Cryptic boundaries in roof plate and choroid plexus identified by intersectional gene activation
Abstract
The hindbrain roof plate and choroid plexus are essential organizing centers for inducing dorsal neuron fates and sustaining neuron function. To map the formation of these structures, we developed a broadly applicable, high resolution, recombinase-based method for mapping the fate of cells originating from coordinates defined by intersecting combinations of expressed genes. Using this method, we show that distinct regions of hindbrain roof plate originate from discrete subdomains of rhombencephalic neuroectoderm expressing Wnt1; that choroid plexus, a secretory epithelium important for patterning later-formed hindbrain structures and maintaining neuron function, derives from the same embryonic primordium as the hindbrain roof plate; and that, unlike the floor plate, these dorsal organizing centers develop in a patterned, segmental manner, built from lineage-restricted compartments. Our data suggest that the roof plate and choroid plexus may be formed of functional units that are capable of differentially organizing the generation of distinct neuronal cell types at different axial levels.
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Gene programs and graded expression patterns, particularly across 4V choroid plexus epithelial cells, may arise from the segmental development of the 4V choroid plexus from distinct rhombomeres.
“Gene programs and graded expression patterns, particularly across 4V ChP epithelial cells, may arise from the segmental development of the 4V ChP from distinct rhombomeres (Awatramani et al., 2003; Hunter and Dymecki, 2007).”
From A cellular and spatial map of the choroid plexus across brain ventricles and ages (2021) · cites this paper as Awatramani et al., 2003
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- Authors
- Awatramani, R., Soriano, P., Rodriguez, C., Mai, J. J., & Dymecki, S. M.
- Affiliations
- Harvard University (US)
- Fred Hutch Cancer Center (US)
- Corresponding author
- Dymecki, Susan M
- Venue
- Nature Genetics
- Published
- 2003-08-17
- Volume
- 35
- Issue
- 1
- Pages
- 70-75
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2004207259
- Cited by
- 215
- References
- 30
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 4 · 2023: 7 · 2022: 18 · 2021: 13 · 2020: 12 · 2019: 10 · 2018: 13 · 2017: 11 · 2016: 7 · 2015: 11 · 2014: 10 · 2013: 11 · 2012: 11
- FWCI
- 2.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of California, San Francisco
- National Human Genome Research Institute (F31HG000180)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Keywords
- roof plate, choroid plexus, hindbrain, Wnt1, neuroectoderm, segmental patterning, floor plate, neuronal cell types
- MeSH terms
- Alkaline Phosphatase, Animals, Choroid Plexus, DNA Nucleotidyltransferases, Mice, Transgenic, Neurons, Proto-Oncogene Proteins, Rhombencephalon, Viral Proteins, Gene Expression, Cell Lineage, Integrases, Zebrafish Proteins, Wnt Proteins, Wnt1 Protein, Mice
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