. I., Bracco, L., Piacentini, S., & Amaducci, L. A. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90054-x · Cited by 143
Genetics of Longevity and Aging
Vijg, J., & Suh, Y. (2005) · Annual Review of Medicine · doi:10.1146/annurev.med.56.082103.104617 · Cited by 142
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Castellano, M., Muiesan, M. L., Rizzoni, D., Beschi, M., Pasini, G., Cinelli, A., Salvetti, M., Porteri, E., Bettoni, G., Kreutz, R. H., et al. (1995) · Circulation · doi:10.1161/01.cir.91.11.2721 · Cited by 142
Angiotensin I-Converting Enzyme
Crisan, D., & Carr, J. (2000) · Journal of Molecular Diagnostics · doi:10.1016/s1525-1578(10)60624-1 · Cited by 143
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Muiras, M.-L., Müller, M. C., Schächter, F., & Bürkle, A. (1998) · Journal of Molecular Medicine · doi:10.1007/s001090050226 · Cited by 140
Self-citation
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Hendrie, H. C., Hall, K. S., Hui, S. L., Unverzagt, F. W., Yu, C., Lahiri, D. K., Sahota, A. S., Farlow, M. R., Musick, B. S., Brashear, A., et al. (1995) · Annals of Neurology · doi:10.1002/ana.410370123 · Cited by 141
Different frequencies of angiotensin-converting enzyme genotypes in older hypertensive individuals.
Morris, B. J., Zee, R. Y. L., & Schrader, A. P. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117423 · Cited by 140
Dehydroepiandrosterone, glucose-6-phosphate dehydrogenase, and longevity
Schwartz, A. (2004) · Ageing Research Reviews · doi:10.1016/j.arr.2003.05.001 · Cited by 138
Elite athletes and the gene for angiotensin-converting enzyme
Taylor, R. R., Mamotte, C. D. S., Fallon, K. E., & BOCKXMEER, F. M. V. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.3.1035 · Cited by 139
A polymorphism of the angiotensinogen gene associated with variation in blood pressure in a genetic isolate.
Hegele, R. A., Brunt, J., & Connelly, P. W. (1994) · Circulation · doi:10.1161/01.cir.90.5.2207 · Cited by 139
Predictive value of apolipoprotein E genotyping in Alzheimer's disease: Results of an autopsy series and an analysis of several combined studies
Nalbantoglu, J. N., Gilfix, B. M., Bertrand, P., Robitaille, Y., Gauthier, S. G., Rosenblatt, D. S., & Poirier, J. (1994) · Annals of Neurology · doi:10.1002/ana.410360614 · Cited by 137
APOE genotype and stress response - a mini review
Dose, J., Huebbe, P., Nebel, A., & Rimbach, G. (2016) · Lipids in Health and Disease · doi:10.1186/s12944-016-0288-2 · Cited by 137
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Tian, X., & Yang, L. (2014) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2014.08.001 · Cited by 139
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TANG, M., Maestre, G. E., TSAI, W., Liu, X., FENG, L., Chung, W., Chun, M. R., Schofield, P. W., Stern, Y., Tycko, B., et al. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb32593.x · Cited by 135
Racial Difference in the Relationship of an Angiotensin I–Converting Enzyme Gene Polymorphism to Serum Angiotensin I– Converting Enzyme Activity
Bloem, L. J., Manatunga, A. K., & Pratt, J. H. (1996) · Hypertension · doi:10.1161/01.hyp.27.1.62 · Cited by 134
The genetics of human longevity: an intricacy of genes, environment, culture and microbiome
Dato, S., Rose, G., Crocco, P., Monti, D., Garagnani, P., Franceschi, C., & Passarino, G. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.03.011 · Cited by 135
Apolipoproteins and aging: emerging mechanisms
Smith, J. D. (2002) · Ageing Research Reviews · doi:10.1016/s1568-1637(02)00005-3 · Cited by 133
Coronary heart disease: an older woman's major health risk
WENGER, N. K. (1997) · BMJ · doi:10.1136/bmj.315.7115.1085 · Cited by 129
The apolipoprotein E ε2 allele is associated with an increased risk of early‐onset alzheimer's disease and a reduced survival
van Duijn, C. M., de Knijff, P., Wehnert, A., Voecht, J. D., Bronzova, J., Havekes, L. M., Albert Hofman, D., & Broeckhoven, C. V. (1995) · Annals of Neurology · doi:10.1002/ana.410370510 · Cited by 130
The Epidemiology of Longevity and Exceptional Survival
Newman, A. B., & Murabito, J. M. (2013) · Epidemiologic Reviews · doi:10.1093/epirev/mxs013 · Cited by 126
Frequency of the apolipoprotein E ε2 allele is diminished in sporadic Alzheimer disease
West, H. L., William Rebeck, G., & Hyman, B. T. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)91074-x · Cited by 125
Influence of apolipoprotein E genotype on senile dementia of the Alzheimer and Lewy body types. Significance for etiological theories of Alzheimer's disease
Harrington, C. R., Louwagie, J., Rossau, R., Vanmechelen, E., Perry, R. H., Perry, E. K., Xuereb, J. H., Roth, M., & Wischik, C. M. (1994) · PubMed Central · doi:10.25405/ncl.34087548 · Cited by 127
Evidence for Linkage and Association with Reading Disability, on 6p21.3-22
Kaplan, D. E., Gayán, J., Ahn, J., Won, T.-W., Pauls, D. L., Olson, R. K., DeFries, J. C., Wood, F., Pennington, B. F., Page, G. P., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/340449 · Cited by 126
The Genetics of Exceptional Human Longevity
Perls, T. T., Kunkel, L. M., & Puca, A. A. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.49283.x · Cited by 122
Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism and Cerebrovascular Disease
Catto, A. J., Carter, A. M., Barrett, J. H., Stickland, M. H., Bamford, J., Davies, J. A., & Grant, P. J. (1996) · Stroke · doi:10.1161/01.str.27.3.435 · Cited by 125
Centenarians: An excellent example of resilience for successful ageing
Borrás, C., Inglés, M., Mas‐Bargues, C., Dromant, M., Sanz‐Ros, J., Román-Domínguez, A., Gimeno-Mallench, L., Gambini, J., & Viña, J. (2019) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2019.111199 · Cited by 124
A study of French centenarians: are ACE and APOE associated with longevity?
Blanché, H., Cabanne, L., Sahbatou, M., & Thomas, G. D. (2001) · Comptes Rendus de l Académie des Sciences - Series III - Sciences de la Vie · doi:10.1016/s0764-4469(00)01274-9 · Cited by 121
Apolipoprotein E ε4 Allele and the Lifetime Risk of Alzheimer's Disease: What Physicians Know, and What They Should Know
Seshadri, S. (1995) · Archives of Neurology · doi:10.1001/archneur.1995.00540350068018 · Cited by 163
Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphic Variant as a Marker of Coronary Artery Disease A Meta-analysis
Zintzaras, E. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.10.1077 · Cited by 122
Apolipoprotein E Genotype Determines Survival in the Oldest Old (85 Years or Older) Who Have Good Cognition
Corder, E. H., Lannfelt, L., Viitanen, M. H., Corder, L. S., Manton, K., Winblad, B. G., & Basun, H. (1996) · Archives of Neurology · doi:10.1001/archneur.1996.00550050048022 · Cited by 120
Cancer—Incidence, prevalence and mortality in the oldest-old. A comprehensive review
Nolen, S. C., Evans, M. A., Fischer, A., Corrada, M. M., Kawas, C. H., & Bota, D. A. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.05.002 · Cited by 126
Quality of life and longevity: a study of centenarians
Buono, M. D., Urciuoli, O., & Leo, D. D. (1998) · Age and Ageing · doi:10.1093/ageing/27.2.207 · Cited by 121
Heteroplasmy for the 1555A>G mutation in the mitochondrial 12S rRNA gene in six Spanish families with non-syndromic hearing loss
del Castillo, F. J., Rodríguez-Ballesteros, M., Martín, Y., Arellano, B., Gallo-Terán, J., Morales‐Angulo, C., Ramírez-Camacho, R., Tapia, M. C., Solanellas, J., Martínez-Conde, A., et al. (2003) · Journal of Medical Genetics · doi:10.1136/jmg.40.8.632 · Cited by 123
Non-coding variability at the APOE locus contributes to the Alzheimer’s risk
Zhou, X., Chen, Y., Mok, K. Y., Kwok, T. C. Y., Mok, V. C. T., Guo, Q., Ip, F. C., Chen, Y., Mullapudi, N., Initiative, A. D. N., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10945-z · Cited by 120
Unbiased tensor-based morphometry: Improved robustness and sample size estimates for Alzheimer's disease clinical trials
Hua, X., Hibar, D. P., Ching, C. R. K., Boyle, C. P., Rajagopalan, P., Gutman, B. A., Leow, A., Toga, A. W., Jack, C. R., Harvey, D. J., et al. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.10.086 · Cited by 114
Genome-wide association studies for Alzheimer’s disease: bigger is not always better
Escott-Price, V., & Hardy, J. (2022) · Brain Communications · doi:10.1093/braincomms/fcac125 · Cited by 119
The Genetics of Coronary Heart Disease: The Contribution of Twin Studies
Evans, A., van Baal, G. C. M., McCarron, P., deLange, M., Soerensen, T. I., de Geus, E. J. C., Kyvik, K. O., Pedersen, N. L., Spector, T. D., Andrew, T., et al. (2003) · Twin Research · doi:10.1375/136905203770326439 · Cited by 119
Population aging and health
Butler, R. N. (1997) · BMJ · doi:10.1136/bmj.315.7115.1082 · Cited by 120
The ACE gene and Alzheimer's disease susceptibility
Narain, Y., Yip, A., Murphy, T., Brayne, C., Easton, D., Evans, J. G., Xuereb, J., Cairns, N., Esiri, M., Furlong, R., et al. (2000) · Journal of Medical Genetics · doi:10.1136/jmg.37.9.695 · Cited by 121
Evidence of RPGRIP1 gene mutations associated with recessive cone-rod dystrophy
Hameed, A. (2003) · Journal of Medical Genetics · doi:10.1136/jmg.40.8.616 · Cited by 117
Genetic factors associated with longevity: A review of recent findings
Shadyab, A. H., & LaCroix, A. Z. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.10.005 · Cited by 112
Methodological Considerations in Studying Centenarians: Lessons Learned From the Georgia Centenarian Studies.
Poon, L. W., Jazwinski, S. M., Green, R. C., Woodard, J. L., Martin, P., Rodgers, W. L., Johnson, M. A., Hausman, D. B., Arnold, J., Davey, A., et al. (2007) · PubMed · Cited by 113
The Future of Aging Therapies
Hadley, E. C., Lakatta, E. G., Morrison‐Bogorad, M., Warner, H. R., & Hodes, R. J. (2005) · Cell · doi:10.1016/j.cell.2005.01.030 · Cited by 111
The Neurobiology and Age-Related Prevalence of the ε4 Allele of Apolipoprotein E in Alzheimer’s Disease Cohorts
Heffernan, A. L., Chidgey, C., Peng, P., Masters, C. L., & Roberts, B. R. (2016) · Journal of Molecular Neuroscience · doi:10.1007/s12031-016-0804-x · Cited by 113
ApoE and Neurodegenerative Diseases in Aging
Yin, Y., & Wang, Z. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1117-8_5 · Cited by 111
Theories of Aging: An Ever-Evolving Field
Владимирович, С. П., Dontsova, O. А., & Berezkin, G. V. (2015) · Acta Naturae · doi:10.32607/20758251-2015-7-1-9-18 · Cited by 116
Impact of Apolipoprotein E ε4 and Vascular Disease on Brain Morphology in Men From the NHLBI Twin Study
DeCarli, C. S., Reed, T., Miller, B. L., Wolf, P. A., Swan, G. E., & Carmelli, D. (1999) · Stroke · doi:10.1161/01.str.30.8.1548 · Cited by 114
Alzheimer's disease and soluble Aβ
Wısnıewskı, T., Ghiso, J. A., & Frangione, B. (1994) · Neurobiology of Aging · doi:10.1016/0197-4580(94)90105-8 · Cited by 112
RNA Editing Genes Associated with Extreme Old Age in Humans and with Lifespan in C. elegans
Paola Sebastiani, B., Montano, M. A., Puca, A. A., Solovieff, N., Kojima, T., Wang, M. C., Melista, E., Meltzer, M., Fischer, S. E. J., Andersen, S. L., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008210 · Cited by 111
Understanding the Determinants of Exceptional Longevity
Perls, T. T., & Terry, D. F. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-5_part_2-200309021-00013 · Cited by 110
Pharmacogenomics in Alzheimer's Disease
Cacabelos, R. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-205-2_10 · Cited by 109
APOE3 -Jacksonville (V236E) variant reduces self-aggregation and risk of dementia
Liu, C.-C., Murray, M. E., Li, X., Zhao, N., Wang, N., Heckman, M. G., Shue, F., Martens, Y., Li, Y., Raulin, A.-C., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abc9375 · Cited by 108
Identification and characterization of two functional variants in the human longevity gene FOXO3
Flachsbart, F., Dose, J., Gentschew, L., Geismann, C., Caliebe, A., Knecht, C., Nygaard, M., Badarinarayan, N., ElSharawy, A., May, S., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-02183-y · Cited by 110
Between Zeus and the Salmon
National Research Council (1997) · National Academies Press eBooks · doi:10.17226/5740 · Cited by 109
APOE polymorphisms and the development of diabetic nephropathy in type 1 diabetes: results of case-control and family-based studies.
Araki, S., Moczulski, D. K., Ficociello, L., Scott, L. J., Warram, J. H., & Królewski, A. S. (2000) · Diabetes · doi:10.2337/diabetes.49.12.2190 · Cited by 109
Association of a Functional Polymorphism in the Cholesteryl Ester Transfer Protein ( CETP ) Gene With Memory Decline and Incidence of Dementia
Sanders, A. E. (2010) · JAMA · doi:10.1001/jama.2009.1988 · Cited by 107
Gene Polymorphisms Predicting High Plasma Levels of Coagulation and Fibrinolysis Proteins
Mannucci, P. M., Mari, D., Merati, G., Peyvandi, F., Tagliabue, L., Sacchi, E., Taioli, E., Sansoni, P., Bertolini, S., & Franceschi, C. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.4.755 · Cited by 106
Apolipoprotein (APOE) gene is associated with progression of age-related macular degeneration (AMD)
Baird, P. N., Richardson, A. J., Robman, L. D., Dimitrov, P. N., Tikellis, G., McCarty, C. A., & Guymer, R. H. (2006) · Human Mutation · doi:10.1002/humu.20288 · Cited by 105
Distributions of ACE and APOE Polymorphisms and Their Relations With Dementia Status in Korean Centenarians
Choi, Y. H., Kim, J.-H., Kim, D. K., Kim, J.-W., Kim, D., Lee, M. S., Kim, C. H., & Park, S. C. (2003) · The Journals of Gerontology Series A · doi:10.1093/gerona/58.3.m227 · Cited by 103
Apolipoprotein E polymorphism and susceptibility to Alzheimer's disease.
Kamboh, M. I. (1995) · PubMed · Cited by 105
Physical Activity and Alzheimer Disease Course
Scarmeas, N., Luchsinger, J. A., Brickman, A. M., Cosentino, S., Schupf, N., Xin-Tang, M., Gu, Y., & Stern, Y. (2010) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181eb00a9 · Cited by 112
Longevity: Lesson from Model Organisms
Taormina, G., Ferrante, F., Vieni, S., Grassi, N., Russo, A. G., & Mirisola, M. G. (2019) · Genes · doi:10.3390/genes10070518 · Cited by 112
REVIEW ARTICLE. MICROSATELLITES AND PCR GENOMIC ANALYSIS
Koreth, J., O’Leary, J. J., & McGee, J. O. (1996) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(199603)178:3 · Cited by 104
Metabolic age modelling: the lesson from centenarians
Paolisso, G., Barbieri, M., Bonafè, M., & Franceschi, C. (2000) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2000.00729.x · Cited by 102
Age-Dependent Association of Apolipoprotein E Genotypes With Stroke Subtypes in a Japanese Rural Population
Kokubo, Y., Chowdhury, A. H., Date, C., Yokoyama, A., Sobue, H., & Tanaka, H. (2000) · Stroke · doi:10.1161/01.str.31.6.1299 · Cited by 103
Genetic determinants of exceptional human longevity: insights from the Okinawa Centenarian Study
Willcox, D. C., Willcox, B. J., Hsueh, W., & Suzuki, M. (2006) · AGE · doi:10.1007/s11357-006-9020-x · Cited by 105
HLA-DR alleles display sex-dependent effects on survival and discriminate between individual and familial longevity
Ivanova, R. (1998) · Human Molecular Genetics · doi:10.1093/hmg/7.2.187 · Cited by 103
Polymorphism of the angiotensin-converting enzyme gene and cardiovascular disease
Schunkert, H. (1997) · Journal of Molecular Medicine · doi:10.1007/s001090050178 · Cited by 102
Association of Apo E Polymorphism With Plasma Lipid Levels in a Multiethnic Elderly Population
Pablos-Méndez, A., Mayeux, R. P., Ngai, C. I., Shea, S., & Berglund, L. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.12.3534 · Cited by 102
Angiotensin converting enzyme and endothelial nitric oxide synthase DNA polymorphisms and late onset Alzheimer's disease
Álvarez, R., Álvarez, V., Lahoz, C. H., Martinez, C., Pena, J., Sanchez, J. M., Guisasola, L. M., Salas‐Puig, J., Morís, G., Vidal, J. A. C., et al. (1999) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.67.6.733 · Cited by 98
Review and meta-analysis of genetic polymorphisms associated with exceptional human longevity
Revelas, M., Thalamuthu, A., Oldmeadow, C. J., Evans, T., Armstrong, N. J., Kwok, J. B., Brodaty, H., Schofield, P. R., Scott, R. J., Sachdev, P. S., et al. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.06.002 · Cited by 96
A forkhead in the road to longevity: the molecular basis of lifespan becomes clearer
Morris, B. J. (2005) · Journal of Hypertension · doi:10.1097/01.hjh.0000173509.45363.dd · Cited by 98
Recent advances in human gene–longevity association studies
BENEDICTIS, G. D. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00247-0 · Cited by 97
Changes in the Renin-Angiotensin-Aldosterone Axis in Later Life
Belmin, J., Levy, B. I., & Michel, J. (1994) · Drugs & Aging · doi:10.2165/00002512-199405050-00007 · Cited by 96
Association Between Angiotensin-Converting Enzyme and Alzheimer Disease
Farrer, L. A., Sherbatich, T., Keryanov, S. A., Коровайцева, Г. И., Rogaeva, E. A., Petruk, S., Premkumar, S., Moliaka, Y., Song, Y., Pei, Y., et al. (2000) · Archives of Neurology · doi:10.1001/archneur.57.2.210 · Cited by 94
Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: A disease susceptibility polymorphism
Kammerer, S., Hamuro, L., Ma, Y., Hamon, S., Cánaves, J. M., Shi, M. M., Nelson, M. R., Sing, C. F., Cantor, C. R., Taylor, S. S., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2628028100 · Cited by 95
APOE and the risk of PD with or without dementia in a population-based study
Harhangi, B. S., de Rijk, M. C., van Duijn, C. M., Broeckhoven, C. V., Albert Hofman, D., & Breteler, M. M. B. (2000) · Neurology · doi:10.1212/wnl.54.6.1272 · Cited by 95
Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan
Joshi, P. K., Fischer, K., Schraut, K. E., Campbell, H. J., Esko, T., & Wilson, J. F. (2016) · Nature Communications · doi:10.1038/ncomms11174 · Cited by 91
Relation of Coronary Atherosclerosis and Apolipoprotein E Genotypes in Alzheimer Patients
Kosunen, O., Talasniemi, S., Lehtovirta, M., Heinonen, O., Helisalmi, S., Mannermaa, A., Paljärvi, L., Ryynänen, M., Riekkinen, P. J., & Soininen, H. (1995) · Stroke · doi:10.1161/01.str.26.5.743 · Cited by 95

Authors: Schächter, F., Faure-Delanef, L., Guénot, F., Rouger, H., Froguel, P., Lesueur-Ginot, L., & Cohen, D.
Affiliations: Fondation Jean Dausset-CEPH (FR)
ORCID: Froguel, Philippe
Cohen, Daniel
Venue: Nature Genetics
Publisher: Springer Science and Business Media LLC
Published: 1994-01
Volume: 6
Issue: 1
Pages: 29-32
ISSN: 1061-4036 (ISSN-L)
1546-1718
DOI: 10.1038/ng0194-29
OpenAlex: W2069863984
Cited by: 1,095
References: 36
Citations by year: 2026: 11 · 2025: 15 · 2024: 17 · 2023: 14 · 2022: 22 · 2021: 18 · 2020: 26 · 2019: 30 · 2018: 22 · 2017: 29 · 2016: 33 · 2015: 28 · 2014: 33 · 2013: 27 · 2012: 33
FWCI: 39.36
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Genetics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
Keywords: human longevity, centenarians, apolipoprotein E, APOE ε4, angiotensin-converting enzyme, ACE I/D polymorphism, genetic association, atherosclerosis, coronary artery disease, cardiovascular risk, hyperlipidemia, pleiotropy, differential survival
MeSH terms: Adult, Aged, Aged, 80 and over, Alleles, Apolipoproteins E, Base Sequence, Female, France, Gene Frequency, Genotype, Humans, Peptidyl-Dipeptidase A, Longevity, Male, Middle Aged, Molecular Sequence Data, Polymorphism, Genetic, Sex Characteristics, Case-Control Studies

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Genetic associations with human longevity at the APOE and ACE loci

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