Genetic associations with human longevity at the APOE and ACE loci

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268

Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction.

Weber, J. L., & May, P. E. (1989) · Europe PMC (PubMed Central) · Cited by 3,399

Aging, natural death, and the compression of morbidity

Fries, J. F. (1980) · New England Journal of Medicine · doi:10.1056/nejm198007173030304 · Cited by 3,356

Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.

Hixson, J., & Vernier, D. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)43176-1 · Cited by 2,933

Apolipoprotein E polymorphism and atherosclerosis.

Davignon, J., Gregg, R. E., & Sing, C. F. (1988) · Arteriosclerosis: An Official Journal of the American Heart Association, Inc. · doi:10.1161/01.atv.8.1.1 · Cited by 1,981

Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction

Cambien, F., Poirier, O., Lecerf, L., Evans, A., Cambou, J., Arveiler, D., Luc, G., Bard, J., Bara, L., Ricard, S., et al. (1992) · Nature · doi:10.1038/359641a0 · Cited by 1,908

PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1)

Rigat, B. A., Hübert, C., Corvol, P. L., & Soubrier, R. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.6.1433-a · Cited by 1,237

Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels.

Tiret, L., Rigat, B. A., Visvikis‐Siest, S., Breda, C., Corvol, P. L., Cambien, F., & Soubrier, F. (1992) · Europe PMC (PubMed Central) · Cited by 1,174

Evolution of senescence: late survival sacrificed for reproduction

Kirkwood, T. B. L., & Rose, M. R. (1991) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1991.0028 · Cited by 1,127

We Are Ageing

Kolovou, G. D., Kolovou, V., & Mavrogeni, S. I. (2014) · BioMed Research International · doi:10.1155/2014/808307 · Cited by 33

SARS CoV2 infection _The longevity study perspectives

Lio, D., Scola, L., Giarratana, R. M., Candore, G., Colonna‐Romano, G., Caruso, C., & Balistreri, C. R. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101299 · Cited by 33

Variation in NPC1, the gene encoding Niemann–Pick C1, a protein involved in intracellular cholesterol transport, is associated with Alzheimer disease and/or aging in the Polish population

Erickson, R. P., Larson‐Thomé, K., Weberg, L., Szybińska, A., Mossakowska, M., Styczyńska, M., Barcikowska, M., & Kuźnicki, J. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.09.046 · Cited by 33

The genotype interactions of methylenetetrahydrofolate reductase and renin-angiotensin system genes are associated with myocardial infarction

Fernández‐Arcás, N., Dieguez-Lucena, J. L., Muñoz‐Morán, E., Ruiz-Galdón, M., Caliani, S. E., Aranda-Lara, P., Martinez-Espigares, S., Banderas-Donaire, M. J., de Teresa–Galván, E., & Reyes‐Engel, A. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(99)00080-5 · Cited by 33

ICC-dementia (International Centenarian Consortium - dementia): an international consortium to determine the prevalence and incidence of dementia in centenarians across diverse ethnoracial and sociocultural groups

Brodaty, H., Woolf, C., Andersen, S. L., Barzilai, N., Brayne, C., Cheung, K. S.-L., Corrada, M. M., Crawford, J. D., Daly, C., Gondo, Y., et al. (2016) · BMC Neurology · doi:10.1186/s12883-016-0569-4 · Cited by 33

Parental longevity and mortality amongst Japanese men and women: the JACC Study

Ikeda, A., Iso, H., Toyoshima, H., Kondo, T., Mizoue, T., Koizumi, A., Inaba, Y., Tamakoshi, A., & JACC STUDY GROUP (2006) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2005.01609.x · Cited by 33

Aging and longevity genes.

Jazwinski, S. M. (2000) · Acta Biochimica Polonica · doi:10.18388/abp.2000_4007 · Cited by 33

Human apolipoprotein E allele-specific brain expressing transgenic mice

Smith, J. D., Sikes, J. L., & Levin-Allerhand, J. A. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00076-1 · Cited by 33

Apolipoprotein E type ϵ4 allele frequency is not increased in patients with sporadic inclusion-body myositis

Harringtonaa, C. R., Anderson, J. R., & Chan, K. K. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(94)11108-u · Cited by 33

The biology of senescence: potential for prevention of disease

Kirkland, J. L. (2002) · Clinics in Geriatric Medicine · doi:10.1016/s0749-0690(02)00023-x · Cited by 33

DNA polymorphism-diet-cofactor-development hypothesis and the gene-teratogen model for schizophrenia and other developmental disorders

Johnson, W. G. (1999) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19990820)88:4 · Cited by 33

Genetics of human longevity: From variants to genes to pathways

Smulders, L., & Deelen, J. (2023) · Journal of Internal Medicine · doi:10.1111/joim.13740 · Cited by 41

Study on a possible effect of four longevity candidate genes (ACE, PON1, PPAR-γ, and APOE) on human fertility

Corbo, R. M., Ulizzi, L., Piombo, L., & Scacchi, R. (2008) · Biogerontology · doi:10.1007/s10522-008-9143-9 · Cited by 32

Stem cells and aging from a quasi‐immortal point of view

Böhm, A.-M., Rosenstiel, P. C., & Bosch, T. C. G. (2013) · BioEssays · doi:10.1002/bies.201300075 · Cited by 33

The Epsilon 2 and 4 Alleles of Apolipoprotein E and Ischemic Vascular Events in the Greek Population — Implications for the Interpretation of Similar Studies

Kolovou, G. D., Daskalova, D. C., Hatzivassiliou, M., Yiannakouris, N., Pilatis, N. D., Elisaf, M., Mikhailidis, D. P., Cariolou, M. A., & Cokkinos, D. V. (2003) · Angiology · doi:10.1177/000331970305400107 · Cited by 33

Promoter polymorphism (-491A/T) in the APOE gene of Finnish Alzheimer's disease patients and control individuals

Helisalmi, S., Hiltunen, M. O., Valonen, P. K., Mannermaa, A., Koivisto, A. M., Lehtovirta, M., Ryynänen, M., & Soininen, H. S. (1999) · Journal of Neurology · doi:10.1007/s004150050461 · Cited by 32

The ApoE Locus and COVID-19: Are We Going Where We Have Been?

Finch, C. E., & Kulminski, A. M. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa200 · Cited by 31

A Genome Wide Association Study for Longevity in Cattle

Mészáros, G., Eaglen, S., Waldmann, P., & Sölkner, J. (2014) · Open Journal of Genetics · doi:10.4236/ojgen.2014.41007 · Cited by 31

Centenarians as Models of Resistance and Resilience to Alzheimer’s Disease and Related Dementias

Andersen, S. L. (2020) · Advances in Geriatric Medicine and Research · doi:10.20900/agmr20200018 · Cited by 35

Birth cohort differences in the prevalence of longevity-associated variants in APOE and FOXO3A in Danish long-lived individuals

Nygaard, M., Lindahl‐Jacobsen, R., Soerensen, M., Mengel‐From, J., Andersen‐Ranberg, K., Jeune, B., Vaupel, J. W., Tan, Q., Christiansen, L., & Christensen, K. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.04.018 · Cited by 31

The heritability of cause‐specific mortality: a correlated gamma‐frailty model applied to mortality due to respiratory diseases in Danish twins born 1870–1930

Wienke, A., Holm, N. V., Christensen, K., Skytthe, A., Vaupel, J. W., & Yashin, A. I. (2003) · Statistics in Medicine · doi:10.1002/sim.1669 · Cited by 31

Relation of a Common Mutation in Methylenetetrahydrofolate Reductase to Plasma Homocysteine and Early Onset Coronary Artery Disease

Dunn, J., Title, L. M., Bata, I. R., Johnstone, D. E., Kirkland, S., O’Neill, B. J., Zayed, E., MacDonald, M. C., Dempsey, G. I., & Nassar, B. A. (1998) · Clinical Biochemistry · doi:10.1016/s0009-9120(97)00165-3 · Cited by 31

Angiotensin I–converting enzyme and plasminogen activator inhibitor-1 gene variants: risk of mortality and fatal cardiovascular disease in an elderly population-based cohort

Heijmans, B. T., Westendorp, R. G. J., Knook, D. L., Kluft, C., & Slagboom, P. E. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00337-x · Cited by 31

Cost-Effectiveness of Magnetic Resonance Imaging with a New Contrast Agent for the Early Diagnosis of Alzheimer's Disease

Biasutti, M., Dufour, N., Ferroud, C., Dab, W., & Temime, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035559 · Cited by 33

Genetics of frailty: A longevity perspective

Sathyan, S., & Verghese, J. (2020) · Translational research · doi:10.1016/j.trsl.2020.03.005 · Cited by 32

Particle Nanoarchitectonics for Nanomedicine and Nanotherapeutic Drugs with Special Emphasis on Nasal Drugs and Aging

Aziz, T. A., Nadeem, A. A., Sarwar, A., Perveen, I., Hussain, N., Khan, A. A., Daudzai, Z., Cui, H., & Lin, L. (2023) · Biomedicines · doi:10.3390/biomedicines11020354 · Cited by 31

Genes Against Aging

Miller, R. A. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls082 · Cited by 30

Angiotensin converting enzyme insertion/deletion polymorphism in sporadic and familial Alzheimer's disease and longevity

Nacmias, B., Bagnoli, S., Tedde, A., Cellini, E., Bessi, V., Guarnieri, B., Ortensi, L., Piacentini, S., Bracco, L., & Sorbi, S. (2006) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2006.10.011 · Cited by 30

Apolipoprotein E allele in centenarians

Asada, T., Kariya, T., Yamagata, Z., Kinoshita, T., & Asaka, A. (1996) · Neurology · doi:10.1212/wnl.46.5.1484 · Cited by 30

Alzheimer's Disease, ß-Amyloidosis, and Aging

Coria, F., Rubio, I., & Bayón, C. (1994) · Reviews in the Neurosciences · doi:10.1515/revneuro.1994.5.4.275 · Cited by 34

Angiotensin I-converting enzyme gene polymorphism in a Serbian population: a gender-specific association with hypertension

Stanković, A., Živković, M., & Alavantić, D. (2002) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365510260390028 · Cited by 30

Genetic influences on aging

Johnson, T. (1997) · Experimental Gerontology · doi:10.1016/s0531-5565(96)00079-4 · Cited by 30

Angiotensin-converting enzyme deletion allele is beneficial for the longevity of Europeans

Petranović, M. Z., Škarić‐Jurić, T., Narančić, N. S., Tomas, Ž., Krajačić, P., Miličić, J., Barbalić, M., & Tomek-Roksandić, S. (2011) · AGE · doi:10.1007/s11357-011-9270-0 · Cited by 29

Stem Cell Transcription Factor FoxO Controls Microbiome Resilience in Hydra

Mortzfeld, B. M., Taubenheim, J., Fraune, S., Klimovich, A. V., & Bosch, T. C. G. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00629 · Cited by 33

Living long and ageing well: is epigenomics the missing link between nature and nurture?

The ACUME2 Project, Rea, I. M., Dellett, M., & Mills, K. (2015) · Biogerontology · doi:10.1007/s10522-015-9589-5 · Cited by 29

The biology of ageing

de Magalhães, J. P. (2011) · Cambridge University Press eBooks · doi:10.1017/cbo9780511973697.002 · Cited by 33

High-Density Genomewide Linkage Analysis of Exceptional Human Longevity Identifies Multiple Novel Loci

Boyden, S. E., & Kunkel, L. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012432 · Cited by 29

Apolipoprotein E Genotype and Age at Menopause

Koochmeshgi, J., HOSSEINI‐MAZINANI, S. M., Seifati, S. M., HOSEIN‐PUR‐NOBARI, N., & Teimoori‐Toolabi, L. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1297.105 · Cited by 29

Tracking the decline in cerebral glucose metabolism in persons and laboratory animals at genetic risk for Alzheimer's disease

Reiman, E. M., Caselli, R. J., Alexander, G. E., & Chen, K. (2001) · Clinical Neuroscience Research · doi:10.1016/s1566-2772(01)00006-8 · Cited by 28

Apolipoprotein E genotype in Spanish patients of Alzheimer's or Parkinson's disease

Ibarreta, D., Gómez‐Isla, T., Portera‐Sánchez, A., Parrilla, R., & Ayuso, M. S. (1995) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(95)00238-3 · Cited by 29

Single nucleotide polymorphism spectra in newborns and centenarians: identification of genes coding for rise of mortal disease1Published in conjunction with A Wisconsin Gathering Honouring Waclaw Szybalski on the occasion of his 75th year and 20 years of Editorship-in-Chief of Gene, 10–11 August 1997, University of Wisconsin, Madison, WI, USA.1

Tomita‐Mitchell, A., Muniappan, B. P., Herrero-Jimenez, P., Zarbl, H., & Thilly, W. G. (1998) · Gene · doi:10.1016/s0378-1119(98)00408-9 · Cited by 29

Limitations and risks of meta-analyses of longevity studies

Sebastiani, P., Bae, H. T., Gurinovich, A., Soerensen, M., Puca, A. A., & Perls, T. T. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.01.008 · Cited by 29

Analysis of Common Polymorphisms in Angiotensin-converting Enzyme and Apolipoprotein E Genes and Human Longevity in Colombia

Forero, D. A., Pinzón, J. E., Arboleda, G., Yunis, J. J., Álvarez, C., Cataño, N., & Arboleda, H. (2006) · Archives of Medical Research · doi:10.1016/j.arcmed.2006.04.001 · Cited by 28

Assessment of APOE in atypical parkinsonism syndromes

Sabir, M. S., Blauwendraat, C., Ahmed, S., Serrano, G. E., Beach, T. G., Perkins, M., Rice, A. C., Masliah, E., Morris, C. M., Pihlstrom, L., et al. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.02.016 · Cited by 28

Aging and Longevity: A Paradigm of Complementation between Homeostatic Mechanisms and Genetic Control?

Petropoulou, C., Chondrogianni, N., Simoes, D. C. M., Agiostratidou, G., DROSOPOULOS, N., KOTSOTA, V., & Gonos, E. S. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06642.x · Cited by 27

Frequency of replication/transcription errors in (A)/(T) runs of human genes

Paoloni‐Giacobino, A., Rossier, C., Papasavvas, M.-P., & Antonarakis, S. E. (2001) · Human Genetics · doi:10.1007/s004390100541 · Cited by 28

Genetic Epidemiology in Aging Research

Fallin, M. D., & Matteini, A. M. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/gln021 · Cited by 27

The impact of apolipoprotein E4 on cause of death in Alzheimer's disease

Olichney, J., Sabbagh, M. N., Hofstetter, C. R., Galasko, D. R., Grundman, M., Katzman, R., & Thal, L. J. (1997) · Neurology · doi:10.1212/wnl.49.1.76 · Cited by 28

APOLIPOPROTEIN E AND LONGEVITY: THE ROTTERDAM STUDY

Slooter, A. J. C., Cruts, M., Broeckhoven, C. V., Albert Hofman, D., & van Duijin, C. M. (2001) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2001.49251.x · Cited by 28

Loss of renal function following bone marrow transplantation: an analysis of angiotensin converting enzyme D/I polymorphism and other clinical risk factors

Juckett, M. B., Cohen, E., Keever-Taylor, C. A., Zheng, Y., Lawton, C., Moulder, J. E., & Klein, J. P. (2001) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1702797 · Cited by 28

Relation of genetic polymorphisms of apolipoprotein E, angiotensin converting enzyme, apolipoprotein B-100, and glycoprotein IIIa and early-onset coronary heart disease

Nassar, B. A., Dunn, J., Title, L. M., O’Neill, B. J., Kirkland, S., Zayed, E., Bata, I. R., Cantrill, R. C., Johnstone, J., Dempsey, G. I., et al. (1999) · Clinical Biochemistry · doi:10.1016/s0009-9120(99)00017-x · Cited by 28

Influence of apolipoprotein E polymorphism on plasma vitamin A and vitamin E levels

Gómez‐Coronado, D., Bueno, A. E., Álvarez, J. J., Ortega, H., Olmos, J. M., Castro, M., Sastre, A., Herrera, E., & Lasunción, M. A. (2002) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2002.00983.x · Cited by 27

GWAS and Meta-Analysis in Aging/Longevity

Broer, L., & van Duijn, C. M. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-2404-2_5 · Cited by 29

Evolution, developmental plasticity, and metabolic disease

Kuzawa, C. W., Gluckman, P. D., Hanson, M. A., & Beedle, A. S. (2007) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199207466.003.0019 · Cited by 27

Lipoproteins, Vascular-Related Genetic Factors, and Human Longevity

Panza, F., D’Introno, A., Capurso, C. A., Colacicco, A. M., Seripa, D., Pilotto, A., Santamato, A., Capurso, A., & Solfrizzi, V. (2007) · Rejuvenation Research · doi:10.1089/rej.2007.0537 · Cited by 27

Genes and longevity: a genetic-demographic approach reveals sex- and age-specific gene effects not shown by the case–control approach (APOE and HSP70.1 loci)

Dato, S., Carotenuto, L., & BENEDICTIS, G. D. (2006) · Biogerontology · doi:10.1007/s10522-006-9030-1 · Cited by 27

Preservation of cognitive and functional ability as markers of longevity

Schupf, N., Costa, R., Tang, M., Andrews, H., Tycko, B., Lee, J. H., & Mayeux, R. P. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.11.010 · Cited by 27

Angiotensin I-Converting Enzyme Gene Polymorphism in Two Ethnic Groups Living in Brazil's Southern Region: Association With Age

da Cruz, I. B. M., Oliveira, G., Taufer, M., Leal, N. F., Schwanke, C. H. A., Glock, L., Moriguchi, Y., & Moriguchi, E. H. (2003) · The Journals of Gerontology Series A · doi:10.1093/gerona/58.9.m851 · Cited by 27

The tRNA(Gln) 4336 mitochondrial DNA variant is not a high penetrance mutation which predisposes to dementia before the age of 75 years.

Tysoe, C. J., Robinson, D., Brayne, C., Dening, T., Paykel, E. S., Huppert, F. A., & Rubinsztein, D. C. (1996) · Journal of Medical Genetics · doi:10.1136/jmg.33.12.1002 · Cited by 26

Impact of apolipoprotein E genotype variation on means, variances, and correlations of plasma lipid, lipoprotein, and apolipoprotein traits in octogenarians

Haviland, M. B., Lussier‐Cacan, S., Davignon, J., & Sing, C. F. (1995) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320580405 · Cited by 26

Apolipoprotein E, Alzheimer disease, and African Americans

Mayeux, R. (2003) · Archives of Neurology · doi:10.1001/archneur.60.2.161 · Cited by 26

Familial Longevity Is Marked by Better Cognitive Performance at Middle Age: The Leiden Longevity Study

Stijntjes, M., de Craen, A. J. M., van Heemst, D., Meskers, C. G. M., van Buchem, M. A., Westendorp, R. G. J., Slagboom, P. E., & Maier, A. B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057962 · Cited by 27

Genomes of Strongylocentrotus franciscanus and Lytechinus variegatus: are there any genomic explanations for the two order of magnitude difference in the lifespan of sea urchins?

Владимирович, С. П., Artemov, A. V., Prokhortchouk, E., Dontsova, O. А., & Berezkin, G. V. (2016) · Aging · doi:10.18632/aging.100889 · Cited by 26

Centenarians as models of healthy aging: Example of REST

Marcos-Pérez, D., Saenz‐Antoñanzas, A., & Matheu, A. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101392 · Cited by 26

Who Are the Okinawans? Ancestry, Genome Diversity, and Implications for the Genetic Study of Human Longevity From a Geographically Isolated Population

Bendjilali, N., Hsueh, W.-C., He, Q., Willcox, D. C., Nievergelt, C. M., Donlon, T. A., Kwok, P., Suzuki, M., & Willcox, B. J. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt203 · Cited by 26

Societal development and the shifting influence of the genome on status attainment

Adkins, D. E., & Guo, G. (2008) · Research in Social Stratification and Mobility · doi:10.1016/j.rssm.2008.06.001 · Cited by 26

Association of common variants in TOMM40/APOE/APOC1 region with human longevity in a Chinese population

Lin, R., Zhang, Y., Yan, D., Liao, X., Gong, G., Hu, J., Fu, Y., & Cai, W. (2015) · Journal of Human Genetics · doi:10.1038/jhg.2015.150 · Cited by 28

Lifestyle, diet, and disease: comparative perspectives on the determinants of chronic health risks

Leonard, W. R. (2007) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199207466.003.0020 · Cited by 26

Aging and Apolipoprotein E in HIV Infection

Geffin, R., & McCarthy, M. (2018) · Journal of NeuroVirology · doi:10.1007/s13365-018-0660-2 · Cited by 29

Lack of genetic association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and longevity in a Han Chinese population

Yang, J., Gong, Y., Xie, L., Lian, S.-G., Yang, J., Xu, L., Gao, S., & Zhang, Y. (2009) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320309104873 · Cited by 25

Exceptional survival in human populations: National Institute on Aging perspectives and programs

Hadley, E. C., & Rossi, W. K. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.08.014 · Cited by 26

Genome Survey for Loci That Influence Successful Aging: Sample Characterization, Method Validation, and Initial Results for the Y Chromosome

Zubenko, G. S., Stiffler, J. S., Hughes, H. B., Fatigati, M. J., & Zubenko, W. N. (2002) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200209000-00016 · Cited by 26

Apolipoprotein E and mortality in African-Americans and Yoruba

Lane, K. A., Gao, S., Hui, S. L., Murrell, J. R., Hall, K. S., & Hendrie, H. C. (2003) · Journal of Alzheimer s Disease · doi:10.3233/jad-2003-5505 · Cited by 26

Discovery of a brain promoter from the human transferrin gene and its utilization for development of transgenic mice that express human apolipoprotein E alleles.

Bowman, B. H., Jansen, L., Yang, F., Adrian, G. S., Zhao, M., Atherton, S. S., Buchanan, J. M., Greene, R., Walter, C. A., & Herbert, D. C. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.26.12115 · Cited by 26

Apolipoprotein E Genotype: Utility in Clinical Practice in Alzheimer's Disease

Roses, A. D., Bryan, J., & Bryan, K. (1996) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1996.tb04077.x · Cited by 26

DNA methylation in genes associated with the evolution of ageing and disease: A critical review

Auley, M. T. M. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101488 · Cited by 25

One step closer to fixing association studies: evidence for age- and gender-specific allele frequency variations and deviations from Hardy-Weinberg expectations in controls

Payami, H., Zhu, M., Montimurro, J. S., Keefe, R. G., McCulloch, C. C., & Moses, L. (2005) · Human Genetics · doi:10.1007/s00439-005-0057-1 · Cited by 25

Age-Dependent Cytokine Responses: Trimethyltin Hippocampal Injury in Wild-Type, APOE Knockout, and APOE4 Mice

Harry, G. J., d’Hellencourt, C. L., Bruccoleri, A., & Schmechel, D. E. (2000) · Brain Behavior and Immunity · doi:10.1006/brbi.2000.0606 · Cited by 26

Interaction between apolipoprotein-E and angiotensin-converting enzyme genotype in Alzheimer's disease

İşbir, T., Ağaçhan, B., Yılmaz, H., Aydın, M., Kara, İ., Eker, D., & Eker, E. (2001) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/153331750101600407 · Cited by 24

Genetic influences on life span and survival among elderly African‐Americans, Caribbean Hispanics, and Caucasians

Lee, J. H., Flaquer, A., Costa, R., Andrews, H., Cross, P. S., Lantigua, R., Schupf, N., Tang, M., & Mayeux, R. P. (2004) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.30062 · Cited by 25

Genetic determinants of ageing processes and diseases in later life

Bostock, C. V., Soiza, R. L., & Whalley, L. J. (2009) · Maturitas · doi:10.1016/j.maturitas.2008.12.012 · Cited by 24

Small babies receive the cardiovascular protective apolipoprotein ε2 allele less frequently than expected

Infante‐Rivard, C., Levy, E. H., Rivard, G., Guiguet, M., & Feoli-Fonseca, J.-C. (2003) · Journal of Medical Genetics · doi:10.1136/jmg.40.8.626 · Cited by 25

Angiotensin-Converting Enzyme Gene Polymorphisms in Patients with Pulmonary Sarcoidosis

Schürmann, M. (2003) · American Journal of PharmacoGenomics · doi:10.2165/00129785-200303040-00002 · Cited by 24

Logistic Regression Models for Polymorphic and Antagonistic Pleiotropic Gene Action on Human Aging and Longevity

Tan, Q., Bathum, L., Christiansen, L., BENEDICTIS, G. D., Dahlgaard, J., Frizner, N., Vach, W., Vaupel, J. W., Yashin, A. I., Christensen, K., et al. (2003) · Annals of Human Genetics · doi:10.1046/j.1529-8817.2003.00051.x · Cited by 25

Is Angiotensin I-Converting Enzyme a "Master" Disease Gene?

Moskowitz, D. W. (2002) · Diabetes Technology & Therapeutics · doi:10.1089/152091502320798321 · Cited by 25

Human APOE4 Protects High-Fat and High-Sucrose Diet Fed Targeted Replacement Mice against Fatty Liver Disease Compared to APOE3

Huebbe, P., Bilke, S., Rueter, J., Schloesser, A., Campbel, G., Glüer, C.-C., Lucius, R., Röcken, C., Tholey, A., & Rimbach, G. (2024) · Aging and disease · doi:10.14336/ad.2023.0530 · Cited by 24

Aspectos genéticos do envelhecimento e doenças associadas: uma complexa rede de interações entre genes e ambiente

Gottlieb, M. G. V., Carvalho, D., Schneider, R. H., & da Cruz, I. B. M. (2007) · Revista Brasileira de Geriatria e Gerontologia · doi:10.1590/1809-9823.2007.10032 · Cited by 24

Varying Effects of APOE Alleles on Extreme Longevity in European Ethnicities

Gurinovich, A., Andersen, S. L., Puca, A. A., Atzmon, G., Barzilai, N., & Sebastiani, P. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz179 · Cited by 24

Genes and life-style factors in BELFAST nonagenarians: Nature, Nurture and Narrative

Rea, J. N. M., Carvalho, A., McNerlan, S., Alexander, H. D., & Rea, I. M. (2015) · Biogerontology · doi:10.1007/s10522-015-9567-y · Cited by 24

Design and analysis in genetic studies of human ageing and longevity

Tan, Q., Kruse, T. A., & Christensen, K. (2005) · Ageing Research Reviews · doi:10.1016/j.arr.2005.10.002 · Cited by 25

Association Study of Apolipoprotein Eε4with Clinical Phenotype and Clozapine Response in Schizophrenia

Hong, C., Yu, Y. W. ‐., Lin, C., Song, H., Lai, H., Yang, K., & Tsai, S. (2000) · Neuropsychobiology · doi:10.1159/000026689 · Cited by 24

Apolipoprotein E4 and Alzheimer's disease in São Paulo - Brazil

Almeida, O. P., & Shimokomaki, C. M. (1997) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x1997000100001 · Cited by 25

No association between DCP1 genotype and late‐onset Alzheimer disease

Buss, S., Müller‐Thomsen, T., Hock, C., Alberici, A., Binetti, G. G., Nitsch, R. M., Gal, A., & Finckh, U. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10306 · Cited by 24

No implication of apolipoprotein E polymorphism in Italian schizophrenic patients

Sorbi, S., Nacmias, B., Tedde, A., Latorraca, S., Forleo, P., Guarnieri, B., Petruzzi, C., Daneluzzo, E., Ortenzi, L., Piacentini, S., et al. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00144-x · Cited by 24

Molecular biology of brain aging and neurodegenerative disorders

Wısnıewskı, T., & Frangione, B. (1996) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-1996-1132 · Cited by 24

There Is a Pathologic Relationship Between ApoE- 4 and Alzheimer's Disease

Corder, E. H., Saunders, A. M., Pericak‐Vance, M. A., & Roses, A. D. (1995) · Archives of Neurology · doi:10.1001/archneur.1995.00540310012003 · Cited by 24

The genetics of neurodegenerative diseases is the genetics of age-related damage clearance failure

Hardy, J., & Escott‐Price, V. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-02911-7 · Cited by 25

Exome-Wide Association Study Identifies FN3KRP and PGP as New Candidate Longevity Genes

Torres, G. G., Nygaard, M., Caliebe, A., Blanché, H., Chantalat, S., Galan, P., Lieb, W., Christiansen, L., Deleuze, J., Christensen, K., et al. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glab023 · Cited by 23

Burden of disease variants in participants of the long life family Study

Duncan, M. S., Bae, H. T., Schupf, N., Andersen, S. L., Zhang, Q., Perls, T. T., & Sebastiani, P. (2015) · Aging · doi:10.18632/aging.100724 · Cited by 23

The Frequency of 4 Common Gene Polymorphisms in Nonagenarians, Centenarians, and Average Life Span Individuals

Kolovou, G. D., Kolovou, V., Vasiliadis, I. K., Giannakopoulou, V., Mihas, C. C., Bilianou, H. I., Kollia, A., Papadopoulou, E., Marvaki, A., Goumas, G., et al. (2013) · Angiology · doi:10.1177/0003319712475075 · Cited by 22

Vascular genetic factors and human longevity

Panza, F., D’Introno, A., Colacicco, A. M., Capurso, C. A., Capurso, S. A., Kehoe, P. G., Capurso, A., & Solfrizzi, V. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2003.12.005 · Cited by 41

Sex Differences in the Association of Apolipoprotein E and Angiotensin-Converting Enzyme Gene Polymorphisms With Healthy Aging and Longevity: A Population-Based Study From Southern Italy

Seripa, D., Franceschi, M., Matera, M. G., Panza, F., Kehoe, P. G., Gravina, C., Orsitto, G., Solfrizzi, V., Minno, G. D., Dallapiccola, B., et al. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.9.918 · Cited by 78

APOE and longevity: study of a population of Sardinian Centenarians

Bellia, C., Sasso, B. L., Caruso, A., Liga, L., Raineri, R., Agnello, L., Bazza, F., & Ciaccio, M. (2011) · Nova Science Publishers (Nova Science Publishers, Inc.)

APOLIPOPROTEIN E, DEMENTIA, AND HUMAN LONGEVITY

Panza, F., Frisardi, V., Capurso, C. A., D’Introno, A., Colacicco, A. M., Seripa, D., Pilotto, A., Vendemiale, G., Capurso, A., & Solfrizzi, V. (2009) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2009.02211.x · Cited by 8

The ApoE Gene Is Related with Exceptional Longevity: A Systematic Review and Meta-Analysis

Garatachea, N., Marin, P. J., Santos‐Lozano, A., Sanchis‐Gomar, F., Emanuele, E., & Lucía, A. (2014) · Rejuvenation Research · doi:10.1089/rej.2014.1605 · Cited by 59